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Sung Ho Jang - One of the best experts on this subject based on the ideXlab platform.
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Injury of leg somatotopy of corticospinal tract at Corona Radiata by ventriculoperitoneal shunt: A case report.
Medicine, 2018Co-Authors: Sung Ho Jang, Younghyeon KwonAbstract:RATIONALE A 45-year-old right-handed female patient suffered head trauma after being hit by a truck that ran into a house. PATIENT CONCERNS The patient lost consciousness for 1 hour and experienced posttraumatic amnesia for 1 month after the accident. DIAGNOSES She underwent conservative management for a subdural hematoma in the left frontotemporal lobes and intracerebral hematoma in the left frontal lobe. INTERVENTIONS The patient's Glasgow Coma Scale score was 11. She underwent a VP shunt operation, approached through the right posterior parietal area of the brain, at 4 months after onset. Approximately, 6 months after onset, she was admitted to the rehabilitation department of a university hospital. She presented with moderate weakness of the left leg: Medical Research Council scores: hip flexor; 3, knee extensor; 3+, ankle dorsiflexor; 3-. Brain magnetic resonance imaging revealed a leukomalactic lesion in the right posterior Corona Radiata along the shunt. OUTCOMES On 6-month (2 months after the shunt operation) diffusion tensor tractography, the left CST showed partial injury in the posterior portion compared with the right CST. On 6-month transcranial magnetic stimulation study, the motor-evoked potential obtained at the left tibialis anterior muscle revealed lower amplitude than that on the right side. LESSONS Injury of leg somatotopy of a CST was demonstrated in a patient with leg weakness following a VP shunt operation.
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Limb-kinetic apraxia due to injury of corticofugal tracts from secondary motor area in patients with Corona Radiata infarct
Acta Neurologica Belgica, 2016Co-Authors: Sung Ho JangAbstract:Limb-kinetic apraxia (LKA) is defined as an execution disorder of movements, resulting from injury of the corticofugal tract (CFT) from the secondary motor area. Diagnosis of LKA is difficult because it is made by clinical observation of movements. In this study, using diffusion tensor tractography (DTT), we attempted to investigate injury of the CFT from the secondary motor area in patients with Corona Radiata infarct. Twenty patients with Corona Radiata infarct were recruited. A probabilistic tractography method was used in fiber tracking for reconstruction of the corticospinal tract (CST) and CFT. Fractional anisotropy (FA), mean diffusivity, and tract volume of the CSTs and CFTs from the dorsal premotor cortex (dPMC) and supplementary motor area (SMA) were measured. In the affected hemisphere, FA values of the CST from the precentral hand knob and the CFT from the dPMC were significantly decreased compared with those of the unaffected hemisphere ( p
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limb kinetic apraxia due to injury of corticofugal tracts from secondary motor area in patients with Corona Radiata infarct
Acta Neurologica Belgica, 2016Co-Authors: Sung Ho Jang, Jeong Pyo SeoAbstract:Limb-kinetic apraxia (LKA) is defined as an execution disorder of movements, resulting from injury of the corticofugal tract (CFT) from the secondary motor area. Diagnosis of LKA is difficult because it is made by clinical observation of movements. In this study, using diffusion tensor tractography (DTT), we attempted to investigate injury of the CFT from the secondary motor area in patients with Corona Radiata infarct. Twenty patients with Corona Radiata infarct were recruited. A probabilistic tractography method was used in fiber tracking for reconstruction of the corticospinal tract (CST) and CFT. Fractional anisotropy (FA), mean diffusivity, and tract volume of the CSTs and CFTs from the dorsal premotor cortex (dPMC) and supplementary motor area (SMA) were measured. In the affected hemisphere, FA values of the CST from the precentral hand knob and the CFT from the dPMC were significantly decreased compared with those of the unaffected hemisphere (p < 0.05). The tract volumes of the CST from the precentral hand knob and the CFTs from the dPMC and SMA in the affected hemisphere were also significantly decreased compared with those of the unaffected hemisphere (p < 0.05). We demonstrated concurrent injury of the CFTs from the secondary motor area along with injury of the CST in patients with Corona Radiata infarct, using DTT. Our results suggest that LKA ascribed to injury of the CFTs from the secondary motor area could be accompanied by injury of the CST ascribed to the Corona Radiata infarct.
