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Santiago Mascoma - One of the best experts on this subject based on the ideXlab platform.

  • phenotypes of intermediate forms of fasciola hepatica and f gigantica in buffaloes from central punjab pakistan
    Journal of Helminthology, 2014
    Co-Authors: K Afshan, M A Valero, Mazhar Qayyum, Raquel V Peixoto, A Magraner, Santiago Mascoma
    Abstract:

    Fascioliasis is an important food-borne parasitic disease caused by the two trematode species, Fasciola hepatica and Fasciola gigantica. The phenotypic features of fasciolid adults and eggs infecting buffaloes inhabiting the Central Punjab area, Pakistan, have been studied to characterize fasciolid populations involved. Morphometric analyses were made with a Computer Image Analysis system (CIAS) applied on the basis of standardized measurements. Since it is the first study of this kind undertaken in Pakistan, the results are compared to pure fasciolid populations: (a) F. hepatica from the European Mediterranean area; and (b) F. gigantica from Burkina Faso; i.e. geographical areas where both species do not co-exist. Only parasites obtained from bovines were used. The multivariate Analysis showed that the characteristics, including egg morphometrics, of fasciolids from Central Punjab, Pakistan, are between F. hepatica and F. gigantica standard populations. Similarly, the morphometric measurements of fasciolid eggs from Central Punjab are also between F. hepatica and F. gigantica standard populations. These results demonstrate the existence of fasciolid intermediate forms in endemic areas in Pakistan.

  • phenotypic comparison of allopatric populations of fasciola hepatica and fasciola gigantica from european and african bovines using a Computer Image Analysis system cias
    Parasitology Research, 2006
    Co-Authors: Maria Victoria Periago, M A Valero, Miroslava Panova, Santiago Mascoma
    Abstract:

    The quantification of the different sizes and shapes of Fasciola hepatica and Fasciola gigantica from bovines has been achieved for the first time in natural allopatric populations. Linear measurements, areas and ratios of gravid adults and eggs of F. hepatica (from France and Spain) and F. gigantica (from Burkina Faso) were analysed using a Computer Image Analysis system and an allometric model: \({{\left( {y_{{2{\text{m}}}} - y_{2} } \right)}} \mathord{\left/ {\vphantom {{{\left( {y_{{2{\text{m}}}} - y_{2} } \right)}} {y_{2} }}} \right. \kern-\nulldelimiterspace} {y_{2} } = c{\left[ {{{\left( {y_{{1{\text{m}}}} - y_{1} } \right)}} \mathord{\left/ {\vphantom {{{\left( {y_{{1{\text{m}}}} - y_{1} } \right)}} {y_{1} }}} \right. \kern-\nulldelimiterspace} {y_{1} }} \right]}^{b}\), where y1=body area or body length, y2=one of the measurements analysed, y1m, y2m=maximum values towards which y1 and y2, respectively, tend and c, b=constants. All the measurements overlap in the two fasciolids, apart from the distance between the ventral sucker and the posterior end of the body, body roundness and body length/body width ratio. The results obtained may be useful in Fasciola species identification in countries where both species coexist.

  • human and animal fascioliasis in mazandaran province northern iran
    Parasitology Research, 2004
    Co-Authors: A S Moghaddam, Maria Victoria Periago, J Massoud, M Mahmoodi, Amir Hossein Mahvi, Patricio Artigas, Marius V Fuentes, M D Bargues, Santiago Mascoma
    Abstract:

    The fascioliasis situation in humans and livestock of Iranian Mazandaran is analysed for the first time. Coprological studies showed 7.3% and 25.4% global prevalences in sheep and cattle, respectively. Studies in slaughterhouses indicate that sheep and cattle may be the main reservoir species, buffaloes may play local roles in the transmission, and goats and horses probably only participate sporadically. Morphometric studies by Computer Image Analysis showed that forms intermediate between Fasciola hepatica and F. gigantica appear in addition to both species. A total of 107 infected humans were diagnosed during the 1999–2002 period, which suggests that fascioliasis may be widespread. The absence of differences in human fascioliasis among gender and age groups differs from other human endemic areas. Both human and animal infections show marked differences between western and eastern Mazandaran. Traditions in herbal condiments for human consumption, methods of animal husbandry and annual rainfall may explain the higher prevalences in western Mazandaran.

Maria Victoria Periago - One of the best experts on this subject based on the ideXlab platform.

