The Experts below are selected from a list of 546045 Experts worldwide ranked by ideXlab platform
S. Randall Thomas - One of the best experts on this subject based on the ideXlab platform.
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Integration of detailed modules in a Core Model of body fluid homeostasis and blood pressure regulation
Progress in Biophysics & Molecular Biology, 2011Co-Authors: Alfredo Hernandez, Virginie Le Rolle, Julie Fontecave-jallon, François Guillaud, Thibault Grosse, Robert Moss, David Ojeda, Patrick Hannaert, Pierre Baconnier, S. Randall ThomasAbstract:Abstract This paper presents a contribution to the definition of the interfaces required to perform heterogeneous Model integration in the context of integrative physiology. A formalization of the Model integration problem is proposed and a coupling method is presented. The extension of the classic Guyton Model, a multi-organ, integrated systems Model of blood pressure regulation, is used as an example of the application of the proposed method. To this end, the Guyton Model has been restructured, extensive sensitivity analyses have been performed, and appropriate transformations have been applied to replace a subset of its constituting modules by integrating a pulsatile heart and an updated representation of the renin–angiotensin system. Simulation results of the extended integrated Model are presented and the impacts of their integration within the original Model are evaluated.
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SAPHIR: a physiome Core Model of body fluid homeostasis and blood pressure regulation.
Philosophical Transactions of the Royal Society A: Mathematical Physical and Engineering Sciences, 2008Co-Authors: S. Randall Thomas, Virginie Le Rolle, François Guillaud, Alfredo Hernandez, Patrick Hannaert, Pierre Baconnier, Julie Fontecave, Jean-pierre Françoise, Pierre Maziere, Fariza TahiAbstract:We present the current state of the development of the SAPHIR project (a Systems Approach for PHysiological Integration of Renal, cardiac and respiratory function). The aim is to provide an open-source multi-resolution Modelling environment that will permit, at a practical level, a plug-and-play construction of integrated systems Models using lumped-parameter components at the organ/tissue level while also allowing focus on cellular- or molecular-level detailed sub-Models embedded in the larger Core Model. Thus, an in silico exploration of gene-to-organ-to-organism scenarios will be possible, while keeping computation time manageable. As a first prototype implementation in this environment, we describe a Core Model of human physiology targeting the short- and long-term regulation of blood pressure, body fluids and homeostasis of the major solutes. In tandem with the development of the Core Models, the project involves database implementation and ontology development.
Yangkyu Choi - One of the best experts on this subject based on the ideXlab platform.
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a universal Core Model for multiple gate field effect transistors part i charge Model
IEEE Transactions on Electron Devices, 2013Co-Authors: Juan Pablo Duarte, Sungjin Choi, Dongil Moon, Jaehyuk Ahn, Jeeyeon Kim, Sungho Kim, Yangkyu ChoiAbstract:A universal Core Model for multiple-gate field-effect transistors (Mug-FETs) is proposed. The proposed charge and drain current Models are presented in Parts I and II, respectively. It is first demonstrated that an exact potential profile in the entire channel is not necessary for the derivation of accurate charge Models in inversion-mode FETs. With application of this new concept, a universal charge Model is derived for Mug-FETs by assuming an arbitrary channel potential profile, which simplifies the mathematical formulation. Thereafter, using the Pao-Sah integral, a drain current Model is obtained from the charge Model of Part I. The proposed Model can be expressed as an explicit and continuous form for all operation regimes; therefore, it is well suited for compact Modeling to support fast circuit simulations. The Model shows good agreement with 2-D and 3-D numerical simulations for several multiple-gate structures, such as single-gate, double-gate, triple-gate, rectangular gate-all-around, and cylindrical gate-all-around FETs.
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a universal Core Model for multiple gate field effect transistors part ii drain current Model
IEEE Transactions on Electron Devices, 2013Co-Authors: Juan Pablo Duarte, Sungjin Choi, Dongil Moon, Yangkyu ChoiAbstract:A universal drain current Model for multiple-gate field-effect transistors (FETs) (Mug-FETs) is proposed. In Part I, a universal charge Model was derived using the arbitrary potential method. Using this charge Model, Pao-Sah's integral is analytically carried out by approximating its integrand. The Model describes both the subthreshold inversion for undoped FETs and the effects of finite doping density in the channel. With an explicit and continuous expression, the proposed drain current Model covers all regions of device operation: subthreshold, linear, and saturation. The accuracy from the proposed Model is comparable with that from well-known previous Models for double-gate (DG) and cylindrical gate-all-around (Cy-GAA) FETs with an undoped channel. In addition, the Model shows good agreement with 2-D and 3-D numerical simulations for doped-channel multiple-gate structures such as single-gate, DG, triple-gate, rectangular gate-all-around, and Cy-GAA FETs. The proposed Model is well suited to be a Core Model for Mug-FETs due to its good computational efficiency and high accuracy; hence, it is useful for compact Modeling.
Alfredo Hernandez - One of the best experts on this subject based on the ideXlab platform.
