The Experts below are selected from a list of 1839 Experts worldwide ranked by ideXlab platform

Chunshui Yu - One of the best experts on this subject based on the ideXlab platform.

  • impact of comt haplotypes on functional Connectivity Density and its association with the gene expression of dopamine receptors
    Brain Structure & Function, 2019
    Co-Authors: Jie Tang, Jiayuan Xu, Tianzi Jiang, Qiang Xu, Yanjun Li, Qian Su, Chunshui Yu
    Abstract:

    Catechol-O-methyltransferase (COMT) affects brain Connectivity via modulating the dopamine system, with an expected greater effect of haplotypes than single-nucleotide polymorphism (SNP). The action pathway from COMT to dopamine to Connectivity is theoretically dependent on the gene expression of dopamine receptors. Here, we aimed to investigate the impact of COMT haplotypes on brain functional Connectivity Density (FCD) in hundreds of healthy young subjects, and to disclose the association between the COMT-FCD statistical map and the spatial expression of the dopamine receptor genes. We found an inverted U-shaped modulation of COMT haplotypes on FCD in the left inferior parietal lobule that is mainly connected to the frontal and parietal cortices, with APS homozygotes exhibiting greater FCD than the other five groups. However, we failed to identify any significant effect of any SNP on FCD. Utilizing gene expression data collected from Allen human brain atlas, we found the COMT-FCD statistical map was significantly associated with the expression patterns of the dopamine receptor genes. Our results suggest that COMT haplotypes have greater impact on functional Connectivity than a single genetic variation and that the association between COMT and functional Connectivity may be dependent on the gene expression of dopamine receptors.

  • modulation effect of the sorl1 gene on functional Connectivity Density in healthy young adults
    Brain Structure & Function, 2016
    Co-Authors: Junlin Shen, Jiayuan Xu, Tianzi Jiang, Peng Zhang, Lixue Xu, Chunshui Yu
    Abstract:

    The sortilin-related receptor 1 (SORL1) gene has been associated with late-onset Alzheimer’s disease (LOAD) and structural impairments in several ethnic populations. However, how this gene affects brain function properties remains unclear. We investigated associations of SORL1 rs2070045 with functional Connectivity Density (FCD) in healthy young adults. This single-nucleotide polymorphism was selected because it is the SORL1 variant that has been frequently associated with LOAD in several populations, including the Chinese Han population. A total of 275 healthy young Chinese Han subjects with successful genotyping and MRI examinations were included. The effect of SORL1 rs2070045 was explored using a voxel-wise FCD analysis. A significant effect of SORL1 rs2070045 on the FCD was found in the right inferior temporal gyrus. The risk G allele carriers of the rs2070045 exhibited a lower FCD than the protective TT carriers. This effect was independent of the status of apolipoprotein E. This study provides the first evidence that the SORL1 gene is associated with brain FCD differences in healthy young adults. In the genetic risk subjects, Connectivity impairment already starts during young adulthood, which may predispose the risk allele carriers to be susceptible to LOAD after several decades.

  • altered functional Connectivity Density in high myopia
    Behavioural Brain Research, 2016
    Co-Authors: Liying Zhai, Chunshui Yu, Qian Li, Tianyue Wang, Honghuan Dong, Yanmin Peng
    Abstract:

    Abnormal visual experience can affect the brain structure and function. Visual functional performances of high myopia (HM) individuals were observed to be abnormal in contrast to emmetropics, even with a corrected visual acuity. Attention deficits and brain morphological changes have been revealed in the HM, but it is unknown whether there are functional Connectivity (FC) alterations. The current study combined the resting-state functional Connectivity Density (FCD) mapping and seed-based correlation analysis to investigate FC alterations in the brain of HM. In our results, the HM exhibited decreased short- and long-range FCD in the posterior cingulate cortex/precuneus and decreased long-range FCD in the inferior temporal gyrus, supramarginal gyrus and rostrolateral prefrontal cortex. Specially, long-range FCD in the rostrolateral prefrontal cortex showed a significant positive correlation with the uncorrected visual acuity in the HM. Moreover, the HM showed significantly decreased FC not only between the supramarginal gyrus and rostrolateral prefrontal cortex, but also between networks they belong to, the ventral attention and frontoparietal control networks. These results provide evidence for the FC changes in the HM and may help to understand the attention deficits in myopes.

