The Experts below are selected from a list of 62289 Experts worldwide ranked by ideXlab platform
Pramod Kumar - One of the best experts on this subject based on the ideXlab platform.
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Clinical Study Patch Testing in Suspected Allergic Contact Dermatitis to Cosmetics
2020Co-Authors: Pramod Kumar, Rekha PauloseAbstract:Background. Increasing use of Cosmetics has contributed to a rise in the incidence of allergic contact dermatitis (ACD) to Cosmetics. It is estimated that 1-5.4% of the population is sensitized to a cosmetic ingredient. Patch testing helps to confirm the presence of an allergy and to identify the actual allergens which are chemical mixtures of various ingredients. Objectives. The aims of this study are to perform patch testing in suspected ACD to Cosmetics and to identify the most common allergen and cosmetic product causing dermatitis. Methods. Fifty patients with suspected ACD to Cosmetics were patch-tested with 38 antigens of the Indian Cosmetic Series and 12 antigens of the Indian Standard Series. Results. The majority (58%) of patients belonged to the 21-40 years age group. The presence of ACD to Cosmetics was confirmed in 38 (76%) patients. Face creams (20%), hair dyes (14%), and soaps (12%) were the most commonly implicated. The most common allergens identified were gallate mix (40%), cetrimide (28%), and thiomersal (20%). Out of a total of 2531 patches applied, positive reactions were obtained in 3.75%. Conclusion. Incidence of ACD to Cosmetics was greater in females. Face creams and hair dyes were the most common cosmetic products implicated. The principal allergens were gallate mix, cetrimide, and thiomersal
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Clinical Study Patch Testing in Suspected Allergic Contact Dermatitis to Cosmetics
2016Co-Authors: Pramod Kumar, Rekha PauloseAbstract:Copyright © 2014 P. Kumar and R. Paulose. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Increasing use of Cosmetics has contributed to a rise in the incidence of allergic contact dermatitis (ACD) to Cosmetics. It is estimated that 1–5.4 % of the population is sensitized to a cosmetic ingredient. Patch testing helps to confirm the presence of an allergy and to identify the actual allergens which are chemical mixtures of various ingredients.Objectives.The aims of this study are to perform patch testing in suspected ACD to Cosmetics and to identify the most common allergen and cosmetic product causing dermatitis. Methods. Fifty patients with suspected ACD to Cosmetics were patch-tested with 38 antigens of the Indian Cosmetic Series and 12 antigens of the Indian Standard Series. Results. The majority (58%) of patients belonged to the 21–40 years age group. The presence of ACD to Cosmetics was confirmed in 38 (76%) patients. Face creams (20%), hair dyes (14%), and soaps (12%) were the most commonly implicated. The most common allergens identified were gallate mix (40%), cetrimide (28%), and thiomersal (20%). Out of a total of 2531 patches applied, positive reactions were obtained in 3.75%. Conclusion. Incidence of ACD to Cosmetics was greater in females. Face creams and hair dyes were the most common cosmetic products implicated. The principal allergens were gallate mix, cetrimide, and thiomersal. 1
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patch testing in suspected allergic contact dermatitis to Cosmetics
Dermatology Research and Practice, 2014Co-Authors: Pramod Kumar, Rekha PauloseAbstract:Background. Increasing use of Cosmetics has contributed to a rise in the incidence of allergic contact dermatitis (ACD) to Cosmetics. It is estimated that 1–5.4% of the population is sensitized to a cosmetic ingredient. Patch testing helps to confirm the presence of an allergy and to identify the actual allergens which are chemical mixtures of various ingredients. Objectives. The aims of this study are to perform patch testing in suspected ACD to Cosmetics and to identify the most common allergen and cosmetic product causing dermatitis. Methods. Fifty patients with suspected ACD to Cosmetics were patch-tested with 38 antigens of the Indian Cosmetic Series and 12 antigens of the Indian Standard Series. Results. The majority (58%) of patients belonged to the 21–40 years age group. The presence of ACD to Cosmetics was confirmed in 38 (76%) patients. Face creams (20%), hair dyes (14%), and soaps (12%) were the most commonly implicated. The most common allergens identified were gallate mix (40%), cetrimide (28%), and thiomersal (20%). Out of a total of 2531 patches applied, positive reactions were obtained in 3.75%. Conclusion. Incidence of ACD to Cosmetics was greater in females. Face creams and hair dyes were the most common cosmetic products implicated. The principal allergens were gallate mix, cetrimide, and thiomersal.
