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Milton Santamaria - One of the best experts on this subject based on the ideXlab platform.
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Effect of two Corticotomy protocols on periodontal tissue and orthodontic movement.
Journal of applied oral science : revista FOB, 2020Co-Authors: Marcelo Lelis Zuppardo, Milton Santamaria, Camila Lopes Ferreira, Mariellen Longo, Mauro Pedrine Santamaria, Joni Augusto Cirelli, Maria Aparecida Neves JardiniAbstract:Objective To compare two Corticotomy surgical protocols in rats to verify whether they alter conventional orthodontic movement. Methodology Sixty Wistar rats were divided into three groups - orthodontic movement (CG), orthodontic movement and Corticotomy (G1) and orthodontic movement with Corticotomy and decortication (G2) - and euthanized after 7 and 14 days. Tooth movement (mm), bone volume fraction and bone volume ratio to total volume (BV/TV), and bone mineral density (BMD) were evaluated by micro-CT. The total amount of bone was measured in square millimeters and expressed as the percentage of bone area in the histomorphometry. The number of positive TRAP cells and RANK/RANKL/OPG interaction were also investigated. Results Day 14 showed a statistically significant difference in orthodontic tooth movement in CG compared with G1 (7.52 mm; p=0.009) and G2 (7.36 mm; p=0.016). A micro-CT analysis revealed a difference between CG, G1 and G2 regarding BV/TV, with G1 and G2 presenting a lower BV/TV ratio at 14 days (0.77 and 0.73 respectively); we found no statistically significant differences regarding BMD. There was a difference in the total amount of bone in the CG group between 7 and 14 days. At 14 days, CG presented a significantly higher bone percentage than G1 and G2. Regarding TRAP, G2 had more positive cells at 7 and 14 days compared with CG and G1. Conclusion Corticotomy accelerates orthodontic movement. Decortication does not improve Corticotomy efficiency.
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Do electrical current and laser therapies improve bone remodeling during an orthodontic treatment with Corticotomy?
Clinical Oral Investigations, 2019Co-Authors: Ewerton Zaniboni, Leonardo Bagne, Thaís Camargo, Maria Esméria Corezola Amaral, Maira Felonato, Thiago Antônio Moretti Andrade, Gláucia Maria Tech Santos, Guilherme Ferreira Caetano, Marcelo Augusto Marreto Esquisatto, Milton SantamariaAbstract:ObjectivesEvaluate the bone remodeling during orthodontic movement with Corticotomy when submitted to low-intensity electrical stimulation application (microcurrent—MC) and low-level laser therapy (LLLT).Material and methodsOne hundred and fifty Wistar rats were divided into the following 5 groups: (C) submitted to tooth movement; (Cort) tooth movement/Corticotomy; (Cort-L) tooth movement/Corticotomy/laser AsGaAl 808 nm (4.96J/50s); (Cort-Mc) tooth movement/Corticotomy/microcurrent (10 μA/5 min); (Cort-L-Mc) tooth movement/Corticotomy and laser/microcurrent alternated. Inflammation, angiogenesis, and osteogenesis were evaluated in the periodontal ligament (PDL) and alveolar bone on the 7th, 14th, and 21st days of orthodontic movement.ResultsThe quantification of inflammatory infiltrate, angiogenesis and expression of TGF-β1, VEGF, and collagen type I were favorably modulated by the application of therapies such as low-level laser therapy (LLLT), MC, or both combined. However, electrical stimulation increased fibroblasts, osteoclasts and RANK numbers, birefringent collagen fiber organization, and BMP-7 and IL-6 expression.ConclusionsLow-level laser therapy (LLLT) and MC application both improved the process of bone remodeling during orthodontic treatment with Corticotomy. Still, electrical current therapy promoted a more effective tooth displacement but presented expected root resorption similar to all experimental treatments.Clinical relevanceIt is important to know the effects of minimally invasive therapies on cellular and molecular elements involved in the bone remodeling of orthodontic treatment associated with Corticotomy surgery, in order to reduce the adverse effects in the use of this technique and to establish a safer clinical routine.