  • altered functional Connectivity Density in major depressive disorder at rest
    European Archives of Psychiatry and Clinical Neuroscience, 2016
    Co-Authors: Bin Zhang, Chunshui Yu, Meng Li, Liliana Ramona Demenescu, Coraline D Metzger, Bernhard Bogerts, Martin Walter
    Abstract:

    Major depressive disorder is characterized by abnormal brain Connectivity at rest. Currently, most studies investigating resting-state activity rely on a priori restrictions on specific networks or seed regions, which may bias observations. We hence sought to elicit functional alterations in a hypothesis-free approach. We applied functional Connectivity Density (FCD) to identify abnormal Connectivity for each voxel in the whole brain separately. Comparing resting-state fMRI in 21 MDD patients and 23 matched healthy controls, we identified atypical connections for regions exhibiting abnormal FCD and compared our results to those of an independent component analysis (ICA) on networks previously investigated in MDD. Patients showed reduced FCD in mid-cingulate cortex (MCC) and increased FCD in occipital cortex (OCC). These changes in global FCD were driven by abnormal local Connectivity changes and reduced functional Connectivity (FC) toward the left amygdala for MCC, and increased FC toward the right supplementary motor area for OCC. The altered Connectivity was not reflected in ICA comparison of the salience and visual networks. Abnormal FC in MDD is present in cingulate and OCC in terms of global FCD. This converges with previous structural and metabolic findings; however, these particular changes in Connectivity would not have been identified using canonical seed regions or networks. This implies the importance of FC measures in the investigation of brain pathophysiology in depression.

  • interaction of comt rs4680 and bdnf rs6265 polymorphisms on functional Connectivity Density of the left frontal eye field in healthy young adults
    Human Brain Mapping, 2016
    Co-Authors: Wei Li, Jiayuan Xu, Tianzi Jiang, Chunshui Yu
    Abstract:

    As modulators of dopamine availability and release in the brain, COMT and BDNF polymorphisms have demonstrated interactions on human cognition; however, the underlying neural mechanisms remain largely unknown. In this study, we aimed to investigate the interactions of COMT rs4680 and BDNF rs6265 on global functional Connectivity Density (gFCD) of the brain in 265 healthy young subjects. We found a significant COMT × BDNF interaction on the gFCD in the left frontal eye field (FEF), showing an inverted U-shape modulation by the presumed dopamine signaling. This finding was consistently repeated in the gFCD analyses using other four connection thresholds. Our findings reveal a COMT × BDNF interaction on the FCD in the left FEF, which may be helpful for understanding the neural mechanisms of the COMT × BDNF interactions on the FEF-related cognitive functions. Hum Brain Mapp 37:2468-2478, 2016. © 2016 Wiley Periodicals, Inc.

Hesheng Chen - One of the best experts on this subject based on the ideXlab platform.

  • abnormal dynamic functional Connectivity Density in patients with generalized anxiety disorder
    Journal of Affective Disorders, 2020
    Co-Authors: Yuyan Chen, Yifeng Wang, Yajing Pang, Wei Sheng, Qin Tang, Di Li, Jing Huang, Zongling He, Hesheng Chen
    Abstract:

    Abstract Background Numerous studies have revealed the abnormal static functional Connectivity (FC) among different brain regions in patients with generalized anxiety disorder (GAD). However, little is known about the dynamic changes of FC in patients with GAD. Methods This study investigated the whole-brain dynamic changes of FC in patients with GAD by combining global FC Density (FCD) and sliding window correlation analyses. The standard deviation of dynamic FCD (dFCD) was calculated to evaluate its temporal variability along time. Support vector regression was then employed to predict the symptom severity of patients based on abnormal dynamic Connectivity patterns. Results The abnormal dFCD variability between 81 GAD patients and 80 healthy controls showed that the patients had higher dFCD variability in the bilateral dorsomedial prefrontal cortex (dmPFC) and left hippocampus while lower dFCD variability in the right postcentral gyrus. The abnormal dFCD variability of the left dmPFC is an important feature for anxiety prediction. Limitations The selection of sliding window length remains controversial, and most of our patients have been treated with medications. Future studies are expected to rule out the potential confounding effects from applying different parameters of the sliding window and recruiting large samples of medication-free patients. Conclusion The altered patterns of time-varying brain Connectivity in the frontolimbic and sensorimotor areas may reflect abnormal dynamic neural communication between these regions and other regions of the brain, which may deepen our understanding of the disease.

