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Douglas C. Chang - One of the best experts on this subject based on the ideXlab platform.
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national outbreak of acanthamoeba keratitis associated with use of a Contact Lens Solution united states
Emerging Infectious Diseases, 2009Co-Authors: Jennifer R Verani, Jonathan S Yoder, Suchita Lorick, Jacquelin M Roberts, Michael J Beach, Christopher R Braden, Craig Conover, Sue Chen, Kateesha A Mcconnell, Douglas C. ChangAbstract:An outbreak of Acanthamoeba keratitis, a rare, potentially blinding, corneal infection, was detected in the United States in 2007; cases had been increasing since 2004. A case–control study was conducted to investigate the outbreak. We interviewed 105 case-patients from 30 states and 184 controls matched geographically and by Contact Lens use. Available Contact Lenses, cases, Solutions, and corneal specimens from case-patients were cultured and tested by molecular methods. In multivariate analyses, case-patients had significantly greater odds of having used Advanced Medical Optics Complete Moisture Plus (AMOCMP) Solution (odds ratio 16.9, 95% confidence interval 4.8–59.5). AMOCMP manufacturing lot information was available for 22 case-patients, but none of the lots were identical. Three unopened bottles of AMOCMP tested negative for Acanthamoeba spp. Our findings suggest that the Solution was not intrinsically contaminated and that its anti-Acanthamoeba efficacy was insufficient. Premarket standardized testing of Contact Lens Solutions for activity against Acanthamoeba spp. is warranted.
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phylogenetic diversity and microsphere array based genotyping of human pathogenic fusaria including isolates from the multistate Contact Lens associated u s keratitis outbreaks of 2005 and 2006
Journal of Clinical Microbiology, 2007Co-Authors: Kerry Odonnell, Douglas C. Chang, Brice A J Sarver, Mary E Brandt, Judith Noblewang, Benjamin J Park, Deanna A Sutton, Lynette Benjamin, Mark D Lindsley, A A PadhyeAbstract:Fusarium keratitis (FK) is a rare sight-threatening corneal infection among the many Contact Lens wearers in the United States and abroad (5, 20). After an increase in FK among Contact Lens wearers was suspected in Singapore, an investigation in that country suggested a link with the use of ReNu brand Contact Lens Solution (20), based on the disproportionate number of FK cases associated with this product. After an increase in cases of FK was suspected in the United States, the Centers for Disease Control and Prevention (CDC) in conjunction with other public health agencies in the United States conducted a case-control study, which demonstrated that the
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Multistate outbreak of Fusarium keratitis associated with use of a Contact Lens Solution
Journal of the American Medical Association, 2006Co-Authors: Douglas C. Chang, Gavin B. Grant, Lara M. Jacobson, Claudia S. Crowell, Carol Y Rao, Kathleen A. Wannemuehler, Rodlescia S Sneed, Kerry O'donnell, Judith Noble-wang, Felicia M T LewisAbstract:CONTEXT: Fusarium keratitis is a serious corneal infection, most commonly associated with corneal injury. Beginning in March 2006, the Centers for Disease Control and Prevention received multiple reports of Fusarium keratitis among Contact Lens wearers. OBJECTIVE: To define the specific activities, Contact Lens hygiene practices, or products associated with this outbreak. DESIGN, SETTING, AND PARTICIPANTS: Epidemiological investigation of Fusarium keratitis occurring in the United States. A confirmed case was defined as keratitis with illness onset after June 1, 2005, with no history of recent ocular trauma and a corneal culture growing Fusarium species. Data were obtained by patient and ophthalmologist interviews for case patients and neighborhood-matched controls by trained personnel. Available Fusarium isolates from patients' clinical and environmental specimens were genotyped by multilocus sequence typing. Environmental sampling for Fusarium was conducted at a Contact Lens Solution manufacturing plant. MAIN OUTCOME MEASURES: Keratitis infection with Fusarium species. RESULTS: As of June 30, 2006, we identified 164 confirmed case patients in 33 states and 1 US territory. Median age was 41 years (range, 12-83 years). Corneal transplantation was required or planned in 55 (34%). One hundred fifty-four (94%) of the confirmed case patients wore soft Contact Lenses. Forty-five case patients and 78 controls were included in the case-control study. Case patients were significantly more likely than controls to report using a specific Contact Lens Solution, ReNu with MoistureLoc (69% vs 15%; odds ratio, 13.3; 95% confidence interval, 3.1-119.5). The prevalence of reported use of ReNu MultiPlus Solution was similar between case patients and controls (18% vs 20%; odds ratio, 0.7; 95% confidence interval, 0.2-2.8). Fusarium was not recovered from the factory, warehouse, Solution filtrate, or unopened Solution bottles; production of implicated lots was not clustered in time. Among 39 isolates tested, at least 10 different Fusarium species were identified, comprising 19 unique multilocus genotypes. CONCLUSIONS: The findings from this investigation indicate that this outbreak of Fusarium keratitis was associated with use of ReNu with MoistureLoc Contact Lens Solution. Contact Lens users should not use ReNu with MoistureLoc.
