The Experts below are selected from a list of 672 Experts worldwide ranked by ideXlab platform

Vishal Jhanji - One of the best experts on this subject based on the ideXlab platform.

Tommy C. Y. Chan - One of the best experts on this subject based on the ideXlab platform.

Hunter K. L. Yuen - One of the best experts on this subject based on the ideXlab platform.

Emmy Y. M. Li - One of the best experts on this subject based on the ideXlab platform.

Scheffer C G Tseng - One of the best experts on this subject based on the ideXlab platform.

  • recent advances in Conjunctivochalasis
    2018
    Co-Authors: Anny M S Cheng, Scheffer C G Tseng
    Abstract:

    Conjunctivo chalasis (CCh) presents as loose and redundant conjunctival folds interspersed between the globe and eyelids and may cause a variety of ocular symptoms that mimic dry eye. It disturbs the preocular tear film by blocking the tear drainage, disrupting the tear meniscus, and obliterating the fornix tear reservoir to interfere tear flow from the fornix reservoir to the tear meniscus. Elimination of intrinsic irritative stimuli/inflammation by topical preservative-free dexamethasone is the initial treatment for delayed tear clearance (DTC) associated CCh. After differentiating dry eye caused by CCh from that caused by aqueous tear deficiency (ATD) and determining that CCh is the cause of ocular symptoms, restoration of the fornix tear reservoir by fornix reconstruction with conjunctival recession and amniotic membrane transplantation is an effective surgical procedure to treat CCh. After elimination of CCh, punctal occlusion remains ultimate and specific management of genuine ATD dry eye. Identification of DTC, symptomatic CCh and evaluation of genuine ATD dry eye that is independent of CCh led physicians to adopt an effective treatment algorithm to restore the integrity of the ocular surface.

  • restoration of fornix tear reservoir in Conjunctivochalasis with fornix reconstruction
    Cornea, 2016
    Co-Authors: Anny M S Cheng, Victoria Casas, Rendian Chen, Sean Tighe, Hosam Sheha, Dandan Zhao, Scheffer C G Tseng
    Abstract:

    Purpose:To determine whether Conjunctivochalasis (CCh) obliterates the fornix tear reservoir and to discern whether there is concomitant aqueous tear deficiency (ATD) dry eye.Methods:Retrospective review of 18 eyes of 12 patients with CCh and ATD (CCh + ATD) and 18 eyes of 13 patients with CCh witho

  • ptx3 controls activation of matrix metalloproteinase 1 and apoptosis in Conjunctivochalasis fibroblasts
    Investigative Ophthalmology & Visual Science, 2012
    Co-Authors: Suzhen Zhang, Hua He, Scheffer C G Tseng
    Abstract:

    Purpose. Conjunctivochalasis (CCh) is an age-related inflammatory ocular surface disease manifesting redundant, loose conjunctiva folds. The pathogenic role of Pentraxin 3 (PTX3) in controlling upregulation of matrix metalloproteinase 1 (MMP-1) and MMP-3 in CCh remains undefined.

  • amniotic membrane transplantation with fibrin glue for Conjunctivochalasis
    American Journal of Ophthalmology, 2007
    Co-Authors: Ahmad Kheirkhah, Victoria Casas, Gabriela Blanco, Wei Li, Yasutaka Hayashida, Yingting Chen, Scheffer C G Tseng
    Abstract:

    Purpose To evaluate the feasibility of performing sutureless amniotic membrane transplantation (AMT) using fibrin glue for Conjunctivochalasis. Design Noncomparative interventional case series. Methods In 25 eyes of 16 patients with refractory Conjunctivochalasis (CCh), AMT using fibrin glue was performed to cover the bare sclera. Results The mean age was 55.2 ± 18.5 years with nine patients (56.2%) younger than 60 years. The Tenon capsule was dissolved in all eyes. Fibrin glue was effective in securing the amniotic membrane to the sclera. For a mean follow-up of 10.6 ± 4.3 months, all eyes achieved a smooth conjunctival surface with complete or significant improvement of symptoms in 44% and 56%, respectively. Complications included focal conjunctival inflammation in four eyes and pyogenic granuloma in one eye. Conclusion AMT using fibrin glue can be performed for refractory CCh resulting in alleviating its symptoms and signs.

  • regulation of collagenase stromelysin and gelatinase b in human conjunctival and Conjunctivochalasis fibroblasts by interleukin 1beta and tumor necrosis factor alpha
    Investigative Ophthalmology & Visual Science, 2000
    Co-Authors: Daniel Meller, Scheffer C G Tseng, Dequan Li
    Abstract:

    PURPOSE: Overexpression and increased activities of matrix metalloproteinases (MMPs) have recently been reported in cultured conjunctival fibroblasts from patients with Conjunctivochalasis. The role of inflammatory cytokines in modulating expression of MMPs, their tissue inhibitors (TIMPs), and urokinase plasminogen activator (uPA) as potential contributors to the pathogenesis of Conjunctivochalasis was investigated. METHODS: Interleukin-1beta (IL-1beta) or tumor necrosis factor-alpha (TNF-alpha) was added at 10 ng/ml to a serum-free medium. Expression of transcripts and proteins of MMPs, TIMPs, and uPA by cultured normal human conjunctival and Conjunctivochalasis fibroblasts was determined by Northern hybridization, enzyme-linked immunosorbent assay (ELISA) and Western blot analysis, respectively. Gelatin and casein zymographies were performed in serum-free conditioned media with and without the respective enzyme inhibitors. RESULTS: Without challenging the cells, Conjunctivochalasis fibroblasts showed mRNA and protein overexpression of MMP-1 and MMP-3 compared with normal conjunctival fibroblasts, which showed minor or no expression of these enzymes. IL-1beta markedly and TNF-alpha to lesser extent increased mRNA and protein expression of MMP-1 and MMP-3 in Conjunctivochalasis fibroblasts from 2 subjects when compared with normal conjunctival fibroblasts from 2 subjects and with their nonstimulated counterparts. In Conjunctivochalasis fibroblasts and normal conjunctival fibroblasts, TNF-alpha, but not IL-1beta, induced a gelatinolytic activity of MMP-9, which was further confirmed by Western blot analysis and ELISA. Expression of MMP-2, TIMP-1, and TIMP-2 mRNA and protein was not influenced by IL-1beta or TNF-alpha, and no difference was found in the gelatinolytic activity of MMP-2 between both cell types. CONCLUSIONS: Inflammatory cytokines such as IL-1beta and TNF-alpha, which can potentially be derived from the ocular surface and tears, may be responsible for increased expression of MMPs in cultured Conjunctivochalasis fibroblasts. Ocular inflammation might be one important denominator in the pathogenesis of Conjunctivochalasis.