  • abnormal dynamics of functional Connectivity Density in children with benign epilepsy with centrotemporal spikes
    Brain Imaging and Behavior, 2019
    Co-Authors: Rong Li, Hesheng Chen, Wei Liao, Lijie Wang, Yuwen Tang
    Abstract:

    Converging evidence has shown the link between benign epilepsy with centrotemporal spikes (BECTS) and abnormal functional Connectivity among distant brain regions. However, prior research in BECTS has not examined the dynamic changes in functional Connectivity as networks form. We combined functional Connectivity Density (FCD) mapping and sliding windows correlation analyses, to fully capture the functional dynamics in patients with respect to the presence of interictal epileptic discharges (IEDs). Resting-state fMRI was performed in 43 BECTS patients and 28 healthy controls (HC). Patients were further classified into two subgroups, namely, IED (n = 20) and non-IED (n = 23) depending on the simultaneous EEG–fMRI recordings. The global dynamic FCD (dFCD) was measured using sliding window correlation. Then we quantified dFCD variability using their standard deviation. Compared with HC, patients with and without IEDs both showed invariable dFCD (decreased) among the orbital fontal cortex, anterior cingulate cortex and striatum, as well as variable dFCD (increased) in the posterior default mode network (P < 0.05, AlphaSim corrected). Correlation analysis indicated that the variable dFCD in precuneus was related to seizure onset age (P < 0.05, uncorrected). BECTS with IEDs showed variable dFCD in regions related to the typical seizure semiology. The abnormal patterns of fluctuating FCD in BECTS suggest that both active and chronic epileptic state may contribute to altered dynamics of functional Connectivity associated with cognitive disturbances and developmental alterations. These findings highlight the importance of considering fluctuating dynamic neural communication among brain systems to deepen our understanding of epilepsy diseases.

  • abnormal functional Connectivity Density in post stroke aphasia
    Brain Topography, 2019
    Co-Authors: Mi Yang, Wei Liao, Bharat B Biswal, Pu Yang, Hesheng Chen
    Abstract:

    Post-stroke aphasia (PSA), which refers to the loss or impairment of language, is typically caused by left hemisphere lesions. Previous neuroimaging studies have indicated that the pathology of PSA may be related to abnormalities in functional integration. In this study, we used resting-state functional magnetic resonance imaging (rs-fMRI) to examine functional Connectivity Density (FCD) in PSA. We compared short- and long-range FCD between individuals with PSA (n = 17) and healthy controls (HC, n = 20). We then performed Pearson’s correlation analysis on the FCD values from the affected brain regions and the speech scores in the PSA group. Compared with HCs, individuals with PSA showed increased short-range FCD in the contralesional temporal gyrus, the inferior frontal gyrus, the thalamus, the insula, and the mesial temporal gyrus [hippocampus/parahippocampus (HIP/ParaHIP)]. PSA demonstrated an increased long-range FCD in the contralesional mesial temporal gyrus (HIP/ParaHIP). PSA also displayed decreased short-range FCD in the ipsilesional part of the frontal gyrus, the caudate, the thalamus, the fusiform gyrus, and the mesial temporal gyrus (HIP/ParaHIP), and decreased long-range FCD in the ipsilesional superior temporal gyrus, the fusiform gyrus, and the mesial temporal gyrus (HIP/ParaHIP). The decreased long-range FCD in the left superior temporal gyrus in PSA subjects was positively correlated with the spontaneous speech score. The altered FCD observed due to disrupted functional Connectivity after stroke may lead to language production, semantic processing, and cognitive impairments. Our findings expand previous functional studies on stroke and provide new evidence of the intraregional and interregional interactions at the voxel level in the pathophysiology of PSA.

