The Experts below are selected from a list of 1479 Experts worldwide ranked by ideXlab platform
Kai He - One of the best experts on this subject based on the ideXlab platform.
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the hypoglycemic and synergistic effect of loganin morroniside and ursolic acid isolated from the fruits of Cornus officinalis
Phytotherapy Research, 2016Co-Authors: Kai He, Shanghua Song, Min Feng, Dezhen Wang, Yanzhi Wang, Xuegang Li, Xiaoli YeAbstract:Hypoglycemic activity-guided separation of ethanol extracts from the fruits of Cornus officinalis Sieb. et Zucc (CO) led to the isolation of loganin, morroniside, and ursolic acid. The antidiabetic capacity of CO extracts and related compounds was further investigated in diabetes mellitus mice. The results suggested that both CO extracts and pure compounds could ameliorate diabetes-associated damages and complications. Oral administration of loganin and morroniside decreased fasting blood glucose levels in diabetes mellitus mice. Ursolic acid exhibited the highest reactive oxygen species scavenging activity and α-glucosidase inhibitory activity. Notably, we noticed an interesting synergistic effect between loganin and ursolic acid. Given these favorable hypoglycemic properties, C. officinalis, a food and medicinal plant in China, may be used as a valuable food supplement for the treatment of diabetes mellitus. Copyright © 2015 John Wiley & Sons, Ltd.
Xian-sheng Ye - One of the best experts on this subject based on the ideXlab platform.
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Cornusglucosides A and B, Two New Iridoid Glucosides from the Fruit of Cornus officinalis
Chemistry & Biodiversity, 2019Co-Authors: Jun He, Jie-kun Xu, Xian-sheng Ye, Yuan Xu, Xiao‐xiao Zhang, Wei-ku ZhangAbstract:: Phytochemical study on the fruit of Cornus officinalis Sieb. et Zucc. yielded two new iridoid glucosides, named Cornusglucoside A (1) and Cornusglucoside B (2). The structures of 1 and 2 were elucidated via comprehensive NMR and HR-ESI-MS data analysis. Additionally, their inhibitory effects on IL-6-induced STAT3 activation were assessed.
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unusual cadinane type sesquiterpene glycosides with α glucosidase inhibitory activities from the fruit of Cornus officinalis sieb et zuuc
Bioorganic Chemistry, 2019Co-Authors: Jun He, Jie-kun Xu, Xian-sheng Ye, Yungchi Cheng, Chunyang Xu, Guifen Qiang, Guanhua Du, Wei-ku ZhangAbstract:Abstract Five novel and rare cadinane-type sesquiterpene glycosides, cornucadinoside A-E ( 1 – 5 ) were isolated from water extract of the fruit of Cornus officinalis Sieb. et Zuuc.. The new chemical structures, together with their absolute configurations, were elucidated on the basis of extensive spectroscopic analysis, including a comparison of their experimental and calculated electronic circular dichroism (ECD) spectra. Their structures, which possess a naphthalene skeleton, are the first report on the occurrence of cadinane sesquiterpene glycosides in Cornus . Additionally, all the compounds exhibited marked α -glucosidase inhibitory activity except for 3 in vitro .
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A new phenylpropanoid glycoside from fruit of Cornus officinalis
China journal of Chinese materia medica, 2018Co-Authors: Jun He, Jie-kun Xu, Xian-sheng Ye, Ying-ying Liang, Ge-fan Yang, Wei-ku ZhangAbstract:: To investigate the chemical compounds from the ripe fruit of Cornus officinalis, a new phenylpropanoid glycoside 1-O-(6'-O-p-hydroxybenzoyl-β-D-glucopyranosyl)-p-phenylpropanol, named cornuphenylpropanoid A (1), were separated and purified by D101 macroporous resin, silica gel and ODS column chromatography. Its structure was extensively determined on basis of ¹H-NMR, ¹³C-NMR, DEPT, HSQC, HMBC and HR-ESI-MS spectroscopic data.
