The Experts below are selected from a list of 109371 Experts worldwide ranked by ideXlab platform
Alexander V Rodriguez - One of the best experts on this subject based on the ideXlab platform.
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a wirelessly powered and Controlled Device for optical neural control of freely behaving animals
Journal of Neural Engineering, 2011Co-Authors: Christian T Wentz, Jacob G Bernstein, Patrick E Monahan, Alexander Guerra, Alexander V RodriguezAbstract:Optogenetics, the ability to use light to activate and silence specific neuron types within neural networks in vivo and in vitro, is revolutionizing neuroscientists' capacity to understand how defined neural circuit elements contribute to normal and pathological brain functions. Typically, awake behaving experiments are conducted by inserting an optical fiber into the brain, tethered to a remote laser, or by utilizing an implanted light-emitting diode (LED), tethered to a remote power source. A fully wireless system would enable chronic or longitudinal experiments where long duration tethering is impractical, and would also support high-throughput experimentation. However, the high power requirements of light sources (LEDs, lasers), especially in the context of the extended illumination periods often desired in experiments, precludes battery-powered approaches from being widely applicable. We have developed a headborne Device weighing 2 g capable of wirelessly receiving power using a resonant RF power link and storing the energy in an adaptive supercapacitor circuit, which can algorithmically control one or more headborne LEDs via a microcontroller. The Device can deliver approximately 2 W of power to the LEDs in steady state, and 4.3 W in bursts. We also present an optional radio transceiver module (1 g) which, when added to the base headborne Device, enables real-time updating of light delivery protocols; dozens of Devices can be Controlled simultaneously from one computer. We demonstrate use of the technology to wirelessly drive cortical control of movement in mice. These Devices may serve as prototypes for clinical ultra-precise neural prosthetics that use light as the modality of biological control.
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a wirelessly powered and Controlled Device for optical neural control of freely behaving animals
Journal of Neural Engineering, 2011Co-Authors: Christian T Wentz, Patrick E Monahan, Alexander Guerra, Alexander V Rodriguez, Jacob BernsteinAbstract:Optogenetics, the ability to use light to activate and silence specific neuron types within neural networks in vivo and in vitro, is revolutionizing neuroscientists’ capacity to understand how defined neural circuit elements contribute to normal and pathological brain functions. Typically awake behaving experiments are conducted by inserting an optical fiber into the brain, tethered to a remote laser, or by utilizing an implanted LED, tethered to a remote power source. A fully wireless system would enable chronic or longitudinal experiments where long duration tethering is impractical, and would also support high-throughput experimentation. However, the high power requirements of light sources (LEDs, lasers), especially in the context of the high-frequency pulse trains often desired in experiments, precludes battery-powered approaches from being widely applicable. We have developed a headborne Device weighing 2 grams capable of wirelessly receiving power using a resonant RF power link and storing the energy in an adaptive supercapacitor circuit, which can algorithmically control one or more headborne LEDs via a microcontroller. The Device can deliver approximately 2W of power to the LEDs in steady state, and 4.3W in bursts. We also present an optional radio transceiver module (1 gram) which, when added to the base headborne Device, enables real-time updating of light delivery protocols; dozens of Devices can be simultaneously Controlled from one computer. We demonstrate use of the technology to wirelessly drive cortical control of movement in mice. These Devices may serve as prototypes for clinical ultra-precise neural prosthetics that use light as the modality of biological control.
Christian T Wentz - One of the best experts on this subject based on the ideXlab platform.