  • frequency specific alteration of functional Connectivity Density in antipsychotic naive adolescents with early onset schizophrenia
    Journal of Psychiatric Research, 2017
    Co-Authors: Xiao Wang, Youxue Zhang, Mi Yang, Yifeng Wang, Zhiliang Long, Yan Zhang, Junjie Zheng, Xujun Duan, Jingping Zhao, Hesheng Chen
    Abstract:

    Abstract Early-onset schizophrenia (EOS) is a severe mental illness associated with dysConnectivity that widespread in the brain. However, the functional dysConnectivity in EOS are still mixed. Recently, studies have identified that functional Connectivity (FC) arises from a band-limited slow rhythmic mechanism and suggested that the dysConnectivity at specific frequency bands may provide more robust biomarkers for schizophrenia. The frequency-specific changes of FC pattern in EOS remain unclear. To address this issue, resting-state functional magnetic resonance imaging data scans from 39 EOS patients (drug-naive) and 31 healthy controls (HCs) were used to assess the FC Density (FCD) across slow-4 (0.027–0.073 Hz) and slow-5 (0.01–0.027 Hz). Results revealed that a remarkable difference between the FCD of the two bands existed mainly in the default mode network (DMN) and subcortical areas. Compared with the HCs, EOS patients showed significantly altered FCD involved in audiovisual information processing, sensorimotor system, and social cognition. Importantly, a significant frequency-by-group interaction was observed in the left precuneus with significantly lower FCD in the slow-4 frequency band, but no significant effect in the slow-5 frequency band. In addition, decreased FC was found between the precuneus and other DMN regions in the slow-4 band. Furthermore, the change in FCD in precuneus was inversely proportional to the clinical symptom in slow-4 band, indicating the key role of precuneus in schizophrenia progress. Our findings demonstrated that the dysConnectivity pattern in EOS could be frequency-dependent.

  • abnormal functional Connectivity Density in patients with ischemic white matter lesions an observational study
    Medicine, 2016
    Co-Authors: Jurong Ding, Xin Ding, Xingzhong Xiong, Qingsong Wang, Hesheng Chen
    Abstract:

    Abstract White matter lesions (WMLs) are frequently detected in elderly people. Previous structural and functional studies have demonstrated that WMLs are associated with cognitive and motor decline. However, the underlying mechanism of how WMLs lead to cognitive decline and motor disturbance remains unclear. We used functional Connectivity Density mapping (FCDM) to investigate changes in brain functional Connectivity in 16 patients with ischemic WMLs and 13 controls. Both short- and long-range FCD maps were computed, and group comparisons were performed between the 2 groups. A correlation analysis was further performed between regions with altered FCD and cognitive test scores (Mini-Mental State Examination [MMSE] and Montreal Cognitive Assessment [MoCA]) in the patient group. We found that patients with ischemic WMLs showed reduced short-range FCD in the temporal cortex, primary motor cortex, and subcortical region, which may account for inadequate top-down attention, impaired motor, memory, and executive function associated with WMLs. The positive correlation between primary motor cortex and MoCA scores may provide evidence for the influences of cognitive function on behavioral performance. The inferior parietal cortex exhibited increased short-range FCD, reflecting a hyper bottom-up attention to compensate for the inadequate top-down attention for language comprehension and information retrieval in patients with WMLs. Moreover, the prefrontal and primary motor cortex showed increased long-range FCD and the former positively correlated with MoCA scores, which may suggest a strategy of cortical functional reorganization to compensate for motor and executive deficits. Our findings provide new insights into how WMLs cause cognitive and motor decline from cortical functional Connectivity perspective.

Nora D. Volkow - One of the best experts on this subject based on the ideXlab platform.

  • Association Between Brain Activation and Functional Connectivity
    Cerebral Cortex, 2018
    Co-Authors: Dardo Tomasi, Nora D. Volkow
    Abstract:

    The origin of the "resting-state" brain activity recorded with functional magnetic resonance imaging (fMRI) is still uncertain. Here we provide evidence for the neurovascular origins of the amplitude of the low-frequency fluctuations (ALFF) and the local functional Connectivity Density (lFCD) by comparing them with task-induced blood-oxygen level dependent (BOLD) responses, which are considered a proxy for neuronal activation. Using fMRI data for 2 different tasks (Relational and Social) collected by the Human Connectome Project in 426 healthy adults, we show that ALFF and lFCD have linear associations with the BOLD response. This association was significantly attenuated by a novel task signal regression (TSR) procedure, indicating that task performance enhances lFCD and ALFF in activated regions. We also show that lFCD predicts BOLD activation patterns, as was recently shown for other functional Connectivity metrics, which corroborates that resting functional Connectivity architecture impacts brain activation responses. Thus, our findings indicate a common source for BOLD responses, ALFF and lFCD, which is consistent with the neurovascular origin of local hemodynamic synchrony presumably reflecting coordinated fluctuations in neuronal activity. This study also supports the development of task-evoked functional Connectivity Density mapping.

