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Nicholas J. Talley - One of the best experts on this subject based on the ideXlab platform.

  • cumulative incidence of chronic Constipation a population based study 1988 2003
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: R. S. Choung, Giles R. Locke, Cathy D. Schleck, Alan R. Zinsmeister, Nicholas J. Talley
    Abstract:

    Summary Aim  To estimate the cumulative incidence of chronic Constipation and evaluate potential risk factors. Methods  In previous cross-sectional studies in 1988, random samples of Olmsted County, MN residents were mailed valid gastrointestinal symptoms surveys. A similar survey was mailed in 2003 to all the remaining eligible subjects who had been mailed to previously. An incident case of chronic Constipation was defined as no reported Constipation or irritable bowel syndrome on their initial survey but reported Constipation on the second survey. Results  In all, 5507 (79%) subjects responded to the initial survey and 2298 (55%) subjects responded to the second survey in which chronic Constipation could be defined. Over 12 years, the cumulative incidence of chronic Constipation was 17.4% (14.5, 20.5). Among those less than age 50 years at baseline, the incidence of chronic Constipation differed by gender (9.2% in men vs. 18.3% in women). In those over 70 years, the incidence of chronic Constipation was more similar for men and women (20.6% vs. 25.0%). The other risk factor associated with new onset chronic Constipation was the presence of abdominal pain at baseline [OR = 2.0 (1.3, 3.0)]. Conclusion  The cumulative incidence of chronic Constipation over more than a decade was almost one in six, and more pronounced in women and the elderly.

  • Cumulative incidence of chronic Constipation: a population-based study 1988–2003
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: R. S. Choung, Giles R. Locke, Cathy D. Schleck, Alan R. Zinsmeister, Nicholas J. Talley
    Abstract:

    Summary Aim  To estimate the cumulative incidence of chronic Constipation and evaluate potential risk factors. Methods  In previous cross-sectional studies in 1988, random samples of Olmsted County, MN residents were mailed valid gastrointestinal symptoms surveys. A similar survey was mailed in 2003 to all the remaining eligible subjects who had been mailed to previously. An incident case of chronic Constipation was defined as no reported Constipation or irritable bowel syndrome on their initial survey but reported Constipation on the second survey. Results  In all, 5507 (79%) subjects responded to the initial survey and 2298 (55%) subjects responded to the second survey in which chronic Constipation could be defined. Over 12 years, the cumulative incidence of chronic Constipation was 17.4% (14.5, 20.5). Among those less than age 50 years at baseline, the incidence of chronic Constipation differed by gender (9.2% in men vs. 18.3% in women). In those over 70 years, the incidence of chronic Constipation was more similar for men and women (20.6% vs. 25.0%). The other risk factor associated with new onset chronic Constipation was the presence of abdominal pain at baseline [OR = 2.0 (1.3, 3.0)]. Conclusion  The cumulative incidence of chronic Constipation over more than a decade was almost one in six, and more pronounced in women and the elderly.

  • Differentiating functional Constipation from Constipation-predominant irritable bowel syndrome: management implications.
    Reviews in gastroenterological disorders, 2005
    Co-Authors: Nicholas J. Talley
    Abstract:

    Symptoms of Constipation are commonly seen in medical practice. Once other medical causes have been excluded, distinguishing patients who have Constipation-predominant irritable bowel syndrome (IBS) from those with functional Constipation has been considered useful in terms of planning management. However, the criteria used to distinguish IBS from functional Constipation are arguably arbitrary, and the availability of new therapeutic approaches may render such distinctions of little practical relevance. In this article, the author presents a review of the management implications of differentiating Constipation-predominant IBS from functional Constipation.