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Macroscopic and radiographic aspects of orthodontic movement associated with Corticotomy: animal study
Oral and Maxillofacial Surgery, 2019Co-Authors: Marcelo Lelis Zuppardo, Milton Santamaria, Camila Lopes Ferreira, Nicole Berton Moura, Mariellen Longo, Sergio Lucio Pereira Castro Lopes, Mauro Pedrine Santamaria, Maria Aparecida Neves JardiniAbstract:Introduction To quantify the rate of tooth movement in two Corticotomy protocols in an experimental model in rats through macroscopic and radiographic analysis. Methods The animals were divided into three groups: orthodontic movement (CO), orthodontic movement plus Corticotomy surgery (G2), and orthodontic movement and Corticotomy surgery with decorticalization (G3).The euthanasia occurred in 7 and 14 days. The data were statistically analyzed ( p
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Do electrical current and laser therapies improve bone remodeling during an orthodontic treatment with Corticotomy
Clinical oral investigations, 2019Co-Authors: Ewerton Zaniboni, Leonardo Bagne, Maira Felonato, Thiago Antônio Moretti Andrade, Guilherme Ferreira Caetano, Marcelo Augusto Marreto Esquisatto, Thaís Furtado Camargo, Maria Esméria Corezola Do Amaral, Gláucia Maria Tech Dos Santos, Milton SantamariaAbstract:Evaluate the bone remodeling during orthodontic movement with Corticotomy when submitted to low-intensity electrical stimulation application (microcurrent—MC) and low-level laser therapy (LLLT). One hundred and fifty Wistar rats were divided into the following 5 groups: (C) submitted to tooth movement; (Cort) tooth movement/Corticotomy; (Cort-L) tooth movement/Corticotomy/laser AsGaAl 808 nm (4.96J/50s); (Cort-Mc) tooth movement/Corticotomy/microcurrent (10 μA/5 min); (Cort-L-Mc) tooth movement/Corticotomy and laser/microcurrent alternated. Inflammation, angiogenesis, and osteogenesis were evaluated in the periodontal ligament (PDL) and alveolar bone on the 7th, 14th, and 21st days of orthodontic movement. The quantification of inflammatory infiltrate, angiogenesis and expression of TGF-β1, VEGF, and collagen type I were favorably modulated by the application of therapies such as low-level laser therapy (LLLT), MC, or both combined. However, electrical stimulation increased fibroblasts, osteoclasts and RANK numbers, birefringent collagen fiber organization, and BMP-7 and IL-6 expression. Low-level laser therapy (LLLT) and MC application both improved the process of bone remodeling during orthodontic treatment with Corticotomy. Still, electrical current therapy promoted a more effective tooth displacement but presented expected root resorption similar to all experimental treatments. It is important to know the effects of minimally invasive therapies on cellular and molecular elements involved in the bone remodeling of orthodontic treatment associated with Corticotomy surgery, in order to reduce the adverse effects in the use of this technique and to establish a safer clinical routine.
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Macroscopic and radiographic aspects of orthodontic movement associated with Corticotomy: animal study.
Oral and maxillofacial surgery, 2019Co-Authors: Marcelo Lelis Zuppardo, Milton Santamaria, Camila Lopes Ferreira, Nicole Berton Moura, Mariellen Longo, Mauro Pedrine Santamaria, Sérgio Lúcio Pereira De Castro Lopes, Maria Aparecida Neves JardiniAbstract:To quantify the rate of tooth movement in two Corticotomy protocols in an experimental model in rats through macroscopic and radiographic analysis. The animals were divided into three groups: orthodontic movement (CO), orthodontic movement plus Corticotomy surgery (G2), and orthodontic movement and Corticotomy surgery with decorticalization (G3).The euthanasia occurred in 7 and 14 days. The data were statistically analyzed (p
Ewerton Zaniboni - One of the best experts on this subject based on the ideXlab platform.
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Do electrical current and laser therapies improve bone remodeling during an orthodontic treatment with Corticotomy?
Clinical Oral Investigations, 2019Co-Authors: Ewerton Zaniboni, Leonardo Bagne, Thaís Camargo, Maria Esméria Corezola Amaral, Maira Felonato, Thiago Antônio Moretti Andrade, Gláucia Maria Tech Santos, Guilherme Ferreira Caetano, Marcelo Augusto Marreto Esquisatto, Milton SantamariaAbstract:ObjectivesEvaluate the bone remodeling during orthodontic movement with Corticotomy when submitted to low-intensity electrical stimulation application (microcurrent—MC) and low-level laser therapy (LLLT).Material and methodsOne hundred and fifty Wistar rats were divided into the following 5 groups: (C) submitted to tooth movement; (Cort) tooth movement/Corticotomy; (Cort-L) tooth movement/Corticotomy/laser AsGaAl 808 nm (4.96J/50s); (Cort-Mc) tooth movement/Corticotomy/microcurrent (10 μA/5 min); (Cort-L-Mc) tooth movement/Corticotomy and laser/microcurrent alternated. Inflammation, angiogenesis, and osteogenesis were evaluated in the periodontal ligament (PDL) and alveolar bone on the 7th, 14th, and 21st days of orthodontic movement.ResultsThe quantification of inflammatory infiltrate, angiogenesis and expression of TGF-β1, VEGF, and collagen type I were favorably modulated by the application of therapies such as low-level laser therapy (LLLT), MC, or both combined. However, electrical stimulation increased fibroblasts, osteoclasts and RANK numbers, birefringent collagen fiber organization, and BMP-7 and IL-6 expression.ConclusionsLow-level laser therapy (LLLT) and MC application both improved the process of bone remodeling during orthodontic treatment with Corticotomy. Still, electrical current therapy promoted a more effective tooth displacement but presented expected root resorption similar to all experimental treatments.Clinical relevanceIt is important to know the effects of minimally invasive therapies on cellular and molecular elements involved in the bone remodeling of orthodontic treatment associated with Corticotomy surgery, in order to reduce the adverse effects in the use of this technique and to establish a safer clinical routine.