Rekha Paulose - One of the best experts on this subject based on the ideXlab platform.
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Clinical Study Patch Testing in Suspected Allergic Contact Dermatitis to Cosmetics
2020Co-Authors: Pramod Kumar, Rekha PauloseAbstract:Background. Increasing use of Cosmetics has contributed to a rise in the incidence of allergic contact dermatitis (ACD) to Cosmetics. It is estimated that 1-5.4% of the population is sensitized to a cosmetic ingredient. Patch testing helps to confirm the presence of an allergy and to identify the actual allergens which are chemical mixtures of various ingredients. Objectives. The aims of this study are to perform patch testing in suspected ACD to Cosmetics and to identify the most common allergen and cosmetic product causing dermatitis. Methods. Fifty patients with suspected ACD to Cosmetics were patch-tested with 38 antigens of the Indian Cosmetic Series and 12 antigens of the Indian Standard Series. Results. The majority (58%) of patients belonged to the 21-40 years age group. The presence of ACD to Cosmetics was confirmed in 38 (76%) patients. Face creams (20%), hair dyes (14%), and soaps (12%) were the most commonly implicated. The most common allergens identified were gallate mix (40%), cetrimide (28%), and thiomersal (20%). Out of a total of 2531 patches applied, positive reactions were obtained in 3.75%. Conclusion. Incidence of ACD to Cosmetics was greater in females. Face creams and hair dyes were the most common cosmetic products implicated. The principal allergens were gallate mix, cetrimide, and thiomersal
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Clinical Study Patch Testing in Suspected Allergic Contact Dermatitis to Cosmetics
2016Co-Authors: Pramod Kumar, Rekha PauloseAbstract:Copyright © 2014 P. Kumar and R. Paulose. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Increasing use of Cosmetics has contributed to a rise in the incidence of allergic contact dermatitis (ACD) to Cosmetics. It is estimated that 1–5.4 % of the population is sensitized to a cosmetic ingredient. Patch testing helps to confirm the presence of an allergy and to identify the actual allergens which are chemical mixtures of various ingredients.Objectives.The aims of this study are to perform patch testing in suspected ACD to Cosmetics and to identify the most common allergen and cosmetic product causing dermatitis. Methods. Fifty patients with suspected ACD to Cosmetics were patch-tested with 38 antigens of the Indian Cosmetic Series and 12 antigens of the Indian Standard Series. Results. The majority (58%) of patients belonged to the 21–40 years age group. The presence of ACD to Cosmetics was confirmed in 38 (76%) patients. Face creams (20%), hair dyes (14%), and soaps (12%) were the most commonly implicated. The most common allergens identified were gallate mix (40%), cetrimide (28%), and thiomersal (20%). Out of a total of 2531 patches applied, positive reactions were obtained in 3.75%. Conclusion. Incidence of ACD to Cosmetics was greater in females. Face creams and hair dyes were the most common cosmetic products implicated. The principal allergens were gallate mix, cetrimide, and thiomersal. 1
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patch testing in suspected allergic contact dermatitis to Cosmetics
Dermatology Research and Practice, 2014Co-Authors: Pramod Kumar, Rekha PauloseAbstract:Background. Increasing use of Cosmetics has contributed to a rise in the incidence of allergic contact dermatitis (ACD) to Cosmetics. It is estimated that 1–5.4% of the population is sensitized to a cosmetic ingredient. Patch testing helps to confirm the presence of an allergy and to identify the actual allergens which are chemical mixtures of various ingredients. Objectives. The aims of this study are to perform patch testing in suspected ACD to Cosmetics and to identify the most common allergen and cosmetic product causing dermatitis. Methods. Fifty patients with suspected ACD to Cosmetics were patch-tested with 38 antigens of the Indian Cosmetic Series and 12 antigens of the Indian Standard Series. Results. The majority (58%) of patients belonged to the 21–40 years age group. The presence of ACD to Cosmetics was confirmed in 38 (76%) patients. Face creams (20%), hair dyes (14%), and soaps (12%) were the most commonly implicated. The most common allergens identified were gallate mix (40%), cetrimide (28%), and thiomersal (20%). Out of a total of 2531 patches applied, positive reactions were obtained in 3.75%. Conclusion. Incidence of ACD to Cosmetics was greater in females. Face creams and hair dyes were the most common cosmetic products implicated. The principal allergens were gallate mix, cetrimide, and thiomersal.
