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Denis Malvy - One of the best experts on this subject based on the ideXlab platform.
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Interpretation of Plasma PTH Concentrations According to 25OHD Status, Gender, Age, Weight Status, and Calcium Intake: Importance of the Reference Values
Journal of Clinical Endocrinology and Metabolism, 2014Co-Authors: Mathilde Touvier, Mélanie Deschasaux, Marion Montourcy, Angela Sutton, Nathalie Charnaux, Emmanuelle Kesse-guyot, Léopold Fezeu, Paule Latino-martel, Nathalie Druesne-pecollo, Denis MalvyAbstract:Context: Reference values for plasma PTH assessment were generally established on small samples of apparently healthy subjects, without considering their 25-hydroxyvitamin D (25OHD) status or other potential modifiers of PTH concentration. Objective: Our objective was to assess ranges of plasma PTH concentration in a large sample of adults, stratifying by 25OHD status, age, gender, weight status, and calcium intake. Design, Setting, and Participants: This cross-sectional survey is based on 1824 middle-aged Caucasian adults from the Supplementation en Vitamines et Mineraux Antioxydants study (1994). Main Outcome Measures: Plasma PTH and 25OHD concentrations were measured by an electro-chemoluminescent immunoassay. Extreme percentiles of plasma PTH concentrations were assessed specifically in subjects who had plasmatic values of 25OHD of 20 ng/mL or greater and 30 ng/mL or greater. Results: Among subjects with 25OHD status of 20ng/mL or greater, the 97.5th percentile of plasma PTH concentration was 45.5 ng/L. By using this value as a Reference, 5% of the subjects with plasma 25OHD less than 20 nmol/L had a high plasma PTH level, reflecting secondary hyperparathyroidism. Among vitamin D-replete subjects (25OHD status of 20 ng/mL or greater), the 97.5th percentile of plasma PTH was higher in overweight/obese subjects (51.9 vs 43.5 ng/L among normal weight subjects). Conclusions: The Reference value for plasma PTH defined in this vitamin D-replete population was far below the value currently provided by the manufacturer (65 ng/L) and varied according to overweight status. These results may contribute to improve the diagnosis of primary and secondary hyperparathyroidism and subsequent therapeutic indication.
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Interpretation of Plasma PTH Concentrations According to 25OHD Status, Gender, Age, Weight Status, and Calcium Intake: Importance of the Reference Values
The Journal of clinical endocrinology and metabolism, 2014Co-Authors: Mathilde Touvier, Mélanie Deschasaux, Marion Montourcy, Angela Sutton, Nathalie Charnaux, Emmanuelle Kesse-guyot, Léopold Fezeu, Paule Latino-martel, Nathalie Druesne-pecollo, Denis MalvyAbstract:Context: Reference values for plasma PTH assessment were generally established on small samples of apparently healthy subjects, without considering their 25-hydroxyvitamin D (25OHD) status or other potential modifiers of PTH concentration. Objective: Our objective was to assess ranges of plasma PTH concentration in a large sample of adults, stratifying by 25OHD status, age, gender, weight status, and calcium intake. Design, Setting, and Participants: This cross-sectional survey is based on 1824 middle-aged Caucasian adults from the Supplementation en Vitamines et Mineraux Antioxydants study (1994). Main Outcome Measures: Plasma PTH and 25OHD concentrations were measured by an electrochemoluminescent immunoassay. Extreme percentiles of plasma PTH concentrations were assessed specifically in subjects who had plasmatic values of 25OHD of 20 ng/mL or greater and 30 ng/mL or greater. Results: Among subjects with 25OHD status of 20 ng/mL or greater, the 97.5th percentile of plasma PTH concentration was 45.5 ng/...
Mathilde Touvier - One of the best experts on this subject based on the ideXlab platform.