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Integration of detailed modules in a Core Model of body fluid homeostasis and blood pressure regulation
Progress in Biophysics & Molecular Biology, 2011Co-Authors: Alfredo Hernandez, Virginie Le Rolle, Julie Fontecave-jallon, François Guillaud, Thibault Grosse, Robert Moss, David Ojeda, Patrick Hannaert, Pierre Baconnier, S. Randall ThomasAbstract:Abstract This paper presents a contribution to the definition of the interfaces required to perform heterogeneous Model integration in the context of integrative physiology. A formalization of the Model integration problem is proposed and a coupling method is presented. The extension of the classic Guyton Model, a multi-organ, integrated systems Model of blood pressure regulation, is used as an example of the application of the proposed method. To this end, the Guyton Model has been restructured, extensive sensitivity analyses have been performed, and appropriate transformations have been applied to replace a subset of its constituting modules by integrating a pulsatile heart and an updated representation of the renin–angiotensin system. Simulation results of the extended integrated Model are presented and the impacts of their integration within the original Model are evaluated.
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SAPHIR: a physiome Core Model of body fluid homeostasis and blood pressure regulation.
Philosophical Transactions of the Royal Society A: Mathematical Physical and Engineering Sciences, 2008Co-Authors: S. Randall Thomas, Virginie Le Rolle, François Guillaud, Alfredo Hernandez, Patrick Hannaert, Pierre Baconnier, Julie Fontecave, Jean-pierre Françoise, Pierre Maziere, Fariza TahiAbstract:We present the current state of the development of the SAPHIR project (a Systems Approach for PHysiological Integration of Renal, cardiac and respiratory function). The aim is to provide an open-source multi-resolution Modelling environment that will permit, at a practical level, a plug-and-play construction of integrated systems Models using lumped-parameter components at the organ/tissue level while also allowing focus on cellular- or molecular-level detailed sub-Models embedded in the larger Core Model. Thus, an in silico exploration of gene-to-organ-to-organism scenarios will be possible, while keeping computation time manageable. As a first prototype implementation in this environment, we describe a Core Model of human physiology targeting the short- and long-term regulation of blood pressure, body fluids and homeostasis of the major solutes. In tandem with the development of the Core Models, the project involves database implementation and ontology development.
Richard J Sadus - One of the best experts on this subject based on the ideXlab platform.
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thermodynamic properties in the molecular dynamics ensemble applied to the gaussian Core Model fluid
Journal of Chemical Physics, 2011Co-Authors: Peter Mausbach, Richard J SadusAbstract:The thermodynamic properties of pressure, energy, isothermal pressure coefficient, thermal expansion coefficient, isothermal and adiabatic compressibilities, isobaric and isochoric heat capacities, Joule–Thomson coefficient, and speed of sound are considered in a classical molecular dynamics ensemble. These properties were obtained using the treatment of Lustig [J. Chem. Phys. 100, 3048 (1994)] and Meier and Kabelac [J. Chem. Phys. 124, 064104 (2006)], whereby thermodynamic state variables are expressible in terms of phase-space functions determined directly from molecular dynamics simulations. The complete thermodynamic information about an equilibrium system can be obtained from this general formalism. We apply this method to the Gaussian Core Model fluid because the complex phase behavior of this simple Model provides a severe test for this treatment. Waterlike and other anomalies are observed for some of the thermodynamic properties of the Gaussian Core Model fluid.
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solid liquid phase equilibria of the gaussian Core Model fluid
Journal of Chemical Physics, 2009Co-Authors: Peter Mausbach, Alauddin Ahmed, Richard J SadusAbstract:The solid-liquid phase equilibria of the Gaussian Core Model are determined using the GWTS [J. Ge, G.-W. Wu, B. D. Todd, and R. J. Sadus, J. Chem. Phys. 119, 11017 (2003)] algorithm, which combines equilibrium and nonequilibrium molecular dynamics simulations. This is the first reported use of the GWTS algorithm for a fluid system displaying a reentrant melting scenario. Using the GWTS algorithm, the phase envelope of the Gaussian Core Model can be calculated more precisely than previously possible. The results for the low-density and the high-density (reentrant melting) sides of the solid state are in good agreement with those obtained by Monte Carlo simulations in conjunction with calculations of the solid free energies. The common point on the Gaussian Core envelope, where equal-density solid and liquid phases are in coexistence, could be determined with high precision.
Fariza Tahi - One of the best experts on this subject based on the ideXlab platform.
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SAPHIR: a physiome Core Model of body fluid homeostasis and blood pressure regulation.
Philosophical Transactions of the Royal Society A: Mathematical Physical and Engineering Sciences, 2008Co-Authors: S. Randall Thomas, Virginie Le Rolle, François Guillaud, Alfredo Hernandez, Patrick Hannaert, Pierre Baconnier, Julie Fontecave, Jean-pierre Françoise, Pierre Maziere, Fariza TahiAbstract:We present the current state of the development of the SAPHIR project (a Systems Approach for PHysiological Integration of Renal, cardiac and respiratory function). The aim is to provide an open-source multi-resolution Modelling environment that will permit, at a practical level, a plug-and-play construction of integrated systems Models using lumped-parameter components at the organ/tissue level while also allowing focus on cellular- or molecular-level detailed sub-Models embedded in the larger Core Model. Thus, an in silico exploration of gene-to-organ-to-organism scenarios will be possible, while keeping computation time manageable. As a first prototype implementation in this environment, we describe a Core Model of human physiology targeting the short- and long-term regulation of blood pressure, body fluids and homeostasis of the major solutes. In tandem with the development of the Core Models, the project involves database implementation and ontology development.