The Experts below are selected from a list of 54 Experts worldwide ranked by ideXlab platform

James M. Reecy - One of the best experts on this subject based on the ideXlab platform.

  • Genome-wide association study of infectious bovine keratoconjunctivitis in Angus cattle
    BMC genetics, 2013
    Co-Authors: Kadir Kizilkaya, Richard G. Tait, Dorian J. Garrick, Rohan L. Fernando, James M. Reecy
    Abstract:

    Background Infectious Bovine Keratoconjunctivitis (IBK) in beef cattle, commonly known as pinkeye, is a bacterial disease caused by Moraxellabovis. IBK is characterized by excessive tearing and ulceration of the Cornea. Perforation of the Cornea may also occur in severe cases. IBK is considered the most important ocular disease in cattle production, due to the decreased growth performance of infected individuals and its subsequent economic effects. IBK is an economically important, lowly heritable categorical disease trait. Mass selection of unaffected animals has not been successful at reducing disease incidence. Genome-wide studies can determine chromosomal regions associated with IBK susceptibility. The objective of the study was to detect single-nucleotide polymorphism (SNP) markers in linkage disequilibrium (LD) with genetic variants associated with IBK in American Angus cattle.

  • Genome-wide association study of infectious bovine keratoconjunctivitis in Angus cattle
    BMC Genetics, 2013
    Co-Authors: Kadir Kizilkaya, Richard G. Tait, Dorian J. Garrick, Rohan L. Fernando, James M. Reecy
    Abstract:

    Background Infectious Bovine Keratoconjunctivitis (IBK) in beef cattle, commonly known as pinkeye, is a bacterial disease caused by M o r a x e l l a bovis . IBK is characterized by excessive tearing and ulceration of the Cornea. Perforation of the Cornea may also occur in severe cases. IBK is considered the most important ocular disease in cattle production, due to the decreased growth performance of infected individuals and its subsequent economic effects. IBK is an economically important, lowly heritable categorical disease trait. Mass selection of unaffected animals has not been successful at reducing disease incidence. Genome-wide studies can determine chromosomal regions associated with IBK susceptibility. The objective of the study was to detect single-nucleotide polymorphism (SNP) markers in linkage disequilibrium (LD) with genetic variants associated with IBK in American Angus cattle. Results The proportion of phenotypic variance explained by markers was 0.06 in the whole genome analysis of IBK incidence classified as two, three or nine categories. Whole-genome analysis using any categorisation of (two, three or nine) IBK scores showed that locations on chromosomes 2, 12, 13 and 21 were associated with IBK disease. The genomic locations on chromosomes 13 and 21 overlap with QTLs associated with Bovine spongiform encephalopathy, clinical mastitis or somatic cell count. Conclusions Results of these genome-wide analyses indicated that if the underlying genetic factors confer not only IBK susceptibility but also IBK severity, treating IBK phenotypes as a two-categorical trait can cause information loss in the genome-wide analysis. These results help our overall understanding of the genetics of IBK and have the potential to provide information for future use in breeding schemes.

  • genome wide association study of infectious bovine keratoconjunctivitis in angus cattle
    BMC Genetics, 2013
    Co-Authors: Kadir Kizilkaya, Richard G. Tait, Dorian J. Garrick, Rohan L. Fernando, James M. Reecy
    Abstract:

    Infectious Bovine Keratoconjunctivitis (IBK) in beef cattle, commonly known as pinkeye, is a bacterial disease caused by M o r a x e l l a bovis. IBK is characterized by excessive tearing and ulceration of the Cornea. Perforation of the Cornea may also occur in severe cases. IBK is considered the most important ocular disease in cattle production, due to the decreased growth performance of infected individuals and its subsequent economic effects. IBK is an economically important, lowly heritable categorical disease trait. Mass selection of unaffected animals has not been successful at reducing disease incidence. Genome-wide studies can determine chromosomal regions associated with IBK susceptibility. The objective of the study was to detect single-nucleotide polymorphism (SNP) markers in linkage disequilibrium (LD) with genetic variants associated with IBK in American Angus cattle. The proportion of phenotypic variance explained by markers was 0.06 in the whole genome analysis of IBK incidence classified as two, three or nine categories. Whole-genome analysis using any categorisation of (two, three or nine) IBK scores showed that locations on chromosomes 2, 12, 13 and 21 were associated with IBK disease. The genomic locations on chromosomes 13 and 21 overlap with QTLs associated with Bovine spongiform encephalopathy, clinical mastitis or somatic cell count. Results of these genome-wide analyses indicated that if the underlying genetic factors confer not only IBK susceptibility but also IBK severity, treating IBK phenotypes as a two-categorical trait can cause information loss in the genome-wide analysis. These results help our overall understanding of the genetics of IBK and have the potential to provide information for future use in breeding schemes.

