The Experts below are selected from a list of 35877 Experts worldwide ranked by ideXlab platform
John H Krystal - One of the best experts on this subject based on the ideXlab platform.
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Transcranial Magnetic Stimulation of left temporoparietal cortex and medication resistant auditory hallucinations
Archives of General Psychiatry, 2003Co-Authors: Ralph E Hoffman, Nashaat N Boutros, Keith A Hawkins, Ralitza Gueorguieva, Fady Rachid, Kathleen M Carroll, John H KrystalAbstract:Background Neuroimaging studies suggest that auditory hallucinations (AHs) of speech arise, at least in part, from activation of brain areas underlying speech perception. One-hertz repetitive Transcranial Magnetic Stimulation (rTMS) produces sustained reductions in cortical activation. Recent results of 4-day administration of 1-Hz rTMS to left temporoparietal cortex were superior to those of sham Stimulation in reducing AHs. We sought to determine if a more extended trial of rTMS could significantly reduce AHs that were resistant to antipsychotic medication. Methods Twenty-four patients with schizophrenia or schizoaffective disorder and medication-resistant AHs were randomly allocated to receive rTMS or sham Stimulation for 9 days at 90% of motor threshold. Patients receiving sham Stimulation were subsequently offered an open-label trial of rTMS. Neuropsychological assessments were administered at baseline and during and following each arm of the trial. Results Auditory hallucinations were robustly improved with rTMS relative to sham Stimulation. Frequency and attentional salience were the 2 aspects of hallucinatory experience that showed greatest improvement. Duration of putative treatment effects ranged widely, with 52% of patients maintaining improvement for at least 15 weeks. Repetitive Transcranial Magnetic Stimulation was well tolerated, without evidence of neuropsychological impairment. Conclusions These data suggest that the mechanism of AHs involves activation of the left temporoparietal cortex. One-hertz rTMS deserves additional study as a possible treatment for this syndrome.
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Transcranial Magnetic Stimulation of left temporoparietal cortex and medication resistant auditory hallucinations
Archives of General Psychiatry, 2003Co-Authors: Ralph E Hoffman, Nashaat N Boutros, Keith A Hawkins, Ralitza Gueorguieva, Fady Rachid, Kathleen M Carroll, John H KrystalAbstract:Background: Neuroimaging studies suggest that auditory hallucinations (AHs) of speech arise, at least in part, from activation of brain areas underlying speech perception. One-hertz repetitive Transcranial Magnetic Stimulation (rTMS) produces sustained reductions in cortical activation. Recent results of 4-day administration of 1-Hz rTMS to left temporoparietal cortex were superior to those of sham Stimulation in reducing AHs. We sought to determine if a more extended trial of rTMS could significantly reduce AHs that were resistant to antipsychotic medication. Methods: Twenty-four patients with schizophrenia or schizoaffective disorder and medication-resistant AHs were randomly allocated to receive rTMS or sham Stimulation for 9 days at 90% of motor threshold. Patients receiving sham Stimulation were subsequently offered an open-label trial of rTMS. Neuropsychological assessments were administered at baseline and during and following each arm of the trial. Results: Auditory hallucinations were robustly improved with rTMS relative to sham Stimulation. Frequency and attentional salience were the 2 aspects of hallucinatory experience that showed greatest improvement. Duration of putative treatment effects ranged widely, with 52% of patients maintaining improvement for at least 15 weeks. Repetitive Transcranial Magnetic Stimulation was well tolerated, without evidence of neuropsychological impairment. Conclusions: These data suggest that the mechanism of AHs involves activation of the left temporoparietal cortex. One-hertz rTMS deserves additional study as a possible treatment for this syndrome. Arch Gen Psychiatry. 2003;60:49-56
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Transcranial Magnetic Stimulation and auditory hallucinations in schizophrenia
The Lancet, 2000Co-Authors: Ralph E Hoffman, Nashaat N Boutros, Sylvia Hu, Robert M Berman, John H Krystal, Dennis S CharneyAbstract:Summary 12 patients with schizophrenia and auditory hallucinations received 1 Hz Transcranial Magnetic Stimulation of left temporoparietlal cortex. In a double-blind crossover trial, active Stimulation significantly reduced hallucinations relative to sham Stimulation.