  • temporal changes in local functional Connectivity Density reflect the temporal variability of the amplitude of low frequency fluctuations in gray matter
    PLOS ONE, 2016
    Co-Authors: Dardo Tomasi, Ehsan Shokrikojori, Nora D. Volkow
    Abstract:

    Data-driven functional Connectivity Density (FCD) mapping is being increasingly utilized to assess brain connectomics at rest in the healthy brain and its disruption in neuropsychiatric diseases with the underlying assumption that the spatiotemporal hub distribution is stationary. However, recent studies show that functional Connectivity is highly dynamic. Here we study the temporal variability of the local FCD (lFCD) at high spatiotemporal resolution (2-mm isotropic; 0.72s) using a sliding-window approach and ‘resting-state’ datasets from 40 healthy subjects collected under the Human Connectome Project. Prominent functional Connectivity hubs in visual and posterior parietal cortices had pronounced temporal changes in local FCD. These dynamic patterns in the strength of the lFCD hubs occurred in cortical gray matter with high sensitivity (up to 85%) and specificity (> 85%) and showed high reproducibility (up to 72%) across sessions and high test-retest reliability (ICC(3,1) > 0.5). The temporal changes in lFCD predominantly occurred in medial occipitoparietal regions and were proportional to the strength of the Connectivity hubs. The temporal variability of the lFCD was associated with the amplitude of the low frequency fluctuations (ALFF). Pure randomness did not account for the probability distribution of lFCD. Shannon entropy increased in proportion to the strength of the lFCD hubs suggesting high average flow of information per unit of time in the lFCD hubs, particularly in medial occipitoparietal regions. Thus, the higher dynamic range of the lFCD hubs is consistent with their role in the complex orchestration of interacting brain networks.

  • High-Resolution Functional Connectivity Density: Hub Locations, Sensitivity, Specificity, Reproducibility, and Reliability
    Cerebral Cortex, 2015
    Co-Authors: Dardo Tomasi, Ehsan Shokri-kojori, Nora D. Volkow
    Abstract:

    Brain regions with high Connectivity have high metabolic cost and their disruption is associated with neuropsychiatric disorders. Prior neuroimaging studies have identified at the group-level local functional Connectivity Density ( L: FCD) hubs, network nodes with high degree of Connectivity with neighboring regions, in occipito-parietal cortices. However, the individual patterns and the precision for the location of the hubs were limited by the restricted spatiotemporal resolution of the magnetic resonance imaging (MRI) measures collected at rest. In this work, we show that MRI datasets with higher spatiotemporal resolution (2-mm isotropic; 0.72 s), collected under the Human Connectome Project (HCP), provide a significantly higher precision for hub localization and for the first time reveal L: FCD patterns with gray matter (GM) specificity >96% and sensitivity >75%. High temporal resolution allowed effective 0.01-0.08 Hz band-pass filtering, significantly reducing spurious L: FCD effects in white matter. These high spatiotemporal resolution L: FCD measures had high reliability [intraclass correlation, ICC(3,1) > 0.6] but lower reproducibility (>67%) than the low spatiotemporal resolution equivalents. GM sensitivity and specificity benchmarks showed the robustness of L: FCD to changes in model parameter and preprocessing steps. Mapping individual's brain hubs with high sensitivity, specificity, and reproducibility supports the use of L: FCD as a biomarker for clinical applications in neuropsychiatric disorders.

  • gender differences in brain functional Connectivity Density
    Human Brain Mapping, 2012
    Co-Authors: Dardo Tomasi, Nora D. Volkow
    Abstract:

    The neural bases of gender differences in emotional, cognitive, and socials behaviors are largely unknown. Here, magnetic resonance imaging data from 336 women and 225 men revealed a gender dimorphism in the functional organization of the brain. Consistently across five research sites, women had 14% higher local functional Connectivity Density (lFCD) and up to 5% higher gray matter Density than men in cortical and subcortical regions. The negative power scaling of the lFCD was steeper for men than for women, suggesting that the balance between strongly and weakly connected nodes in the brain is different across genders. The more distributed organization of the male brain than that of the female brain could help explain the gender differences in cognitive style and behaviors and in the prevalence of neuropsychiatric diseases (i.e., autism spectrum disorder).

