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Edgar G Hertwich - One of the best experts on this subject based on the ideXlab platform.

Peter Berrill - One of the best experts on this subject based on the ideXlab platform.

Joseph Classen - One of the best experts on this subject based on the ideXlab platform.

  • can partial volume effect Correction or gray white matter boundary delineation improve the visual reading of 18f florbetaben pet images
    The Journal of Nuclear Medicine, 2020
    Co-Authors: Michael Rullmann, Solveig Tiepolt, Konstantin Messerschmidt, Thilo Gerhards, Matti Schurer, Swen Hesse, Dorothee Saur, Christopher M Weise, Matthias L Schroeter, Joseph Classen
    Abstract:

    1567 Introduction: The approved clinical use of beta-amyloid (As) PET tracers like [18F]Florbetaben is based on the binary visual evaluation of the existing (As-negative) or missing (As-positive) contrast between specific gray matter (GM) and non-specific white matter (WM) uptake. Consequently, a priori reader training focusses on evaluating the GM/WM contrast within the PET images. So far, the influence of partial volume effects (PVEs) is not considered in this clinical routine visual reading. Thus, we hypothesize that amyloid PET reading is improved by WM/GM boundary superimposition and/or PVE Correction. Material and Methods: Six nuclear medicine physicians (three experts, three novices after reader training) blindly and independently evaluated 480 [18F]Florbetaben PET datasets (90-110min p.i.) including 20% duplicates and four modalities: (A) Standard PET images, (B) PET images with superimposed WM/GM boundaries (individual T1 MPRAGE MRI, segmentation in SPM12), (C) PVE-corrected (Van-Cittert deconvolution approach) PET images, (D) combined B and C. Evaluation included binary diagnosis and diagnostic confidence (five-point Likert scale). Results of the clinical consensus board served as standard of truth. Sensitivity, specificity, accuracy, multi-rater Fleiss’ kappa and percentage of agreement for duplicates were assessed for all four modalities. Differences in sensitivity, specificity, accuracy and confidence were tested by paired t-tests. Results: Assessment (A) showed high sensitivity, specificity, accuracy and confidence (97%, 82%, 90%, 81%, respectively). Here, experts and novices did not significantly differ. Assessment (B) decreased sensitivity (-7%, p=0.04) while specificity increased (+10%, p=0.004). Assessment (C) only decreased sensitivity (-6%, p=0.05). Assessment (D) decreased sensitivity (-14%, p=0.002) and increased specificity (+15%, p=0.003). As compared to assessment (A), inter-reader agreement was higher for assessment (B) (0.80, p=5×10-211 vs. 0.76, p=2×10-192). Intra-reader agreement did not relevantly differ between the assessment types (85-90%). Conclusions: Standard visual evaluation of [18F]Florbetaben PET images already has high sensitivity, which cannot be further improved by the applied approaches. However, reliability and at the expense of sensitivity, specificity can be increased by superimposing WM/GM contrast and/or PVE Correction of the PET data. A prospective evaluation of this promising approach is warranted.

Yin Xiaolin - One of the best experts on this subject based on the ideXlab platform.

  • method for comprehensive utilization of red mud phosphogypsum and coal gangue
    2014
    Co-Authors: Yin Xiaolin
    Abstract:

    A method for comprehensive utilization of red mud, phosphogypsum and coal gangue comprises the following steps: red mud, phosphogypsum and coal gangue are used as main original burning Materials, a Correction Material is taken as a secondary original burning Material, a homogeneous moisture Material is prepared through two-stage batching process and is shaped or dried and crushed, and then a clinker product including main ingredients of dicalcium silicate, calcium sulphoaluminate and calcium sulphoferrite is prepared through calcination. The clinker produced by the method can be not only directly sold as a product but also further processed into a cementing Material or product for sale by utilizing the prior art. The method provided by the invention is simple in process and low in investment, the production scale can be either big or small, a rapid hardening early strength clinker produced by the method is wide in use and relatively higher in value, not only are lots of clay resources and non-renewable burning coal saved, but also environmental pollution caused by waste pollutants are effectively reduced, secondary disasters is prevented, and high industrial competitiveness and favorable investment economical efficiency are realized.

Zhao Fengqing - One of the best experts on this subject based on the ideXlab platform.

  • Preparation of Autoclaved Foamed Concrete Block from Fly Ash and Carbide Slag
    EDP Sciences, 2018
    Co-Authors: Tan Xing, Han Fuqiang, Zhao Fengqing
    Abstract:

    To achieve the comprehensive utilization of solid waste and reduce costs, fly ash, carbide slag, and low-clinker cement were used to produce lightweight foamed concrete block. Granulated blast-furnace slag (GBFS) was used as composition Correction Material in the block. The effects of curing temperature and dosage of low-clinker cement on the performance of foamed concrete block were investigated. The optimal Material proportioning is obtained: fly ash 58.5%, carbide slag 20%, GBFS 10%, gypsum 1.5% and low-clinker cement 10%. The proper curing regime is “temperature rising 4h-180°C constant temperature 4h-natural cooling”. The results indicate that the compressive strength of the block reaches 3.55 MPa while the density is 616.9 kg/m3. The performance of the product meets JC/T 1062-2007 (China professional standard of foamed concrete block)

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