Ralph E Hoffman - One of the best experts on this subject based on the ideXlab platform.
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Transcranial Magnetic Stimulation of left temporoparietal cortex and medication resistant auditory hallucinations
Archives of General Psychiatry, 2003Co-Authors: Ralph E Hoffman, Nashaat N Boutros, Keith A Hawkins, Ralitza Gueorguieva, Fady Rachid, Kathleen M Carroll, John H KrystalAbstract:Background Neuroimaging studies suggest that auditory hallucinations (AHs) of speech arise, at least in part, from activation of brain areas underlying speech perception. One-hertz repetitive Transcranial Magnetic Stimulation (rTMS) produces sustained reductions in cortical activation. Recent results of 4-day administration of 1-Hz rTMS to left temporoparietal cortex were superior to those of sham Stimulation in reducing AHs. We sought to determine if a more extended trial of rTMS could significantly reduce AHs that were resistant to antipsychotic medication. Methods Twenty-four patients with schizophrenia or schizoaffective disorder and medication-resistant AHs were randomly allocated to receive rTMS or sham Stimulation for 9 days at 90% of motor threshold. Patients receiving sham Stimulation were subsequently offered an open-label trial of rTMS. Neuropsychological assessments were administered at baseline and during and following each arm of the trial. Results Auditory hallucinations were robustly improved with rTMS relative to sham Stimulation. Frequency and attentional salience were the 2 aspects of hallucinatory experience that showed greatest improvement. Duration of putative treatment effects ranged widely, with 52% of patients maintaining improvement for at least 15 weeks. Repetitive Transcranial Magnetic Stimulation was well tolerated, without evidence of neuropsychological impairment. Conclusions These data suggest that the mechanism of AHs involves activation of the left temporoparietal cortex. One-hertz rTMS deserves additional study as a possible treatment for this syndrome.
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Transcranial Magnetic Stimulation of left temporoparietal cortex and medication resistant auditory hallucinations
Archives of General Psychiatry, 2003Co-Authors: Ralph E Hoffman, Nashaat N Boutros, Keith A Hawkins, Ralitza Gueorguieva, Fady Rachid, Kathleen M Carroll, John H KrystalAbstract:Background: Neuroimaging studies suggest that auditory hallucinations (AHs) of speech arise, at least in part, from activation of brain areas underlying speech perception. One-hertz repetitive Transcranial Magnetic Stimulation (rTMS) produces sustained reductions in cortical activation. Recent results of 4-day administration of 1-Hz rTMS to left temporoparietal cortex were superior to those of sham Stimulation in reducing AHs. We sought to determine if a more extended trial of rTMS could significantly reduce AHs that were resistant to antipsychotic medication. Methods: Twenty-four patients with schizophrenia or schizoaffective disorder and medication-resistant AHs were randomly allocated to receive rTMS or sham Stimulation for 9 days at 90% of motor threshold. Patients receiving sham Stimulation were subsequently offered an open-label trial of rTMS. Neuropsychological assessments were administered at baseline and during and following each arm of the trial. Results: Auditory hallucinations were robustly improved with rTMS relative to sham Stimulation. Frequency and attentional salience were the 2 aspects of hallucinatory experience that showed greatest improvement. Duration of putative treatment effects ranged widely, with 52% of patients maintaining improvement for at least 15 weeks. Repetitive Transcranial Magnetic Stimulation was well tolerated, without evidence of neuropsychological impairment. Conclusions: These data suggest that the mechanism of AHs involves activation of the left temporoparietal cortex. One-hertz rTMS deserves additional study as a possible treatment for this syndrome. Arch Gen Psychiatry. 2003;60:49-56
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Transcranial Magnetic Stimulation and auditory hallucinations in schizophrenia
The Lancet, 2000Co-Authors: Ralph E Hoffman, Nashaat N Boutros, Sylvia Hu, Robert M Berman, John H Krystal, Dennis S CharneyAbstract:Summary 12 patients with schizophrenia and auditory hallucinations received 1 Hz Transcranial Magnetic Stimulation of left temporoparietlal cortex. In a double-blind crossover trial, active Stimulation significantly reduced hallucinations relative to sham Stimulation.