Annette Kirst - One of the best experts on this subject based on the ideXlab platform.
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a tiered approach to the use of alternatives to animal testing for the safety assessment of Cosmetics genotoxicity a colipa analysis
Regulatory Toxicology and Pharmacology, 2010Co-Authors: Stefan Pfuhler, Carsten Goebel, Eric K Dufour, Daisuke Araki, Margit Costabelfarkas, Annette Kirst, Marilyn J Aardema, Norbert Dr Banduhn, Rolf Fautz, James HarveyAbstract:For the assessment of genotoxic effects of cosmetic ingredients, a number of well-established and regulatory accepted in vitro assays are in place. A caveat to the use of these assays is their relatively low specificity and high rate of false or misleading positive results. Due to the 7th amendment to the EU Cosmetics Directive ban on in vivo genotoxicity testing for Cosmetics that was enacted March 2009, it is no longer possible to conduct follow-up in vivo genotoxicity tests for cosmetic ingredients positive in in vitro genotoxicity tests to further assess the relevance of the in vitro findings. COLIPA, the European Cosmetics Association, has initiated a research programme to improve existing and develop new in vitro methods. A COLIPA workshop was held in Brussels in April 2008 to analyse the best possible use of available methods and approaches to enable a sound assessment of the genotoxic hazard of cosmetic ingredients. Common approaches of cosmetic companies are described, with recommendations for evaluating in vitro genotoxins using non-animal approaches. A weight of evidence approach was employed to set up a decision-tree for the integration of alternative methods into tiered testing strategies.
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a tiered approach to the use of alternatives to animal testing for the safety assessment of Cosmetics eye irritation
Regulatory Toxicology and Pharmacology, 2009Co-Authors: Martin Macfarlane, Penny Jones, Carsten Goebel, Eric K Dufour, Joanna Rowland, Daisuke Araki, Margit Costabelfarkas, Nicola J Hewitt, Jalila Hibatallah, Annette KirstAbstract:The need for alternative approaches to replace the in vivo rabbit Draize eye test for evaluation of eye irritation of cosmetic ingredients has been recognised by the Cosmetics industry for many years. Extensive research has lead to the development of several assays, some of which have undergone formal validation. Even though, to date, no single in vitro assay has been validated as a full replacement for the rabbit Draize eye test, organotypic assays are accepted for specific and limited regulatory purposes. Although not formally validated, several other in vitro models have been used for over a decade by the Cosmetics industry as valuable tools in a weight of evidence approach for the safety assessment of ingredients and finished products. In light of the deadlines established in the EU Cosmetics Directive for cessation of animal testing for cosmetic ingredients, a COLIPA scientific meeting was held in Brussels on 30th January, 2008 to review the use of alternative approaches and to set up a decision-tree approach for their integration into tiered testing strategies for hazard and safety assessment of cosmetic ingredients and their use in products. Furthermore, recommendations are given on how remaining data gaps and research needs can be addressed.
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a tiered approach to the use of alternatives to animal testing for the safety assessment of Cosmetics skin irritation
Regulatory Toxicology and Pharmacology, 2009Co-Authors: Martin Macfarlane, Penny Jones, Carsten Goebel, Eric K Dufour, Joanna Rowland, Daisuke Araki, Margit Costabelfarkas, Nicola J Hewitt, Jalila Hibatallah, Annette KirstAbstract:The need for alternative approaches to replace the in vivo rabbit Draize eye test for evaluation of eye irritation of cosmetic ingredients has been recognised by the Cosmetics industry for many years. Extensive research has lead to the development of several assays, some of which have undergone formal validation. Even though, to date, no single in vitro assay has been validated as a full replacement for the rabbit Draize eye test, organotypic assays are accepted for specific and limited regulatory purposes. Although not formally validated, several other in vitro models have been used for over a decade by the Cosmetics industry as valuable tools in a weight of evidence approach for the safety assessment of ingredients and finished products. In light of the deadlines established in the EU Cosmetics Directive for cessation of animal testing for cosmetic ingredients, a COLIPA scientific meeting was held in Brussels on 30th January, 2008 to review the use of alternative approaches and to set up a decision-tree approach for their integration into tiered testing strategies for hazard and safety assessment of cosmetic ingredients and their use in products. Furthermore, recommendations are given on how remaining data gaps and research needs can be addressed.