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Interpretation of Plasma PTH Concentrations According to 25OHD Status, Gender, Age, Weight Status, and Calcium Intake: Importance of the Reference Values
Journal of Clinical Endocrinology and Metabolism, 2014Co-Authors: Mathilde Touvier, Mélanie Deschasaux, Marion Montourcy, Angela Sutton, Nathalie Charnaux, Emmanuelle Kesse-guyot, Léopold Fezeu, Paule Latino-martel, Nathalie Druesne-pecollo, Denis MalvyAbstract:Context: Reference values for plasma PTH assessment were generally established on small samples of apparently healthy subjects, without considering their 25-hydroxyvitamin D (25OHD) status or other potential modifiers of PTH concentration. Objective: Our objective was to assess ranges of plasma PTH concentration in a large sample of adults, stratifying by 25OHD status, age, gender, weight status, and calcium intake. Design, Setting, and Participants: This cross-sectional survey is based on 1824 middle-aged Caucasian adults from the Supplementation en Vitamines et Mineraux Antioxydants study (1994). Main Outcome Measures: Plasma PTH and 25OHD concentrations were measured by an electro-chemoluminescent immunoassay. Extreme percentiles of plasma PTH concentrations were assessed specifically in subjects who had plasmatic values of 25OHD of 20 ng/mL or greater and 30 ng/mL or greater. Results: Among subjects with 25OHD status of 20ng/mL or greater, the 97.5th percentile of plasma PTH concentration was 45.5 ng/L. By using this value as a Reference, 5% of the subjects with plasma 25OHD less than 20 nmol/L had a high plasma PTH level, reflecting secondary hyperparathyroidism. Among vitamin D-replete subjects (25OHD status of 20 ng/mL or greater), the 97.5th percentile of plasma PTH was higher in overweight/obese subjects (51.9 vs 43.5 ng/L among normal weight subjects). Conclusions: The Reference value for plasma PTH defined in this vitamin D-replete population was far below the value currently provided by the manufacturer (65 ng/L) and varied according to overweight status. These results may contribute to improve the diagnosis of primary and secondary hyperparathyroidism and subsequent therapeutic indication.
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Interpretation of Plasma PTH Concentrations According to 25OHD Status, Gender, Age, Weight Status, and Calcium Intake: Importance of the Reference Values
The Journal of clinical endocrinology and metabolism, 2014Co-Authors: Mathilde Touvier, Mélanie Deschasaux, Marion Montourcy, Angela Sutton, Nathalie Charnaux, Emmanuelle Kesse-guyot, Léopold Fezeu, Paule Latino-martel, Nathalie Druesne-pecollo, Denis MalvyAbstract:Context: Reference values for plasma PTH assessment were generally established on small samples of apparently healthy subjects, without considering their 25-hydroxyvitamin D (25OHD) status or other potential modifiers of PTH concentration. Objective: Our objective was to assess ranges of plasma PTH concentration in a large sample of adults, stratifying by 25OHD status, age, gender, weight status, and calcium intake. Design, Setting, and Participants: This cross-sectional survey is based on 1824 middle-aged Caucasian adults from the Supplementation en Vitamines et Mineraux Antioxydants study (1994). Main Outcome Measures: Plasma PTH and 25OHD concentrations were measured by an electrochemoluminescent immunoassay. Extreme percentiles of plasma PTH concentrations were assessed specifically in subjects who had plasmatic values of 25OHD of 20 ng/mL or greater and 30 ng/mL or greater. Results: Among subjects with 25OHD status of 20 ng/mL or greater, the 97.5th percentile of plasma PTH concentration was 45.5 ng/...
Fuad A. Ghaleb - One of the best experts on this subject based on the ideXlab platform.
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Context-aware data-centric misbehaviour detection scheme for vehicular ad hoc networks using sequential analysis of the temporal and spatial correlation of the consistency between the cooperative awareness messages
Vehicular Communications, 2019Co-Authors: Fuad A. Ghaleb, Mohd Aizaini Maarof, Anazida Zainal, Murad A. Rassam, Faisal Saeed, Mohammed AlsaediAbstract:Abstract Vehicular ad hoc Networks (VANETs) have emerged mainly to improve road safety, traffic efficiency, and passenger comfort. The performance of most VANET applications and services relies on the availability of accurate and up-to-date mobility-information, through so-called Cooperative Awareness Messages (CAMs), shared by neighbouring vehicles. However, sharing false mobility information can disrupt any potential VANET application. As cryptographic techniques used to protect CAMs in VANETs are expensive, complicated, and vulnerable to internal misbehaviour, security lapses are inevitable. Although several misbehaviour detection solutions have been proposed, those solutions assume that the VANET's Context is stationary, which does not hold for VANETs in a real scenario, as the vehicle's Context changes continuously. The use of static and predefined security thresholds in highly dynamic and harsh environments is the major drawback of those solutions. To address this issue, a Context-aware data-centric misbehaviour detection scheme (CA-DC-MDS) is proposed, using sequential analysis of temporal and spatial correlation of the consistency between neighbouring vehicles' mobility information. The static thresholds have been replaced by a dynamic Context Reference model that is constructed online and updated in a timely fashion using statistical techniques. Firstly, the Kalman filter algorithm is used to track the mobility information received from neighbouring vehicles. Then, the innovation errors of the Kalman filter are utilized to construct a temporal consistency assessment model for each neighbouring vehicle, using a box-and-whisker plot. After that, the Hampel filter is used to construct a spatial consistency assessment model that represents the current Context Reference. Similarly, plausibility assessment Reference models are built online and updated in a timely fashion using the Hampel filter and by utilizing the consistency assessment Reference model of neighbouring information. Finally, a message is classified as suspicious if its consistency and plausibility scores deviate significantly from the Context Reference model. The proposed Context-aware scheme achieved a 73% reduction in the false alarm rate while achieving a 37% improvement in the detection rate. This demonstrates the effectiveness of the proposed Context-aware scheme compared with the existing static solutions.