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a wirelessly powered and Controlled Device for optical neural control of freely behaving animals
Journal of Neural Engineering, 2011Co-Authors: Christian T Wentz, Jacob G Bernstein, Patrick E Monahan, Alexander Guerra, Alexander V RodriguezAbstract:Optogenetics, the ability to use light to activate and silence specific neuron types within neural networks in vivo and in vitro, is revolutionizing neuroscientists' capacity to understand how defined neural circuit elements contribute to normal and pathological brain functions. Typically, awake behaving experiments are conducted by inserting an optical fiber into the brain, tethered to a remote laser, or by utilizing an implanted light-emitting diode (LED), tethered to a remote power source. A fully wireless system would enable chronic or longitudinal experiments where long duration tethering is impractical, and would also support high-throughput experimentation. However, the high power requirements of light sources (LEDs, lasers), especially in the context of the extended illumination periods often desired in experiments, precludes battery-powered approaches from being widely applicable. We have developed a headborne Device weighing 2 g capable of wirelessly receiving power using a resonant RF power link and storing the energy in an adaptive supercapacitor circuit, which can algorithmically control one or more headborne LEDs via a microcontroller. The Device can deliver approximately 2 W of power to the LEDs in steady state, and 4.3 W in bursts. We also present an optional radio transceiver module (1 g) which, when added to the base headborne Device, enables real-time updating of light delivery protocols; dozens of Devices can be Controlled simultaneously from one computer. We demonstrate use of the technology to wirelessly drive cortical control of movement in mice. These Devices may serve as prototypes for clinical ultra-precise neural prosthetics that use light as the modality of biological control.
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a wirelessly powered and Controlled Device for optical neural control of freely behaving animals
Journal of Neural Engineering, 2011Co-Authors: Christian T Wentz, Patrick E Monahan, Alexander Guerra, Alexander V Rodriguez, Jacob BernsteinAbstract:Optogenetics, the ability to use light to activate and silence specific neuron types within neural networks in vivo and in vitro, is revolutionizing neuroscientists’ capacity to understand how defined neural circuit elements contribute to normal and pathological brain functions. Typically awake behaving experiments are conducted by inserting an optical fiber into the brain, tethered to a remote laser, or by utilizing an implanted LED, tethered to a remote power source. A fully wireless system would enable chronic or longitudinal experiments where long duration tethering is impractical, and would also support high-throughput experimentation. However, the high power requirements of light sources (LEDs, lasers), especially in the context of the high-frequency pulse trains often desired in experiments, precludes battery-powered approaches from being widely applicable. We have developed a headborne Device weighing 2 grams capable of wirelessly receiving power using a resonant RF power link and storing the energy in an adaptive supercapacitor circuit, which can algorithmically control one or more headborne LEDs via a microcontroller. The Device can deliver approximately 2W of power to the LEDs in steady state, and 4.3W in bursts. We also present an optional radio transceiver module (1 gram) which, when added to the base headborne Device, enables real-time updating of light delivery protocols; dozens of Devices can be simultaneously Controlled from one computer. We demonstrate use of the technology to wirelessly drive cortical control of movement in mice. These Devices may serve as prototypes for clinical ultra-precise neural prosthetics that use light as the modality of biological control.
Alexander Guerra - One of the best experts on this subject based on the ideXlab platform.
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a wirelessly powered and Controlled Device for optical neural control of freely behaving animals
Journal of Neural Engineering, 2011Co-Authors: Christian T Wentz, Jacob G Bernstein, Patrick E Monahan, Alexander Guerra, Alexander V RodriguezAbstract:Optogenetics, the ability to use light to activate and silence specific neuron types within neural networks in vivo and in vitro, is revolutionizing neuroscientists' capacity to understand how defined neural circuit elements contribute to normal and pathological brain functions. Typically, awake behaving experiments are conducted by inserting an optical fiber into the brain, tethered to a remote laser, or by utilizing an implanted light-emitting diode (LED), tethered to a remote power source. A fully wireless system would enable chronic or longitudinal experiments where long duration tethering is impractical, and would also support high-throughput experimentation. However, the high power requirements of light sources (LEDs, lasers), especially in the context of the extended illumination periods often desired in experiments, precludes battery-powered approaches from being widely applicable. We have developed a headborne Device weighing 2 g capable of wirelessly receiving power using a resonant RF power link and storing the energy in an adaptive supercapacitor circuit, which can algorithmically control one or more headborne LEDs via a microcontroller. The Device can deliver approximately 2 W of power to the LEDs in steady state, and 4.3 W in bursts. We also present an optional radio transceiver module (1 g) which, when added to the base headborne Device, enables real-time updating of light delivery protocols; dozens of Devices can be Controlled simultaneously from one computer. We demonstrate use of the technology to wirelessly drive cortical control of movement in mice. These Devices may serve as prototypes for clinical ultra-precise neural prosthetics that use light as the modality of biological control.