Dusinska Maria - One of the best experts on this subject based on the ideXlab platform.
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The way forward for assessing the human health safety of Cosmetics in the EU - Workshop proceedings
'Elsevier BV', 2020Co-Authors: Rogiers Vera, Coenraads, Pieter Jan, Benfenati Emilio, Bernauer Ulrike, Bodin Laurent, Carmichael Paul, Chaudhry Qasim, Cronin, Mark T.d., Dent Matthew, Dusinska MariaAbstract:From Elsevier via Jisc Publications RouterHistory: accepted 2020-02-25, epub 2020-03-09, issue date 2020-04-30Article version: AMPublication status: PublishedAbstract Although the need for non-animal alternatives has been well recognised for the human health hazard assessment of chemicals in general, it has become especially pressing for cosmetic ingredients due to the full implementation of testing and marketing bans on animal testing under the European Cosmetics Regulation. This means that for the safety assessment of Cosmetics, the necessary safety data for both the ingredients and the finished product can be drawn from validated (or scientifically-valid), so-called “Replacement methods”. In view of the challenges for safety assessment without recourse to animal test data, the Methodology Working Group of the Scientific Committee on Consumer Safety organised a workshop in February 2019 to discuss the key issues in regard to the use of animal-free alternative methods for the safety evaluation of cosmetic ingredients. This perspective article summarises the outcomes of this workshop and reflects on the state-of-the-art and possible way forward for the safety assessment of cosmetic ingredients for which no experimental animal data exist. The use and optimisation of “New Approach Methodology” that could be useful tools in the context of the “Next Generation Risk Assessment” and the strategic framework for safety assessment of Cosmetics were discussed in depth
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The way forward for assessing the human health safety of Cosmetics in the EU - Workshop Proceedings
'Elsevier BV', 2020Co-Authors: Rogiers Vera, Coenraads, Pieter Jan, Benfenati Emilio, Bernauer Ulrike, Bodin Laurent, Carmichael Paul, Chaudhry Qasim, Dent Matthew, Cronin Mark, Dusinska MariaAbstract:Although the need for non-animal alternatives has been well recognised for the human health hazard assessment of chemicals in general, it has become especially pressing for cosmetic ingredients due to the full implementation of testing and marketing bans on animal testing under the European Cosmetic Regulation. This means that for the safety assessment of Cosmetics, the necessary safety data for both the ingredients and the finished product can be drawn from validated (or scientifically-valid), so-called “Replacement methods”. In view of the challenges for safety assessment without recourse to animal test data, the Methodology Working Group of the Scientific Committee on Consumer Safety organised a workshop in February 2019 to discuss the key issues in regard to the use of animal-free alternative methods for the safety evaluation of cosmetic ingredients. This perspective article summarises the outcomes of this workshop and reflects on the state-of-the-art and possible way forward for the safety assessment of cosmetic ingredients for which no experimental animal data exist. The use and optimisation of “New Approach Methodologies” that could be useful tools in the context of the “Next Generation Risk Assessment and the strategic framework for safety assessment of Cosmetics were discussed in depth.JRC.F.3-Chemicals Safety and Alternative Method
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The way forward for assessing the human health safety of Cosmetics in the EU - Workshop proceedings.
'Elsevier BV', 2020Co-Authors: Rogiers Vera, Coenraads, Pieter Jan, Benfenati Emilio, Bernauer Ulrike, Bodin Laurent, Carmichael Paul, Chaudhry Qasim, Dent Matthew, Cronin, Mark T D, Dusinska MariaAbstract:From PubMed via Jisc Publications RouterHistory: received 2020-01-31, revised 2020-02-21, accepted 2020-02-25Publication status: aheadofprintAlthough the need for non-animal alternatives has been well recognised for the human health hazard assessment of chemicals in general, it has become especially pressing for cosmetic ingredients due to the full implementation of testing and marketing bans on animal testing under the European Cosmetics Regulation. This means that for the safety assessment of Cosmetics, the necessary safety data for both the ingredients and the finished product can be drawn from validated (or scientifically-valid), so-called "Replacement methods". In view of the challenges for safety assessment without recourse to animal test data, the Methodology Working Group of the Scientific Committee on Consumer Safety organised a workshop in February 2019 to discuss the key issues in regard to the use of animal-free alternative methods for the safety evaluation of cosmetic ingredients. This perspective article summarises the outcomes of this workshop and reflects on the state-of-the-art and possible way forward for the safety assessment of cosmetic ingredients for which no experimental animal data exist. The use and optimisation of "New Approach Methodology" that could be useful tools in the context of the "Next Generation Risk Assessment" and the strategic framework for safety assessment of Cosmetics were discussed in depth. [Abstract copyright: Copyright © 2020 Elsevier B.V. All rights reserved.