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Hybrid and Multifaceted Context-Aware Misbehavior Detection Model for Vehicular Ad Hoc Network
IEEE Access, 2019Co-Authors: Fuad A. Ghaleb, Mohd Aizaini Maarof, Anazida Zainal, Faisal Saeed, Bander Ali Saleh Al-rimy, Tawfik Al-hadhramiAbstract:Vehicular Ad Hoc Networks (VANETs) have emerged mainly to improve road safety and traffic efficiency and provide user comfort. The performance of such networks' applications relies on the availability of accurate and recent mobility-information shared among vehicles. This means that misbehaving vehicles that share false mobility information can lead to catastrophic losses of life and property. However, the current solutions proposed to detect misbehaving vehicles are not able to cope with the dynamic vehicular Context and the diverse cyber-threats, leading to a decrease in detection accuracy and an increase in false alarms. This paper addresses these issues by proposing a Hybrid and Multifaceted Context-aware Misbehavior Detection model (HCA-MDS), which consists of four phases: data-collection, Context-representation, Context-Reference construction, and misbehavior detection. Data-centric and behavioral-detection-based features are derived to represent the vehicular Context. An online and timely updated Context-Reference model is built using unsupervised nonparametric statistical methods, namely Kalman and Hampel filters, through analyzing the temporal and spatial correlation of the consistency between mobility information to adapt to the highly dynamic vehicular Context. Vehicles' behaviors are evaluated locally and autonomously according to the consistency, plausibility, and reliability of their mobility information. The results from extensive simulations show that HCA-MDS outperforms existing solutions in increasing the detection rate by 38% and decreasing the false positive rate by 7%. These results demonstrate the effectiveness and robustness of the proposed HCA-MDS model to strengthen the security of VANET applications and protocols.
Léopold Fezeu - One of the best experts on this subject based on the ideXlab platform.
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Interpretation of Plasma PTH Concentrations According to 25OHD Status, Gender, Age, Weight Status, and Calcium Intake: Importance of the Reference Values
Journal of Clinical Endocrinology and Metabolism, 2014Co-Authors: Mathilde Touvier, Mélanie Deschasaux, Marion Montourcy, Angela Sutton, Nathalie Charnaux, Emmanuelle Kesse-guyot, Léopold Fezeu, Paule Latino-martel, Nathalie Druesne-pecollo, Denis MalvyAbstract:Context: Reference values for plasma PTH assessment were generally established on small samples of apparently healthy subjects, without considering their 25-hydroxyvitamin D (25OHD) status or other potential modifiers of PTH concentration. Objective: Our objective was to assess ranges of plasma PTH concentration in a large sample of adults, stratifying by 25OHD status, age, gender, weight status, and calcium intake. Design, Setting, and Participants: This cross-sectional survey is based on 1824 middle-aged Caucasian adults from the Supplementation en Vitamines et Mineraux Antioxydants study (1994). Main Outcome Measures: Plasma PTH and 25OHD concentrations were measured by an electro-chemoluminescent immunoassay. Extreme percentiles of plasma PTH concentrations were assessed specifically in subjects who had plasmatic values of 25OHD of 20 ng/mL or greater and 30 ng/mL or greater. Results: Among subjects with 25OHD status of 20ng/mL or greater, the 97.5th percentile of plasma PTH concentration was 45.5 ng/L. By using this value as a Reference, 5% of the subjects with plasma 25OHD less than 20 nmol/L had a high plasma PTH level, reflecting secondary hyperparathyroidism. Among vitamin D-replete subjects (25OHD status of 20 ng/mL or greater), the 97.5th percentile of plasma PTH was higher in overweight/obese subjects (51.9 vs 43.5 ng/L among normal weight subjects). Conclusions: The Reference value for plasma PTH defined in this vitamin D-replete population was far below the value currently provided by the manufacturer (65 ng/L) and varied according to overweight status. These results may contribute to improve the diagnosis of primary and secondary hyperparathyroidism and subsequent therapeutic indication.