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Do electrical current and laser therapies improve bone remodeling during an orthodontic treatment with Corticotomy
Clinical oral investigations, 2019Co-Authors: Ewerton Zaniboni, Leonardo Bagne, Maira Felonato, Thiago Antônio Moretti Andrade, Guilherme Ferreira Caetano, Marcelo Augusto Marreto Esquisatto, Thaís Furtado Camargo, Maria Esméria Corezola Do Amaral, Gláucia Maria Tech Dos Santos, Milton SantamariaAbstract:Evaluate the bone remodeling during orthodontic movement with Corticotomy when submitted to low-intensity electrical stimulation application (microcurrent—MC) and low-level laser therapy (LLLT). One hundred and fifty Wistar rats were divided into the following 5 groups: (C) submitted to tooth movement; (Cort) tooth movement/Corticotomy; (Cort-L) tooth movement/Corticotomy/laser AsGaAl 808 nm (4.96J/50s); (Cort-Mc) tooth movement/Corticotomy/microcurrent (10 μA/5 min); (Cort-L-Mc) tooth movement/Corticotomy and laser/microcurrent alternated. Inflammation, angiogenesis, and osteogenesis were evaluated in the periodontal ligament (PDL) and alveolar bone on the 7th, 14th, and 21st days of orthodontic movement. The quantification of inflammatory infiltrate, angiogenesis and expression of TGF-β1, VEGF, and collagen type I were favorably modulated by the application of therapies such as low-level laser therapy (LLLT), MC, or both combined. However, electrical stimulation increased fibroblasts, osteoclasts and RANK numbers, birefringent collagen fiber organization, and BMP-7 and IL-6 expression. Low-level laser therapy (LLLT) and MC application both improved the process of bone remodeling during orthodontic treatment with Corticotomy. Still, electrical current therapy promoted a more effective tooth displacement but presented expected root resorption similar to all experimental treatments. It is important to know the effects of minimally invasive therapies on cellular and molecular elements involved in the bone remodeling of orthodontic treatment associated with Corticotomy surgery, in order to reduce the adverse effects in the use of this technique and to establish a safer clinical routine.
Dongliang Zhang - One of the best experts on this subject based on the ideXlab platform.
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three dimensional morphology of alveolar trabecular bone after Corticotomy in rats
Chinese Journal of Orthodontics, 2016Co-Authors: Li Zhuang, Yuling Zhou, Dongliang ZhangAbstract:Objective To explore the metabolic changes of alveolar trabecular bone following the Corticotomy. Methods 10 healthy Wistar rats were selected. The Corticotomy was operated on the mesial and distal alveolar bone of upper left first molars, and the opposite side served as control. The animals were scanned by micro-computed tomography at different time points (Pre, 7 d, 14 d and 42 d). Structural properties of the trabecular bone around the operation zone were analyzed. Results the bone mineral density decreased significantly at 14 d after operation (P<0.05), and then increased to a level which was more than pre-operation at 42 d (P<0.01). The indices of alveolar bone architecture showed a trend of bone loss first then formation in the operation zone. Conclusions After the Corticotomy, bone loss will be observed in the first two weeks, then bone formation increase with time, and the bone will be denser than pre-operation at 42 d. Key words: Corticotomy; alveolar bone; regional acceleration phenomenon
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Three-dimensional morphology of alveolar trabecular bone after Corticotomy in rats
Chinese Journal of Orthodontics, 2016Co-Authors: Li Zhuang, Yuling Zhou, Dongliang ZhangAbstract:Objective To explore the metabolic changes of alveolar trabecular bone following the Corticotomy. Methods 10 healthy Wistar rats were selected. The Corticotomy was operated on the mesial and distal alveolar bone of upper left first molars, and the opposite side served as control. The animals were scanned by micro-computed tomography at different time points (Pre, 7 d, 14 d and 42 d). Structural properties of the trabecular bone around the operation zone were analyzed. Results the bone mineral density decreased significantly at 14 d after operation (P
Maira Felonato - One of the best experts on this subject based on the ideXlab platform.
