The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform

Hideto Matsuyama - One of the best experts on this subject based on the ideXlab platform.

  • Biofouling resistance of reverse osmosis membrane modified with polydopamine
    Desalination, 2014
    Co-Authors: Hamed Karkhanechi, Hiroyuki Matsuyama, Ryosuke Takagi, Hideto Matsuyama
    Abstract:

    It has been reported that surface modification with polydopamine (PDA) increases the hydrophilicity and the negative charge density of membrane surfaces, which improves their antifouling potential against organic foulants. Thus, in this paper, we attempted to modify a reverse osmosis (RO) membrane with PDA to improve antibiofouling potential. The deposition of PDA was confirmed by several methods, including X-ray photoelectron and Fourier-transform infrared spectroscopy. However, increases in hydrophilicity and negative charge density were not clearly observed. Nevertheless, the improvement of antibiofouling properties was confirmed by cross-flow Filtration of a bacterial ( Pseudomonas putida) suspension. The high antiadhesion property of the PDA-modified membrane was confirmed by scanning electron microscope surface images after 1200. minute Continuous Filtration of the bacterial suspension. In addition, it was confirmed by using a shake flask test with Escherichia coli that the PDA-modified membrane had a bactericidal property. Using shake flask tests in the different pH solutions, it was concluded that the antibiofouling property of PDA-modified membranes could be attributed to the bactericidal property of protonated amine groups of PDA deposited on the membrane surface. © 2014 Elsevier B.V.

Zoltan K Nagy - One of the best experts on this subject based on the ideXlab platform.

  • development of Continuous Filtration in a novel Continuous Filtration carousel integrated with Continuous crystallization
    Organic Process Research & Development, 2019
    Co-Authors: Andras Domokos, Paul Firth, Simon Coleman, Zoltan K Nagy
    Abstract:

    Pharmaceutical manufacturing has been largely carried out in batch mode, which has disadvantages such as batch-to-batch variations and difficult scale-up. As a result, the pharmaceutical industry i...

  • evaluation of mixed suspension mixed product removal crystallization processes coupled with a Continuous Filtration system
    Chemical Engineering and Processing, 2016
    Co-Authors: David Acevedo, Ramon Pena, Yang Yang, Alastair Barton, Paul Firth, Zoltan K Nagy
    Abstract:

    Abstract As the pharmaceutical industry evolves and goes through the paradigm shift from batch to Continuous manufacturing, innovative processes need to be developed to replace unit operations that have historically been batch operations. This requires innovation in the Continuous crystallization field of study as well as innovation in downstream processes ( e.g. Filtration, drying, milling, and granulation). Herein a novel and commercially available Continuous filter carousel (CFC) system was assessed for its feasibility of Continuous Filtration while coupled with a Continuous mixed suspension mixed product removal (MSMPR) crystallizer. The Filtration system was assessed using two different crystallization systems ( i.e. cooling and antisolvent) with significantly different kinetics and morphologies to assess the robustness of the integrated platform. With proper optimization of the various Filtration parameters for the different crystallization systems a controlled state of operation was achieved in each case. The crystal product from the CFC system shows good consistency with the crystals in the slurry in the MSMPR. Moisture content and productivity of the Filtration system were reported and show dependency on crystal properties. The CFC system was equipped with solvent vessels that aided the Continuous Filtration by acting as a wash or a clean-in-place solvent, preventing or removing filter clogging, respectively.

Paul Firth - One of the best experts on this subject based on the ideXlab platform.

  • development of Continuous Filtration in a novel Continuous Filtration carousel integrated with Continuous crystallization
    Organic Process Research & Development, 2019
    Co-Authors: Andras Domokos, Paul Firth, Simon Coleman, Zoltan K Nagy
    Abstract:

    Pharmaceutical manufacturing has been largely carried out in batch mode, which has disadvantages such as batch-to-batch variations and difficult scale-up. As a result, the pharmaceutical industry i...

  • development of a novel Continuous Filtration unit for pharmaceutical process development and manufacturing
    Journal of Pharmaceutical Sciences, 2019
    Co-Authors: Sara Ottoboni, Chris John Price, Alastair Barton, Paul Firth, Christopher Steven, Elizabeth Meehan, Andy Mitchell, Furqan Tahir
    Abstract:

    The lack of a commercial laboratory, pilot and small manufacturing scale dead end Continuous Filtration and drying unit it is a significant gap in the development of Continuous pharmaceutical manufacturing processes for new active pharmaceutical ingredients (APIs). To move small-scale pharmaceutical isolation forward from traditional batch Nutsche Filtration to Continuous processing a Continuous filter dryer prototype unit (CFD20) was developed in collaboration with Alconbury Weston Ltd. The performance of the prototype was evaluated by comparison with manual best practice exemplified using a modified Biotage VacMaster unit to gather data and process understanding for API Filtration and washing. The ultimate objective was to link the chemical and physical attributes of an API slurry with equipment and processing parameters to improve API isolation processes. Filtration performance was characterized by assessing filtrate flow rate by application of Darcy's law, the impact on product crystal size distribution and product purity were investigated using classical analytical methods. The overall performance of the 2 units was similar, showing that the prototype CFD20 can match best manual lab practice for Filtration and washing while allowing Continuous processing and real-time data logging. This result is encouraging and the data gathered provides further insight to inform the development of CFD20.