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The anatomical location of the corticobulbar tract at the Corona Radiata in the human brain: diffusion tensor tractography study.
Neuroscience Letters, 2015Co-Authors: Sung Ho Jang, Jeong Pyo SeoAbstract:Many studies have reported on the anatomical location of the corticobulbar tract (CBT). However, no study has reported on the anatomical location of the Corona Radiata (CR). Using diffusion tensor tractography, we investigated the anatomical location of the CBT at the CR in normal subjects. Forty healthy normal subjects were enrolled in this study. Diffusion tensor images were acquired at 1.5-T, and the CBT was reconstructed using FMRIB software. The highest probabilistic location of the CBT was defined as the location on an axial slice in the upper and lower CRs. The CBT was located at an average of 49.13% and 49.91% in the antero-posterior direction between the most anterior point and the most posterior point of the lateral ventricle at the upper and lower CR, respectively. Regarding medio-lateral direction, between the midline and the most lateral point of the brain, the CBT was located at an average of 36.58% and 32.73% at the upper and lower CR, respectively. According to our findings, the CBT was located almost halfway between the most anterior point and the most posterior point of the lateral ventricle at the CR, and almost one third between the midline and the most lateral point of the brain at the CR.
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The effects of hydrocephalus on the periventricular white matter in intracerebral hemorrhage: a diffuser tensor imaging study.
International Journal of Neuroscience, 2013Co-Authors: Sung Ho Jang, Woo Mok Byun, Byung Yeon Choi, Chul Hoon Chang, Young Jin Jung, Seong Ho Kim, Sang Seok YeoAbstract:Objectives: Many diffusion tensor imaging (DTI) studies have described the effects of hydrocephalus on periventricular white matter in patients with normal pressure hydrocephalus. However, little is known about hydrocephalus following stroke. We investigated the effect of hydrocephalus on periventricular white matter in patients with hydrocephalus after an intracerebral hemorrhage (ICH) using DTI. Methods: Fourteen patients with ICH and hydrocephalus, and 17 age- and sex-matched normal control subjects were recruited. DTI parameters were estimated in six regions of interest (ROIs) in periventricular white matter: the anterior Corona Radiata, the posterior Corona Radiata, the genu of the corpus callosum, the splenium of corpus callosum, the anterior limb of the internal capsule, and the posterior limb of the internal capsule. Results: Mean fractional anisotropy of the anterior Corona Radiata in patients was significantly higher than in controls (p < 0.05), but apparent diffusion coefficient (ADC) was not d...
Young-mok Song - One of the best experts on this subject based on the ideXlab platform.
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Distinct location of subcortical silent infarcts compared with symptomatic lacunar infarcts.
Journal of the Neurological Sciences, 2009Co-Authors: Young-mok SongAbstract:Abstract Objective To determine whether the location of subcortical silent infarcts differs from that of symptomatic lacunar infarcts. Methods 32 silent infarcts and 59 acute lacunar infarcts located in the Corona Radiata were examined. The relative anterior-to-posterior locations of the silent infarcts in the Corona Radiata were compared with those of the symptomatic lacunes on T2-weighed MR imaging. Results The locations of the silent infarcts differed from those of the symptomatic lacunar lesions in the Corona Radiata ( p Conclusion The asymptomatic nature of subcortical silent infarcts may be attributable to their location in ineloquent portions of brain structures.
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Distinct location of subcortical silent infarcts compared with symptomatic lacunar infarcts.
Journal of the neurological sciences, 2009Co-Authors: Young-mok SongAbstract:To determine whether the location of subcortical silent infarcts differs from that of symptomatic lacunar infarcts. 32 silent infarcts and 59 acute lacunar infarcts located in the Corona Radiata were examined. The relative anterior-to-posterior locations of the silent infarcts in the Corona Radiata were compared with those of the symptomatic lacunes on T2-weighed MR imaging. The locations of the silent infarcts differed from those of the symptomatic lacunar lesions in the Corona Radiata (p<0.001). Silent infarcts were distributed principally in the anterior half of the Corona Radiata, whereas most of the symptomatic lacunes were located in the posterior half of the Corona Radiata. The asymptomatic nature of subcortical silent infarcts may be attributable to their location in ineloquent portions of brain structures.
