The Experts below are selected from a list of 321 Experts worldwide ranked by ideXlab platform

Carlo Menon - One of the best experts on this subject based on the ideXlab platform.

  • Diastolic Timed Vibrator: Noninvasive Pre-Hospitalization Treatment of Acute Coronary Ischemia
    IEEE transactions on biomedical circuits and systems, 2013
    Co-Authors: Marcin Marzencki, Behrad Kajbafzadeh, Kouhyar Tavakolian, Bozena Kaminska, Farzad Khosrow-khavar, Carlo Menon
    Abstract:

    The speed of intervention is one of the major factors in increasing the survival rate of patients suffering from acute Coronary Ischemia. The two principal techniques currently in use: pharmacological and interventional, can be employed to re-canalize Coronary arteries, but the former is slow acting and often leads to incomplete reperfusion, while the latter requires specialized personnel in a hospital with a cardiac catheterization laboratory. In this paper, we introduce a novel method intended for pre-hospitalization treatment of patients with acute Coronary Ischemia that can be safely applied by a minimally trained individual prior to or during patient transportation to hospital. It consists in applying low frequency mechanical vibrations to the left intercostal space of patient's chest during diastole of the heart cycle, to induce vibrations of the heart and thus of the Coronary arteries. Mechanical vibrations stimulate mixing of blood which improves drug delivery to the occlusion site, applies mechanical force on the clot leading to its faster dissolution and finally acts as a strong vasodilator in case of spasms. We introduce the principle of operation and the architecture of the Diastolic Timed Vibrator (DTV), including a custom ECG processing algorithm, vibration pattern generator and active braking methods. Experimental results demonstrate the functionality of the DTV device and pave way for in-vivo tests necessary for clinical confirmation of the proposed method.

  • diastolic timed vibrator applying direct vibration in diastole to patients with acute Coronary Ischemia during the pre hospitalization phase
    Autonomous and Intelligent Systems, 2011
    Co-Authors: Farzad Khosrowkhavar, Marcin Marzencki, Behrad Kajbafzadeh, Kouhyar Tavakolian, Bozena Kaminska, Carlo Menon
    Abstract:

    A biomedical device that applies vibration to the chest of a patient during the pre-hospitalization phase of acute Coronary Ischemia is introduced. This device improves the blood flow in order to remove the thrombosis. In order to help the heart pumping mechanism, vibration is applied during diastole only and hence this device is called a Diastolic Timed Vibrator (DTV). We introduce two algorithms (slope-lookup and slope-energy) to detect diastole by using an electrocardiogram signal available in most ambulances and pre-emergency units. The robustness of the algorithms were examined by considering many types of arrhythmias that might occur during acute Ischemia. We show that the slope-energy is a robust method and can be used to detect diastole interval in most types of arrhythmias.

  • EMBC - Preferred patterns of diastolic timed vibrations for pre-hospitalization treatment of acute Coronary Ischemia
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Inte, 2011
    Co-Authors: Behrad Kajbafzadeh, Marcin Marzencki, Kouhyar Tavakolian, Carlo Menon, Farzad Khosrow-khavar, Nezam Alavi, Bozena Kaminska
    Abstract:

    This paper presents and evaluates preferred patterns of vibrations and active breaking techniques for the Diastolic Timed Vibrator (DTV). DTV uses low frequency mechanical vibrations applied to the chest to help in clot dissolution in pre-hospitalization treatment of acute Coronary Ischemia. In this work, we argue that random and ramp type vibration patterns increase the performance of the DTV method. Furthermore, we present results for various methods of vibration stopping aiming at reduction of vibration overspill into the systole of heart cycle of the patient.

  • AIS - Diastolic timed vibrator: applying direct vibration in diastole to patients with acute Coronary Ischemia during the pre-hospitalization phase
    Autonomous and Intelligent Systems, 2011
    Co-Authors: Farzad Khosrow-khavar, Marcin Marzencki, Behrad Kajbafzadeh, Kouhyar Tavakolian, Bozena Kaminska, Carlo Menon
    Abstract:

    A biomedical device that applies vibration to the chest of a patient during the pre-hospitalization phase of acute Coronary Ischemia is introduced. This device improves the blood flow in order to remove the thrombosis. In order to help the heart pumping mechanism, vibration is applied during diastole only and hence this device is called a Diastolic Timed Vibrator (DTV). We introduce two algorithms (slope-lookup and slope-energy) to detect diastole by using an electrocardiogram signal available in most ambulances and pre-emergency units. The robustness of the algorithms were examined by considering many types of arrhythmias that might occur during acute Ischemia. We show that the slope-energy is a robust method and can be used to detect diastole interval in most types of arrhythmias.

Masashi Katsura - One of the best experts on this subject based on the ideXlab platform.

Toyotaka Yada - One of the best experts on this subject based on the ideXlab platform.

Christopher K. Zarins - One of the best experts on this subject based on the ideXlab platform.

