The Experts below are selected from a list of 126 Experts worldwide ranked by ideXlab platform
Ian A Oneil - One of the best experts on this subject based on the ideXlab platform.
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the synthesis of highly functionalized morpholine n oxides from ephedrine and pseudoephedrine utilizing a tandem Cope Elimination reverse Cope Elimination protocol
Tetrahedron Letters, 2007Co-Authors: Neil Henry, Ian A OneilAbstract:Highly functionalized monocyclic morpholine N-oxides can be prepared in three steps starting from ephedrine and pseudoephedrine utlizing a tandem Cope Elimination/reverse Cope Elimination.
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the synthesis of functionalised chiral bicyclic lactam and lactone n oxides using a tandem Cope Elimination reverse Cope Elimination protocol
Tetrahedron Letters, 2007Co-Authors: Gemma L Ellis, Ian A Oneil, Ed Cleator, Elena V Ramos, Alan P Chorlton, Barret S Kalindjian, David J TapolczayAbstract:Functionalised hydroxylamine derivatives of (S)-proline and (R)-pipecolic acid have been prepared using a Cope Elimination. These undergo reverse Cope Elimination onto a pendant double bond to give bicyclic lactam and lactone N-oxides containing three contiguous chiral centres, this extends the sCope and applicability of the reverse Cope Elimination in the synthesis of heterocyclic systems by incorporation of the lactone and lactam structural motifs.
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the diastereoselective synthesis of functionalised spirocyclic lactams and lactones using a Cope Elimination intramolecular nitrone cycloaddition strategy
Tetrahedron Letters, 2007Co-Authors: Gemma L Ellis, Ian A Oneil, Elena V Ramos, Alan P Chorlton, Barret S Kalindjian, David J TapolczayAbstract:Functionalised hydroxylamine derivatives of (S)-proline and pipecolic acid have been prepared using a Cope Elimination. These hydroxylamines have been found to undergo oxidation to the nitrone either in the presence of air or a catalytic quantity of TPAP. An intramolecular 1,3-dipolar cycloaddition then occurs between the nitrone and pendant double bond to give tricyclic lactams and lactones with high diastereoselectivity.
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the synthesis of chiral functionalised morpholine n oxides using a tandem Cope Elimination reverse Cope Elimination protocol
Tetrahedron Letters, 2004Co-Authors: Ian A Oneil, Ed Cleator, Elena V Ramos, Alan P Chorlton, David J TapolczayAbstract:Hydroxylamine derivatives of (S)-prolinol have been generated using a Cope Elimination. These undergo reverse-Cope Elimination onto a pendant double bond to give morpholine N-oxides containing three contiguous chiral centres.
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the diastereoselective synthesis of functionalised isoxazolidines using a Cope Elimination intramolecular nitrone cycloaddition strategy
Tetrahedron Letters, 2004Co-Authors: Ian A Oneil, Ed Cleator, Elena V Ramos, Alan P Chorlton, David J Tapolczay, Gemma L Ellis, Barret S KalindjianAbstract:Functionalised hydroxylamine derivatives of (S)-prolinol prepared by a Cope Elimination have been found to undergo oxidation to the nitrone either in the presence of air or a catalytic quantity of TPAP. These undergo intramolecular cycloaddition to give tricyclic isoxazolidines with high diastereoselectivity.
David J Tapolczay - One of the best experts on this subject based on the ideXlab platform.
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the synthesis of functionalised chiral bicyclic lactam and lactone n oxides using a tandem Cope Elimination reverse Cope Elimination protocol
Tetrahedron Letters, 2007Co-Authors: Gemma L Ellis, Ian A Oneil, Ed Cleator, Elena V Ramos, Alan P Chorlton, Barret S Kalindjian, David J TapolczayAbstract:Functionalised hydroxylamine derivatives of (S)-proline and (R)-pipecolic acid have been prepared using a Cope Elimination. These undergo reverse Cope Elimination onto a pendant double bond to give bicyclic lactam and lactone N-oxides containing three contiguous chiral centres, this extends the sCope and applicability of the reverse Cope Elimination in the synthesis of heterocyclic systems by incorporation of the lactone and lactam structural motifs.
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the diastereoselective synthesis of functionalised spirocyclic lactams and lactones using a Cope Elimination intramolecular nitrone cycloaddition strategy
Tetrahedron Letters, 2007Co-Authors: Gemma L Ellis, Ian A Oneil, Elena V Ramos, Alan P Chorlton, Barret S Kalindjian, David J TapolczayAbstract:Functionalised hydroxylamine derivatives of (S)-proline and pipecolic acid have been prepared using a Cope Elimination. These hydroxylamines have been found to undergo oxidation to the nitrone either in the presence of air or a catalytic quantity of TPAP. An intramolecular 1,3-dipolar cycloaddition then occurs between the nitrone and pendant double bond to give tricyclic lactams and lactones with high diastereoselectivity.