  • definitions epidemiology and impact of chronic Constipation
    Reviews in Gastroenterological Disorders, 2004
    Co-Authors: Nicholas J. Talley
    Abstract:

    Constipation, however it is defined, is a common problem in the community. The exact prevalence of Constipation depends on the definition used; prevalence estimates range from 2% to 28%. The prevalence of Constipation has been stable because the onset and disappearance rates over time are similar, but accurate data on the incidence of Constipation are lacking. Approximately one third of those individuals with Constipation seek health care; this is an expensive fraction due to investigational and medication costs. The evidence that life-style factors are causally linked to Constipation is weak, although nonsteroidal anti-inflammatory drug use and the use of other Constipation-inducing medications are important risk factors. Constipation is not of clinical importance until it causes physical risks or impairs quality of life. There is accumulating evidence that self-reported Constipation and functional Constipation as defined by the Rome Criteria lead to significant impairment of quality of life, with the implication that this is a serious condition in the majority of people afflicted. Constipation may have other serious consequences; an increased risk of colon cancer has been reported but could be explained by confounding. Although hemorrhoids have been attributed to Constipation, this association has been questioned. The costs of testing in patients presenting with Constipation has been conservatively estimated to be 6.9 billion dollars annually in the United States; treatment costs add substantially to the health care burden.

R. S. Choung - One of the best experts on this subject based on the ideXlab platform.

  • cumulative incidence of chronic Constipation a population based study 1988 2003
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: R. S. Choung, Giles R. Locke, Cathy D. Schleck, Alan R. Zinsmeister, Nicholas J. Talley
    Abstract:

    Summary Aim  To estimate the cumulative incidence of chronic Constipation and evaluate potential risk factors. Methods  In previous cross-sectional studies in 1988, random samples of Olmsted County, MN residents were mailed valid gastrointestinal symptoms surveys. A similar survey was mailed in 2003 to all the remaining eligible subjects who had been mailed to previously. An incident case of chronic Constipation was defined as no reported Constipation or irritable bowel syndrome on their initial survey but reported Constipation on the second survey. Results  In all, 5507 (79%) subjects responded to the initial survey and 2298 (55%) subjects responded to the second survey in which chronic Constipation could be defined. Over 12 years, the cumulative incidence of chronic Constipation was 17.4% (14.5, 20.5). Among those less than age 50 years at baseline, the incidence of chronic Constipation differed by gender (9.2% in men vs. 18.3% in women). In those over 70 years, the incidence of chronic Constipation was more similar for men and women (20.6% vs. 25.0%). The other risk factor associated with new onset chronic Constipation was the presence of abdominal pain at baseline [OR = 2.0 (1.3, 3.0)]. Conclusion  The cumulative incidence of chronic Constipation over more than a decade was almost one in six, and more pronounced in women and the elderly.

  • Cumulative incidence of chronic Constipation: a population-based study 1988–2003
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: R. S. Choung, Giles R. Locke, Cathy D. Schleck, Alan R. Zinsmeister, Nicholas J. Talley
    Abstract:

    Summary Aim  To estimate the cumulative incidence of chronic Constipation and evaluate potential risk factors. Methods  In previous cross-sectional studies in 1988, random samples of Olmsted County, MN residents were mailed valid gastrointestinal symptoms surveys. A similar survey was mailed in 2003 to all the remaining eligible subjects who had been mailed to previously. An incident case of chronic Constipation was defined as no reported Constipation or irritable bowel syndrome on their initial survey but reported Constipation on the second survey. Results  In all, 5507 (79%) subjects responded to the initial survey and 2298 (55%) subjects responded to the second survey in which chronic Constipation could be defined. Over 12 years, the cumulative incidence of chronic Constipation was 17.4% (14.5, 20.5). Among those less than age 50 years at baseline, the incidence of chronic Constipation differed by gender (9.2% in men vs. 18.3% in women). In those over 70 years, the incidence of chronic Constipation was more similar for men and women (20.6% vs. 25.0%). The other risk factor associated with new onset chronic Constipation was the presence of abdominal pain at baseline [OR = 2.0 (1.3, 3.0)]. Conclusion  The cumulative incidence of chronic Constipation over more than a decade was almost one in six, and more pronounced in women and the elderly.

Cathy D. Schleck - One of the best experts on this subject based on the ideXlab platform.

