The Experts below are selected from a list of 195 Experts worldwide ranked by ideXlab platform
Keitaro Hashimoto - One of the best experts on this subject based on the ideXlab platform.
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Effects of bidisomide (SC-40230), a new class I antiarrhythmic agent, on ventricular arrhythmias induced by Coronary Artery Occlusion and reperfusion in anesthetized rats; comparison with mexiletine and disopyramide
Heart and Vessels, 1995Co-Authors: Sadayoshi Komori, Ken Umetani, Akinori Watanabe, Sunao Mochizuki, Hiroshi Ijiri, Soichi Sano, Kuniyoshi Matsumura, Akitaka Naitoh, Tsukasa Ishihara, Keitaro HashimotoAbstract:We investigated the antiarrhythmic effects of bidisomide (SC-40230), a new class I antiarrhythmic drug, in early-phase ventricular arrhythmias induced by Coronary Artery Occlusion and reperfusion in anesthetized rats. The effects of bidisomide were compared with those of mexiletine (MXT) and disopyramide (DSP), established class I antiarrhythmic drugs. Drugs were administered intravenously, 5 min before induction of Coronary Occlusion. Bidisomide (5 mg/kg) reduced the number of premature ventricular complexes and the incidence of ventricular tachycardia and ventricular fibrillation similarly to MXT and DSP in rats with ventricular arrhythmias induced by Coronary Artery Occlusion. In rats with ventricular arrhythmias induced by Coronary Artery reperfusion following a 5min Coronary Occlusion, the antiarrhythmic effects of 5 mg/kg of bidisomide were similar to those of the same doses of MXT and DSP. All three drugs significantly slowed the heart rate. Our results suggest that bidisomide may effectively reduce the severity of lifethreatening ventricular arrhythmias that occur during acute Coronary syndrome.
Paolo Biglioli - One of the best experts on this subject based on the ideXlab platform.
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left main Coronary Artery Occlusion after percutaneous aortic valve implantation
The Annals of Thoracic Surgery, 2010Co-Authors: Antonio L Bartorelli, Daniele Andreini, Erminio Sisillo, Gloria Tamborini, Melissa Fusari, Paolo BiglioliAbstract:Left main Coronary Artery Occlusion occurred immediately after transfemoral aortic valve implantation in an 87-year-old woman, which resulted in ventricular fibrillation and hemodynamic collapse. This life-threatening complication was promptly diagnosed with transesophageal echocardiography, which showed the disappearance of diastolic left main Coronary Artery jet flow and was confirmed with aortic root angiography. After prompt defibrillation, hemodynamic support was obtained with intra-aortic balloon pump and inotropic drugs. Functional recovery and survival were achieved with Coronary stenting. This report highlights the importance of an integrated team approach of highly skilled specialists for these novel interventions.
Sadayoshi Komori - One of the best experts on this subject based on the ideXlab platform.
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Inhibitory Effect of CV4151, a Thromboxane A2 Synthetase Inhibitor, on Ventricular Arrhythmias Induced by Coronary Artery Occlusion in Rats
Japanese circulation journal, 1996Co-Authors: Ken Umetani, Kohji Tamura, Sadayoshi Komori, Akinori Watanabe, Tukasa Ishihara, Sunao Mochizuki, Hiroshi IjiriAbstract:The purpose of this study was to determine whether thromboxane A2 (TXA2) is involved in the development of ventricular arrhythmias produced by Coronary Artery Occlusion. Ventricular arrhythmias were induced by Coronary Artery Occlusion in 66 male Sprague-Dawley rats. Rats were separated into 4 groups, and saline (n=19) or CV4151 (a TXA2 synthetase inhibitor)(10 mg/kg, n=14; 30 mg/kg, n=15; or 100 mg/kg, n=18) was injected intravenously 5 min before Coronary Artery Occlusion. The antiarrhythmic effect of CV4151 was assessed in terms of the number of ventricular premature complexes (VPCs), the combined duration of ventricular tachycardia (VT) and ventricular fibrillation (Vf) , the incidence of Vf, and the mortality rate within 30 min after Occlusion. The total number of VPCs was as follows; control: 1789±330 beats: 10 mg/kg group: 1289±302 beats: 30 mg/kg group: 1008±229 beats: 100 mg/kg group: 986±275 beats, with no significant differences between groups. The incidence of Vf was significantly reduced in the 30 mg/kg and 100 mg/kg groups, as was the combined duration of VT and Vf and the mortality rate. Our results indicate that the TXA2 synthetase inhibitor CV4151 reduces the incidence of lethal arrhythmias induced by Coronary Artery Occlusion in rats. (Jpn Circ J 1996; 60: 349 - 354)
