The Experts below are selected from a list of 41805 Experts worldwide ranked by ideXlab platform
Leo L.m. Poon - One of the best experts on this subject based on the ideXlab platform.
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longitudinal study of middle east respiratory syndrome Coronavirus Infection in dromedary camel herds in saudi arabia 2014 2015
Emerging microbes & infections, 2017Co-Authors: Maged Gomaa Hemida, Samuel Ms Chan, Faisal Almathen, Emily Yau, Brian Cy Ng, Abdulmohsen Alnaeem, Daniel Kw Chu, Ranawaka A.p.m. Perera, Richard J. Webby, Leo L.m. PoonAbstract:Longitudinal study of Middle East Respiratory Syndrome Coronavirus Infection in dromedary camel herds in Saudi Arabia, 2014–2015
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longitudinal study of middle east respiratory syndrome Coronavirus Infection in dromedary camel herds in saudi arabia 2014 2015
Emerging microbes & infections, 2017Co-Authors: Maged Gomaa Hemida, Samuel Ms Chan, Faisal Almathen, Emily Yau, Brian Cy Ng, Abdulmohsen Alnaeem, Daniel Kw Chu, Ranawaka A.p.m. Perera, Richard J. Webby, Leo L.m. PoonAbstract:Longitudinal study of Middle East Respiratory Syndrome Coronavirus Infection in dromedary camel herds in Saudi Arabia, 2014–2015
Emily M Eichenberger - One of the best experts on this subject based on the ideXlab platform.
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incidence significance and persistence of human Coronavirus Infection in hematopoietic stem cell transplant recipients
Bone Marrow Transplantation, 2019Co-Authors: Catherine Butkus Small, Emily M Eichenberger, Dana Zappetti, Tsiporah B Shore, Koen Van Besien, Claire Douglass, Rosemary Soave, Lars F Westblade, Michael J SatlinAbstract:Hematopoietic stem cell transplant (HSCT) recipients are at increased risk of respiratory viral Infections and their associated complications. Unlike other respiratory viruses, little is known about the clinical significance of human Coronavirus Infection (HCoV) in this population. We retrospectively identified all HSCT recipients who were transplanted between May 2013 and June 2017 at our institution and characterized the cumulative incidence of post-transplant HCoV Infection. Of 678 patients who underwent HSCT during the study period, 112 (17%) developed HCoV Infection, making HCoV the fourth most common respiratory viral Infection. Thirty-four (30%) HCoV-infected patients progressed to proven or probable lower respiratory tract Infection (LRTI). Age ≥50, graft-versus-host disease, corticosteroids, hypoalbuminemia, and inpatient status at the time of Infection were independently associated with progression to LRTI. Twenty-seven (59%) patients who underwent repeat NP swab had persistent viral shedding for ≥21 days, with a median duration of 4 weeks of viral shedding. We conclude that HCoV is common and clinically significant in HSCT recipients, with nearly one-third of patients progressing to proven or probable LRTI. Evaluating for LRTI risk factors found in this study may identify patients who require closer surveillance and aggressive supportive care when infected with HCoV.
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incidence significance and persistence of human Coronavirus Infection in hematopoietic stem cell transplant recipients
Bone Marrow Transplantation, 2019Co-Authors: Catherine Butkus Small, Emily M Eichenberger, Dana Zappetti, Tsiporah B Shore, Koen Van Besien, Claire Douglass, Rosemary Soave, Lars F Westblade, Michael J SatlinAbstract:Hematopoietic stem cell transplant (HSCT) recipients are at increased risk of respiratory viral Infections and their associated complications. Unlike other respiratory viruses, little is known about the clinical significance of human Coronavirus Infection (HCoV) in this population. We retrospectively identified all HSCT recipients who were transplanted between May 2013 and June 2017 at our institution and characterized the cumulative incidence of post-transplant HCoV Infection. Of 678 patients who underwent HSCT during the study period, 112 (17%) developed HCoV Infection, making HCoV the fourth most common respiratory viral Infection. Thirty-four (30%) HCoV-infected patients progressed to proven or probable lower respiratory tract Infection (LRTI). Age ≥50, graft-versus-host disease, corticosteroids, hypoalbuminemia, and inpatient status at the time of Infection were independently associated with progression to LRTI. Twenty-seven (59%) patients who underwent repeat NP swab had persistent viral shedding for ≥21 days, with a median duration of 4 weeks of viral shedding. We conclude that HCoV is common and clinically significant in HSCT recipients, with nearly one-third of patients progressing to proven or probable LRTI. Evaluating for LRTI risk factors found in this study may identify patients who require closer surveillance and aggressive supportive care when infected with HCoV.