Felicia M T Lewis - One of the best experts on this subject based on the ideXlab platform.
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Multistate outbreak of Fusarium keratitis associated with use of a Contact Lens Solution
Journal of the American Medical Association, 2006Co-Authors: Douglas C. Chang, Gavin B. Grant, Lara M. Jacobson, Claudia S. Crowell, Carol Y Rao, Kathleen A. Wannemuehler, Rodlescia S Sneed, Kerry O'donnell, Judith Noble-wang, Felicia M T LewisAbstract:CONTEXT: Fusarium keratitis is a serious corneal infection, most commonly associated with corneal injury. Beginning in March 2006, the Centers for Disease Control and Prevention received multiple reports of Fusarium keratitis among Contact Lens wearers. OBJECTIVE: To define the specific activities, Contact Lens hygiene practices, or products associated with this outbreak. DESIGN, SETTING, AND PARTICIPANTS: Epidemiological investigation of Fusarium keratitis occurring in the United States. A confirmed case was defined as keratitis with illness onset after June 1, 2005, with no history of recent ocular trauma and a corneal culture growing Fusarium species. Data were obtained by patient and ophthalmologist interviews for case patients and neighborhood-matched controls by trained personnel. Available Fusarium isolates from patients' clinical and environmental specimens were genotyped by multilocus sequence typing. Environmental sampling for Fusarium was conducted at a Contact Lens Solution manufacturing plant. MAIN OUTCOME MEASURES: Keratitis infection with Fusarium species. RESULTS: As of June 30, 2006, we identified 164 confirmed case patients in 33 states and 1 US territory. Median age was 41 years (range, 12-83 years). Corneal transplantation was required or planned in 55 (34%). One hundred fifty-four (94%) of the confirmed case patients wore soft Contact Lenses. Forty-five case patients and 78 controls were included in the case-control study. Case patients were significantly more likely than controls to report using a specific Contact Lens Solution, ReNu with MoistureLoc (69% vs 15%; odds ratio, 13.3; 95% confidence interval, 3.1-119.5). The prevalence of reported use of ReNu MultiPlus Solution was similar between case patients and controls (18% vs 20%; odds ratio, 0.7; 95% confidence interval, 0.2-2.8). Fusarium was not recovered from the factory, warehouse, Solution filtrate, or unopened Solution bottles; production of implicated lots was not clustered in time. Among 39 isolates tested, at least 10 different Fusarium species were identified, comprising 19 unique multilocus genotypes. CONCLUSIONS: The findings from this investigation indicate that this outbreak of Fusarium keratitis was associated with use of ReNu with MoistureLoc Contact Lens Solution. Contact Lens users should not use ReNu with MoistureLoc.
Jennifer R Verani - One of the best experts on this subject based on the ideXlab platform.