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Somatotopic Organization of Motor Fibers in the Corona Radiata in Monoparetic Patients With Small Subcortical Infarct
Stroke, 2007Co-Authors: Young-mok SongAbstract:Background and Purpose— The somatotopic organization of the corticospinal fibers is of importance because it is related to certain stroke syndromes. Although it has been suggested that motor fibers are somatotopically arranged in the Corona Radiata, the evidence is still insufficient in human. Methods— The relative anteroposterior and mediolateral location of the lesions was measured on T2-weighted MRI in 28 patients who developed isolated motor deficit limited to the arm, leg, or bulbofacial muscles after a small Corona Radiata infarct. Results— The location of the lesions associated with bulbofacial, arm, and leg paresis showed anterolateral-to-posteromedial distribution. Conclusions— The results suggest that motor fibers subserving the bulbofacial, arm, and leg muscles are somatotopically arranged at the level of the Corona Radiata.
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Ipsilateral hemiparesis caused by a Corona Radiata infarct after a previous stroke on the opposite side.
JAMA Neurology, 2005Co-Authors: Young-mok Song, Jee-young Lee, Jong-moo Park, Byung-woo Yoon, Jae-kyu RohAbstract:Ipsilateral hemiparesis after a supratentorial stroke is rare. However, the role of the reorganization of the unaffected hemisphere in recovery after a stroke is poorly understood. Two patients developed ipsilateral hemiparesis after a left Corona Radiata infarct. Both of these patients had previously experienced contralateral hemiparesis after a right-sided supratentorial stroke. Functional magnetic resonance imaging demonstrated bilateral motor area activation during paretic left hand movement. This finding suggests that the ipsilateral hemiparesis was caused by a new stroke in the ipsilateral motor system that was functionally reorganized after the previous stroke.
Jun-ichi Kira - One of the best experts on this subject based on the ideXlab platform.
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Pure dysarthria and dysarthria-facial paresis syndrome due to internal capsule and/or Corona Radiata infarction
BMC Neurology, 2015Co-Authors: Koji Tanaka, Takeshi Yamada, Takako Torii, Takeo Yoshimura, Kei Ichiro Takase, Osamu Togao, Yoshifumi Wakata, Akio Hiwatashi, Naoki Nakashima, Jun-ichi KiraAbstract:Background Pure dysarthria (PD) and dysarthria-facial paresis syndrome (DFP) mainly result from lenticulostriate artery territory infarction. PD and DFP are rare clinical entities, often grouped without distinction. The purpose of this study was to examine clinical and radiographic differences between PD and DFP due to unilateral internal capsule and/or Corona Radiata infarction.
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pure dysarthria and dysarthria facial paresis syndrome due to internal capsule and or Corona Radiata infarction
BMC Neurology, 2015Co-Authors: Koji Tanaka, Takeshi Yamada, Takako Torii, Takeo Yoshimura, Kei Ichiro Takase, Osamu Togao, Yoshifumi Wakata, Akio Hiwatashi, Naoki Nakashima, Jun-ichi KiraAbstract:Background Pure dysarthria (PD) and dysarthria-facial paresis syndrome (DFP) mainly result from lenticulostriate artery territory infarction. PD and DFP are rare clinical entities, often grouped without distinction. The purpose of this study was to examine clinical and radiographic differences between PD and DFP due to unilateral internal capsule and/or Corona Radiata infarction.
