The Experts below are selected from a list of 267 Experts worldwide ranked by ideXlab platform

Steven A. Grover - One of the best experts on this subject based on the ideXlab platform.

  • Can Computerized Risk Profiles Help Patients Improve Their Coronary Risk? The Results of The Coronary Health Assessment Study (CHAS)
    Preventive Medicine, 1998
    Co-Authors: Ilka Lowensteyn, Lawrence Joseph, Carey Levinton, Michal Abrahamowicz, Yvonne Steinert, Steven A. Grover
    Abstract:

    Background.The Coronary Health Assessment Study (CHAS) was developed to determine the feasibility of using patient-specific, multifactorial computerized Coronary Risk profiles as a clinical decision aid to support primary prevention of CHD. Methods.Study participants included 253 community based physicians, randomized into profile and control groups, and 958 of their patients. The profile group physicians received Coronary Risk profiles for their patients within 10 working days after the baseline patient assessment providing early feedback. The control group received their profiles only if the patient was clinically reevaluated during a 3-month follow-up visit. Patients' Coronary Risk factors were evaluated at baseline and at follow-up. Results.The profile group had a significantly higher (P< 0.05) ratio of high-Risk/low-Risk patients who returned for a follow-up visit compared to the control group (1.23 vs 0.77). The patients in the profile group also had significantly (P< 0.05) greater mean reductions in total cholesterol (−0.5 vs −0.1 mmol/L), LDL cholesterol (−0.4 vs 0.0 mmol/L), the total cholesterol/ HDL ratio (−0.6 vs −0.2), and the predicted 8-year Coronary Risk (−1.8 vs −0.3%). Conclusions.Computer-generated Coronary Risk profiles can be effective in assisting physicians to identify high-Risk patients. Their use is also associated with significantly greater improvements in the serum lipid profiles and the overall Coronary Risk of these patients.

David Gee - One of the best experts on this subject based on the ideXlab platform.

Nobuhiko Koga - One of the best experts on this subject based on the ideXlab platform.

  • Relation of thoracic aorta calcification on computed tomography and Coronary Risk factors to obstructive Coronary artery disease on angiography.
    Angiology, 2003
    Co-Authors: Kazuo Watanabe, Tadayuki Hiroki, Nobuhiko Koga
    Abstract:

    The aim of this study was to investigate whether thoracic aorta calcification (TAC) on computed tomography (CT) and Coronary Risk factors had any correlation with obstructive Coronary artery disease (CAD) on angiography. A total of 225 consecutive Japanese patients underwent both thoracic conventional helical CT and Coronary angiography. The thoracic aorta was divided into 4 locations according to the aortic anatomy (inner curve of the aortic arch, aortic arch but not on the inner curve, ascending aorta, and thoracic descending aorta). The classified TAC and Coronary Risk factors were evaluated for the presence or absence of obstructive CAD. TAC was detected in 185 patients; 141 of 225 patients had significant obstructive CAD. All of the 13 patients with no TAC and no Coronary Risk factors had no CAD. The obstructive CAD rate with 1 thoracic calcified location and with no, 1, or 2 Coronary Risk factors was 10%, 58%, and 90%, respectively, and each showed a significant difference (p < 0.0001). The combinations of TAC and Coronary Risk factors with obstructive CAD were 1 or 2 thoracic calcified locations with 3 Coronary Risk factors, and 3 thoracic calcified locations with more than 2 Coronary Risk factors. Increasing thoracic calcified locations and increasing Coronary Risk factors indicated a higher likelihood of CAD.

M. H. Frick - One of the best experts on this subject based on the ideXlab platform.

  • Serum ferritin and ceruloplasmin as Coronary Risk factors
    European heart journal, 1994
    Co-Authors: Matti Mänttäri, Vesa Manninen, Jussi K. Huttunen, T Palosuo, C Ehnholm, Olli P. Heinonen, M. H. Frick
    Abstract:

    Iron and copper catalyze lipid peroxidation in vitro, and recent epidemiological data suggest that these metal ions might also be involved in human Coronary heart disease. We tested the hypothesis by investigating whether the storage proteins ferritin and ceruloplasmin were Coronary Risk factors. A nested case-control study was set up in middle-aged dyslipidaemic participants of the Helsinki Heart Study: a placebo-controlled Coronary primary prevention trial with gemfibrozil. Of the 140 subjects with cardiac end-points (non-fatal myocardial infarction or cardiac death) 136 were matched with controls for geographical area and drug treatment (gemfibrozil-placebo). Frozen baseline serum samples were used in the analyses of ferritin and ceruloplasmin. Using logistic regression analyses no increment in Coronary Risk was detected with increasing ferritin levels (P = 0.8 for trend). Ceruloplasmin was higher 349 +/- 86 vs 317 +/- 77 mg.l-1 (P < 0.001) in cases than in controls and the Risk in the highest tertile was two-fold (odds ratio 2.1; 95% CI 1.1-4.2) compared to the lowest (P < 0.005 for trend). The Risk of high ceruloplasmin was influenced by lipoprotein cholesterol concentrations, with an odds ratio of 2.4 (95% CI 1.3-4.4) in subjects with high low density lipoprotein cholesterol and of 11.3 (95% CI 2.5-52.2) in subjects with low high density lipoprotein cholesterol. It was concluded that ferritin was not associated with Coronary heart disease in dyslipidaemic, middle-aged men, while there was a continuous and graded increment in Coronary Risk with elevating ceruloplasmin level.

  • Leukocytes as a Coronary Risk factor in a dyslipidemic male population.
    American heart journal, 1992
    Co-Authors: M Mänttäri, V Manninen, P Koskinen, J K Huttunen, E Oksanen, L Tenkanen, O P Heinonen, M. H. Frick
    Abstract:

    The role of an elevated serum leukocyte count (WBC) as a Coronary Risk factor was investigated using a nested case-control design in dyslipidemic middle-aged men (n = 420) participating in the Helsinki Heart Study, a Coronary primary prevention trial. Baseline WBC was significantly higher, 6.93 (2.11) x 10(9)/L in subjects with cardiac events, than in controls, 6.26 (1.88) x 10(9)/L; p less than 0.002. This association was time-dependent, however, since the difference was not significant for events occurring during the second half of the 5-year study. Using nonsmokers in the lowest WBC tertile as the reference sample, the relative Risks in the highest WBC tertile were 1.86 (95% confidence intervals [CI] 0.81 to 4.28) for nonsmokers and 3.07 (95% CI 2.23 to 8.19) for smokers. Logistic regression analysis including smoking in the model disclosed an independent contribution of elevated WBC to Coronary heart disease. We conclude that elevated leukocyte count was a Coronary Risk factor even in this dyslipidemic population.

Masami Murakami - One of the best experts on this subject based on the ideXlab platform.

  • impaired blood rheology is associated with endothelial dysfunction in patients with Coronary Risk factors
    Clinical Hemorheology and Microcirculation, 2016
    Co-Authors: Hideki Yagi, Takayuki Ogiwara, Osamu Araki, Hiroyuki Sumino, M Nara, Tomoyuki Aoki, Takao Kimura, Katsuhiko Tsunekawa, Masami Murakami
    Abstract:

    : To investigate the relationship between blood rheology and endothelial function in patients with Coronary Risk factors, brachial arterial flow-mediated vasodilatation (FMD), an index of endothelial function and blood passage time (BPT), an index of blood rheology, and fasting blood cell count, glucose metabolism, and plasma fibrinogen, lipid, C-reactive protein, and whole blood viscosity levels were measured in 95 patients with Coronary Risk factors and 37 healthy controls. Brachial arterial FMD after reactive hyperemia was assessed by ultrasonography. BPT was assessed using the microchannel method. In healthy controls, BPT significantly correlated with FMD (r = - 0.325, p <  0.05), HDL cholesterol (r = - 0.393, p <  0.05), body mass index (BMI; r = 0.530, p <  0.01), and plasma fibrinogen concentration (r = 0.335, p <  0.05). In a multivariate regression analysis adjusted for all clinical variables, BPT remained significantly associated with BMI and fibrinogen, but not with FMD, in healthy controls. In patients with Coronary Risk factors, BPT significantly correlated with FMD (r = - 0.331, p <  0.01), HDL cholesterol (r = - 0.241, p <  0.05), BMI (r = 0.290, p <  0.01), hematocrit (r = 0.422, p <  0.001), white blood cell count (r = 0.295, p <  0.01), platelet count (r = 0.204, p <  0.05), and insulin (r = 0.210, p <  0.05). In a multivariate regression analysis adjusted for all clinical variables, BPT remained strongly associated with FMD and hematocrit in patients with Coronary Risk factors. These data indicate that BPT is closely associated with FMD in patients with Coronary Risk factors and suggest that the measurement of blood rheology using the microchannel method may be useful in evaluating brachial arterial endothelial function as a marker of atherosclerosis in these patients.