The Experts below are selected from a list of 12954 Experts worldwide ranked by ideXlab platform
Lawrence De Koning - One of the best experts on this subject based on the ideXlab platform.
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Serum Total 25-OH Vitamin D Adds Little Prognostic Value in Patients Undergoing Coronary Catheterization.
Journal of the American Heart Association, 2016Co-Authors: Michael Gerling, Matthew T. James, Stephen B. Wilton, Christopher Naugler, Danielle A. Southern, P Diane Galbraith, Merril L. Knudtson, Lawrence De KoningAbstract:Background Vitamin D deficiency is associated with an increased risk of cardiovascular disease; however, it is unclear whether vitamin D status should be considered in clinical risk assessments of patients with cardiovascular disease. Methods and Results This study included 2975 patients who had their first serum total 25‐hydroxy vitamin D (25‐OH vitamin D) measurement before their first Coronary Catheterization in Alberta, Canada. Cox regression was used to examine associations between 25‐OH vitamin D and mortality risk after adjusting for demographic and clinical risk factors. Interactions were tested using multiplicative terms, and prognostic value was assessed using measures of model discrimination, fit, calibration and net reclassification improvement. There were 401 deaths over a median of 5.8 years of follow‐up. Serum total 25‐OH vitamin D was inversely associated with mortality after adjusting for demographic and clinical risk factors, which was largely driven by excess risk in the bottom quintile (hazard ratio 1.84 for bottom versus top quintile, 95% CI 1.36–2.50, P for trend
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Abstract P294: 25-OH Vitamin D concentration and All-Cause Mortality Following Coronary Catheterization in Alberta, Canada.
Circulation, 2015Co-Authors: Lawrence De Koning, Christopher Naugler, Michael Gerling, Mei Zhang, Merril L. KnudtsonAbstract:Background: While vitamin D deficiency has been identified as a potential risk marker for cardiovascular disease, little information exists on whether it is associated with outcomes following Coronary interventions (e.g. angioplasty). Objective: To examine the association between total 25-OH vitamin D concentration and all-cause mortality among patients undergoing Coronary Catheterizations in Calgary and Edmonton Alberta for the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH). Methods: Provincial laboratory data containing the first measurement of 25-OH vitamin D prior to Coronary Catheterization was merged to APPROACH covariate and outcome data from 2009-2013, defining a sub-cohort of 3358 participants. Data from the 2011 National Household Survey was merged by postal code to provide neighborhood level socioeconomic data. Multiple logistic regression was used to examine the association between 25-OH vitamin D and all-cause mortality. Results: There were a total of 2...
Merril L. Knudtson - One of the best experts on this subject based on the ideXlab platform.
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Simple Laboratory Test-Based Risk Scores in Coronary Catheterization: Development, Validation, and Comparison to Conventional Risk Factors.
The journal of applied laboratory medicine, 2020Co-Authors: Michael E Gerling, Yuan Dong, Beelal Abdalla, Matthew T. James, Stephen B. Wilton, Christopher Naugler, Danielle A. Southern, P Diane Galbraith, Blair J. O'neill, Merril L. KnudtsonAbstract:Background We developed and validated laboratory test-based risk scores (i.e., lab risk scores) to reclassify mortality risk among patients undergoing their first Coronary Catheterization. Methods Patients were catheterized between 2009 and 2015 in Calgary, Alberta, Canada (n = 14 135, derivation cohort), and in Edmonton, Alberta, Canada (n = 12 143, validation cohort). Logistic regression with group LASSO (least absolute shrinkage and selection operator) penalty was used to select quintiles of the last laboratory tests (red blood cell count, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, mean corpuscular volume, red cell distribution width, platelet count, total white blood cell count, plasma sodium, potassium, chloride, CO2, international normalized ratio, estimated glomerular filtration rate) performed 60 days after Catheterization. Follow-up was until 2016. Risk scores were developed from significant tests, internally validated in Calgary among bootstrap samples and externally validated in Edmonton after recalibration using coefficients developed in Calgary. Interaction tests were performed, and net reclassification improvement vs conventional demographic and clinical risk factors was determined. Results Lab risk scores were strongly associated with mortality (29-40× for top vs bottom quintile, P for trends 60 days) after Catheterization vs demographic and clinical risk factors. Conclusions In 2 populations of patients undergoing their first Coronary Catheterization, risk scores based on simple laboratory tests were as powerful as a combination of demographic and clinical risk factors in predicting mortality. Lab risk scores should be used for patients undergoing Coronary Catheterization.