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The way forward for assessing the human health safety of Cosmetics in the eu workshop proceedings
'Elsevier BV', 2020Co-Authors: Rogiers Vera, Coenraads, Pieter Jan, Benfenati Emilio, Bernauer Ulrike, Bodin Laurent, Carmichael Paul, Chaudhry Qasim, Cronin, Mark T.d., Dent Matthew, Dusinska MariaAbstract:From Elsevier via Jisc Publications RouterHistory: accepted 2020-02-25, issue date 2020-02-28Article version: AMPublication status: AcceptedAbstract Although the need for non-animal alternatives has been well recognised for the human health hazard assessment of chemicals in general, it has become especially pressing for cosmetic ingredients due to the full implementation of testing and marketing bans on animal testing under the European Cosmetic Regulation. This means that for the safety assessment of Cosmetics, the necessary safety data for both the ingredients and the finished product can be drawn from validated (or scientifically-valid), so-called “Replacement methods”. In view of the challenges for safety assessment without recourse to animal test data, the Methodology Working Group of the Scientific Committee on Consumer Safety organised a workshop in February 2019 to discuss the key issues in regard to the use of animal-free alternative methods for the safety evaluation of cosmetic ingredients. This perspective article summarises the outcomes of this workshop and reflects on the state-of-the-art and possible way forward for the safety assessment of cosmetic ingredients for which no experimental animal data exist. The use and optimisation of “New Approach Methodologies” that could be useful tools in the context of the “Next Generation Risk Assessment and the strategic framework for safety assessment of Cosmetics were discussed in depth
Fabien Durif - One of the best experts on this subject based on the ideXlab platform.
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not tested on animals how consumers react to cruelty free Cosmetics proposed by manufacturers and retailers
International Journal of Retail & Distribution Management, 2021Co-Authors: Cindy G Grappe, Cindy Lombart, Didier Louis, Fabien DurifAbstract:Animal welfare is increasingly favoured by consumers in their choice of food and cosmetic products, proposed by manufacturers and retailers. This study aims to investigate the impact of the “not tested on animals” claim on consumers' attitude and behavioural intention towards a cosmetic product through an enriched version of Ajzen's theory of planned behaviour.,A between-subjects design has been used. 450 participants were recruited through the social network of a Cosmetics and personal hygiene brand in Quebec, Canada, and answered a questionnaire. They were randomly assigned to either a manipulation group (n = 226) or a control group (n = 224). Data were analysed with partial least squares structural equation modelling.,This study shows that external (credibility and attitude towards marketing claims) and internal psychological variables (subjective norms and altruistic concerns with animal welfare) influence attitude towards and purchase intention of “not tested on animals” personal care products. More egotistic concerns, such as personal appearance, also explain the formation of attitude towards cruelty-free Cosmetics.,This research supplements Ajzen's original model with internal psychological (individuals' concerns with animal welfare and personal appearance) and external (general credibility of cosmetic products claims, credibility of the “not tested on animals” claim and attitude towards this claim) variables. These variables, as suggested by previous research on Cosmetics and their claims, improve the understanding of consumer attitude and purchase behaviour patterns.,The study's findings point out the role of companies to increase consumers' knowledge on the significance and transparency of their messages, notably the “not tested on animals” claim. They also stress that policymakers in regions where regulation is unclear should at least punish untruthful communication pertaining to animal testing in cosmetic and personal care products.,Prior studies on cosmetic products did not investigate the difference of consumer attitude formation towards cruelty-free products compared to conventional cosmetic products. Consequently, this research shows that the construction of attitude towards cruelty-free products highly differs from conventional personal care.