Kadir Kizilkaya - One of the best experts on this subject based on the ideXlab platform.

  • Genome-wide association study of infectious bovine keratoconjunctivitis in Angus cattle
    BMC genetics, 2013
    Co-Authors: Kadir Kizilkaya, Richard G. Tait, Dorian J. Garrick, Rohan L. Fernando, James M. Reecy
    Abstract:

    Background Infectious Bovine Keratoconjunctivitis (IBK) in beef cattle, commonly known as pinkeye, is a bacterial disease caused by Moraxellabovis. IBK is characterized by excessive tearing and ulceration of the Cornea. Perforation of the Cornea may also occur in severe cases. IBK is considered the most important ocular disease in cattle production, due to the decreased growth performance of infected individuals and its subsequent economic effects. IBK is an economically important, lowly heritable categorical disease trait. Mass selection of unaffected animals has not been successful at reducing disease incidence. Genome-wide studies can determine chromosomal regions associated with IBK susceptibility. The objective of the study was to detect single-nucleotide polymorphism (SNP) markers in linkage disequilibrium (LD) with genetic variants associated with IBK in American Angus cattle.

  • Genome-wide association study of infectious bovine keratoconjunctivitis in Angus cattle
    BMC Genetics, 2013
    Co-Authors: Kadir Kizilkaya, Richard G. Tait, Dorian J. Garrick, Rohan L. Fernando, James M. Reecy
    Abstract:

    Background Infectious Bovine Keratoconjunctivitis (IBK) in beef cattle, commonly known as pinkeye, is a bacterial disease caused by M o r a x e l l a bovis . IBK is characterized by excessive tearing and ulceration of the Cornea. Perforation of the Cornea may also occur in severe cases. IBK is considered the most important ocular disease in cattle production, due to the decreased growth performance of infected individuals and its subsequent economic effects. IBK is an economically important, lowly heritable categorical disease trait. Mass selection of unaffected animals has not been successful at reducing disease incidence. Genome-wide studies can determine chromosomal regions associated with IBK susceptibility. The objective of the study was to detect single-nucleotide polymorphism (SNP) markers in linkage disequilibrium (LD) with genetic variants associated with IBK in American Angus cattle. Results The proportion of phenotypic variance explained by markers was 0.06 in the whole genome analysis of IBK incidence classified as two, three or nine categories. Whole-genome analysis using any categorisation of (two, three or nine) IBK scores showed that locations on chromosomes 2, 12, 13 and 21 were associated with IBK disease. The genomic locations on chromosomes 13 and 21 overlap with QTLs associated with Bovine spongiform encephalopathy, clinical mastitis or somatic cell count. Conclusions Results of these genome-wide analyses indicated that if the underlying genetic factors confer not only IBK susceptibility but also IBK severity, treating IBK phenotypes as a two-categorical trait can cause information loss in the genome-wide analysis. These results help our overall understanding of the genetics of IBK and have the potential to provide information for future use in breeding schemes.

