The Experts below are selected from a list of 1335 Experts worldwide ranked by ideXlab platform
S Sivakumar - One of the best experts on this subject based on the ideXlab platform.
-
a rare presentation of a rare disease Congenital Tuberculosis presenting as subdural haematoma
Archives of Disease in Childhood, 2010Co-Authors: V Gali, R Sathanantharajah, S SivakumarAbstract:Congenital Tuberculosis is a rare disease. Only 21 cases have been reported in English language journals since 2001. Subdural haematoma associated with Congenital Tuberculosis has never been reported. A 26-year-old cachectic looking, Asian lady presented acutely in labour at 33 weeks. She had an uneventful antenatal period and normal antenatal scans. Fetal distress and a suboptimal cardiotocogram led to emergency caesarean section. Abnormal caseating peritoneal material was noted during the Caesarean section raising suspicion of maternal Tuberculosis. The preterm baby girl was born in poor condition and needed resuscitation including mechanical ventilation. Following admission to neonatal intensive care, she was noted to have deranged clotting, thrombocytopenia and anaemia. She received fresh frozen plasma, platelet and packed cell transfusions. Antituberculous treatment was added to the antibiotics, with a suspicion of Congenital Tuberculosis. Cerebrospinal fluid analysis was highly suggestive of tuberculous meningitis. Following an abnormal cranial ultrasound scan, CT brain confirmed a large left subdural parieto-temporal collection with a significant mass effect. The baby was immediately transferred to the nearest tertiary centre and the subdural collection was urgently evacuated by neurosurgeons. This lead to a dramatic improvement in clinical condition followed by extubation on day 6. Congenital Tuberculosis was confirmed by microbiological evidence from baby9s gastric aspirate and mother9s peritoneal fluid. In this case, the presence of acid-fast bacilli on microscopic examination of the nasogastric aspirate suggests possible ingestion of infected amniotic fluid by the fetus. Secondly, the biochemical and microbiological analysis of cerebrospinal fluid is highly suggestive of Tuberculosis meningitis which suggests haematogenous spread of infection from mother. Significant inflammation and disseminated intravascular coagulopathy in Tuberculosis could cause subdural haematoma. Early imaging in conjunction to clinical suspicion is the key in managing this complication.
-
A rare presentation of a rare disease—Congenital Tuberculosis presenting as subdural haematoma
Archives of Disease in Childhood, 2010Co-Authors: V Gali, R Sathanantharajah, S SivakumarAbstract:Congenital Tuberculosis is a rare disease. Only 21 cases have been reported in English language journals since 2001. Subdural haematoma associated with Congenital Tuberculosis has never been reported. A 26-year-old cachectic looking, Asian lady presented acutely in labour at 33 weeks. She had an uneventful antenatal period and normal antenatal scans. Fetal distress and a suboptimal cardiotocogram led to emergency caesarean section. Abnormal caseating peritoneal material was noted during the Caesarean section raising suspicion of maternal Tuberculosis. The preterm baby girl was born in poor condition and needed resuscitation including mechanical ventilation. Following admission to neonatal intensive care, she was noted to have deranged clotting, thrombocytopenia and anaemia. She received fresh frozen plasma, platelet and packed cell transfusions. Antituberculous treatment was added to the antibiotics, with a suspicion of Congenital Tuberculosis. Cerebrospinal fluid analysis was highly suggestive of tuberculous meningitis. Following an abnormal cranial ultrasound scan, CT brain confirmed a large left subdural parieto-temporal collection with a significant mass effect. The baby was immediately transferred to the nearest tertiary centre and the subdural collection was urgently evacuated by neurosurgeons. This lead to a dramatic improvement in clinical condition followed by extubation on day 6. Congenital Tuberculosis was confirmed by microbiological evidence from baby9s gastric aspirate and mother9s peritoneal fluid. In this case, the presence of acid-fast bacilli on microscopic examination of the nasogastric aspirate suggests possible ingestion of infected amniotic fluid by the fetus. Secondly, the biochemical and microbiological analysis of cerebrospinal fluid is highly suggestive of Tuberculosis meningitis which suggests haematogenous spread of infection from mother. Significant inflammation and disseminated intravascular coagulopathy in Tuberculosis could cause subdural haematoma. Early imaging in conjunction to clinical suspicion is the key in managing this complication.