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Interpretation of Plasma PTH Concentrations According to 25OHD Status, Gender, Age, Weight Status, and Calcium Intake: Importance of the Reference Values
The Journal of clinical endocrinology and metabolism, 2014Co-Authors: Mathilde Touvier, Mélanie Deschasaux, Marion Montourcy, Angela Sutton, Nathalie Charnaux, Emmanuelle Kesse-guyot, Léopold Fezeu, Paule Latino-martel, Nathalie Druesne-pecollo, Denis MalvyAbstract:Context: Reference values for plasma PTH assessment were generally established on small samples of apparently healthy subjects, without considering their 25-hydroxyvitamin D (25OHD) status or other potential modifiers of PTH concentration. Objective: Our objective was to assess ranges of plasma PTH concentration in a large sample of adults, stratifying by 25OHD status, age, gender, weight status, and calcium intake. Design, Setting, and Participants: This cross-sectional survey is based on 1824 middle-aged Caucasian adults from the Supplementation en Vitamines et Mineraux Antioxydants study (1994). Main Outcome Measures: Plasma PTH and 25OHD concentrations were measured by an electrochemoluminescent immunoassay. Extreme percentiles of plasma PTH concentrations were assessed specifically in subjects who had plasmatic values of 25OHD of 20 ng/mL or greater and 30 ng/mL or greater. Results: Among subjects with 25OHD status of 20 ng/mL or greater, the 97.5th percentile of plasma PTH concentration was 45.5 ng/...
Emmanuelle Kesse-guyot - One of the best experts on this subject based on the ideXlab platform.
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Interpretation of Plasma PTH Concentrations According to 25OHD Status, Gender, Age, Weight Status, and Calcium Intake: Importance of the Reference Values
Journal of Clinical Endocrinology and Metabolism, 2014Co-Authors: Mathilde Touvier, Mélanie Deschasaux, Marion Montourcy, Angela Sutton, Nathalie Charnaux, Emmanuelle Kesse-guyot, Léopold Fezeu, Paule Latino-martel, Nathalie Druesne-pecollo, Denis MalvyAbstract:Context: Reference values for plasma PTH assessment were generally established on small samples of apparently healthy subjects, without considering their 25-hydroxyvitamin D (25OHD) status or other potential modifiers of PTH concentration. Objective: Our objective was to assess ranges of plasma PTH concentration in a large sample of adults, stratifying by 25OHD status, age, gender, weight status, and calcium intake. Design, Setting, and Participants: This cross-sectional survey is based on 1824 middle-aged Caucasian adults from the Supplementation en Vitamines et Mineraux Antioxydants study (1994). Main Outcome Measures: Plasma PTH and 25OHD concentrations were measured by an electro-chemoluminescent immunoassay. Extreme percentiles of plasma PTH concentrations were assessed specifically in subjects who had plasmatic values of 25OHD of 20 ng/mL or greater and 30 ng/mL or greater. Results: Among subjects with 25OHD status of 20ng/mL or greater, the 97.5th percentile of plasma PTH concentration was 45.5 ng/L. By using this value as a Reference, 5% of the subjects with plasma 25OHD less than 20 nmol/L had a high plasma PTH level, reflecting secondary hyperparathyroidism. Among vitamin D-replete subjects (25OHD status of 20 ng/mL or greater), the 97.5th percentile of plasma PTH was higher in overweight/obese subjects (51.9 vs 43.5 ng/L among normal weight subjects). Conclusions: The Reference value for plasma PTH defined in this vitamin D-replete population was far below the value currently provided by the manufacturer (65 ng/L) and varied according to overweight status. These results may contribute to improve the diagnosis of primary and secondary hyperparathyroidism and subsequent therapeutic indication.
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Interpretation of Plasma PTH Concentrations According to 25OHD Status, Gender, Age, Weight Status, and Calcium Intake: Importance of the Reference Values
The Journal of clinical endocrinology and metabolism, 2014Co-Authors: Mathilde Touvier, Mélanie Deschasaux, Marion Montourcy, Angela Sutton, Nathalie Charnaux, Emmanuelle Kesse-guyot, Léopold Fezeu, Paule Latino-martel, Nathalie Druesne-pecollo, Denis MalvyAbstract:Context: Reference values for plasma PTH assessment were generally established on small samples of apparently healthy subjects, without considering their 25-hydroxyvitamin D (25OHD) status or other potential modifiers of PTH concentration. Objective: Our objective was to assess ranges of plasma PTH concentration in a large sample of adults, stratifying by 25OHD status, age, gender, weight status, and calcium intake. Design, Setting, and Participants: This cross-sectional survey is based on 1824 middle-aged Caucasian adults from the Supplementation en Vitamines et Mineraux Antioxydants study (1994). Main Outcome Measures: Plasma PTH and 25OHD concentrations were measured by an electrochemoluminescent immunoassay. Extreme percentiles of plasma PTH concentrations were assessed specifically in subjects who had plasmatic values of 25OHD of 20 ng/mL or greater and 30 ng/mL or greater. Results: Among subjects with 25OHD status of 20 ng/mL or greater, the 97.5th percentile of plasma PTH concentration was 45.5 ng/...