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a wirelessly powered and Controlled Device for optical neural control of freely behaving animals
Journal of Neural Engineering, 2011Co-Authors: Christian T Wentz, Patrick E Monahan, Alexander Guerra, Alexander V Rodriguez, Jacob BernsteinAbstract:Optogenetics, the ability to use light to activate and silence specific neuron types within neural networks in vivo and in vitro, is revolutionizing neuroscientists’ capacity to understand how defined neural circuit elements contribute to normal and pathological brain functions. Typically awake behaving experiments are conducted by inserting an optical fiber into the brain, tethered to a remote laser, or by utilizing an implanted LED, tethered to a remote power source. A fully wireless system would enable chronic or longitudinal experiments where long duration tethering is impractical, and would also support high-throughput experimentation. However, the high power requirements of light sources (LEDs, lasers), especially in the context of the high-frequency pulse trains often desired in experiments, precludes battery-powered approaches from being widely applicable. We have developed a headborne Device weighing 2 grams capable of wirelessly receiving power using a resonant RF power link and storing the energy in an adaptive supercapacitor circuit, which can algorithmically control one or more headborne LEDs via a microcontroller. The Device can deliver approximately 2W of power to the LEDs in steady state, and 4.3W in bursts. We also present an optional radio transceiver module (1 gram) which, when added to the base headborne Device, enables real-time updating of light delivery protocols; dozens of Devices can be simultaneously Controlled from one computer. We demonstrate use of the technology to wirelessly drive cortical control of movement in mice. These Devices may serve as prototypes for clinical ultra-precise neural prosthetics that use light as the modality of biological control.
Patrick E Monahan - One of the best experts on this subject based on the ideXlab platform.
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a wirelessly powered and Controlled Device for optical neural control of freely behaving animals
Journal of Neural Engineering, 2011Co-Authors: Christian T Wentz, Jacob G Bernstein, Patrick E Monahan, Alexander Guerra, Alexander V RodriguezAbstract:Optogenetics, the ability to use light to activate and silence specific neuron types within neural networks in vivo and in vitro, is revolutionizing neuroscientists' capacity to understand how defined neural circuit elements contribute to normal and pathological brain functions. Typically, awake behaving experiments are conducted by inserting an optical fiber into the brain, tethered to a remote laser, or by utilizing an implanted light-emitting diode (LED), tethered to a remote power source. A fully wireless system would enable chronic or longitudinal experiments where long duration tethering is impractical, and would also support high-throughput experimentation. However, the high power requirements of light sources (LEDs, lasers), especially in the context of the extended illumination periods often desired in experiments, precludes battery-powered approaches from being widely applicable. We have developed a headborne Device weighing 2 g capable of wirelessly receiving power using a resonant RF power link and storing the energy in an adaptive supercapacitor circuit, which can algorithmically control one or more headborne LEDs via a microcontroller. The Device can deliver approximately 2 W of power to the LEDs in steady state, and 4.3 W in bursts. We also present an optional radio transceiver module (1 g) which, when added to the base headborne Device, enables real-time updating of light delivery protocols; dozens of Devices can be Controlled simultaneously from one computer. We demonstrate use of the technology to wirelessly drive cortical control of movement in mice. These Devices may serve as prototypes for clinical ultra-precise neural prosthetics that use light as the modality of biological control.