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acanthamoeba keratitis among rigid gas permeable Contact Lens wearers in the united states 2005 through 2011
Ophthalmology, 2016Co-Authors: Jennifer R Cope, Jennifer R Verani, Michael J Beach, Sarah A Collier, Oliver D Schein, Allison C Brown, Rachel Gallen, Jonathan S YoderAbstract:Purpose To describe the clinical presentation and outcomes of Acanthamoeba keratitis (AK) in rigid gas permeable (RGP) Contact Lens wearers and to identify modifiable risk factors. Design Case-control investigation. Participants Patients were RGP Contact Lens–wearing United States residents with a diagnosis of AK from 2005 through 2011. Controls were RGP Contact Lens wearers with no history of AK who were at least 12 years of age. Methods Patients were identified during 2 multistate AK outbreak investigations. Controls from the first investigation in 2007 were identified using a reverse address directory. In the second investigation, controls were recruited from participating ophthalmology and optometry practices. Patients and controls were interviewed by phone using a standardized questionnaire. Odds ratios (ORs) and Fisher exact P values were calculated to assess risk factors associated with infection. Main Outcome Measures Acanthamoeba keratitis, a rare eye disease primarily affecting Contact Lens wearers, is caused by free-living amebae, Acanthamoeba species. Results We identified 37 patients in the 2 investigations, 10 (27%) from the 2007 investigation and 27 (73%) from 2011. There were 17 healthy controls, 9 (53%) from 2007 and 8 (47%) from 2011. Among patients, 9 (24%) wore RGP Lenses for orthokeratology or therapeutic indication; no controls wore RGP Lenses for these indications. Significant risk factors for AK were wearing Lenses for orthokeratology (OR, undefined; P = 0.02), sleeping while wearing Lenses (OR, 8.00; P = 0.04), storing Lenses in tap water (OR, 16.00; P = 0.001), and topping off Contact Lens Solution in the case (OR, 4.80; P = 0.01). After stratifying by use of RGP Lenses for orthokeratology, storing Lenses in tap water and topping off remained significant exposures. Conclusions Nearly one quarter of patients were orthokeratology wearers. Using tap water to store RGP Lenses and topping off Solution in the Lens case were modifiable risk behaviors identified in RGP wearers who wore Lenses for both orthokeratology and nonorthokeratology indications. Rigid gas permeable wearers should avoid exposing their Lenses to tap water and should empty their cases and use fresh Lens Solution each time they take out their Lenses.
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national outbreak of acanthamoeba keratitis associated with use of a Contact Lens Solution united states
Emerging Infectious Diseases, 2009Co-Authors: Jennifer R Verani, Jonathan S Yoder, Suchita Lorick, Jacquelin M Roberts, Michael J Beach, Christopher R Braden, Craig Conover, Sue Chen, Kateesha A Mcconnell, Douglas C. ChangAbstract:An outbreak of Acanthamoeba keratitis, a rare, potentially blinding, corneal infection, was detected in the United States in 2007; cases had been increasing since 2004. A case–control study was conducted to investigate the outbreak. We interviewed 105 case-patients from 30 states and 184 controls matched geographically and by Contact Lens use. Available Contact Lenses, cases, Solutions, and corneal specimens from case-patients were cultured and tested by molecular methods. In multivariate analyses, case-patients had significantly greater odds of having used Advanced Medical Optics Complete Moisture Plus (AMOCMP) Solution (odds ratio 16.9, 95% confidence interval 4.8–59.5). AMOCMP manufacturing lot information was available for 22 case-patients, but none of the lots were identical. Three unopened bottles of AMOCMP tested negative for Acanthamoeba spp. Our findings suggest that the Solution was not intrinsically contaminated and that its anti-Acanthamoeba efficacy was insufficient. Premarket standardized testing of Contact Lens Solutions for activity against Acanthamoeba spp. is warranted.
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resistance of acanthamoeba cysts to disinfection in multiple Contact Lens Solutions
Journal of Clinical Microbiology, 2009Co-Authors: Stephanie P Johnston, Yvonne Qvarnstrom, Rama Sriram, Sharon L Roy, Jennifer R Verani, Jonathan S Yoder, Suchita Lorick, Jacquelin M Roberts, Michael J Beach, Govinda S. VisvesvaraAbstract:Acanthamoebae are free-living amoebae found in the environment, including soil, freshwater, brackish water, seawater, hot tubs, and Jacuzzis. Acanthamoeba species can cause keratitis, a painful vision-threatening infection of the cornea, and fatal granulomatous encephalitis in humans. More than 20 species of Acanthamoeba belonging to morphological groups I, II, and III distributed in 15 genotypes have been described. Among these, Acanthamoeba castellanii, A. polyphaga, and A. hatchetti are frequently identified as causing Acanthamoeba keratitis (AK). Improper Contact Lens care and Contact with nonsterile water while wearing Contact Lenses are known risk factors for AK. During a recent multistate outbreak, AK was found to be associated with the use of Advanced Medical Optics Complete MoisturePlus multipurpose Contact Lens Solution, which was hypothesized to have had insufficient anti-Acanthamoeba activity. As part of the investigation of that outbreak, we compared the efficacies of 11 different Contact Lens Solutions against cysts of A. castellanii, A. polyphaga, and A. hatchetti (the isolates of all species were genotype T4), which were isolated in 2007 from specimens obtained during the outbreak investigation. The data, generated with A. castellanii, A. polyphaga, and A. hatchetti cysts, suggest that the two Contact Lens Solutions containing hydrogen peroxide were the only Solutions that showed any disinfection ability, with 0% and 66% growth, respectively, being detected with A. castellanii and 0% and 33% growth, respectively, being detected with A. polyphaga. There was no statistically significant difference in disinfection efficacy between the 11 Solutions for A. hatchetti.