  • evaluation of mixed suspension mixed product removal crystallization processes coupled with a Continuous Filtration system
    Chemical Engineering and Processing, 2016
    Co-Authors: David Acevedo, Ramon Pena, Yang Yang, Alastair Barton, Paul Firth, Zoltan K Nagy
    Abstract:

    Abstract As the pharmaceutical industry evolves and goes through the paradigm shift from batch to Continuous manufacturing, innovative processes need to be developed to replace unit operations that have historically been batch operations. This requires innovation in the Continuous crystallization field of study as well as innovation in downstream processes ( e.g. Filtration, drying, milling, and granulation). Herein a novel and commercially available Continuous filter carousel (CFC) system was assessed for its feasibility of Continuous Filtration while coupled with a Continuous mixed suspension mixed product removal (MSMPR) crystallizer. The Filtration system was assessed using two different crystallization systems ( i.e. cooling and antisolvent) with significantly different kinetics and morphologies to assess the robustness of the integrated platform. With proper optimization of the various Filtration parameters for the different crystallization systems a controlled state of operation was achieved in each case. The crystal product from the CFC system shows good consistency with the crystals in the slurry in the MSMPR. Moisture content and productivity of the Filtration system were reported and show dependency on crystal properties. The CFC system was equipped with solvent vessels that aided the Continuous Filtration by acting as a wash or a clean-in-place solvent, preventing or removing filter clogging, respectively.

Hamed Karkhanechi - One of the best experts on this subject based on the ideXlab platform.

  • Biofouling resistance of reverse osmosis membrane modified with polydopamine
    Desalination, 2014
    Co-Authors: Hamed Karkhanechi, Hiroyuki Matsuyama, Ryosuke Takagi, Hideto Matsuyama
    Abstract:

    It has been reported that surface modification with polydopamine (PDA) increases the hydrophilicity and the negative charge density of membrane surfaces, which improves their antifouling potential against organic foulants. Thus, in this paper, we attempted to modify a reverse osmosis (RO) membrane with PDA to improve antibiofouling potential. The deposition of PDA was confirmed by several methods, including X-ray photoelectron and Fourier-transform infrared spectroscopy. However, increases in hydrophilicity and negative charge density were not clearly observed. Nevertheless, the improvement of antibiofouling properties was confirmed by cross-flow Filtration of a bacterial ( Pseudomonas putida) suspension. The high antiadhesion property of the PDA-modified membrane was confirmed by scanning electron microscope surface images after 1200. minute Continuous Filtration of the bacterial suspension. In addition, it was confirmed by using a shake flask test with Escherichia coli that the PDA-modified membrane had a bactericidal property. Using shake flask tests in the different pH solutions, it was concluded that the antibiofouling property of PDA-modified membranes could be attributed to the bactericidal property of protonated amine groups of PDA deposited on the membrane surface. © 2014 Elsevier B.V.

Sara Ottoboni - One of the best experts on this subject based on the ideXlab platform.

  • development of a novel Continuous Filtration unit for pharmaceutical process development and manufacturing
    Journal of Pharmaceutical Sciences, 2019
    Co-Authors: Sara Ottoboni, Chris John Price, Alastair Barton, Paul Firth, Christopher Steven, Elizabeth Meehan, Andy Mitchell, Furqan Tahir
    Abstract:

    The lack of a commercial laboratory, pilot and small manufacturing scale dead end Continuous Filtration and drying unit it is a significant gap in the development of Continuous pharmaceutical manufacturing processes for new active pharmaceutical ingredients (APIs). To move small-scale pharmaceutical isolation forward from traditional batch Nutsche Filtration to Continuous processing a Continuous filter dryer prototype unit (CFD20) was developed in collaboration with Alconbury Weston Ltd. The performance of the prototype was evaluated by comparison with manual best practice exemplified using a modified Biotage VacMaster unit to gather data and process understanding for API Filtration and washing. The ultimate objective was to link the chemical and physical attributes of an API slurry with equipment and processing parameters to improve API isolation processes. Filtration performance was characterized by assessing filtrate flow rate by application of Darcy's law, the impact on product crystal size distribution and product purity were investigated using classical analytical methods. The overall performance of the 2 units was similar, showing that the prototype CFD20 can match best manual lab practice for Filtration and washing while allowing Continuous processing and real-time data logging. This result is encouraging and the data gathered provides further insight to inform the development of CFD20.

  • Addressing the challenges of Continuous Filtration, washing and drying
    2017
    Co-Authors: Chris John Price, Sara Ottoboni
    Abstract:

    Continuous synthesis and formulation are becoming established in the pharmaceutical industry, however connecting the two through Continuous particle formation and isolation still poses significant challenges. This presentation focuses on Continuous Filtration, washing and drying. Darcy’s law and subsequent modifications describe the rate of Filtration; however, there is no equivalent which addresses the removal of closely related impurities of synthesis by Filtration and washing, especially when the product exhibits solubility. API solubility also poses challenges during drying. Presuming the upstream crystallization has delivered particles of the desired size and they are largely unaffected by Filtration and washing then drying process has the potential to break fragile particles and to granulate all particles through the formation of crystal-crystal bridges. In order to develop a successful Continuous system for API Filtration, washing and drying all of these problems must be overcome.

  • Development of a novel Continuous Filtration unit for pharmaceutical process development and manufacturing: a case study using paracetamol
    2016
    Co-Authors: Sara Ottoboni, Chris John Price, Alastair Barton, Christopher Steven, Elisabeth Meehan, Andy Mitchell
    Abstract:

    The pharmaceutical industry is starting to adopt Continuous processing; however one missing component is an appropriately scaled unit for Continuous isolation which can filter, wash and dry active pharmaceutical ingredients (APIs). This gap is particularly pressing in process development where API is available in limited quantities yet it is desirable to develop the isolation using Continuous equipment which matches the equipment to be used in manufacturing to minimise scale up risks. This paper explores what such a unit must achieve and evaluates a prototype system.