  • Abnormal Functional Connectivity in Children with Attention-Deficit/Hyperactivity Disorder
    Biological Psychiatry, 2011
    Co-Authors: Dardo Tomasi, Nora D. Volkow
    Abstract:

    Background Attention-deficit/hyperactivity disorder (ADHD) is typically characterized by symptoms of inattention and hyperactivity/impulsivity, but there is increased recognition of a motivation deficit too. This neuropathology may reflect dysfunction of both attention and reward-motivation networks. Methods To test this hypothesis, we compared the functional Connectivity Density between 247 ADHD and 304 typically developing control children from a public magnetic resonance imaging database. We quantified short- and long-range functional Connectivity Density in the brain using an ultrafast data-driven approach. Results Children with ADHD had lower Connectivity (short- and long-range) in regions of the dorsal attention (superior parietal cortex) and default-mode (precuneus) networks and in cerebellum and higher Connectivity (short-range) in reward-motivation regions (ventral striatum and orbitofrontal cortex) than control subjects. In ADHD children, the orbitofrontal cortex (region involved in salience attribution) had higher Connectivity with reward-motivation regions (striatum and anterior cingulate) and lower Connectivity with superior parietal cortex (region involved in attention processing). Conclusions The enhanced Connectivity within reward-motivation regions and their decreased Connectivity with regions from the default-mode and dorsal attention networks suggest impaired interactions between control and reward pathways in ADHD that might underlie attention and motivation deficits in ADHD.

Xiaodong Zhang - One of the best experts on this subject based on the ideXlab platform.

  • Altered local and distant functional Connectivity Density relate to headache frequency in migraine without aura
    2020
    Co-Authors: Jun Ke, Yang Yu, Xiaodong Zhang, Yunyan Su, Ximing Wang, Su Hu, Chunhong Hu, Hongru Zhao
    Abstract:

    Abstract Background Episodic migraine (EM) is associated with alterations in functional Connectivity of several regions or resting-state networks, but it is not well known how large-scale functional Connectivity pattern of the whole brain is affected in chronic migraine (CM). Methods Fifty-six migraineurs without aura (39 with EM, 17 with CM) and 35 healthy controls (HC) underwent clinical assessment and resting-state functional MRI. Functional Connectivity Density (FCD) was calculated in a voxel-wise way to examine large-scale brain network property over the whole brain. Results Compared with HC, both migraine groups showed increased local FCD in the left orbital frontal gyrus (OFG), right hippocampus/parahippocampal gyrus (HP/PHG), cerebellum, and decreased local FCD in the bilateral dorsolateral prefrontal cortex. Local FCD of the left OFG increased in CM compared to EM. In comparison with HC, EM showed increased local FCD in the left middle temporal gyrus, and CM exhibited decreased local FCD in the left sensorimotor cortex and bilateral precuneus. Furthermore, relative to HC, EM showed increased distant FCD in the right PHG while CM showed increased distant FCD in the right HP and OFG. Importantly, majority of the observed local and distant FCD alterations were associated with migraine frequency across all migraineurs. Conclusion Patients with higher migraine frequency present more extensive and pronounced functional Connectivity dysfunctions in regions involved in pain processing and modulation. FCD, especially local FCD may be a sensitive biomarker for examining the neural mechanism of migraine.