Paul B Fitzgerald - One of the best experts on this subject based on the ideXlab platform.
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left handedness and response to repetitive Transcranial Magnetic Stimulation in major depressive disorder
World Journal of Biological Psychiatry, 2020Co-Authors: Paul B Fitzgerald, Kate Elizabeth Hoy, Zafiris J DaskalakisAbstract:Considerable research has demonstrated the efficacy of repetitive Transcranial Magnetic Stimulation treatment (rTMS) in patients with major depressive disorder (MDD) with differences in effects rel...
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a meta analysis of cortical inhibition and excitability using Transcranial Magnetic Stimulation in psychiatric disorders
Clinical Neurophysiology, 2013Co-Authors: Natasha Radhu, Paul B Fitzgerald, Danilo Rocha De Jesus, Lakshmi N Ravindran, Anosha Zanjani, Zafiris J DaskalakisAbstract:highlights Motor cortex inhibitory and excitatory Transcranial Magnetic Stimulation paradigms were quantita- tively assessed in severe psychiatric illnesses. Inhibitory deficits are a ubiquitous finding across obsessive-compulsive disorder, major depressive dis- order and schizophrenia, by contrast, enhancement of intracortical facilitation is specific to obsessive- compulsive disorder. Limitations of Transcranial Magnetic Stimulation studies are reviewed and potential future applications are discussed. abstract Objective: To evaluate Transcranial Magnetic Stimulation (TMS) measures of inhibition and excitation in obsessive-compulsive disorder (OCD), major depressive disorder (MDD) and schizophrenia (SCZ). Methods: Paradigms included: short-interval cortical inhibition (SICI), cortical silent period (CSP), resting motor threshold, intracortical facilitation, and motor evoked potential amplitude. A literature search was performed using PubMed, Ovid Medline, Embase Psychiatry and PsycINFO 1990 through April 2012. Results: A significant Hedge's g was found for decreased SICI (g = 0.572, 95% confidence interval (0.179, 0.966), p = 0.004), enhanced intracortical facilitation (g = 0.446, 95% confidence interval (0.042, 0.849), p = 0.030) and decreased CSP (g = 0.466, 95% confidence interval (0.881, 0.052), p = 0.027) within the OCD population. For MDD, significant effect sizes were demonstrated for decreased SICI (g = 0.641, 95% confidence interval (0.384, 0.898), p = 0.000) and shortened CSP (g = 1.232, 95% confidence interval (1.530, 0.933), p = 0.000). In SCZ, a significant Hedge's g was shown for decreased SICI (g = 0.476, 95% confidence interval (0.331, 0.620), p = 0.000). Conclusion: Inhibitory deficits are a ubiquitous finding across OCD, MDD, SCZ and enhancement of intra- cortical facilitation is specific to OCD. Significance: Provides a clear platform from which diagnostic procedures can be developed. 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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the use of repetitive Transcranial Magnetic Stimulation and vagal nerve Stimulation in the treatment of depression
Current Opinion in Psychiatry, 2008Co-Authors: Paul B Fitzgerald, Zafiris J DaskalakisAbstract:Purpose of review Patients with depressive disorders often fail to respond to standard antidepressant medications and have few available treatment alternatives. Repetitive Transcranial Magnetic Stimulation and vagal nerve Stimulation have been developed and investigated over the last 10 years as potential treatment options for this and other psychiatric conditions. The aim of this paper is to review recent therapeutic trials of these techniques. Recent findings Recent studies appear to have confirmed that standard left-sided repetitive Transcranial Magnetic Stimulation has antidepressant efficacy, but that the degree of clinical effect may be somewhat limited. Promising data are emerging suggesting that other approaches, including right unilateral repetitive Transcranial Magnetic Stimulation and sequential bilateral Stimulation, may have equal or potentially greater effects. The evidence for the effectiveness of vagal nerve Stimulation remains restricted to the primary company-sponsored trials. Although limited, these data suggest that valuable treatment effects may develop over time. Summary Further repetitive Transcranial Magnetic Stimulation research should actively investigate novel Stimulation approaches before high-frequency left-sided Stimulation is accepted as the standard approach. Given the invasive nature of vagal nerve Stimulation and potential side effects, further research is urgently required. This should include the development of predictors of clinical response and definition of Stimulation parameters with enhanced efficacy.