  • Diagnosis and management of silent Coronary Ischemia in patients undergoing carotid endarterectomy.
    Journal of Vascular Surgery, 2020
    Co-Authors: Dainis Krievins, Edgars Zellans, Gustavs Latkovskis, Sanda Jegere, Indulis Kumsars, Karlis Kaufmanis, Andrejs Erglis, Christopher K. Zarins
    Abstract:

    Abstract Background Coronary artery disease is the primary cause of death in patients with carotid artery disease and silent Ischemia is a marker for adverse Coronary events. A new noninvasive cardiac diagnostic test, Coronary computed tomography-derived fractional flow reserve (FFRCT) can reliably identify Ischemia-producing Coronary stenosis in patients with Coronary artery disease and help to select patients for Coronary revascularization. The purpose of this study is to determine the prevalence of silent Coronary Ischemia in patients undergoing carotid endarterectomy (CEA) and to evaluate the usefulness of FFRCT in selecting patients for Coronary revascularization to decrease cardiac events and improve survival. Methods Patients with no cardiac history or symptoms admitted for elective CEA were enrolled in a prospective, open-label, institutional review board-approved study and underwent preoperative Coronary computed tomography angiography (CTA) and FFRCT with results available to physicians for patient management. Lesion-specific Coronary Ischemia was defined as FFRCT of 0.80 or less distal to a focal Coronary stenosis with an FFRCT of 0.75 or less, indicating severe Ischemia. Primary end point was incidence of major adverse cardiovascular events (MACE; defined as cardiovascular death, myocardial infarction, or stroke) at 30 days and 1 year. Results Coronary CTA and FFRCT was performed in 90 CEA patients (age 67 ± 8 years; male 66%). Lesion-specific Coronary Ischemia was found in 51 patients (57%) with a mean FFRCT of 0.71 ± 0.14. Severe Coronary Ischemia was present in 39 patients (43%), 26 patients had multivessel Ischemia, and 5 had left main disease. CEA was performed as scheduled in all patients with no postoperative deaths or myocardial infarctions. There were no MACE events at 30 days. After recovery from surgery, 36 patients with significant lesion-specific Ischemia underwent Coronary angiography with Coronary revascularization (percutaneous Coronary intervention or Coronary artery bypass grafting) in 30 patients (33%). Survival at 1 year was 100% and freedom from MACE was 98%. Conclusions Patients undergoing CEA have a high prevalence of unsuspected (silent) Coronary Ischemia, which may place them at risk for Coronary events. Preoperative diagnosis of silent Ischemia using CTA and FFRCT can identify high-risk patients and help to guide patient management. Selective postoperative Coronary revascularization of patients with significant Ischemia may decrease the risk of cardiac events and improve survival, but longer follow-up is needed and prospective, controlled trials are indicated.

  • Diagnosis and management of silent Coronary Ischemia in patients undergoing carotid endarterectomy.
    Journal of vascular surgery, 2020
    Co-Authors: Dainis Krievins, Edgars Zellans, Gustavs Latkovskis, Sanda Jegere, Indulis Kumsars, Karlis Kaufmanis, Andrejs Erglis, Christopher K. Zarins
    Abstract:

    Coronary artery disease is the primary cause of death in patients with carotid artery disease and silent Ischemia is a marker for adverse Coronary events. A new noninvasive cardiac diagnostic test, Coronary computed tomography-derived fractional flow reserve (FFRCT) can reliably identify Ischemia-producing Coronary stenosis in patients with Coronary artery disease and help to select patients for Coronary revascularization. The purpose of this study is to determine the prevalence of silent Coronary Ischemia in patients undergoing carotid endarterectomy (CEA) and to evaluate the usefulness of FFRCT in selecting patients for Coronary revascularization to decrease cardiac events and improve survival. Patients with no cardiac history or symptoms admitted for elective CEA were enrolled in a prospective, open-label, institutional review board-approved study and underwent preoperative Coronary computed tomography angiography (CTA) and FFRCT with results available to physicians for patient management. Lesion-specific Coronary Ischemia was defined as FFRCT of 0.80 or less distal to a focal Coronary stenosis with an FFRCT of 0.75 or less, indicating severe Ischemia. Primary end point was incidence of major adverse cardiovascular events (MACE; defined as cardiovascular death, myocardial infarction, or stroke) at 30 days and 1 year. Coronary CTA and FFRCT was performed in 90 CEA patients (age 67 ± 8 years; male 66%). Lesion-specific Coronary Ischemia was found in 51 patients (57%) with a mean FFRCT of 0.71 ± 0.14. Severe Coronary Ischemia was present in 39 patients (43%), 26 patients had multivessel Ischemia, and 5 had left main disease. CEA was performed as scheduled in all patients with no postoperative deaths or myocardial infarctions. There were no MACE events at 30 days. After recovery from surgery, 36 patients with significant lesion-specific Ischemia underwent Coronary angiography with Coronary revascularization (percutaneous Coronary intervention or Coronary artery bypass grafting) in 30 patients (33%). Survival at 1 year was 100% and freedom from MACE was 98%. Patients undergoing CEA have a high prevalence of unsuspected (silent) Coronary Ischemia, which may place them at risk for Coronary events. Preoperative diagnosis of silent Ischemia using CTA and FFRCT can identify high-risk patients and help to guide patient management. Selective postoperative Coronary revascularization of patients with significant Ischemia may decrease the risk of cardiac events and improve survival, but longer follow-up is needed and prospective, controlled trials are indicated. Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Marcin Marzencki - One of the best experts on this subject based on the ideXlab platform.