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Effects of bidisomide (SC-40230), a new class I antiarrhythmic agent, on ventricular arrhythmias induced by Coronary Artery Occlusion and reperfusion in anesthetized rats; comparison with mexiletine and disopyramide
Heart and Vessels, 1995Co-Authors: Sadayoshi Komori, Ken Umetani, Akinori Watanabe, Sunao Mochizuki, Hiroshi Ijiri, Soichi Sano, Kuniyoshi Matsumura, Akitaka Naitoh, Tsukasa Ishihara, Keitaro HashimotoAbstract:We investigated the antiarrhythmic effects of bidisomide (SC-40230), a new class I antiarrhythmic drug, in early-phase ventricular arrhythmias induced by Coronary Artery Occlusion and reperfusion in anesthetized rats. The effects of bidisomide were compared with those of mexiletine (MXT) and disopyramide (DSP), established class I antiarrhythmic drugs. Drugs were administered intravenously, 5 min before induction of Coronary Occlusion. Bidisomide (5 mg/kg) reduced the number of premature ventricular complexes and the incidence of ventricular tachycardia and ventricular fibrillation similarly to MXT and DSP in rats with ventricular arrhythmias induced by Coronary Artery Occlusion. In rats with ventricular arrhythmias induced by Coronary Artery reperfusion following a 5min Coronary Occlusion, the antiarrhythmic effects of 5 mg/kg of bidisomide were similar to those of the same doses of MXT and DSP. All three drugs significantly slowed the heart rate. Our results suggest that bidisomide may effectively reduce the severity of lifethreatening ventricular arrhythmias that occur during acute Coronary syndrome.
R E Coleman - One of the best experts on this subject based on the ideXlab platform.
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Myocardial perfusion and ventricular function measurements during total Coronary Artery Occlusion in humans. A comparison with rest and exercise radionuclide studies.
Circulation, 1994Co-Authors: Salvador Borges-neto, Joseph A. Puma, Robert H. Jones, Michael H. Sketch, Richard S. Stack, Michael W. Hanson, R E ColemanAbstract:BACKGROUNDThe purpose of this investigation was to compare the magnitude of change in myocardial perfusion and function during exercise with that obtained during total Coronary Artery Occlusion. Radionuclide studies are widely used for the diagnosis and determination of prognosis in patients with suspected or known Coronary Artery disease. These studies are based on the premise that the relative deficit of Coronary blood flow, which is induced by exercise and recognized as increased demand, relates to the jeopardy experienced by the decrease or sudden absolute interruption of Coronary blood flow that is recognized as decreased supply and is associated with Coronary stenosis or total Coronary Artery Occlusion. The magnitude of exercise-induced perfusion and function abnormalities compared with those induced by total Coronary Artery Occlusion in humans has not been previously reported.METHODS AND RESULTSWe prospectively studied 20 patients with > or = 50% diameter stenosis documented by quantitative coronar...
Raj Makkar - One of the best experts on this subject based on the ideXlab platform.
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leaflet length and left main Coronary Artery Occlusion following transcatheter aortic valve replacement
Catheterization and Cardiovascular Interventions, 2013Co-Authors: Kazuaki Okuyama, Hasan Jilaihawi, Raj MakkarAbstract:Coronary Artery Occlusion during transcatheter aortic valve replacement is a rare complication. However, it is a very severe and life-threatening event. Although there are some possible causes of this phenomenon, definite etiologies and predictors are unknown because of the small number. We describe one case of left main Coronary Artery Occlusion immediately after deployment of a prosthetic valve. The patient became hypotensive and developed cardiopulmonary arrest. However, the Coronary Artery was successfully stented with a help of cardiopulmonary bypass and he recovered well. In this case, pre-procedural computed tomography (CT) showed the adequately high Coronary height and no other significant conventional predictor for Coronary Occlusion. The examinations were retrospectively reviewed and the CT showed a long leaflet compared to the Coronary sinus complex. The fluoroscopy appeared to show the long leaflet covering the left main Coronary Artery ostium immediately after the valve deployment. The height of the Coronary Artery ostium from the aortic annulus appeared sufficiently high in this case and did not explain the Coronary compromise; leaflet length in relation to the Coronary sinus dimension seemed more relevant. The ratio between leaflet length and curved Coronary sinus height (L/C) may be one novel predictor for Coronary Artery Occlusion. © 2013 Wiley Periodicals, Inc.