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Cornusides a o bioactive iridoid glucoside dimers from the fruit of Cornus officinalis
Journal of Natural Products, 2017Co-Authors: Xian-sheng Ye, Jun He, Wei-ku Zhang, Lei Zhang, Haoyi Qiao, Jia Zhang, Yungchi Cheng, Jie-kun XuAbstract:Fifteen new and rare iridoid glucoside dimers, Cornusides A–O (1–15), and 10 known iridoid glucosides (16–25) were isolated from the fruit of Cornus officinalis. These new chemical structures were established through spectroscopic analysis (UV, IR, HRESIMS, 1D and 2D NMR). Compounds 1–25 were tested for their inhibitory activities by measuring IL-6-induced STAT3 promoter activity in HepG2 cells, and 3, 12, 17, 22, and 23 showed inhibitory effects, with IC50 values of 11.9, 12.2, 14.0, 7.0, and 6.9 μM, respectively.
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four new iridoid glucosides containing the furan ring from the fruit of Cornus officinalis
Fitoterapia, 2017Co-Authors: Jun He, Xian-sheng Ye, Wei-ku Zhang, Xiaoxue Wang, Yanan Yang, Peicheng Zhang, Jie-kun XuAbstract:Four new and rare iridoid glucosides, Cornusfuroside A–D (1–4), containing the furan ring were identified from water extract of the fruit of Cornus officinalis. These new chemical structures were determined through extensive spectroscopic analysis, including 1D and 2D NMR, IR, HRESIMS, experimental and calculated electronic circular dichroism (ECD). Notably, this study is the first report on the isolation of four iridoid glucoside structures with acetal functions in the sugar moiety. The neuroprotective effects of these compounds were also evaluated in vitro.
Wei-ku Zhang - One of the best experts on this subject based on the ideXlab platform.
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Cornusglucosides A and B, Two New Iridoid Glucosides from the Fruit of Cornus officinalis
Chemistry & Biodiversity, 2019Co-Authors: Jun He, Jie-kun Xu, Xian-sheng Ye, Yuan Xu, Xiao‐xiao Zhang, Wei-ku ZhangAbstract:: Phytochemical study on the fruit of Cornus officinalis Sieb. et Zucc. yielded two new iridoid glucosides, named Cornusglucoside A (1) and Cornusglucoside B (2). The structures of 1 and 2 were elucidated via comprehensive NMR and HR-ESI-MS data analysis. Additionally, their inhibitory effects on IL-6-induced STAT3 activation were assessed.
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unusual cadinane type sesquiterpene glycosides with α glucosidase inhibitory activities from the fruit of Cornus officinalis sieb et zuuc
Bioorganic Chemistry, 2019Co-Authors: Jun He, Jie-kun Xu, Xian-sheng Ye, Yungchi Cheng, Chunyang Xu, Guifen Qiang, Guanhua Du, Wei-ku ZhangAbstract:Abstract Five novel and rare cadinane-type sesquiterpene glycosides, cornucadinoside A-E ( 1 – 5 ) were isolated from water extract of the fruit of Cornus officinalis Sieb. et Zuuc.. The new chemical structures, together with their absolute configurations, were elucidated on the basis of extensive spectroscopic analysis, including a comparison of their experimental and calculated electronic circular dichroism (ECD) spectra. Their structures, which possess a naphthalene skeleton, are the first report on the occurrence of cadinane sesquiterpene glycosides in Cornus . Additionally, all the compounds exhibited marked α -glucosidase inhibitory activity except for 3 in vitro .
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A new phenylpropanoid glycoside from fruit of Cornus officinalis
China journal of Chinese materia medica, 2018Co-Authors: Jun He, Jie-kun Xu, Xian-sheng Ye, Ying-ying Liang, Ge-fan Yang, Wei-ku ZhangAbstract:: To investigate the chemical compounds from the ripe fruit of Cornus officinalis, a new phenylpropanoid glycoside 1-O-(6'-O-p-hydroxybenzoyl-β-D-glucopyranosyl)-p-phenylpropanol, named cornuphenylpropanoid A (1), were separated and purified by D101 macroporous resin, silica gel and ODS column chromatography. Its structure was extensively determined on basis of ¹H-NMR, ¹³C-NMR, DEPT, HSQC, HMBC and HR-ESI-MS spectroscopic data.