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Abstract T P189: Pure Dysarthria and Dysarthria-facial Paresis Syndrome due to Internal Capsule and/or Corona Radiata Infarction
Stroke, 2015Co-Authors: Koji Tanaka, Takeshi Yamada, Takako Torii, Takeo Yoshimura, Kei Ichiro Takase, Hiroyuki Murai, Jun-ichi KiraAbstract:Background and Purpose: Pure dysarthria (PD) and dysarthria-facial paresis syndrome (DFP) are considered as rare clinical entities of dysarthria-clumsy hand syndrome, mainly due to small vessel disease. We aimed to clarify the clinical and radiographic difference between patients with PD and DFP, especially due to internal capsule and/or Corona Radiata infarction, using the database of wide area network-based clinical research. Methods: This multicenter, prospective, observational study included consecutive patients with acute ischemic stroke admitted to 4 stroke centers in Fukuoka prefecture within 7 days from the onset. We included patients with first ever stroke and presenting PD or DFP with a single ischemic lesion localized in the internal capsule and/or Corona Radiata. Patients with any motor-sensory disturbance or cortical symptoms were excluded. Ischemic lesion volume was calculated by the A*B*C/2 method on diffusion weighted imaging. The local ethics committee approved the collection and submission of each patient’s clinical data to the study office in Kyushu University. Results: Between October 2010 and April 2014, a total of 2348 patients including 1773 (1006 men, 73.3±13.1 years) with first ever stroke were registered. Of them, 12 (0.68%) patients with PD and 18 (1.02%) patients with DFP were included for the analysis. Compared to patients with PD, patients with DFP had shorter onset-to-door time (median 10.75 [7.25-27.125] hours vs. 33.75 [14.25-51.5] hours, p = 0.042), larger vertical length (C component) of ischemic lesions (median 18.75 [12-20.625] mm vs. 9.25 [6-13] mm, p = 0.008), and greater ischemic lesion volume (median 828 [291-1664] mm3 vs. 289 [120-416] mm3, p = 0.031). Ischemic lesions causing PD were located more frequently in the left hemisphere than those of DFP (92% vs. 56%, p = 0.049). There was no difference in age, sex, and vascular risk factors between patients with PD and DFP. Symptom progression after admission was seen in one PD case which worsened to DFP. Conclusions: In cerebral infarction of the internal capsule and/or Corona Radiata, DFP might be derived from larger, vertically longer ischemic lesions comparing to PD. There might be stronger association between PD and left-sided lesions.
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abstract t p189 pure dysarthria and dysarthria facial paresis syndrome due to internal capsule and or Corona Radiata infarction
Stroke, 2015Co-Authors: Koji Tanaka, Takeshi Yamada, Takako Torii, Takeo Yoshimura, Kei Ichiro Takase, Hiroyuki Murai, Jun-ichi KiraAbstract:Background and Purpose: Pure dysarthria (PD) and dysarthria-facial paresis syndrome (DFP) are considered as rare clinical entities of dysarthria-clumsy hand syndrome, mainly due to small vessel disease. We aimed to clarify the clinical and radiographic difference between patients with PD and DFP, especially due to internal capsule and/or Corona Radiata infarction, using the database of wide area network-based clinical research. Methods: This multicenter, prospective, observational study included consecutive patients with acute ischemic stroke admitted to 4 stroke centers in Fukuoka prefecture within 7 days from the onset. We included patients with first ever stroke and presenting PD or DFP with a single ischemic lesion localized in the internal capsule and/or Corona Radiata. Patients with any motor-sensory disturbance or cortical symptoms were excluded. Ischemic lesion volume was calculated by the A*B*C/2 method on diffusion weighted imaging. The local ethics committee approved the collection and submission of each patient’s clinical data to the study office in Kyushu University. Results: Between October 2010 and April 2014, a total of 2348 patients including 1773 (1006 men, 73.3±13.1 years) with first ever stroke were registered. Of them, 12 (0.68%) patients with PD and 18 (1.02%) patients with DFP were included for the analysis. Compared to patients with PD, patients with DFP had shorter onset-to-door time (median 10.75 [7.25-27.125] hours vs. 33.75 [14.25-51.5] hours, p = 0.042), larger vertical length (C component) of ischemic lesions (median 18.75 [12-20.625] mm vs. 9.25 [6-13] mm, p = 0.008), and greater ischemic lesion volume (median 828 [291-1664] mm3 vs. 289 [120-416] mm3, p = 0.031). Ischemic lesions causing PD were located more frequently in the left hemisphere than those of DFP (92% vs. 56%, p = 0.049). There was no difference in age, sex, and vascular risk factors between patients with PD and DFP. Symptom progression after admission was seen in one PD case which worsened to DFP. Conclusions: In cerebral infarction of the internal capsule and/or Corona Radiata, DFP might be derived from larger, vertically longer ischemic lesions comparing to PD. There might be stronger association between PD and left-sided lesions.