Jonathan S Yoder - One of the best experts on this subject based on the ideXlab platform.
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acanthamoeba keratitis among rigid gas permeable Contact Lens wearers in the united states 2005 through 2011
Ophthalmology, 2016Co-Authors: Jennifer R Cope, Jennifer R Verani, Michael J Beach, Sarah A Collier, Oliver D Schein, Allison C Brown, Rachel Gallen, Jonathan S YoderAbstract:Purpose To describe the clinical presentation and outcomes of Acanthamoeba keratitis (AK) in rigid gas permeable (RGP) Contact Lens wearers and to identify modifiable risk factors. Design Case-control investigation. Participants Patients were RGP Contact Lens–wearing United States residents with a diagnosis of AK from 2005 through 2011. Controls were RGP Contact Lens wearers with no history of AK who were at least 12 years of age. Methods Patients were identified during 2 multistate AK outbreak investigations. Controls from the first investigation in 2007 were identified using a reverse address directory. In the second investigation, controls were recruited from participating ophthalmology and optometry practices. Patients and controls were interviewed by phone using a standardized questionnaire. Odds ratios (ORs) and Fisher exact P values were calculated to assess risk factors associated with infection. Main Outcome Measures Acanthamoeba keratitis, a rare eye disease primarily affecting Contact Lens wearers, is caused by free-living amebae, Acanthamoeba species. Results We identified 37 patients in the 2 investigations, 10 (27%) from the 2007 investigation and 27 (73%) from 2011. There were 17 healthy controls, 9 (53%) from 2007 and 8 (47%) from 2011. Among patients, 9 (24%) wore RGP Lenses for orthokeratology or therapeutic indication; no controls wore RGP Lenses for these indications. Significant risk factors for AK were wearing Lenses for orthokeratology (OR, undefined; P = 0.02), sleeping while wearing Lenses (OR, 8.00; P = 0.04), storing Lenses in tap water (OR, 16.00; P = 0.001), and topping off Contact Lens Solution in the case (OR, 4.80; P = 0.01). After stratifying by use of RGP Lenses for orthokeratology, storing Lenses in tap water and topping off remained significant exposures. Conclusions Nearly one quarter of patients were orthokeratology wearers. Using tap water to store RGP Lenses and topping off Solution in the Lens case were modifiable risk behaviors identified in RGP wearers who wore Lenses for both orthokeratology and nonorthokeratology indications. Rigid gas permeable wearers should avoid exposing their Lenses to tap water and should empty their cases and use fresh Lens Solution each time they take out their Lenses.
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national outbreak of acanthamoeba keratitis associated with use of a Contact Lens Solution united states
Emerging Infectious Diseases, 2009Co-Authors: Jennifer R Verani, Jonathan S Yoder, Suchita Lorick, Jacquelin M Roberts, Michael J Beach, Christopher R Braden, Craig Conover, Sue Chen, Kateesha A Mcconnell, Douglas C. ChangAbstract:An outbreak of Acanthamoeba keratitis, a rare, potentially blinding, corneal infection, was detected in the United States in 2007; cases had been increasing since 2004. A case–control study was conducted to investigate the outbreak. We interviewed 105 case-patients from 30 states and 184 controls matched geographically and by Contact Lens use. Available Contact Lenses, cases, Solutions, and corneal specimens from case-patients were cultured and tested by molecular methods. In multivariate analyses, case-patients had significantly greater odds of having used Advanced Medical Optics Complete Moisture Plus (AMOCMP) Solution (odds ratio 16.9, 95% confidence interval 4.8–59.5). AMOCMP manufacturing lot information was available for 22 case-patients, but none of the lots were identical. Three unopened bottles of AMOCMP tested negative for Acanthamoeba spp. Our findings suggest that the Solution was not intrinsically contaminated and that its anti-Acanthamoeba efficacy was insufficient. Premarket standardized testing of Contact Lens Solutions for activity against Acanthamoeba spp. is warranted.