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Cornusides a o bioactive iridoid glucoside dimers from the fruit of Cornus officinalis
Journal of Natural Products, 2017Co-Authors: Xian-sheng Ye, Jun He, Wei-ku Zhang, Lei Zhang, Haoyi Qiao, Jia Zhang, Yungchi Cheng, Jie-kun XuAbstract:Fifteen new and rare iridoid glucoside dimers, Cornusides A–O (1–15), and 10 known iridoid glucosides (16–25) were isolated from the fruit of Cornus officinalis. These new chemical structures were established through spectroscopic analysis (UV, IR, HRESIMS, 1D and 2D NMR). Compounds 1–25 were tested for their inhibitory activities by measuring IL-6-induced STAT3 promoter activity in HepG2 cells, and 3, 12, 17, 22, and 23 showed inhibitory effects, with IC50 values of 11.9, 12.2, 14.0, 7.0, and 6.9 μM, respectively.
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four new iridoid glucosides containing the furan ring from the fruit of Cornus officinalis
Fitoterapia, 2017Co-Authors: Jun He, Xian-sheng Ye, Wei-ku Zhang, Xiaoxue Wang, Yanan Yang, Peicheng Zhang, Jie-kun XuAbstract:Four new and rare iridoid glucosides, Cornusfuroside A–D (1–4), containing the furan ring were identified from water extract of the fruit of Cornus officinalis. These new chemical structures were determined through extensive spectroscopic analysis, including 1D and 2D NMR, IR, HRESIMS, experimental and calculated electronic circular dichroism (ECD). Notably, this study is the first report on the isolation of four iridoid glucoside structures with acetal functions in the sugar moiety. The neuroprotective effects of these compounds were also evaluated in vitro.
Xiaoli Ye - One of the best experts on this subject based on the ideXlab platform.
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the hypoglycemic and synergistic effect of loganin morroniside and ursolic acid isolated from the fruits of Cornus officinalis
Phytotherapy Research, 2016Co-Authors: Kai He, Shanghua Song, Min Feng, Dezhen Wang, Yanzhi Wang, Xuegang Li, Xiaoli YeAbstract:Hypoglycemic activity-guided separation of ethanol extracts from the fruits of Cornus officinalis Sieb. et Zucc (CO) led to the isolation of loganin, morroniside, and ursolic acid. The antidiabetic capacity of CO extracts and related compounds was further investigated in diabetes mellitus mice. The results suggested that both CO extracts and pure compounds could ameliorate diabetes-associated damages and complications. Oral administration of loganin and morroniside decreased fasting blood glucose levels in diabetes mellitus mice. Ursolic acid exhibited the highest reactive oxygen species scavenging activity and α-glucosidase inhibitory activity. Notably, we noticed an interesting synergistic effect between loganin and ursolic acid. Given these favorable hypoglycemic properties, C. officinalis, a food and medicinal plant in China, may be used as a valuable food supplement for the treatment of diabetes mellitus. Copyright © 2015 John Wiley & Sons, Ltd.
Min Feng - One of the best experts on this subject based on the ideXlab platform.
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the hypoglycemic and synergistic effect of loganin morroniside and ursolic acid isolated from the fruits of Cornus officinalis
Phytotherapy Research, 2016Co-Authors: Kai He, Shanghua Song, Min Feng, Dezhen Wang, Yanzhi Wang, Xuegang Li, Xiaoli YeAbstract:Hypoglycemic activity-guided separation of ethanol extracts from the fruits of Cornus officinalis Sieb. et Zucc (CO) led to the isolation of loganin, morroniside, and ursolic acid. The antidiabetic capacity of CO extracts and related compounds was further investigated in diabetes mellitus mice. The results suggested that both CO extracts and pure compounds could ameliorate diabetes-associated damages and complications. Oral administration of loganin and morroniside decreased fasting blood glucose levels in diabetes mellitus mice. Ursolic acid exhibited the highest reactive oxygen species scavenging activity and α-glucosidase inhibitory activity. Notably, we noticed an interesting synergistic effect between loganin and ursolic acid. Given these favorable hypoglycemic properties, C. officinalis, a food and medicinal plant in China, may be used as a valuable food supplement for the treatment of diabetes mellitus. Copyright © 2015 John Wiley & Sons, Ltd.