  • decreased coupling between functional Connectivity Density and amplitude of low frequency fluctuation in non neuropsychiatric systemic lupus erythematosus a resting stage functional mri study
    Molecular Neurobiology, 2017
    Co-Authors: Rongfeng Qi, Qiang Xu, Xiaodong Zhang, Xiao Lu Jiang, Zhen Cheng, Yan Zhou, Zhiqiang Zhang, Hui Juan Chen
    Abstract:

    In this study, we seek to explore alterations of coupling between functional Connectivity Density (FCD) and amplitude of low frequency fluctuation (ALFF) in systemic lupus erythematosus patients without overt neuropsychiatric symptoms (non-NPSLE) by using resting-state functional MR imaging. This study was approved by the institutional ethical review board, and all participants signed written informed consent prior to the study. Twenty six non-NPSLE patients and 35 matched healthy controls underwent resting-state functional MR imaging. The correlation analysis between FCD and ALFF was conducted to assess the imaging coupling. Pearson correlation analysis was performed to correlate imaging variables to clinical and neuropsychological data in non-NPSLE patients. According to the consistent alteration of FCD and ALFF, region of interests were identified including the right inferior temporal gyrus, bilateral hippocampus-parahippocampus (H-PH), left posterior cingulate cortex, superior parietal gyrus, postcentral gyrus, and bilateral precuneus. Across-voxel correlation analysis showed decreased coupling strengths in some brain regions. Correlations between FCD, ALFF, and coupling strength in H-PH and C3/C4/MoCA were found. The imaging coupling between FCD and ALFF was decreased in non-NPSLE patients, indicating brain function alteration in non-NPSLE patients, especially the abnormal coupling between FCD and ALFF of the hippocampus-parahippocampus might be an imaging biomarker of brain dysfunction in non-NPSLE patients.

  • long and short range functional Connectivity Density alteration in non alcoholic cirrhotic patients one month after liver transplantation a resting state fmri study
    Brain Research, 2015
    Co-Authors: Rongfeng Qi, Hui Juan Chen, Qiang Xu, Xiang Kong, Xiaodong Zhang, Yue Cheng, Colin S Poon, Guangming Lu
    Abstract:

    Abstract Purpose To longitudinally evaluate long- and short-range functional Connectivity Density (FCD) alteration in cirrhotic patients one month after liver transplantation (LT) and their correlation with cognitive changes by using resting-state functional magnetic resonance imaging (rs-fMRI). Methods Twenty seven candidates awaiting LT and 24 age-, gender-, and education-matched healthy controls (HCs) were studied. All 27 patients and HCs performed rs-fMRI examinations. Of 27 cirrhotic patients, 13 patients received LT underwent the repeated rs-fMRI examinations one month after LT. Laboratory and psychometric tests were carried out. The long- and short-range FCD maps derived from degree centrality calculation were compared. Correlations between FCD alteration and laboratory/psychometric changes were evaluated as well. Results In cirrhotic patients, most of the brain areas with altered long- and short-range FCD could reverse one month after LT, which was accompanied with cognitive and liver functional improvement. The reduced long-range FCD in right posterior cingulate cortex (PCC) and Left middle frontal gyrus (MFG), and reduced short-range FCD in right precuneus (PCu) persisted in the early period after LT. In addition, one month after LT, the post-LT group showed reduced long-range FCD in right rectus gyrus (REC) and left medial prefrontal cortex (MPFC), and reduced short-range FCD in left middle temporal gyrus (MTG), when compared with the pre-LT group. We found Δdigital symbol test (ΔDST) score positively correlated with long-range ΔFCD in right precentral gyrus (preCG) ( r =0.72, P r =0.59, P Conclusion LT results in favorable effect on cognitive function in cirrhotic patient, which can be reflected by FCD alteration. However, persistence of PCC/PCu functional Connectivity disturbance one month after LT indicates complete cognitive function restoration may need a longer time.

Guangming Lu - One of the best experts on this subject based on the ideXlab platform.

  • disrupted functional Connectivity Density in irritable bowel syndrome patients
    Brain Imaging and Behavior, 2017
    Co-Authors: Yifei Weng, Rongfeng Qi, Long Jiang Zhang, Jun Ke, Qiang Xu, Fangyu Wang, Guangming Lu
    Abstract:

    Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder resulting from a dysregulation of the brain-gut axis. However, its exact neural substrate still remains unclear. This study investigated the changes of intrinsic whole brain functional Connectivity pattern in IBS using functional Connectivity Density (FCD). We acquired resting-state functional magnetic resonance imaging (rs-fMRI) data from thirty-two IBS patients and thirty-two healthy controls. Functional Connectivity Density, a data-driven algorithm, was used to compute the long-range and short-range FCD values for each voxel in the brain of each subject, implying the amount of distant and local functional connections of cortical hubs. The FCD maps were compared between IBS patients and healthy controls. Pearson correlations analysis was also performed between abnormal FCD values and clinical/psychometric scores in patients. Compared to healthy controls, IBS patients showed concurrently decreased long- and short-range FCD in bilateral anterior midcingulate cortices (aMCC) and inferior parietal lobules (IPL), and decreased long-range FCD in right anterior insula, and decreased short-range FCD in bilateral prefrontal cortices, subgenual anterior cingulate cortices and caudates. IBS patients also had concurrently increased long- and short-range FCD mainly in primary sensorimotor cortices, as well as increased long-range FCD in right supplementary motor area and increased short-range FCD in occipital lobe. In addition, some regions with altered FCD showed abnormal functional Connectivity in brain regions involved in pain matrix of IBS patients. Furthermore, the abnormal FCD values in right anterior insula and left caudate showed significant correlation with severity of symptoms and disease duration of IBS patients respectively. In conclusion, patients with IBS have widely disrupted FCD, which decreased in brain regions involved in homeostatic afferent network, emotional arouse, and cognitive regulation, while increased in regions associated with sensorimotor modulation. And the observed functional Connectivity alterations unveiled complicated working patterns of pain matrix in IBS patients. This study may provide us with new insight into the underlying brain network topology of IBS.

  • aberrant long range functional Connectivity Density in generalized tonic clonic seizures
    Medicine, 2016
    Co-Authors: Yibo Li, Guangming Lu, Yifeng Wang, Rong Li, Zhiqiang Zhang, Hesheng Chen
    Abstract:

    AbstractStudies in generalized tonic-clonic seizures (GTCS) have reported both structural and functional alterations in the brain. However, changes in spontaneous neuronal functional organization in GTCS remain largely unknown.In this study, 70 patients with idiopathic generalized epilepsy character

  • long and short range functional Connectivity Density alteration in non alcoholic cirrhotic patients one month after liver transplantation a resting state fmri study
    Brain Research, 2015
    Co-Authors: Rongfeng Qi, Hui Juan Chen, Qiang Xu, Xiang Kong, Xiaodong Zhang, Yue Cheng, Colin S Poon, Guangming Lu
    Abstract:

    Abstract Purpose To longitudinally evaluate long- and short-range functional Connectivity Density (FCD) alteration in cirrhotic patients one month after liver transplantation (LT) and their correlation with cognitive changes by using resting-state functional magnetic resonance imaging (rs-fMRI). Methods Twenty seven candidates awaiting LT and 24 age-, gender-, and education-matched healthy controls (HCs) were studied. All 27 patients and HCs performed rs-fMRI examinations. Of 27 cirrhotic patients, 13 patients received LT underwent the repeated rs-fMRI examinations one month after LT. Laboratory and psychometric tests were carried out. The long- and short-range FCD maps derived from degree centrality calculation were compared. Correlations between FCD alteration and laboratory/psychometric changes were evaluated as well. Results In cirrhotic patients, most of the brain areas with altered long- and short-range FCD could reverse one month after LT, which was accompanied with cognitive and liver functional improvement. The reduced long-range FCD in right posterior cingulate cortex (PCC) and Left middle frontal gyrus (MFG), and reduced short-range FCD in right precuneus (PCu) persisted in the early period after LT. In addition, one month after LT, the post-LT group showed reduced long-range FCD in right rectus gyrus (REC) and left medial prefrontal cortex (MPFC), and reduced short-range FCD in left middle temporal gyrus (MTG), when compared with the pre-LT group. We found Δdigital symbol test (ΔDST) score positively correlated with long-range ΔFCD in right precentral gyrus (preCG) ( r =0.72, P r =0.59, P Conclusion LT results in favorable effect on cognitive function in cirrhotic patient, which can be reflected by FCD alteration. However, persistence of PCC/PCu functional Connectivity disturbance one month after LT indicates complete cognitive function restoration may need a longer time.

  • role of local and distant functional Connectivity Density in the development of minimal hepatic encephalopathy
    Scientific Reports, 2015
    Co-Authors: Rongfeng Qi, Long Jiang Zhang, Hui Juan Chen, Jianhui Zhong, Jun Ke, Qiang Xu, Xiang Kong, Guangming Lu
    Abstract:

    Role of local and distant functional Connectivity Density in the development of minimal hepatic encephalopathy