  • phenotypic comparison of allopatric populations of fasciola hepatica and fasciola gigantica from european and african bovines using a Computer Image Analysis system cias
    Parasitology Research, 2006
    Co-Authors: Maria Victoria Periago, M A Valero, Miroslava Panova, Santiago Mascoma
    Abstract:

    The quantification of the different sizes and shapes of Fasciola hepatica and Fasciola gigantica from bovines has been achieved for the first time in natural allopatric populations. Linear measurements, areas and ratios of gravid adults and eggs of F. hepatica (from France and Spain) and F. gigantica (from Burkina Faso) were analysed using a Computer Image Analysis system and an allometric model: \({{\left( {y_{{2{\text{m}}}} - y_{2} } \right)}} \mathord{\left/ {\vphantom {{{\left( {y_{{2{\text{m}}}} - y_{2} } \right)}} {y_{2} }}} \right. \kern-\nulldelimiterspace} {y_{2} } = c{\left[ {{{\left( {y_{{1{\text{m}}}} - y_{1} } \right)}} \mathord{\left/ {\vphantom {{{\left( {y_{{1{\text{m}}}} - y_{1} } \right)}} {y_{1} }}} \right. \kern-\nulldelimiterspace} {y_{1} }} \right]}^{b}\), where y1=body area or body length, y2=one of the measurements analysed, y1m, y2m=maximum values towards which y1 and y2, respectively, tend and c, b=constants. All the measurements overlap in the two fasciolids, apart from the distance between the ventral sucker and the posterior end of the body, body roundness and body length/body width ratio. The results obtained may be useful in Fasciola species identification in countries where both species coexist.

  • Phenotypic comparison of allopatric populations of Fasciola hepatica and Fasciola gigantica from European and African bovines using a Computer Image Analysis system (CIAS)
    Parasitology Research, 2006
    Co-Authors: Maria Victoria Periago, M A Valero, Miroslava Panova, S. Mas-coma
    Abstract:

    The quantification of the different sizes and shapes of Fasciola hepatica and Fasciola gigantica from bovines has been achieved for the first time in natural allopatric populations. Linear measurements, areas and ratios of gravid adults and eggs of F . hepatica (from France and Spain) and F . gigantica (from Burkina Faso) were analysed using a Computer Image Analysis system and an allometric model: % MathType!Translator!2!1!AMS LaTeX.tdl!TeX -- AMS-LaTeX! % MathType!MTEF!2!1!+- % feaaeaart1ev0aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbbjxAHX % garmWu51MyVXgatuuDJXwAK1uy0HwmaeHbfv3ySLgzG0uy0Hgip5wz % aebbnrfifHhDYfgasaacH8qrps0lbbf9q8WrFfeuY-Hhbbf9v8qqaq % Fr0xc9pk0xbba9q8WqFfea0-yr0RYxir-Jbba9q8aq0-yq-He9q8qq % Q8frFve9Fve9Ff0dmeaabaqaciGacaGaaeqabaWaaeWaeaaakeaada % WcgaqaamaabmaabaGaamyEamaaBaaaleaaruavP1wzZbItLDhis9wB % H5gaiuaacaWFYaGaaeyBaaqabaGccqGHsislcaWG5bWaaSbaaSqaai % aa-jdaaeqaaaGccaGLOaGaayzkaaaabaGaamyEamaaBaaaleaacaWF % YaaabeaaaaGccqGH9aqpcaWGJbWaamWaaeaadaWcgaqaamaabmaaba % GaamyEamaaBaaaleaacaWFXaGaaeyBaaqabaGccqGHsislcaWG5bWa % aSbaaSqaaiaa-fdaaeqaaaGccaGLOaGaayzkaaaabaGaamyEamaaBa % aaleaacaWFXaaabeaaaaaakiaawUfacaGLDbaadaahaaWcbeqaaiaa % dkgaaaaaaa!546F! $${{\left( {y_{{2{\text{m}}}} - y_{2} } \right)}} \mathord{\left/ {\vphantom {{{\left( {y_{{2{\text{m}}}} - y_{2} } \right)}} {y_{2} }}} \right. \kern-\nulldelimiterspace} {y_{2} } = c{\left[ {{{\left( {y_{{1{\text{m}}}} - y_{1} } \right)}} \mathord{\left/ {\vphantom {{{\left( {y_{{1{\text{m}}}} - y_{1} } \right)}} {y_{1} }}} \right. \kern-\nulldelimiterspace} {y_{1} }} \right]}^{b}$$ , where y _1=body area or body length, y _2=one of the measurements analysed, y _1m, y _2m=maximum values towards which y _1 and y _2, respectively, tend and c , b =constants. All the measurements overlap in the two fasciolids, apart from the distance between the ventral sucker and the posterior end of the body, body roundness and body length/body width ratio. The results obtained may be useful in Fasciola species identification in countries where both species coexist.