  • Diastolic Timed Vibrator: Noninvasive Pre-Hospitalization Treatment of Acute Coronary Ischemia
    IEEE transactions on biomedical circuits and systems, 2013
    Co-Authors: Marcin Marzencki, Behrad Kajbafzadeh, Kouhyar Tavakolian, Bozena Kaminska, Farzad Khosrow-khavar, Carlo Menon
    Abstract:

    The speed of intervention is one of the major factors in increasing the survival rate of patients suffering from acute Coronary Ischemia. The two principal techniques currently in use: pharmacological and interventional, can be employed to re-canalize Coronary arteries, but the former is slow acting and often leads to incomplete reperfusion, while the latter requires specialized personnel in a hospital with a cardiac catheterization laboratory. In this paper, we introduce a novel method intended for pre-hospitalization treatment of patients with acute Coronary Ischemia that can be safely applied by a minimally trained individual prior to or during patient transportation to hospital. It consists in applying low frequency mechanical vibrations to the left intercostal space of patient's chest during diastole of the heart cycle, to induce vibrations of the heart and thus of the Coronary arteries. Mechanical vibrations stimulate mixing of blood which improves drug delivery to the occlusion site, applies mechanical force on the clot leading to its faster dissolution and finally acts as a strong vasodilator in case of spasms. We introduce the principle of operation and the architecture of the Diastolic Timed Vibrator (DTV), including a custom ECG processing algorithm, vibration pattern generator and active braking methods. Experimental results demonstrate the functionality of the DTV device and pave way for in-vivo tests necessary for clinical confirmation of the proposed method.

  • diastolic timed vibrator applying direct vibration in diastole to patients with acute Coronary Ischemia during the pre hospitalization phase
    Autonomous and Intelligent Systems, 2011
    Co-Authors: Farzad Khosrowkhavar, Marcin Marzencki, Behrad Kajbafzadeh, Kouhyar Tavakolian, Bozena Kaminska, Carlo Menon
    Abstract:

    A biomedical device that applies vibration to the chest of a patient during the pre-hospitalization phase of acute Coronary Ischemia is introduced. This device improves the blood flow in order to remove the thrombosis. In order to help the heart pumping mechanism, vibration is applied during diastole only and hence this device is called a Diastolic Timed Vibrator (DTV). We introduce two algorithms (slope-lookup and slope-energy) to detect diastole by using an electrocardiogram signal available in most ambulances and pre-emergency units. The robustness of the algorithms were examined by considering many types of arrhythmias that might occur during acute Ischemia. We show that the slope-energy is a robust method and can be used to detect diastole interval in most types of arrhythmias.

  • EMBC - Preferred patterns of diastolic timed vibrations for pre-hospitalization treatment of acute Coronary Ischemia
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Inte, 2011
    Co-Authors: Behrad Kajbafzadeh, Marcin Marzencki, Kouhyar Tavakolian, Carlo Menon, Farzad Khosrow-khavar, Nezam Alavi, Bozena Kaminska
    Abstract:

    This paper presents and evaluates preferred patterns of vibrations and active breaking techniques for the Diastolic Timed Vibrator (DTV). DTV uses low frequency mechanical vibrations applied to the chest to help in clot dissolution in pre-hospitalization treatment of acute Coronary Ischemia. In this work, we argue that random and ramp type vibration patterns increase the performance of the DTV method. Furthermore, we present results for various methods of vibration stopping aiming at reduction of vibration overspill into the systole of heart cycle of the patient.

  • AIS - Diastolic timed vibrator: applying direct vibration in diastole to patients with acute Coronary Ischemia during the pre-hospitalization phase
    Autonomous and Intelligent Systems, 2011
    Co-Authors: Farzad Khosrow-khavar, Marcin Marzencki, Behrad Kajbafzadeh, Kouhyar Tavakolian, Bozena Kaminska, Carlo Menon
    Abstract:

    A biomedical device that applies vibration to the chest of a patient during the pre-hospitalization phase of acute Coronary Ischemia is introduced. This device improves the blood flow in order to remove the thrombosis. In order to help the heart pumping mechanism, vibration is applied during diastole only and hence this device is called a Diastolic Timed Vibrator (DTV). We introduce two algorithms (slope-lookup and slope-energy) to detect diastole by using an electrocardiogram signal available in most ambulances and pre-emergency units. The robustness of the algorithms were examined by considering many types of arrhythmias that might occur during acute Ischemia. We show that the slope-energy is a robust method and can be used to detect diastole interval in most types of arrhythmias.