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resistance of acanthamoeba cysts to disinfection in multiple Contact Lens Solutions
Journal of Clinical Microbiology, 2009Co-Authors: Stephanie P Johnston, Yvonne Qvarnstrom, Rama Sriram, Sharon L Roy, Jennifer R Verani, Jonathan S Yoder, Suchita Lorick, Jacquelin M Roberts, Michael J Beach, Govinda S. VisvesvaraAbstract:Acanthamoebae are free-living amoebae found in the environment, including soil, freshwater, brackish water, seawater, hot tubs, and Jacuzzis. Acanthamoeba species can cause keratitis, a painful vision-threatening infection of the cornea, and fatal granulomatous encephalitis in humans. More than 20 species of Acanthamoeba belonging to morphological groups I, II, and III distributed in 15 genotypes have been described. Among these, Acanthamoeba castellanii, A. polyphaga, and A. hatchetti are frequently identified as causing Acanthamoeba keratitis (AK). Improper Contact Lens care and Contact with nonsterile water while wearing Contact Lenses are known risk factors for AK. During a recent multistate outbreak, AK was found to be associated with the use of Advanced Medical Optics Complete MoisturePlus multipurpose Contact Lens Solution, which was hypothesized to have had insufficient anti-Acanthamoeba activity. As part of the investigation of that outbreak, we compared the efficacies of 11 different Contact Lens Solutions against cysts of A. castellanii, A. polyphaga, and A. hatchetti (the isolates of all species were genotype T4), which were isolated in 2007 from specimens obtained during the outbreak investigation. The data, generated with A. castellanii, A. polyphaga, and A. hatchetti cysts, suggest that the two Contact Lens Solutions containing hydrogen peroxide were the only Solutions that showed any disinfection ability, with 0% and 66% growth, respectively, being detected with A. castellanii and 0% and 33% growth, respectively, being detected with A. polyphaga. There was no statistically significant difference in disinfection efficacy between the 11 Solutions for A. hatchetti.
Michael J Beach - One of the best experts on this subject based on the ideXlab platform.
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acanthamoeba keratitis among rigid gas permeable Contact Lens wearers in the united states 2005 through 2011
Ophthalmology, 2016Co-Authors: Jennifer R Cope, Jennifer R Verani, Michael J Beach, Sarah A Collier, Oliver D Schein, Allison C Brown, Rachel Gallen, Jonathan S YoderAbstract:Purpose To describe the clinical presentation and outcomes of Acanthamoeba keratitis (AK) in rigid gas permeable (RGP) Contact Lens wearers and to identify modifiable risk factors. Design Case-control investigation. Participants Patients were RGP Contact Lens–wearing United States residents with a diagnosis of AK from 2005 through 2011. Controls were RGP Contact Lens wearers with no history of AK who were at least 12 years of age. Methods Patients were identified during 2 multistate AK outbreak investigations. Controls from the first investigation in 2007 were identified using a reverse address directory. In the second investigation, controls were recruited from participating ophthalmology and optometry practices. Patients and controls were interviewed by phone using a standardized questionnaire. Odds ratios (ORs) and Fisher exact P values were calculated to assess risk factors associated with infection. Main Outcome Measures Acanthamoeba keratitis, a rare eye disease primarily affecting Contact Lens wearers, is caused by free-living amebae, Acanthamoeba species. Results We identified 37 patients in the 2 investigations, 10 (27%) from the 2007 investigation and 27 (73%) from 2011. There were 17 healthy controls, 9 (53%) from 2007 and 8 (47%) from 2011. Among patients, 9 (24%) wore RGP Lenses for orthokeratology or therapeutic indication; no controls wore RGP Lenses for these indications. Significant risk factors for AK were wearing Lenses for orthokeratology (OR, undefined; P = 0.02), sleeping while wearing Lenses (OR, 8.00; P = 0.04), storing Lenses in tap water (OR, 16.00; P = 0.001), and topping off Contact Lens Solution in the case (OR, 4.80; P = 0.01). After stratifying by use of RGP Lenses for orthokeratology, storing Lenses in tap water and topping off remained significant exposures. Conclusions Nearly one quarter of patients were orthokeratology wearers. Using tap water to store RGP Lenses and topping off Solution in the Lens case were modifiable risk behaviors identified in RGP wearers who wore Lenses for both orthokeratology and nonorthokeratology indications. Rigid gas permeable wearers should avoid exposing their Lenses to tap water and should empty their cases and use fresh Lens Solution each time they take out their Lenses.