Pilar M Sanjuan - One of the best experts on this subject based on the ideXlab platform.
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reduced white matter integrity in the cingulum and anterior Corona Radiata in posttraumatic stress disorder in male combat veterans a diffusion tensor imaging study
Psychiatry Research-neuroimaging, 2013Co-Authors: Pilar M Sanjuan, Robert J Thoma, Eric D Claus, Nicci Mays, Arvind CaprihanAbstract:Abstract Posttraumatic stress (PTSD) and alcohol use (AUD) disorders are associated with abnormal anterior cingulate cortex/ventromedial prefrontal cortex, thalamus , and amygdala function, yet microstructural white matter (WM) differences in executive-limbic tracts are likely also involved. Investigating WM in limbic-thalamo-cortical tracts, this study hypothesized (1) fractional anisotropy (FA) in dorsal cingulum, parahippocampal cingulum, and anterior Corona Radiata (ACR) would be lower in individuals with comorbid PTSD/AUD compared to in individuals with AUD-only and (2) that FA would be related to both AUD and PTSD severity. 22 combat veterans with comorbid PTSD/AUD or AUD-only completed DTI scans. ANCOVAs indicated lower FA in right ( F ( df =1,19)=9.091, P =0.0071) and left ( F ( df =1,19)=10.375, P =0.0045) dorsal cingulum and right ACR ( F ( df =1,19)=18.914, P =0.0003) for individuals with comorbid PTSD/AUD vs. individuals with AUD-only, even controlling for alcohol use. Multiple linear regressions revealed that FA in the right ACR was inversely related to PTSD severity ( r =−0.683, P =0.004). FA was not significantly related to alcohol severity. Reduced WM integrity in limbic-thalamo-cortical tracts is implicated in PTSD, even in the presence of comorbid AUD. These findings suggest that diminished WM integrity in tracts important for top-down control may be an important anomaly in PTSD and/or comorbid PTSD/AUD.
Arvind Caprihan - One of the best experts on this subject based on the ideXlab platform.
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reduced white matter integrity in the cingulum and anterior Corona Radiata in posttraumatic stress disorder in male combat veterans a diffusion tensor imaging study
Psychiatry Research-neuroimaging, 2013Co-Authors: Pilar M Sanjuan, Robert J Thoma, Eric D Claus, Nicci Mays, Arvind CaprihanAbstract:Abstract Posttraumatic stress (PTSD) and alcohol use (AUD) disorders are associated with abnormal anterior cingulate cortex/ventromedial prefrontal cortex, thalamus , and amygdala function, yet microstructural white matter (WM) differences in executive-limbic tracts are likely also involved. Investigating WM in limbic-thalamo-cortical tracts, this study hypothesized (1) fractional anisotropy (FA) in dorsal cingulum, parahippocampal cingulum, and anterior Corona Radiata (ACR) would be lower in individuals with comorbid PTSD/AUD compared to in individuals with AUD-only and (2) that FA would be related to both AUD and PTSD severity. 22 combat veterans with comorbid PTSD/AUD or AUD-only completed DTI scans. ANCOVAs indicated lower FA in right ( F ( df =1,19)=9.091, P =0.0071) and left ( F ( df =1,19)=10.375, P =0.0045) dorsal cingulum and right ACR ( F ( df =1,19)=18.914, P =0.0003) for individuals with comorbid PTSD/AUD vs. individuals with AUD-only, even controlling for alcohol use. Multiple linear regressions revealed that FA in the right ACR was inversely related to PTSD severity ( r =−0.683, P =0.004). FA was not significantly related to alcohol severity. Reduced WM integrity in limbic-thalamo-cortical tracts is implicated in PTSD, even in the presence of comorbid AUD. These findings suggest that diminished WM integrity in tracts important for top-down control may be an important anomaly in PTSD and/or comorbid PTSD/AUD.