Maged Gomaa Hemida - One of the best experts on this subject based on the ideXlab platform.
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longitudinal study of middle east respiratory syndrome Coronavirus Infection in dromedary camel herds in saudi arabia 2014 2015
Emerging microbes & infections, 2017Co-Authors: Maged Gomaa Hemida, Samuel Ms Chan, Faisal Almathen, Emily Yau, Brian Cy Ng, Abdulmohsen Alnaeem, Daniel Kw Chu, Ranawaka A.p.m. Perera, Richard J. Webby, Leo L.m. PoonAbstract:Longitudinal study of Middle East Respiratory Syndrome Coronavirus Infection in dromedary camel herds in Saudi Arabia, 2014–2015
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longitudinal study of middle east respiratory syndrome Coronavirus Infection in dromedary camel herds in saudi arabia 2014 2015
Emerging microbes & infections, 2017Co-Authors: Maged Gomaa Hemida, Samuel Ms Chan, Faisal Almathen, Emily Yau, Brian Cy Ng, Abdulmohsen Alnaeem, Daniel Kw Chu, Ranawaka A.p.m. Perera, Richard J. Webby, Leo L.m. PoonAbstract:Longitudinal study of Middle East Respiratory Syndrome Coronavirus Infection in dromedary camel herds in Saudi Arabia, 2014–2015
Richard J. Webby - One of the best experts on this subject based on the ideXlab platform.
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impaired nlrp3 inflammasome activation pyroptosis leads to robust inflammatory cell death via caspase 8 ripk3 during Coronavirus Infection
Journal of Biological Chemistry, 2020Co-Authors: Min Zheng, Richard J. Webby, Rudragouda Channappanavar, Evan P Williams, R Subbarao K Malireddi, Rajendra Karki, Balaji Banoth, Amanda R Burton, Colleen B Jonsson, Thirumaladevi KannegantiAbstract:Coronaviruses have caused several zoonotic Infections in the past two decades, leading to significant morbidity and mortality globally. Balanced regulation of cell death and inflammatory immune responses is essential to promote protection against Coronavirus Infection; however, the underlying mechanisms that control these processes remain to be resolved. Here we demonstrate that Infection with the murine Coronavirus mouse hepatitis virus (MHV) activated the NLRP3 inflammasome and inflammatory cell death in the form of PANoptosis. Deleting NLRP3 inflammasome components or the downstream cell death executioner gasdermin D (GSDMD) led to an initial reduction in cell death followed by a robust increase in the incidence of caspase-8- and receptor-interacting serine/threonine-protein kinase 3 (RIPK3)-mediated inflammatory cell deathafter Coronavirus Infection. Additionally, loss of GSDMD promoted robust NLRP3 inflammasome activation. Moreover, the amounts of some cytokines released during Coronavirus Infection were significantly altered in the absence of GSDMD. Altogether, our findings show that inflammatory cell death, PANoptosis, is induced by Coronavirus Infection and that impaired NLRP3 inflammasome function or pyroptosis can lead to negative consequences for the host. These findings may have important implications for studies of Coronavirus-induced disease.