  • cumulative incidence of chronic Constipation a population based study 1988 2003
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: R. S. Choung, Giles R. Locke, Cathy D. Schleck, Alan R. Zinsmeister, Nicholas J. Talley
    Abstract:

    Summary Aim  To estimate the cumulative incidence of chronic Constipation and evaluate potential risk factors. Methods  In previous cross-sectional studies in 1988, random samples of Olmsted County, MN residents were mailed valid gastrointestinal symptoms surveys. A similar survey was mailed in 2003 to all the remaining eligible subjects who had been mailed to previously. An incident case of chronic Constipation was defined as no reported Constipation or irritable bowel syndrome on their initial survey but reported Constipation on the second survey. Results  In all, 5507 (79%) subjects responded to the initial survey and 2298 (55%) subjects responded to the second survey in which chronic Constipation could be defined. Over 12 years, the cumulative incidence of chronic Constipation was 17.4% (14.5, 20.5). Among those less than age 50 years at baseline, the incidence of chronic Constipation differed by gender (9.2% in men vs. 18.3% in women). In those over 70 years, the incidence of chronic Constipation was more similar for men and women (20.6% vs. 25.0%). The other risk factor associated with new onset chronic Constipation was the presence of abdominal pain at baseline [OR = 2.0 (1.3, 3.0)]. Conclusion  The cumulative incidence of chronic Constipation over more than a decade was almost one in six, and more pronounced in women and the elderly.

  • Cumulative incidence of chronic Constipation: a population-based study 1988–2003
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: R. S. Choung, Giles R. Locke, Cathy D. Schleck, Alan R. Zinsmeister, Nicholas J. Talley
    Abstract:

    Summary Aim  To estimate the cumulative incidence of chronic Constipation and evaluate potential risk factors. Methods  In previous cross-sectional studies in 1988, random samples of Olmsted County, MN residents were mailed valid gastrointestinal symptoms surveys. A similar survey was mailed in 2003 to all the remaining eligible subjects who had been mailed to previously. An incident case of chronic Constipation was defined as no reported Constipation or irritable bowel syndrome on their initial survey but reported Constipation on the second survey. Results  In all, 5507 (79%) subjects responded to the initial survey and 2298 (55%) subjects responded to the second survey in which chronic Constipation could be defined. Over 12 years, the cumulative incidence of chronic Constipation was 17.4% (14.5, 20.5). Among those less than age 50 years at baseline, the incidence of chronic Constipation differed by gender (9.2% in men vs. 18.3% in women). In those over 70 years, the incidence of chronic Constipation was more similar for men and women (20.6% vs. 25.0%). The other risk factor associated with new onset chronic Constipation was the presence of abdominal pain at baseline [OR = 2.0 (1.3, 3.0)]. Conclusion  The cumulative incidence of chronic Constipation over more than a decade was almost one in six, and more pronounced in women and the elderly.

Alan R. Zinsmeister - One of the best experts on this subject based on the ideXlab platform.

  • cumulative incidence of chronic Constipation a population based study 1988 2003
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: R. S. Choung, Giles R. Locke, Cathy D. Schleck, Alan R. Zinsmeister, Nicholas J. Talley
    Abstract:

    Summary Aim  To estimate the cumulative incidence of chronic Constipation and evaluate potential risk factors. Methods  In previous cross-sectional studies in 1988, random samples of Olmsted County, MN residents were mailed valid gastrointestinal symptoms surveys. A similar survey was mailed in 2003 to all the remaining eligible subjects who had been mailed to previously. An incident case of chronic Constipation was defined as no reported Constipation or irritable bowel syndrome on their initial survey but reported Constipation on the second survey. Results  In all, 5507 (79%) subjects responded to the initial survey and 2298 (55%) subjects responded to the second survey in which chronic Constipation could be defined. Over 12 years, the cumulative incidence of chronic Constipation was 17.4% (14.5, 20.5). Among those less than age 50 years at baseline, the incidence of chronic Constipation differed by gender (9.2% in men vs. 18.3% in women). In those over 70 years, the incidence of chronic Constipation was more similar for men and women (20.6% vs. 25.0%). The other risk factor associated with new onset chronic Constipation was the presence of abdominal pain at baseline [OR = 2.0 (1.3, 3.0)]. Conclusion  The cumulative incidence of chronic Constipation over more than a decade was almost one in six, and more pronounced in women and the elderly.