  • human and animal fascioliasis in mazandaran province northern iran
    Parasitology Research, 2004
    Co-Authors: A S Moghaddam, Maria Victoria Periago, J Massoud, M Mahmoodi, Amir Hossein Mahvi, Patricio Artigas, Marius V Fuentes, M D Bargues, Santiago Mascoma
    Abstract:

    The fascioliasis situation in humans and livestock of Iranian Mazandaran is analysed for the first time. Coprological studies showed 7.3% and 25.4% global prevalences in sheep and cattle, respectively. Studies in slaughterhouses indicate that sheep and cattle may be the main reservoir species, buffaloes may play local roles in the transmission, and goats and horses probably only participate sporadically. Morphometric studies by Computer Image Analysis showed that forms intermediate between Fasciola hepatica and F. gigantica appear in addition to both species. A total of 107 infected humans were diagnosed during the 1999–2002 period, which suggests that fascioliasis may be widespread. The absence of differences in human fascioliasis among gender and age groups differs from other human endemic areas. Both human and animal infections show marked differences between western and eastern Mazandaran. Traditions in herbal condiments for human consumption, methods of animal husbandry and annual rainfall may explain the higher prevalences in western Mazandaran.

Andrzej Wojcik - One of the best experts on this subject based on the ideXlab platform.

  • a cross platform public domain pc Image Analysis program for the comet assay
    Mutation Research-genetic Toxicology and Environmental Mutagenesis, 2003
    Co-Authors: Krzysztof Konca, Anna Lankoff, Anna Banasik, Halina Lisowska, Tomasz Kuszewski, Stanislaw Goźdź, Zbigniew Koza, Andrzej Wojcik
    Abstract:

    The single-cell gel electrophoresis, also known as the comet assay, has gained wide-spread popularity as a simple and reliable method to measure genotoxic and cytotoxic effects of physical and chemical agents as well as kinetics of DNA repair. Cells are generally stained with fluorescent dyes. The Analysis of comets—damaged cells which form a typical comet-shaped pattern—is greatly facilitated by the use of a Computer Image-Analysis program. Although several Image-Analysis programs are available commercially, they are expensive and their source codes are not provided. For Macintosh Computers a cost-free public domain macro is available on the Internet. No ready for use, cost-free program exists for the PC platform. We have, therefore, developed such a public domain program under the GNU license for PC Computers. The program is called CASP and can be run on a variety of hardware and software platforms. Its practical merit was tested on human lymphocytes exposed to -rays and found to yield reproducible results. The binaries for Windows 95 and Linux, together with the source code can be obtained from: http://www.casp.of.pl. © 2002 Elsevier Science B.V. All rights reserved.

  • a cross platform public domain pc Image Analysis program for the comet assay
    Mutation Research-genetic Toxicology and Environmental Mutagenesis, 2003
    Co-Authors: Krzysztof Konca, Anna Lankoff, Anna Banasik, Halina Lisowska, Tomasz Kuszewski, Stanislaw Goźdź, Zbigniew Koza, Andrzej Wojcik
    Abstract:

    The single-cell gel electrophoresis, also known as the comet assay, has gained wide-spread popularity as a simple and reliable method to measure genotoxic and cytotoxic effects of physical and chemical agents as well as kinetics of DNA repair. Cells are generally stained with fluorescent dyes. The Analysis of comets--damaged cells which form a typical comet-shaped pattern--is greatly facilitated by the use of a Computer Image-Analysis program. Although several Image-Analysis programs are available commercially, they are expensive and their source codes are not provided. For Macintosh Computers a cost-free public domain macro is available on the Internet. No ready for use, cost-free program exists for the PC platform. We have, therefore, developed such a public domain program under the GNU license for PC Computers. The program is called CASP and can be run on a variety of hardware and software platforms. Its practical merit was tested on human lymphocytes exposed to gamma-rays and found to yield reproducible results. The binaries for Windows 95 and Linux, together with the source code can be obtained from: http://www.casp.of.pl.

Luke Oakdenrayner - One of the best experts on this subject based on the ideXlab platform.