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longitudinal study of middle east respiratory syndrome Coronavirus Infection in dromedary camel herds in saudi arabia 2014 2015
Emerging microbes & infections, 2017Co-Authors: Maged Gomaa Hemida, Samuel Ms Chan, Faisal Almathen, Emily Yau, Brian Cy Ng, Abdulmohsen Alnaeem, Daniel Kw Chu, Ranawaka A.p.m. Perera, Richard J. Webby, Leo L.m. PoonAbstract:Longitudinal study of Middle East Respiratory Syndrome Coronavirus Infection in dromedary camel herds in Saudi Arabia, 2014–2015
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longitudinal study of middle east respiratory syndrome Coronavirus Infection in dromedary camel herds in saudi arabia 2014 2015
Emerging microbes & infections, 2017Co-Authors: Maged Gomaa Hemida, Samuel Ms Chan, Faisal Almathen, Emily Yau, Brian Cy Ng, Abdulmohsen Alnaeem, Daniel Kw Chu, Ranawaka A.p.m. Perera, Richard J. Webby, Leo L.m. PoonAbstract:Longitudinal study of Middle East Respiratory Syndrome Coronavirus Infection in dromedary camel herds in Saudi Arabia, 2014–2015
Michael J Satlin - One of the best experts on this subject based on the ideXlab platform.
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incidence significance and persistence of human Coronavirus Infection in hematopoietic stem cell transplant recipients
Bone Marrow Transplantation, 2019Co-Authors: Catherine Butkus Small, Emily M Eichenberger, Dana Zappetti, Tsiporah B Shore, Koen Van Besien, Claire Douglass, Rosemary Soave, Lars F Westblade, Michael J SatlinAbstract:Hematopoietic stem cell transplant (HSCT) recipients are at increased risk of respiratory viral Infections and their associated complications. Unlike other respiratory viruses, little is known about the clinical significance of human Coronavirus Infection (HCoV) in this population. We retrospectively identified all HSCT recipients who were transplanted between May 2013 and June 2017 at our institution and characterized the cumulative incidence of post-transplant HCoV Infection. Of 678 patients who underwent HSCT during the study period, 112 (17%) developed HCoV Infection, making HCoV the fourth most common respiratory viral Infection. Thirty-four (30%) HCoV-infected patients progressed to proven or probable lower respiratory tract Infection (LRTI). Age ≥50, graft-versus-host disease, corticosteroids, hypoalbuminemia, and inpatient status at the time of Infection were independently associated with progression to LRTI. Twenty-seven (59%) patients who underwent repeat NP swab had persistent viral shedding for ≥21 days, with a median duration of 4 weeks of viral shedding. We conclude that HCoV is common and clinically significant in HSCT recipients, with nearly one-third of patients progressing to proven or probable LRTI. Evaluating for LRTI risk factors found in this study may identify patients who require closer surveillance and aggressive supportive care when infected with HCoV.
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incidence significance and persistence of human Coronavirus Infection in hematopoietic stem cell transplant recipients
Bone Marrow Transplantation, 2019Co-Authors: Catherine Butkus Small, Emily M Eichenberger, Dana Zappetti, Tsiporah B Shore, Koen Van Besien, Claire Douglass, Rosemary Soave, Lars F Westblade, Michael J SatlinAbstract:Hematopoietic stem cell transplant (HSCT) recipients are at increased risk of respiratory viral Infections and their associated complications. Unlike other respiratory viruses, little is known about the clinical significance of human Coronavirus Infection (HCoV) in this population. We retrospectively identified all HSCT recipients who were transplanted between May 2013 and June 2017 at our institution and characterized the cumulative incidence of post-transplant HCoV Infection. Of 678 patients who underwent HSCT during the study period, 112 (17%) developed HCoV Infection, making HCoV the fourth most common respiratory viral Infection. Thirty-four (30%) HCoV-infected patients progressed to proven or probable lower respiratory tract Infection (LRTI). Age ≥50, graft-versus-host disease, corticosteroids, hypoalbuminemia, and inpatient status at the time of Infection were independently associated with progression to LRTI. Twenty-seven (59%) patients who underwent repeat NP swab had persistent viral shedding for ≥21 days, with a median duration of 4 weeks of viral shedding. We conclude that HCoV is common and clinically significant in HSCT recipients, with nearly one-third of patients progressing to proven or probable LRTI. Evaluating for LRTI risk factors found in this study may identify patients who require closer surveillance and aggressive supportive care when infected with HCoV.