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Serum Total 25-OH Vitamin D Adds Little Prognostic Value in Patients Undergoing Coronary Catheterization.
Journal of the American Heart Association, 2016Co-Authors: Michael Gerling, Matthew T. James, Stephen B. Wilton, Christopher Naugler, Danielle A. Southern, P Diane Galbraith, Merril L. Knudtson, Lawrence De KoningAbstract:Background Vitamin D deficiency is associated with an increased risk of cardiovascular disease; however, it is unclear whether vitamin D status should be considered in clinical risk assessments of patients with cardiovascular disease. Methods and Results This study included 2975 patients who had their first serum total 25‐hydroxy vitamin D (25‐OH vitamin D) measurement before their first Coronary Catheterization in Alberta, Canada. Cox regression was used to examine associations between 25‐OH vitamin D and mortality risk after adjusting for demographic and clinical risk factors. Interactions were tested using multiplicative terms, and prognostic value was assessed using measures of model discrimination, fit, calibration and net reclassification improvement. There were 401 deaths over a median of 5.8 years of follow‐up. Serum total 25‐OH vitamin D was inversely associated with mortality after adjusting for demographic and clinical risk factors, which was largely driven by excess risk in the bottom quintile (hazard ratio 1.84 for bottom versus top quintile, 95% CI 1.36–2.50, P for trend
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Abstract P294: 25-OH Vitamin D concentration and All-Cause Mortality Following Coronary Catheterization in Alberta, Canada.
Circulation, 2015Co-Authors: Lawrence De Koning, Christopher Naugler, Michael Gerling, Mei Zhang, Merril L. KnudtsonAbstract:Background: While vitamin D deficiency has been identified as a potential risk marker for cardiovascular disease, little information exists on whether it is associated with outcomes following Coronary interventions (e.g. angioplasty). Objective: To examine the association between total 25-OH vitamin D concentration and all-cause mortality among patients undergoing Coronary Catheterizations in Calgary and Edmonton Alberta for the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH). Methods: Provincial laboratory data containing the first measurement of 25-OH vitamin D prior to Coronary Catheterization was merged to APPROACH covariate and outcome data from 2009-2013, defining a sub-cohort of 3358 participants. Data from the 2011 National Household Survey was merged by postal code to provide neighborhood level socioeconomic data. Multiple logistic regression was used to examine the association between 25-OH vitamin D and all-cause mortality. Results: There were a total of 2...
Zenon S. Kyriakides - One of the best experts on this subject based on the ideXlab platform.
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TCT-359 ULnar artery Transient compression facilitating Radial Artery patent hemostasis (ULTRA): A novel technique to reduce radial artery occlusion
Journal of the American College of Cardiology, 2016Co-Authors: Michail Koutouzis, Christos Maniotis, Grigorios Avdikos, Andreas Tsoumeleas, Constantinos Andreou, Maria Angelaki, Zenon S. KyriakidesAbstract:Transradial Coronary Catheterization is a world-wide growing technique. Its main complication is radial artery occlusion (RAO), which occurs in 1%-10% of the patients. We evaluate a novel technique with simultaneous compression of the ulnar artery in order to reduce the presentence of RAO.
Michael Gerling - One of the best experts on this subject based on the ideXlab platform.
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Serum Total 25-OH Vitamin D Adds Little Prognostic Value in Patients Undergoing Coronary Catheterization.