  • precision radiology predicting longevity using feature engineering and deep learning methods in a radiomics framework
    Scientific Reports, 2017
    Co-Authors: Luke Oakdenrayner, Gustavo Carneiro, Taryn Bessen, Jacinto C Nascimento, Andrew P Bradley, Lyle J Palmer
    Abstract:

    Precision medicine approaches rely on obtaining precise knowledge of the true state of health of an individual patient, which results from a combination of their genetic risks and environmental exposures. This approach is currently limited by the lack of effective and efficient non-invasive medical tests to define the full range of phenotypic variation associated with individual health. Such knowledge is critical for improved early intervention, for better treatment decisions, and for ameliorating the steadily worsening epidemic of chronic disease. We present proof-of-concept experiments to demonstrate how routinely acquired cross-sectional CT imaging may be used to predict patient longevity as a proxy for overall individual health and disease status using Computer Image Analysis techniques. Despite the limitations of a modest dataset and the use of off-the-shelf machine learning methods, our results are comparable to previous ‘manual’ clinical methods for longevity prediction. This work demonstrates that radiomics techniques can be used to extract biomarkers relevant to one of the most widely used outcomes in epidemiological and clinical research – mortality, and that deep learning with convolutional neural networks can be usefully applied to radiomics research. Computer Image Analysis applied to routinely collected medical Images offers substantial potential to enhance precision medicine initiatives.

  • precision radiology predicting longevity using feature engineering and deep learning methods in a radiomics framework
    Science & Engineering Faculty, 2017
    Co-Authors: Luke Oakdenrayner, Gustavo Carneiro, Taryn Bessen, Jacinto C Nascimento, Andrew P Bradley, Lyle J Palmer
    Abstract:

    Precision medicine approaches rely on obtaining precise knowledge of the true state of health of an individual patient, which results from a combination of their genetic risks and environmental exposures. This approach is currently limited by the lack of effective and efficient non-invasive medical tests to define the full range of phenotypic variation associated with individual health. Such knowledge is critical for improved early intervention, for better treatment decisions, and for ameliorating the steadily worsening epidemic of chronic disease. We present proof-of-concept experiments to demonstrate how routinely acquired cross-sectional CT imaging may be used to predict patient longevity as a proxy for overall individual health and disease status using Computer Image Analysis techniques. Despite the limitations of a modest dataset and the use of off-the-shelf machine learning methods, our results are comparable to previous 'manual' clinical methods for longevity prediction. This work demonstrates that radiomics techniques can be used to extract biomarkers relevant to one of the most widely used outcomes in epidemiological and clinical research - mortality, and that deep learning with convolutional neural networks can be usefully applied to radiomics research. Computer Image Analysis applied to routinely collected medical Images offers substantial potential to enhance precision medicine initiatives. © 2017 The Author(s).

M A Valero - One of the best experts on this subject based on the ideXlab platform.

  • phenotypes of intermediate forms of fasciola hepatica and f gigantica in buffaloes from central punjab pakistan
    Journal of Helminthology, 2014
    Co-Authors: K Afshan, M A Valero, Mazhar Qayyum, Raquel V Peixoto, A Magraner, Santiago Mascoma
    Abstract:

    Fascioliasis is an important food-borne parasitic disease caused by the two trematode species, Fasciola hepatica and Fasciola gigantica. The phenotypic features of fasciolid adults and eggs infecting buffaloes inhabiting the Central Punjab area, Pakistan, have been studied to characterize fasciolid populations involved. Morphometric analyses were made with a Computer Image Analysis system (CIAS) applied on the basis of standardized measurements. Since it is the first study of this kind undertaken in Pakistan, the results are compared to pure fasciolid populations: (a) F. hepatica from the European Mediterranean area; and (b) F. gigantica from Burkina Faso; i.e. geographical areas where both species do not co-exist. Only parasites obtained from bovines were used. The multivariate Analysis showed that the characteristics, including egg morphometrics, of fasciolids from Central Punjab, Pakistan, are between F. hepatica and F. gigantica standard populations. Similarly, the morphometric measurements of fasciolid eggs from Central Punjab are also between F. hepatica and F. gigantica standard populations. These results demonstrate the existence of fasciolid intermediate forms in endemic areas in Pakistan.