V Gali - One of the best experts on this subject based on the ideXlab platform.
-
a rare presentation of a rare disease Congenital Tuberculosis presenting as subdural haematoma
Archives of Disease in Childhood, 2010Co-Authors: V Gali, R Sathanantharajah, S SivakumarAbstract:Congenital Tuberculosis is a rare disease. Only 21 cases have been reported in English language journals since 2001. Subdural haematoma associated with Congenital Tuberculosis has never been reported. A 26-year-old cachectic looking, Asian lady presented acutely in labour at 33 weeks. She had an uneventful antenatal period and normal antenatal scans. Fetal distress and a suboptimal cardiotocogram led to emergency caesarean section. Abnormal caseating peritoneal material was noted during the Caesarean section raising suspicion of maternal Tuberculosis. The preterm baby girl was born in poor condition and needed resuscitation including mechanical ventilation. Following admission to neonatal intensive care, she was noted to have deranged clotting, thrombocytopenia and anaemia. She received fresh frozen plasma, platelet and packed cell transfusions. Antituberculous treatment was added to the antibiotics, with a suspicion of Congenital Tuberculosis. Cerebrospinal fluid analysis was highly suggestive of tuberculous meningitis. Following an abnormal cranial ultrasound scan, CT brain confirmed a large left subdural parieto-temporal collection with a significant mass effect. The baby was immediately transferred to the nearest tertiary centre and the subdural collection was urgently evacuated by neurosurgeons. This lead to a dramatic improvement in clinical condition followed by extubation on day 6. Congenital Tuberculosis was confirmed by microbiological evidence from baby9s gastric aspirate and mother9s peritoneal fluid. In this case, the presence of acid-fast bacilli on microscopic examination of the nasogastric aspirate suggests possible ingestion of infected amniotic fluid by the fetus. Secondly, the biochemical and microbiological analysis of cerebrospinal fluid is highly suggestive of Tuberculosis meningitis which suggests haematogenous spread of infection from mother. Significant inflammation and disseminated intravascular coagulopathy in Tuberculosis could cause subdural haematoma. Early imaging in conjunction to clinical suspicion is the key in managing this complication.
-
A rare presentation of a rare disease—Congenital Tuberculosis presenting as subdural haematoma
Archives of Disease in Childhood, 2010Co-Authors: V Gali, R Sathanantharajah, S SivakumarAbstract:Congenital Tuberculosis is a rare disease. Only 21 cases have been reported in English language journals since 2001. Subdural haematoma associated with Congenital Tuberculosis has never been reported. A 26-year-old cachectic looking, Asian lady presented acutely in labour at 33 weeks. She had an uneventful antenatal period and normal antenatal scans. Fetal distress and a suboptimal cardiotocogram led to emergency caesarean section. Abnormal caseating peritoneal material was noted during the Caesarean section raising suspicion of maternal Tuberculosis. The preterm baby girl was born in poor condition and needed resuscitation including mechanical ventilation. Following admission to neonatal intensive care, she was noted to have deranged clotting, thrombocytopenia and anaemia. She received fresh frozen plasma, platelet and packed cell transfusions. Antituberculous treatment was added to the antibiotics, with a suspicion of Congenital Tuberculosis. Cerebrospinal fluid analysis was highly suggestive of tuberculous meningitis. Following an abnormal cranial ultrasound scan, CT brain confirmed a large left subdural parieto-temporal collection with a significant mass effect. The baby was immediately transferred to the nearest tertiary centre and the subdural collection was urgently evacuated by neurosurgeons. This lead to a dramatic improvement in clinical condition followed by extubation on day 6. Congenital Tuberculosis was confirmed by microbiological evidence from baby9s gastric aspirate and mother9s peritoneal fluid. In this case, the presence of acid-fast bacilli on microscopic examination of the nasogastric aspirate suggests possible ingestion of infected amniotic fluid by the fetus. Secondly, the biochemical and microbiological analysis of cerebrospinal fluid is highly suggestive of Tuberculosis meningitis which suggests haematogenous spread of infection from mother. Significant inflammation and disseminated intravascular coagulopathy in Tuberculosis could cause subdural haematoma. Early imaging in conjunction to clinical suspicion is the key in managing this complication.