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Do electrical current and laser therapies improve bone remodeling during an orthodontic treatment with Corticotomy?
Clinical Oral Investigations, 2019Co-Authors: Ewerton Zaniboni, Leonardo Bagne, Thaís Camargo, Maria Esméria Corezola Amaral, Maira Felonato, Thiago Antônio Moretti Andrade, Gláucia Maria Tech Santos, Guilherme Ferreira Caetano, Marcelo Augusto Marreto Esquisatto, Milton SantamariaAbstract:ObjectivesEvaluate the bone remodeling during orthodontic movement with Corticotomy when submitted to low-intensity electrical stimulation application (microcurrent—MC) and low-level laser therapy (LLLT).Material and methodsOne hundred and fifty Wistar rats were divided into the following 5 groups: (C) submitted to tooth movement; (Cort) tooth movement/Corticotomy; (Cort-L) tooth movement/Corticotomy/laser AsGaAl 808 nm (4.96J/50s); (Cort-Mc) tooth movement/Corticotomy/microcurrent (10 μA/5 min); (Cort-L-Mc) tooth movement/Corticotomy and laser/microcurrent alternated. Inflammation, angiogenesis, and osteogenesis were evaluated in the periodontal ligament (PDL) and alveolar bone on the 7th, 14th, and 21st days of orthodontic movement.ResultsThe quantification of inflammatory infiltrate, angiogenesis and expression of TGF-β1, VEGF, and collagen type I were favorably modulated by the application of therapies such as low-level laser therapy (LLLT), MC, or both combined. However, electrical stimulation increased fibroblasts, osteoclasts and RANK numbers, birefringent collagen fiber organization, and BMP-7 and IL-6 expression.ConclusionsLow-level laser therapy (LLLT) and MC application both improved the process of bone remodeling during orthodontic treatment with Corticotomy. Still, electrical current therapy promoted a more effective tooth displacement but presented expected root resorption similar to all experimental treatments.Clinical relevanceIt is important to know the effects of minimally invasive therapies on cellular and molecular elements involved in the bone remodeling of orthodontic treatment associated with Corticotomy surgery, in order to reduce the adverse effects in the use of this technique and to establish a safer clinical routine.
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Do electrical current and laser therapies improve bone remodeling during an orthodontic treatment with Corticotomy
Clinical oral investigations, 2019Co-Authors: Ewerton Zaniboni, Leonardo Bagne, Maira Felonato, Thiago Antônio Moretti Andrade, Guilherme Ferreira Caetano, Marcelo Augusto Marreto Esquisatto, Thaís Furtado Camargo, Maria Esméria Corezola Do Amaral, Gláucia Maria Tech Dos Santos, Milton SantamariaAbstract:Evaluate the bone remodeling during orthodontic movement with Corticotomy when submitted to low-intensity electrical stimulation application (microcurrent—MC) and low-level laser therapy (LLLT). One hundred and fifty Wistar rats were divided into the following 5 groups: (C) submitted to tooth movement; (Cort) tooth movement/Corticotomy; (Cort-L) tooth movement/Corticotomy/laser AsGaAl 808 nm (4.96J/50s); (Cort-Mc) tooth movement/Corticotomy/microcurrent (10 μA/5 min); (Cort-L-Mc) tooth movement/Corticotomy and laser/microcurrent alternated. Inflammation, angiogenesis, and osteogenesis were evaluated in the periodontal ligament (PDL) and alveolar bone on the 7th, 14th, and 21st days of orthodontic movement. The quantification of inflammatory infiltrate, angiogenesis and expression of TGF-β1, VEGF, and collagen type I were favorably modulated by the application of therapies such as low-level laser therapy (LLLT), MC, or both combined. However, electrical stimulation increased fibroblasts, osteoclasts and RANK numbers, birefringent collagen fiber organization, and BMP-7 and IL-6 expression. Low-level laser therapy (LLLT) and MC application both improved the process of bone remodeling during orthodontic treatment with Corticotomy. Still, electrical current therapy promoted a more effective tooth displacement but presented expected root resorption similar to all experimental treatments. It is important to know the effects of minimally invasive therapies on cellular and molecular elements involved in the bone remodeling of orthodontic treatment associated with Corticotomy surgery, in order to reduce the adverse effects in the use of this technique and to establish a safer clinical routine.