  • phenotypic comparison of allopatric populations of fasciola hepatica and fasciola gigantica from european and african bovines using a Computer Image Analysis system cias
    Parasitology Research, 2006
    Co-Authors: Maria Victoria Periago, M A Valero, Miroslava Panova, Santiago Mascoma
    Abstract:

    The quantification of the different sizes and shapes of Fasciola hepatica and Fasciola gigantica from bovines has been achieved for the first time in natural allopatric populations. Linear measurements, areas and ratios of gravid adults and eggs of F. hepatica (from France and Spain) and F. gigantica (from Burkina Faso) were analysed using a Computer Image Analysis system and an allometric model: \({{\left( {y_{{2{\text{m}}}} - y_{2} } \right)}} \mathord{\left/ {\vphantom {{{\left( {y_{{2{\text{m}}}} - y_{2} } \right)}} {y_{2} }}} \right. \kern-\nulldelimiterspace} {y_{2} } = c{\left[ {{{\left( {y_{{1{\text{m}}}} - y_{1} } \right)}} \mathord{\left/ {\vphantom {{{\left( {y_{{1{\text{m}}}} - y_{1} } \right)}} {y_{1} }}} \right. \kern-\nulldelimiterspace} {y_{1} }} \right]}^{b}\), where y1=body area or body length, y2=one of the measurements analysed, y1m, y2m=maximum values towards which y1 and y2, respectively, tend and c, b=constants. All the measurements overlap in the two fasciolids, apart from the distance between the ventral sucker and the posterior end of the body, body roundness and body length/body width ratio. The results obtained may be useful in Fasciola species identification in countries where both species coexist.

  • Phenotypic comparison of allopatric populations of Fasciola hepatica and Fasciola gigantica from European and African bovines using a Computer Image Analysis system (CIAS)
    Parasitology Research, 2006
    Co-Authors: Maria Victoria Periago, M A Valero, Miroslava Panova, S. Mas-coma
    Abstract:

    The quantification of the different sizes and shapes of Fasciola hepatica and Fasciola gigantica from bovines has been achieved for the first time in natural allopatric populations. Linear measurements, areas and ratios of gravid adults and eggs of F . hepatica (from France and Spain) and F . gigantica (from Burkina Faso) were analysed using a Computer Image Analysis system and an allometric model: % MathType!Translator!2!1!AMS LaTeX.tdl!TeX -- AMS-LaTeX! % MathType!MTEF!2!1!+- % feaaeaart1ev0aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbbjxAHX % garmWu51MyVXgatuuDJXwAK1uy0HwmaeHbfv3ySLgzG0uy0Hgip5wz % aebbnrfifHhDYfgasaacH8qrps0lbbf9q8WrFfeuY-Hhbbf9v8qqaq % Fr0xc9pk0xbba9q8WqFfea0-yr0RYxir-Jbba9q8aq0-yq-He9q8qq % Q8frFve9Fve9Ff0dmeaabaqaciGacaGaaeqabaWaaeWaeaaakeaada % WcgaqaamaabmaabaGaamyEamaaBaaaleaaruavP1wzZbItLDhis9wB % H5gaiuaacaWFYaGaaeyBaaqabaGccqGHsislcaWG5bWaaSbaaSqaai % aa-jdaaeqaaaGccaGLOaGaayzkaaaabaGaamyEamaaBaaaleaacaWF % YaaabeaaaaGccqGH9aqpcaWGJbWaamWaaeaadaWcgaqaamaabmaaba % GaamyEamaaBaaaleaacaWFXaGaaeyBaaqabaGccqGHsislcaWG5bWa % aSbaaSqaaiaa-fdaaeqaaaGccaGLOaGaayzkaaaabaGaamyEamaaBa % aaleaacaWFXaaabeaaaaaakiaawUfacaGLDbaadaahaaWcbeqaaiaa % dkgaaaaaaa!546F! $${{\left( {y_{{2{\text{m}}}} - y_{2} } \right)}} \mathord{\left/ {\vphantom {{{\left( {y_{{2{\text{m}}}} - y_{2} } \right)}} {y_{2} }}} \right. \kern-\nulldelimiterspace} {y_{2} } = c{\left[ {{{\left( {y_{{1{\text{m}}}} - y_{1} } \right)}} \mathord{\left/ {\vphantom {{{\left( {y_{{1{\text{m}}}} - y_{1} } \right)}} {y_{1} }}} \right. \kern-\nulldelimiterspace} {y_{1} }} \right]}^{b}$$ , where y _1=body area or body length, y _2=one of the measurements analysed, y _1m, y _2m=maximum values towards which y _1 and y _2, respectively, tend and c , b =constants. All the measurements overlap in the two fasciolids, apart from the distance between the ventral sucker and the posterior end of the body, body roundness and body length/body width ratio. The results obtained may be useful in Fasciola species identification in countries where both species coexist.