H Zhang - One of the best experts on this subject based on the ideXlab platform.
-
Congenital Tuberculosis detected by T-SPOT.TB assay in a male infant after in vitro fertilization and followed up with radiography
Italian Journal of Pediatrics, 2014Co-Authors: Yangming Zheng, Guanghui Bai, H ZhangAbstract:Congenital Tuberculosis (TB) is a rare disease with a high mortality rate, and is difficult to diagnose. Here we present a case of Congenital TB detected by the T-SPOT.TB assay in a male infant after in vitro fertilization. He ultimately survived after anti-TB therapy despite a delayed diagnosis, and underwent radiological follow-up. The delay in diagnosis of Congenital TB resulted in a severe lung lesion, as evidenced by prolonged oxygen dependence, predisposing to recurrent pneumonia. Radiological follow-up revealed uniform rim calcification of multiple enlarged lymph nodes in the mediastinum, and long-term consolidation in the bilateral lung, with slow radiographic regression of the lung lesion. To the best of our knowledge, this is the first report on using the T-SPOT.TB assay in the detection of Congenital TB, and no case of Congenital TB with such clinical features and image findings has been described in previous reports.
-
Infertility, in vitro fertilization and Congenital Tuberculosis
Journal of Perinatology, 2013Co-Authors: J J Flibotte, G E Lee, G L Buser, K N Feja, B N Kreiswirth, G D Mcsherry, S M Nolan, R W Tolan, H ZhangAbstract:Congenital Tuberculosis (CTB) due to maternal genitourinary (GU) TB infection is a rare occurrence, as infection of the genital tract in women generally leads to infertility. Increasing availability of assisted reproductive technology creates the potential for CTB to emerge as a significant problem. We describe five infants (two sets of twins and a singleton birth) conceived by in vitro fertilization who developed CTB. All five infants were born to mothers who had immigrated to the United States from India and none had GU TB diagnosed before the birth of their infected infants.
R Sathanantharajah - One of the best experts on this subject based on the ideXlab platform.
-
a rare presentation of a rare disease Congenital Tuberculosis presenting as subdural haematoma
Archives of Disease in Childhood, 2010Co-Authors: V Gali, R Sathanantharajah, S SivakumarAbstract:Congenital Tuberculosis is a rare disease. Only 21 cases have been reported in English language journals since 2001. Subdural haematoma associated with Congenital Tuberculosis has never been reported. A 26-year-old cachectic looking, Asian lady presented acutely in labour at 33 weeks. She had an uneventful antenatal period and normal antenatal scans. Fetal distress and a suboptimal cardiotocogram led to emergency caesarean section. Abnormal caseating peritoneal material was noted during the Caesarean section raising suspicion of maternal Tuberculosis. The preterm baby girl was born in poor condition and needed resuscitation including mechanical ventilation. Following admission to neonatal intensive care, she was noted to have deranged clotting, thrombocytopenia and anaemia. She received fresh frozen plasma, platelet and packed cell transfusions. Antituberculous treatment was added to the antibiotics, with a suspicion of Congenital Tuberculosis. Cerebrospinal fluid analysis was highly suggestive of tuberculous meningitis. Following an abnormal cranial ultrasound scan, CT brain confirmed a large left subdural parieto-temporal collection with a significant mass effect. The baby was immediately transferred to the nearest tertiary centre and the subdural collection was urgently evacuated by neurosurgeons. This lead to a dramatic improvement in clinical condition followed by extubation on day 6. Congenital Tuberculosis was confirmed by microbiological evidence from baby9s gastric aspirate and mother9s peritoneal fluid. In this case, the presence of acid-fast bacilli on microscopic examination of the nasogastric aspirate suggests possible ingestion of infected amniotic fluid by the fetus. Secondly, the biochemical and microbiological analysis of cerebrospinal fluid is highly suggestive of Tuberculosis meningitis which suggests haematogenous spread of infection from mother. Significant inflammation and disseminated intravascular coagulopathy in Tuberculosis could cause subdural haematoma. Early imaging in conjunction to clinical suspicion is the key in managing this complication.