  • genome wide association study of infectious bovine keratoconjunctivitis in angus cattle
    BMC Genetics, 2013
    Co-Authors: Kadir Kizilkaya, Richard G. Tait, Dorian J. Garrick, Rohan L. Fernando, James M. Reecy
    Abstract:

    Infectious Bovine Keratoconjunctivitis (IBK) in beef cattle, commonly known as pinkeye, is a bacterial disease caused by M o r a x e l l a bovis. IBK is characterized by excessive tearing and ulceration of the Cornea. Perforation of the Cornea may also occur in severe cases. IBK is considered the most important ocular disease in cattle production, due to the decreased growth performance of infected individuals and its subsequent economic effects. IBK is an economically important, lowly heritable categorical disease trait. Mass selection of unaffected animals has not been successful at reducing disease incidence. Genome-wide studies can determine chromosomal regions associated with IBK susceptibility. The objective of the study was to detect single-nucleotide polymorphism (SNP) markers in linkage disequilibrium (LD) with genetic variants associated with IBK in American Angus cattle. The proportion of phenotypic variance explained by markers was 0.06 in the whole genome analysis of IBK incidence classified as two, three or nine categories. Whole-genome analysis using any categorisation of (two, three or nine) IBK scores showed that locations on chromosomes 2, 12, 13 and 21 were associated with IBK disease. The genomic locations on chromosomes 13 and 21 overlap with QTLs associated with Bovine spongiform encephalopathy, clinical mastitis or somatic cell count. Results of these genome-wide analyses indicated that if the underlying genetic factors confer not only IBK susceptibility but also IBK severity, treating IBK phenotypes as a two-categorical trait can cause information loss in the genome-wide analysis. These results help our overall understanding of the genetics of IBK and have the potential to provide information for future use in breeding schemes.

F. Hendrikse - One of the best experts on this subject based on the ideXlab platform.

  • Abstracts of the 195th meeting of The Dutch Ophthalmological Society Maastricht, 4–6 April 2001
    International Ophthalmology, 2004
    Co-Authors: F. Hendrikse
    Abstract:

    [1.] NEML Tang, WF Treffers, A van der Lelij: Cornea Perforation as a result of keratolysis treated with local and systemic Cyclosporine.

  • Abstracts of the 195th meeting of The Dutch Ophthalmological Society Maastricht, 4–6 April 2001
    International Ophthalmology, 2004
    Co-Authors: F. Hendrikse
    Abstract:

    [1.] NEML Tang, WF Treffers, A van der Lelij: Cornea Perforation as a result of keratolysis treated with local and systemic Cyclosporine. [2.] J Bours: The protein distribution of human aqueous humor, cerebrospinal-, subretinaland tear fluid before and afier disruption of the blood/body fluid barriers. [3.] EC La Heij, MPH van de Waarenburg, HGT Blaauwgeers, J de Vente, AGH Kessels, AT Liem, H Steinbusch, F Hendrikse: Analyses of interleukin-6 (IL-6), basic fibroblast growth factor (BFGF), glutamine synthetase and total protein in subretinal fluid from patients with retinal detachment. [4.] JWR Pott, GP Heeg, NM Jansonius: The nerve fiber analyser in chiasmal compression by pituitary adnomas. [5.] GP Heeg, U Blanksma, PLLJ Hardus, NM Jansonius: Learning effect in frequency doubling perimetry. [6.] F Hendrikse, EC La Heij, ATA Liem, MR Beintema, TD Verbraak, RO Schlingeman:Photodynamic therapy, the situation afier one year. [7.] RJW de Keizer, EJ Schimmel: Iridium^192 brachytherapy of eyelid, conjunctiva and orbital malignancies.

Dorian J. Garrick - One of the best experts on this subject based on the ideXlab platform.

  • Genome-wide association study of infectious bovine keratoconjunctivitis in Angus cattle
    BMC genetics, 2013
    Co-Authors: Kadir Kizilkaya, Richard G. Tait, Dorian J. Garrick, Rohan L. Fernando, James M. Reecy
    Abstract:

    Background Infectious Bovine Keratoconjunctivitis (IBK) in beef cattle, commonly known as pinkeye, is a bacterial disease caused by Moraxellabovis. IBK is characterized by excessive tearing and ulceration of the Cornea. Perforation of the Cornea may also occur in severe cases. IBK is considered the most important ocular disease in cattle production, due to the decreased growth performance of infected individuals and its subsequent economic effects. IBK is an economically important, lowly heritable categorical disease trait. Mass selection of unaffected animals has not been successful at reducing disease incidence. Genome-wide studies can determine chromosomal regions associated with IBK susceptibility. The objective of the study was to detect single-nucleotide polymorphism (SNP) markers in linkage disequilibrium (LD) with genetic variants associated with IBK in American Angus cattle.