Thiago Antônio Moretti Andrade - One of the best experts on this subject based on the ideXlab platform.
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Do electrical current and laser therapies improve bone remodeling during an orthodontic treatment with Corticotomy?
Clinical Oral Investigations, 2019Co-Authors: Ewerton Zaniboni, Leonardo Bagne, Thaís Camargo, Maria Esméria Corezola Amaral, Maira Felonato, Thiago Antônio Moretti Andrade, Gláucia Maria Tech Santos, Guilherme Ferreira Caetano, Marcelo Augusto Marreto Esquisatto, Milton SantamariaAbstract:ObjectivesEvaluate the bone remodeling during orthodontic movement with Corticotomy when submitted to low-intensity electrical stimulation application (microcurrent—MC) and low-level laser therapy (LLLT).Material and methodsOne hundred and fifty Wistar rats were divided into the following 5 groups: (C) submitted to tooth movement; (Cort) tooth movement/Corticotomy; (Cort-L) tooth movement/Corticotomy/laser AsGaAl 808 nm (4.96J/50s); (Cort-Mc) tooth movement/Corticotomy/microcurrent (10 μA/5 min); (Cort-L-Mc) tooth movement/Corticotomy and laser/microcurrent alternated. Inflammation, angiogenesis, and osteogenesis were evaluated in the periodontal ligament (PDL) and alveolar bone on the 7th, 14th, and 21st days of orthodontic movement.ResultsThe quantification of inflammatory infiltrate, angiogenesis and expression of TGF-β1, VEGF, and collagen type I were favorably modulated by the application of therapies such as low-level laser therapy (LLLT), MC, or both combined. However, electrical stimulation increased fibroblasts, osteoclasts and RANK numbers, birefringent collagen fiber organization, and BMP-7 and IL-6 expression.ConclusionsLow-level laser therapy (LLLT) and MC application both improved the process of bone remodeling during orthodontic treatment with Corticotomy. Still, electrical current therapy promoted a more effective tooth displacement but presented expected root resorption similar to all experimental treatments.Clinical relevanceIt is important to know the effects of minimally invasive therapies on cellular and molecular elements involved in the bone remodeling of orthodontic treatment associated with Corticotomy surgery, in order to reduce the adverse effects in the use of this technique and to establish a safer clinical routine.
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Do electrical current and laser therapies improve bone remodeling during an orthodontic treatment with Corticotomy
Clinical oral investigations, 2019Co-Authors: Ewerton Zaniboni, Leonardo Bagne, Maira Felonato, Thiago Antônio Moretti Andrade, Guilherme Ferreira Caetano, Marcelo Augusto Marreto Esquisatto, Thaís Furtado Camargo, Maria Esméria Corezola Do Amaral, Gláucia Maria Tech Dos Santos, Milton SantamariaAbstract:Evaluate the bone remodeling during orthodontic movement with Corticotomy when submitted to low-intensity electrical stimulation application (microcurrent—MC) and low-level laser therapy (LLLT). One hundred and fifty Wistar rats were divided into the following 5 groups: (C) submitted to tooth movement; (Cort) tooth movement/Corticotomy; (Cort-L) tooth movement/Corticotomy/laser AsGaAl 808 nm (4.96J/50s); (Cort-Mc) tooth movement/Corticotomy/microcurrent (10 μA/5 min); (Cort-L-Mc) tooth movement/Corticotomy and laser/microcurrent alternated. Inflammation, angiogenesis, and osteogenesis were evaluated in the periodontal ligament (PDL) and alveolar bone on the 7th, 14th, and 21st days of orthodontic movement. The quantification of inflammatory infiltrate, angiogenesis and expression of TGF-β1, VEGF, and collagen type I were favorably modulated by the application of therapies such as low-level laser therapy (LLLT), MC, or both combined. However, electrical stimulation increased fibroblasts, osteoclasts and RANK numbers, birefringent collagen fiber organization, and BMP-7 and IL-6 expression. Low-level laser therapy (LLLT) and MC application both improved the process of bone remodeling during orthodontic treatment with Corticotomy. Still, electrical current therapy promoted a more effective tooth displacement but presented expected root resorption similar to all experimental treatments. It is important to know the effects of minimally invasive therapies on cellular and molecular elements involved in the bone remodeling of orthodontic treatment associated with Corticotomy surgery, in order to reduce the adverse effects in the use of this technique and to establish a safer clinical routine.