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the synthesis of chiral functionalised morpholine n oxides using a tandem Cope Elimination reverse Cope Elimination protocol
Tetrahedron Letters, 2004Co-Authors: Ian A Oneil, Ed Cleator, Elena V Ramos, Alan P Chorlton, David J TapolczayAbstract:Hydroxylamine derivatives of (S)-prolinol have been generated using a Cope Elimination. These undergo reverse-Cope Elimination onto a pendant double bond to give morpholine N-oxides containing three contiguous chiral centres.
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the diastereoselective synthesis of functionalised isoxazolidines using a Cope Elimination intramolecular nitrone cycloaddition strategy
Tetrahedron Letters, 2004Co-Authors: Ian A Oneil, Ed Cleator, Elena V Ramos, Alan P Chorlton, David J Tapolczay, Gemma L Ellis, Barret S KalindjianAbstract:Functionalised hydroxylamine derivatives of (S)-prolinol prepared by a Cope Elimination have been found to undergo oxidation to the nitrone either in the presence of air or a catalytic quantity of TPAP. These undergo intramolecular cycloaddition to give tricyclic isoxazolidines with high diastereoselectivity.
Elena V Ramos - One of the best experts on this subject based on the ideXlab platform.
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the synthesis of functionalised chiral bicyclic lactam and lactone n oxides using a tandem Cope Elimination reverse Cope Elimination protocol
Tetrahedron Letters, 2007Co-Authors: Gemma L Ellis, Ian A Oneil, Ed Cleator, Elena V Ramos, Alan P Chorlton, Barret S Kalindjian, David J TapolczayAbstract:Functionalised hydroxylamine derivatives of (S)-proline and (R)-pipecolic acid have been prepared using a Cope Elimination. These undergo reverse Cope Elimination onto a pendant double bond to give bicyclic lactam and lactone N-oxides containing three contiguous chiral centres, this extends the sCope and applicability of the reverse Cope Elimination in the synthesis of heterocyclic systems by incorporation of the lactone and lactam structural motifs.
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the diastereoselective synthesis of functionalised spirocyclic lactams and lactones using a Cope Elimination intramolecular nitrone cycloaddition strategy
Tetrahedron Letters, 2007Co-Authors: Gemma L Ellis, Ian A Oneil, Elena V Ramos, Alan P Chorlton, Barret S Kalindjian, David J TapolczayAbstract:Functionalised hydroxylamine derivatives of (S)-proline and pipecolic acid have been prepared using a Cope Elimination. These hydroxylamines have been found to undergo oxidation to the nitrone either in the presence of air or a catalytic quantity of TPAP. An intramolecular 1,3-dipolar cycloaddition then occurs between the nitrone and pendant double bond to give tricyclic lactams and lactones with high diastereoselectivity.
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the synthesis of chiral functionalised morpholine n oxides using a tandem Cope Elimination reverse Cope Elimination protocol
Tetrahedron Letters, 2004Co-Authors: Ian A Oneil, Ed Cleator, Elena V Ramos, Alan P Chorlton, David J TapolczayAbstract:Hydroxylamine derivatives of (S)-prolinol have been generated using a Cope Elimination. These undergo reverse-Cope Elimination onto a pendant double bond to give morpholine N-oxides containing three contiguous chiral centres.
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the diastereoselective synthesis of functionalised isoxazolidines using a Cope Elimination intramolecular nitrone cycloaddition strategy
Tetrahedron Letters, 2004Co-Authors: Ian A Oneil, Ed Cleator, Elena V Ramos, Alan P Chorlton, David J Tapolczay, Gemma L Ellis, Barret S KalindjianAbstract:Functionalised hydroxylamine derivatives of (S)-prolinol prepared by a Cope Elimination have been found to undergo oxidation to the nitrone either in the presence of air or a catalytic quantity of TPAP. These undergo intramolecular cycloaddition to give tricyclic isoxazolidines with high diastereoselectivity.
Alan P Chorlton - One of the best experts on this subject based on the ideXlab platform.