  • Genome-wide association study of infectious bovine keratoconjunctivitis in Angus cattle
    BMC Genetics, 2013
    Co-Authors: Kadir Kizilkaya, Richard G. Tait, Dorian J. Garrick, Rohan L. Fernando, James M. Reecy
    Abstract:

    Background Infectious Bovine Keratoconjunctivitis (IBK) in beef cattle, commonly known as pinkeye, is a bacterial disease caused by M o r a x e l l a bovis . IBK is characterized by excessive tearing and ulceration of the Cornea. Perforation of the Cornea may also occur in severe cases. IBK is considered the most important ocular disease in cattle production, due to the decreased growth performance of infected individuals and its subsequent economic effects. IBK is an economically important, lowly heritable categorical disease trait. Mass selection of unaffected animals has not been successful at reducing disease incidence. Genome-wide studies can determine chromosomal regions associated with IBK susceptibility. The objective of the study was to detect single-nucleotide polymorphism (SNP) markers in linkage disequilibrium (LD) with genetic variants associated with IBK in American Angus cattle. Results The proportion of phenotypic variance explained by markers was 0.06 in the whole genome analysis of IBK incidence classified as two, three or nine categories. Whole-genome analysis using any categorisation of (two, three or nine) IBK scores showed that locations on chromosomes 2, 12, 13 and 21 were associated with IBK disease. The genomic locations on chromosomes 13 and 21 overlap with QTLs associated with Bovine spongiform encephalopathy, clinical mastitis or somatic cell count. Conclusions Results of these genome-wide analyses indicated that if the underlying genetic factors confer not only IBK susceptibility but also IBK severity, treating IBK phenotypes as a two-categorical trait can cause information loss in the genome-wide analysis. These results help our overall understanding of the genetics of IBK and have the potential to provide information for future use in breeding schemes.

  • genome wide association study of infectious bovine keratoconjunctivitis in angus cattle
    BMC Genetics, 2013
    Co-Authors: Kadir Kizilkaya, Richard G. Tait, Dorian J. Garrick, Rohan L. Fernando, James M. Reecy
    Abstract:

    Infectious Bovine Keratoconjunctivitis (IBK) in beef cattle, commonly known as pinkeye, is a bacterial disease caused by M o r a x e l l a bovis. IBK is characterized by excessive tearing and ulceration of the Cornea. Perforation of the Cornea may also occur in severe cases. IBK is considered the most important ocular disease in cattle production, due to the decreased growth performance of infected individuals and its subsequent economic effects. IBK is an economically important, lowly heritable categorical disease trait. Mass selection of unaffected animals has not been successful at reducing disease incidence. Genome-wide studies can determine chromosomal regions associated with IBK susceptibility. The objective of the study was to detect single-nucleotide polymorphism (SNP) markers in linkage disequilibrium (LD) with genetic variants associated with IBK in American Angus cattle. The proportion of phenotypic variance explained by markers was 0.06 in the whole genome analysis of IBK incidence classified as two, three or nine categories. Whole-genome analysis using any categorisation of (two, three or nine) IBK scores showed that locations on chromosomes 2, 12, 13 and 21 were associated with IBK disease. The genomic locations on chromosomes 13 and 21 overlap with QTLs associated with Bovine spongiform encephalopathy, clinical mastitis or somatic cell count. Results of these genome-wide analyses indicated that if the underlying genetic factors confer not only IBK susceptibility but also IBK severity, treating IBK phenotypes as a two-categorical trait can cause information loss in the genome-wide analysis. These results help our overall understanding of the genetics of IBK and have the potential to provide information for future use in breeding schemes.

Richard G. Tait - One of the best experts on this subject based on the ideXlab platform.