Journal of the American Heart Association, 2016Co-Authors: Michael Gerling, Matthew T. James, Stephen B. Wilton, Christopher Naugler, Danielle A. Southern, P Diane Galbraith, Merril L. Knudtson, Lawrence De KoningAbstract:Background Vitamin D deficiency is associated with an increased risk of cardiovascular disease; however, it is unclear whether vitamin D status should be considered in clinical risk assessments of patients with cardiovascular disease. Methods and Results This study included 2975 patients who had their first serum total 25‐hydroxy vitamin D (25‐OH vitamin D) measurement before their first Coronary Catheterization in Alberta, Canada. Cox regression was used to examine associations between 25‐OH vitamin D and mortality risk after adjusting for demographic and clinical risk factors. Interactions were tested using multiplicative terms, and prognostic value was assessed using measures of model discrimination, fit, calibration and net reclassification improvement. There were 401 deaths over a median of 5.8 years of follow‐up. Serum total 25‐OH vitamin D was inversely associated with mortality after adjusting for demographic and clinical risk factors, which was largely driven by excess risk in the bottom quintile (hazard ratio 1.84 for bottom versus top quintile, 95% CI 1.36–2.50, P for trend
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Abstract P294: 25-OH Vitamin D concentration and All-Cause Mortality Following Coronary Catheterization in Alberta, Canada.
Circulation, 2015Co-Authors: Lawrence De Koning, Christopher Naugler, Michael Gerling, Mei Zhang, Merril L. KnudtsonAbstract:Background: While vitamin D deficiency has been identified as a potential risk marker for cardiovascular disease, little information exists on whether it is associated with outcomes following Coronary interventions (e.g. angioplasty). Objective: To examine the association between total 25-OH vitamin D concentration and all-cause mortality among patients undergoing Coronary Catheterizations in Calgary and Edmonton Alberta for the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH). Methods: Provincial laboratory data containing the first measurement of 25-OH vitamin D prior to Coronary Catheterization was merged to APPROACH covariate and outcome data from 2009-2013, defining a sub-cohort of 3358 participants. Data from the 2011 National Household Survey was merged by postal code to provide neighborhood level socioeconomic data. Multiple logistic regression was used to examine the association between 25-OH vitamin D and all-cause mortality. Results: There were a total of 2...
Harald Tillmanns - One of the best experts on this subject based on the ideXlab platform.
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A Randomized Comparison of Transradial Versus Transfemoral Approach for Coronary Angiography and Angioplasty
JACC. Cardiovascular interventions, 2009Co-Authors: Martin Brueck, Dirk Bandorski, Wilfried Kramer, Marcus Wieczorek, Reinhard Höltgen, Harald TillmannsAbstract:Objectives The aim of the study was to evaluate the safety, feasibility, and procedural variables by the transradial approach compared with the transfemoral access in a standard population of patients undergoing Coronary Catheterization. Background Coronary Catheterization is usually performed via the transfemoral approach. Transradial access may offer some advantages in comparison with transfemoral access especially under conditions of aggressive anticoagulation and antiplatelet treatment. Methods Between July 2006 and January 2008, a total of 1,024 patients undergoing Coronary Catheterization were randomly assigned to the transradial or transfemoral approach. Patients with an abnormal Allen9s test, history of Coronary artery bypass surgery, simultaneous right heart Catheterization, chronic renal insufficiency, or known difficulties with the radial or femoral access were excluded. Results Successful Catheterization was achieved in 494 of 512 patients (96.5%) in the transradial and in 511 of 512 patients (99.8%) in the transfemoral group (p 2 , IQR 20.4 to 48.5 Gycm 2 vs. 41.9 Gycm 2 , IQR 22.6 to 52.2 Gycm 2 ; p = 0.034) were significantly lower in the transfemoral group compared with the transradial access group. A median amount of contrast agent was similar among both groups. Vascular access site complications were higher in the transfemoral group (3.71%) than in the transradial group (0.58%; p = 0.0008) Conclusions The findings of the present study show that transradial Coronary angiography and angioplasty are safe, feasible, and effective with similar results to those of the transfemoral approach. However, procedural duration and radiation exposure are higher using the transradial access. In contrast to the transfemoral route, the rate of major vascular complications was negligible using the transradial approach.