  • Cumulative incidence of chronic Constipation: a population-based study 1988–2003
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: R. S. Choung, Giles R. Locke, Cathy D. Schleck, Alan R. Zinsmeister, Nicholas J. Talley
    Abstract:

    Summary Aim  To estimate the cumulative incidence of chronic Constipation and evaluate potential risk factors. Methods  In previous cross-sectional studies in 1988, random samples of Olmsted County, MN residents were mailed valid gastrointestinal symptoms surveys. A similar survey was mailed in 2003 to all the remaining eligible subjects who had been mailed to previously. An incident case of chronic Constipation was defined as no reported Constipation or irritable bowel syndrome on their initial survey but reported Constipation on the second survey. Results  In all, 5507 (79%) subjects responded to the initial survey and 2298 (55%) subjects responded to the second survey in which chronic Constipation could be defined. Over 12 years, the cumulative incidence of chronic Constipation was 17.4% (14.5, 20.5). Among those less than age 50 years at baseline, the incidence of chronic Constipation differed by gender (9.2% in men vs. 18.3% in women). In those over 70 years, the incidence of chronic Constipation was more similar for men and women (20.6% vs. 25.0%). The other risk factor associated with new onset chronic Constipation was the presence of abdominal pain at baseline [OR = 2.0 (1.3, 3.0)]. Conclusion  The cumulative incidence of chronic Constipation over more than a decade was almost one in six, and more pronounced in women and the elderly.

Giles R. Locke - One of the best experts on this subject based on the ideXlab platform.

  • cumulative incidence of chronic Constipation a population based study 1988 2003
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: R. S. Choung, Giles R. Locke, Cathy D. Schleck, Alan R. Zinsmeister, Nicholas J. Talley
    Abstract:

    Summary Aim  To estimate the cumulative incidence of chronic Constipation and evaluate potential risk factors. Methods  In previous cross-sectional studies in 1988, random samples of Olmsted County, MN residents were mailed valid gastrointestinal symptoms surveys. A similar survey was mailed in 2003 to all the remaining eligible subjects who had been mailed to previously. An incident case of chronic Constipation was defined as no reported Constipation or irritable bowel syndrome on their initial survey but reported Constipation on the second survey. Results  In all, 5507 (79%) subjects responded to the initial survey and 2298 (55%) subjects responded to the second survey in which chronic Constipation could be defined. Over 12 years, the cumulative incidence of chronic Constipation was 17.4% (14.5, 20.5). Among those less than age 50 years at baseline, the incidence of chronic Constipation differed by gender (9.2% in men vs. 18.3% in women). In those over 70 years, the incidence of chronic Constipation was more similar for men and women (20.6% vs. 25.0%). The other risk factor associated with new onset chronic Constipation was the presence of abdominal pain at baseline [OR = 2.0 (1.3, 3.0)]. Conclusion  The cumulative incidence of chronic Constipation over more than a decade was almost one in six, and more pronounced in women and the elderly.

  • Cumulative incidence of chronic Constipation: a population-based study 1988–2003
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: R. S. Choung, Giles R. Locke, Cathy D. Schleck, Alan R. Zinsmeister, Nicholas J. Talley
    Abstract:

    Summary Aim  To estimate the cumulative incidence of chronic Constipation and evaluate potential risk factors. Methods  In previous cross-sectional studies in 1988, random samples of Olmsted County, MN residents were mailed valid gastrointestinal symptoms surveys. A similar survey was mailed in 2003 to all the remaining eligible subjects who had been mailed to previously. An incident case of chronic Constipation was defined as no reported Constipation or irritable bowel syndrome on their initial survey but reported Constipation on the second survey. Results  In all, 5507 (79%) subjects responded to the initial survey and 2298 (55%) subjects responded to the second survey in which chronic Constipation could be defined. Over 12 years, the cumulative incidence of chronic Constipation was 17.4% (14.5, 20.5). Among those less than age 50 years at baseline, the incidence of chronic Constipation differed by gender (9.2% in men vs. 18.3% in women). In those over 70 years, the incidence of chronic Constipation was more similar for men and women (20.6% vs. 25.0%). The other risk factor associated with new onset chronic Constipation was the presence of abdominal pain at baseline [OR = 2.0 (1.3, 3.0)]. Conclusion  The cumulative incidence of chronic Constipation over more than a decade was almost one in six, and more pronounced in women and the elderly.