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the synthesis of functionalised chiral bicyclic lactam and lactone n oxides using a tandem Cope Elimination reverse Cope Elimination protocol
Tetrahedron Letters, 2007Co-Authors: Gemma L Ellis, Ian A Oneil, Ed Cleator, Elena V Ramos, Alan P Chorlton, Barret S Kalindjian, David J TapolczayAbstract:Functionalised hydroxylamine derivatives of (S)-proline and (R)-pipecolic acid have been prepared using a Cope Elimination. These undergo reverse Cope Elimination onto a pendant double bond to give bicyclic lactam and lactone N-oxides containing three contiguous chiral centres, this extends the sCope and applicability of the reverse Cope Elimination in the synthesis of heterocyclic systems by incorporation of the lactone and lactam structural motifs.
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the diastereoselective synthesis of functionalised spirocyclic lactams and lactones using a Cope Elimination intramolecular nitrone cycloaddition strategy
Tetrahedron Letters, 2007Co-Authors: Gemma L Ellis, Ian A Oneil, Elena V Ramos, Alan P Chorlton, Barret S Kalindjian, David J TapolczayAbstract:Functionalised hydroxylamine derivatives of (S)-proline and pipecolic acid have been prepared using a Cope Elimination. These hydroxylamines have been found to undergo oxidation to the nitrone either in the presence of air or a catalytic quantity of TPAP. An intramolecular 1,3-dipolar cycloaddition then occurs between the nitrone and pendant double bond to give tricyclic lactams and lactones with high diastereoselectivity.
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the synthesis of chiral functionalised morpholine n oxides using a tandem Cope Elimination reverse Cope Elimination protocol
Tetrahedron Letters, 2004Co-Authors: Ian A Oneil, Ed Cleator, Elena V Ramos, Alan P Chorlton, David J TapolczayAbstract:Hydroxylamine derivatives of (S)-prolinol have been generated using a Cope Elimination. These undergo reverse-Cope Elimination onto a pendant double bond to give morpholine N-oxides containing three contiguous chiral centres.
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the diastereoselective synthesis of functionalised isoxazolidines using a Cope Elimination intramolecular nitrone cycloaddition strategy
Tetrahedron Letters, 2004Co-Authors: Ian A Oneil, Ed Cleator, Elena V Ramos, Alan P Chorlton, David J Tapolczay, Gemma L Ellis, Barret S KalindjianAbstract:Functionalised hydroxylamine derivatives of (S)-prolinol prepared by a Cope Elimination have been found to undergo oxidation to the nitrone either in the presence of air or a catalytic quantity of TPAP. These undergo intramolecular cycloaddition to give tricyclic isoxazolidines with high diastereoselectivity.
Barret S Kalindjian - One of the best experts on this subject based on the ideXlab platform.
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the synthesis of functionalised chiral bicyclic lactam and lactone n oxides using a tandem Cope Elimination reverse Cope Elimination protocol
Tetrahedron Letters, 2007Co-Authors: Gemma L Ellis, Ian A Oneil, Ed Cleator, Elena V Ramos, Alan P Chorlton, Barret S Kalindjian, David J TapolczayAbstract:Functionalised hydroxylamine derivatives of (S)-proline and (R)-pipecolic acid have been prepared using a Cope Elimination. These undergo reverse Cope Elimination onto a pendant double bond to give bicyclic lactam and lactone N-oxides containing three contiguous chiral centres, this extends the sCope and applicability of the reverse Cope Elimination in the synthesis of heterocyclic systems by incorporation of the lactone and lactam structural motifs.
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the diastereoselective synthesis of functionalised spirocyclic lactams and lactones using a Cope Elimination intramolecular nitrone cycloaddition strategy
Tetrahedron Letters, 2007Co-Authors: Gemma L Ellis, Ian A Oneil, Elena V Ramos, Alan P Chorlton, Barret S Kalindjian, David J TapolczayAbstract:Functionalised hydroxylamine derivatives of (S)-proline and pipecolic acid have been prepared using a Cope Elimination. These hydroxylamines have been found to undergo oxidation to the nitrone either in the presence of air or a catalytic quantity of TPAP. An intramolecular 1,3-dipolar cycloaddition then occurs between the nitrone and pendant double bond to give tricyclic lactams and lactones with high diastereoselectivity.
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the diastereoselective synthesis of functionalised isoxazolidines using a Cope Elimination intramolecular nitrone cycloaddition strategy
Tetrahedron Letters, 2004Co-Authors: Ian A Oneil, Ed Cleator, Elena V Ramos, Alan P Chorlton, David J Tapolczay, Gemma L Ellis, Barret S KalindjianAbstract:Functionalised hydroxylamine derivatives of (S)-prolinol prepared by a Cope Elimination have been found to undergo oxidation to the nitrone either in the presence of air or a catalytic quantity of TPAP. These undergo intramolecular cycloaddition to give tricyclic isoxazolidines with high diastereoselectivity.