  • Genome-wide association study of infectious bovine keratoconjunctivitis in Angus cattle
    BMC genetics, 2013
    Co-Authors: Kadir Kizilkaya, Richard G. Tait, Dorian J. Garrick, Rohan L. Fernando, James M. Reecy
    Abstract:

    Background Infectious Bovine Keratoconjunctivitis (IBK) in beef cattle, commonly known as pinkeye, is a bacterial disease caused by Moraxellabovis. IBK is characterized by excessive tearing and ulceration of the Cornea. Perforation of the Cornea may also occur in severe cases. IBK is considered the most important ocular disease in cattle production, due to the decreased growth performance of infected individuals and its subsequent economic effects. IBK is an economically important, lowly heritable categorical disease trait. Mass selection of unaffected animals has not been successful at reducing disease incidence. Genome-wide studies can determine chromosomal regions associated with IBK susceptibility. The objective of the study was to detect single-nucleotide polymorphism (SNP) markers in linkage disequilibrium (LD) with genetic variants associated with IBK in American Angus cattle.

  • Genome-wide association study of infectious bovine keratoconjunctivitis in Angus cattle
    BMC Genetics, 2013
    Co-Authors: Kadir Kizilkaya, Richard G. Tait, Dorian J. Garrick, Rohan L. Fernando, James M. Reecy
    Abstract:

    Background Infectious Bovine Keratoconjunctivitis (IBK) in beef cattle, commonly known as pinkeye, is a bacterial disease caused by M o r a x e l l a bovis . IBK is characterized by excessive tearing and ulceration of the Cornea. Perforation of the Cornea may also occur in severe cases. IBK is considered the most important ocular disease in cattle production, due to the decreased growth performance of infected individuals and its subsequent economic effects. IBK is an economically important, lowly heritable categorical disease trait. Mass selection of unaffected animals has not been successful at reducing disease incidence. Genome-wide studies can determine chromosomal regions associated with IBK susceptibility. The objective of the study was to detect single-nucleotide polymorphism (SNP) markers in linkage disequilibrium (LD) with genetic variants associated with IBK in American Angus cattle. Results The proportion of phenotypic variance explained by markers was 0.06 in the whole genome analysis of IBK incidence classified as two, three or nine categories. Whole-genome analysis using any categorisation of (two, three or nine) IBK scores showed that locations on chromosomes 2, 12, 13 and 21 were associated with IBK disease. The genomic locations on chromosomes 13 and 21 overlap with QTLs associated with Bovine spongiform encephalopathy, clinical mastitis or somatic cell count. Conclusions Results of these genome-wide analyses indicated that if the underlying genetic factors confer not only IBK susceptibility but also IBK severity, treating IBK phenotypes as a two-categorical trait can cause information loss in the genome-wide analysis. These results help our overall understanding of the genetics of IBK and have the potential to provide information for future use in breeding schemes.

  • genome wide association study of infectious bovine keratoconjunctivitis in angus cattle
    BMC Genetics, 2013
    Co-Authors: Kadir Kizilkaya, Richard G. Tait, Dorian J. Garrick, Rohan L. Fernando, James M. Reecy
    Abstract:

    Infectious Bovine Keratoconjunctivitis (IBK) in beef cattle, commonly known as pinkeye, is a bacterial disease caused by M o r a x e l l a bovis. IBK is characterized by excessive tearing and ulceration of the Cornea. Perforation of the Cornea may also occur in severe cases. IBK is considered the most important ocular disease in cattle production, due to the decreased growth performance of infected individuals and its subsequent economic effects. IBK is an economically important, lowly heritable categorical disease trait. Mass selection of unaffected animals has not been successful at reducing disease incidence. Genome-wide studies can determine chromosomal regions associated with IBK susceptibility. The objective of the study was to detect single-nucleotide polymorphism (SNP) markers in linkage disequilibrium (LD) with genetic variants associated with IBK in American Angus cattle. The proportion of phenotypic variance explained by markers was 0.06 in the whole genome analysis of IBK incidence classified as two, three or nine categories. Whole-genome analysis using any categorisation of (two, three or nine) IBK scores showed that locations on chromosomes 2, 12, 13 and 21 were associated with IBK disease. The genomic locations on chromosomes 13 and 21 overlap with QTLs associated with Bovine spongiform encephalopathy, clinical mastitis or somatic cell count. Results of these genome-wide analyses indicated that if the underlying genetic factors confer not only IBK susceptibility but also IBK severity, treating IBK phenotypes as a two-categorical trait can cause information loss in the genome-wide analysis. These results help our overall understanding of the genetics of IBK and have the potential to provide information for future use in breeding schemes.