-
A rare presentation of a rare disease—Congenital Tuberculosis presenting as subdural haematoma
Archives of Disease in Childhood, 2010Co-Authors: V Gali, R Sathanantharajah, S SivakumarAbstract:Congenital Tuberculosis is a rare disease. Only 21 cases have been reported in English language journals since 2001. Subdural haematoma associated with Congenital Tuberculosis has never been reported. A 26-year-old cachectic looking, Asian lady presented acutely in labour at 33 weeks. She had an uneventful antenatal period and normal antenatal scans. Fetal distress and a suboptimal cardiotocogram led to emergency caesarean section. Abnormal caseating peritoneal material was noted during the Caesarean section raising suspicion of maternal Tuberculosis. The preterm baby girl was born in poor condition and needed resuscitation including mechanical ventilation. Following admission to neonatal intensive care, she was noted to have deranged clotting, thrombocytopenia and anaemia. She received fresh frozen plasma, platelet and packed cell transfusions. Antituberculous treatment was added to the antibiotics, with a suspicion of Congenital Tuberculosis. Cerebrospinal fluid analysis was highly suggestive of tuberculous meningitis. Following an abnormal cranial ultrasound scan, CT brain confirmed a large left subdural parieto-temporal collection with a significant mass effect. The baby was immediately transferred to the nearest tertiary centre and the subdural collection was urgently evacuated by neurosurgeons. This lead to a dramatic improvement in clinical condition followed by extubation on day 6. Congenital Tuberculosis was confirmed by microbiological evidence from baby9s gastric aspirate and mother9s peritoneal fluid. In this case, the presence of acid-fast bacilli on microscopic examination of the nasogastric aspirate suggests possible ingestion of infected amniotic fluid by the fetus. Secondly, the biochemical and microbiological analysis of cerebrospinal fluid is highly suggestive of Tuberculosis meningitis which suggests haematogenous spread of infection from mother. Significant inflammation and disseminated intravascular coagulopathy in Tuberculosis could cause subdural haematoma. Early imaging in conjunction to clinical suspicion is the key in managing this complication.
Kamran Yusuf - One of the best experts on this subject based on the ideXlab platform.
-
Congenital Tuberculosis in an extremely preterm infant conceived after in vitro fertilization: case report
BMC Pregnancy and Childbirth, 2017Co-Authors: Veronica Samedi, Stephen K. Field, Essa Al Awad, Gregory Ratcliffe, Kamran YusufAbstract:Background Congenital Tuberculosis is a rare manifestation of Tuberculosis. The diagnosis is often delayed, especially in preterm neonates because of the non-specific clinical presentation and the lack of awareness of maternal disease prior to pregnancy. Case Presentation We report a case of Congenital Tuberculosis in an infant born at 24 weeks of gestation to a mother who presented with uncontrolled seizures during preterm labor. Maternal diagnosis was initially made by placental pathology, and later confirmed by isolation of Mycobacterium Tuberculosis in urine, gastric aspirates and sputum. Full screening was performed on the newborn infant, and both mother and infant were successfully treated for Tuberculosis with a four drug regimen. Conclusion Pregnancy can exacerbate latent Tuberculosis and women originating from endemic areas are especially susceptible. The best way to prevent Congenital Tuberculosis is to have a high index of suspicion and identify and treat Tuberculosis in pregnant women.