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a wirelessly powered and Controlled Device for optical neural control of freely behaving animals
Journal of Neural Engineering, 2011Co-Authors: Christian T Wentz, Patrick E Monahan, Alexander Guerra, Alexander V Rodriguez, Jacob BernsteinAbstract:Optogenetics, the ability to use light to activate and silence specific neuron types within neural networks in vivo and in vitro, is revolutionizing neuroscientists’ capacity to understand how defined neural circuit elements contribute to normal and pathological brain functions. Typically awake behaving experiments are conducted by inserting an optical fiber into the brain, tethered to a remote laser, or by utilizing an implanted LED, tethered to a remote power source. A fully wireless system would enable chronic or longitudinal experiments where long duration tethering is impractical, and would also support high-throughput experimentation. However, the high power requirements of light sources (LEDs, lasers), especially in the context of the high-frequency pulse trains often desired in experiments, precludes battery-powered approaches from being widely applicable. We have developed a headborne Device weighing 2 grams capable of wirelessly receiving power using a resonant RF power link and storing the energy in an adaptive supercapacitor circuit, which can algorithmically control one or more headborne LEDs via a microcontroller. The Device can deliver approximately 2W of power to the LEDs in steady state, and 4.3W in bursts. We also present an optional radio transceiver module (1 gram) which, when added to the base headborne Device, enables real-time updating of light delivery protocols; dozens of Devices can be simultaneously Controlled from one computer. We demonstrate use of the technology to wirelessly drive cortical control of movement in mice. These Devices may serve as prototypes for clinical ultra-precise neural prosthetics that use light as the modality of biological control.
Hani Gabra - One of the best experts on this subject based on the ideXlab platform.
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abstract b51 management of ascites via the alfa pump closed system in platinum resistant ovarian cancer proc a model of sequential non invasive tumor cell sampling through the urinary bladder
Clinical Cancer Research, 2013Co-Authors: Christina Fotopoulou, Sarah P Blagden, Laura Spiers, Emily Pickford, Roberto Dina, Nagy A Habib, Delali Adjogatse, Hani GabraAbstract:Background: Malignant ascites in PROC is a therapeutic dilemma. The Sequana-Medical alfapump-System (AP), a remotely Controlled Device connecting the patients9peritoneal cavity to their urinary bladder, has been evaluated for ascites in liver cirrhosis, but not as yet for malignant ascites. Methods: We implanted the AP in the peritoneal cavity of two heavily pretreated PROC-patients (67y and 70y) who required repetitive ascites drainages monthly. We cross correlated the electronic download of recorded volume pumped (intraperitoneally→bladder) with weekly ultrasound, monthly cystoscopies and QoL-evaluation. Early morning urine for evaluation of cytology and tumor-cell molecular analysis was collected weekly. Results: The implantation was under general anesthesia in a 60- and 35-minute procedure. The pump, draining 350ml – 500ml ascites/day successfully drained the ascites to dryness after 3 days (1stpatient) and 8 days (2ndpatient). The patients did not report pollakiuria or dysuria, merely an increased micturition volume. The 1st patient died of disease progression 2 months later; the 2nd patient we noticed a gradual amelioration of peripheral edemas and overall performance-status within 3 weeks after insertion and was able to commence weekly chemotherapy with paclitaxel. Histopathological analysis of the urine revealed rich malignant cell content; this was used to create FFPE-cell-blocks for molecular- pathological profiling with sequential Caris-Target-Now-analysis and full exome-sequencing. QoL as measured by the EORTC QlQ-C30 and EORTC QLQ-OV28 showed high interindividual differences and only minimal influence by the pump. Conclusion: This innovative approach addresses an area of unmet need for the control of malignant ascites and provides a non-invasive method of collecting tumor tissue for continuous molecular tumor characterization. A EUTROC-multicenter randomized-trial (AMAZE) is planned for evaluation of clinical and translational implications in PROC. Citation Format: Christina Fotopoulou, Laura Spiers, Delali Adjogatse, Emily Pickford, Roberto Dina, Sara Blagden, Nagy Habib, Hani Gabra. Management of ascites via the alfa-pump closed system in platinum-resistant-ovarian-cancer (PROC): A model of sequential non-invasive tumor-cell sampling through the urinary bladder. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr B51.
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continuous low flow ascites drainage and sequential non invasive tumor cell sampling through the urinary bladder via the alfa pump closed system in platinum resistant ovarian cancer proc first clinical experience in a cancer patient
Journal of Clinical Oncology, 2013Co-Authors: Christina Fotopoulou, Sarah P Blagden, Laura Spiers, Emily Pickford, Roberto Dina, Nagy A Habib, Hani GabraAbstract:5562 Background: Malignant ascites in PROC causes significant impairment in quality of life. The Sequana Medical alfapump System (AP), a remotely Controlled Device connecting the patients’ peritone...