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a double blind sham controlled trial of repetitive Transcranial Magnetic Stimulation in the treatment of refractory auditory hallucinations
Journal of Clinical Psychopharmacology, 2005Co-Authors: Paul B Fitzgerald, Jessica Benitez, Jeff Z Daskalakis, Timothy L Brown, Natasha Ausa Upton Marston, Anthony De Castella, Jayashri KulkarniAbstract:Background:Previous research suggests that repetitive Transcranial Magnetic Stimulation (rTMS) applied to the temporoparietal cortex may have therapeutic benefits for patients with schizophrenia and treatment-resistant auditory hallucinations. We aimed to test this hypothesis in a randomized double-
Vikas Menon - One of the best experts on this subject based on the ideXlab platform.
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repetitive Transcranial Magnetic Stimulation in persistent auditory hallucination in schizophrenia predictors of response
Current Behavioral Neuroscience Reports, 2020Co-Authors: Sujita Kumar Kar, Vikas MenonAbstract:This review aims to discuss the role of repetitive Transcranial Magnetic Stimulation (rTMS) in schizophrenia for the management of persistent auditory hallucination, along with the predictors of response. Schizophrenia is a chronic, highly disabling, severe mental illness. Antipsychotic medications are the mainstay of treatment in schizophrenia. Despite adequate pharmacotherapy, a considerable number of patients remain symptomatic, for which brain Stimulation (neuromodulation) techniques like electroconvulsive therapy, repetitive Transcranial Magnetic Stimulation and Transcranial direct current Stimulation are being increasingly used. Persistent auditory hallucination resistant to pharmacotherapy (antipsychotic treatment) is a therapeutic challenge. It is found to be due to abnormal hyperactivity of the neurons at the temporo-parietal junction of dominant hemisphere. Commonly, low-frequency repetitive Transcranial Magnetic Stimulation has been used in the treatment of medication-resistant auditory hallucination. Various factors predict the response to repetitive Transcranial Magnetic Stimulation in the management of resistant auditory hallucination. Identification of various predictors will guide clinicians in the appropriate selection of rTMS to target auditory hallucinations in schizophrenia.
Angel V Peterchev - One of the best experts on this subject based on the ideXlab platform.
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coil design considerations for deep Transcranial Magnetic Stimulation
Clinical Neurophysiology, 2014Co-Authors: Zhide Deng, Sarah H Lisanby, Angel V PeterchevAbstract:Objectives To explore the field characteristics and design tradeoffs of coils for deep Transcranial Magnetic Stimulation (dTMS).
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electric field depth focality tradeoff in Transcranial Magnetic Stimulation simulation comparison of 50 coil designs
Brain Stimulation, 2013Co-Authors: Sarah H Lisanby, Zhide Deng, Angel V PeterchevAbstract:Background Various Transcranial Magnetic Stimulation (TMS) coil designs are available or have been proposed. However, key coil characteristics such as electric field focality and attenuation in depth have not been adequately compared. Knowledge of the coil focality and depth characteristics can help TMS researchers and clinicians with coil selection and interpretation of TMS studies.