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national outbreak of acanthamoeba keratitis associated with use of a Contact Lens Solution united states
Emerging Infectious Diseases, 2009Co-Authors: Jennifer R Verani, Jonathan S Yoder, Suchita Lorick, Jacquelin M Roberts, Michael J Beach, Christopher R Braden, Craig Conover, Sue Chen, Kateesha A Mcconnell, Douglas C. ChangAbstract:An outbreak of Acanthamoeba keratitis, a rare, potentially blinding, corneal infection, was detected in the United States in 2007; cases had been increasing since 2004. A case–control study was conducted to investigate the outbreak. We interviewed 105 case-patients from 30 states and 184 controls matched geographically and by Contact Lens use. Available Contact Lenses, cases, Solutions, and corneal specimens from case-patients were cultured and tested by molecular methods. In multivariate analyses, case-patients had significantly greater odds of having used Advanced Medical Optics Complete Moisture Plus (AMOCMP) Solution (odds ratio 16.9, 95% confidence interval 4.8–59.5). AMOCMP manufacturing lot information was available for 22 case-patients, but none of the lots were identical. Three unopened bottles of AMOCMP tested negative for Acanthamoeba spp. Our findings suggest that the Solution was not intrinsically contaminated and that its anti-Acanthamoeba efficacy was insufficient. Premarket standardized testing of Contact Lens Solutions for activity against Acanthamoeba spp. is warranted.
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resistance of acanthamoeba cysts to disinfection in multiple Contact Lens Solutions
Journal of Clinical Microbiology, 2009Co-Authors: Stephanie P Johnston, Yvonne Qvarnstrom, Rama Sriram, Sharon L Roy, Jennifer R Verani, Jonathan S Yoder, Suchita Lorick, Jacquelin M Roberts, Michael J Beach, Govinda S. VisvesvaraAbstract:Acanthamoebae are free-living amoebae found in the environment, including soil, freshwater, brackish water, seawater, hot tubs, and Jacuzzis. Acanthamoeba species can cause keratitis, a painful vision-threatening infection of the cornea, and fatal granulomatous encephalitis in humans. More than 20 species of Acanthamoeba belonging to morphological groups I, II, and III distributed in 15 genotypes have been described. Among these, Acanthamoeba castellanii, A. polyphaga, and A. hatchetti are frequently identified as causing Acanthamoeba keratitis (AK). Improper Contact Lens care and Contact with nonsterile water while wearing Contact Lenses are known risk factors for AK. During a recent multistate outbreak, AK was found to be associated with the use of Advanced Medical Optics Complete MoisturePlus multipurpose Contact Lens Solution, which was hypothesized to have had insufficient anti-Acanthamoeba activity. As part of the investigation of that outbreak, we compared the efficacies of 11 different Contact Lens Solutions against cysts of A. castellanii, A. polyphaga, and A. hatchetti (the isolates of all species were genotype T4), which were isolated in 2007 from specimens obtained during the outbreak investigation. The data, generated with A. castellanii, A. polyphaga, and A. hatchetti cysts, suggest that the two Contact Lens Solutions containing hydrogen peroxide were the only Solutions that showed any disinfection ability, with 0% and 66% growth, respectively, being detected with A. castellanii and 0% and 33% growth, respectively, being detected with A. polyphaga. There was no statistically significant difference in disinfection efficacy between the 11 Solutions for A. hatchetti.