The Experts below are selected from a list of 12624 Experts worldwide ranked by ideXlab platform
R. S. Eisenberg - One of the best experts on this subject based on the ideXlab platform.
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Coulomb Blockade model of permeation and selectivity in biological ion channels
New Journal of Physics, 2015Co-Authors: Kh. I. Kaufman, P. V. E. Mcclintock, R. S. EisenbergAbstract:Biological ion channels are protein nanotubes embedded in, and passing through, the bilipid membranes of cells. Physiologically, they are of crucial importance in that they allow ions to pass into and out of cells, fast and efficiently, though in a highly selective way. Here we show that the conduction and selectivity of calcium/sodium ion channels can be described in terms of ionic Coulomb Blockade in a simplified electrostatic and Brownian dynamics model of the channel. The Coulomb Blockade phenomenon arises from the discreteness of electrical charge, the strong electrostatic interaction, and an electrostatic exclusion principle. The model predicts a periodic pattern of Ca2+ conduction versus the fixed charge Qf at the selectivity filter (conduction bands) with a period equal to the ionic charge. It thus provides provisional explanations of some observed and modelled conduction and valence selectivity phenomena, including the anomalous mole fraction effect and the calcium conduction bands. Ionic Coulomb Blockade and resonant conduction are similar to electronic Coulomb Blockade and resonant tunnelling in quantum dots. The same considerations may also be applicable to other kinds of channel, as well as to charged artificial nanopores.
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Coulomb Blockade oscillations in biological ion channels
2015 International Conference on Noise and Fluctuations (ICNF), 2015Co-Authors: Kh. I. Kaufman, W. Gibby, D. G. Luchinsky, P. V. E. Mcclintock, R. S. EisenbergAbstract:The conduction and selectivity of calcium/sodium ion channels are described in terms of ionic Coulomb Blockade, a phenomenon based on charge discreteness, an electrostatic exclusion principle, and stochastic ion motion through the channel. This novel approach provides a unified explanation of numerous observed and modelled conductance and selectivity phenomena, including the anomalous mole fraction effect and discrete conduction bands. Ionic Coulomb Blockade and resonant conduction are similar to electronic Coulomb Blockade and resonant tunnelling in quantum dots. The model is equally applicable to other nanopores.
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Ionic Coulomb Blockade and Resonant Conduction in Biological Ion Channels
arXiv: Biological Physics, 2014Co-Authors: I. Kh. Kaufman, P. V. E. Mcclintock, R. S. EisenbergAbstract:The conduction and selectivity of calcium/sodium ion channels are described in terms of ionic Coulomb Blockade, a phenomenon based on charge discreteness and an electrostatic model of an ion channel. This novel approach provides a unified explanation of numerous observed and modelled conductance and selectivity phenomena, including the anomalous mole fraction effect and discrete conduction bands. Ionic Coulomb Blockade and resonant conduction are similar to electronic Coulomb Blockade and resonant tunnelling in quantum dots. The model is equally applicable to other nanopores.
Bradley E. Layton - One of the best experts on this subject based on the ideXlab platform.
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The Effect of Deformation on Room Temperature Coulomb Blockade using Conductive Carbon Nanotubes
2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2007Co-Authors: Benjamin Legum, Ryan Cooper, Davide Mattia, Yury Gogotsi, Bradley E. LaytonAbstract:We report fluctuations in resistivity and the manifestation of Coulomb Blockade phenomena of conductive multiwalled carbon nanotubes under buckling loads. Individual nanotubes were suspended and soldered between two indium-dipped tungsten probe tips. Using the electrical connection between the probes and the nanotube, electrical measurements were taken with the tube straight (unstrained) and bent (strained). Typical resistances were in the 10 GOmega range with resistivities in the 15 to 30 Omega-m range within the Coulomb Blockade region of -1.0 to -0.4 V. Coulomb Blockade, or electron tunneling events, appeared to occur at one of the contact points. This effect was diminished or lost once the carbon weld was broken.
Yuki Sato - One of the best experts on this subject based on the ideXlab platform.
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Coulomb Blockade in a single tunnel junction directly connected to a multiwalled carbon nanotube
Applied Physics Letters, 2000Co-Authors: J Haruyama, Izumi Takesue, Yuki SatoAbstract:We report on Coulomb Blockade in a single tunnel junction directly connected to a multiwalled carbon nanotube (MWNT) by utilizing a nanoporous alumina film. The MWNT exhibits a weak localization effect with strong spin flip scattering. Experimental results and analysis suggest that a high-impedance external environment caused by the weak localization in the MWNT can yield Coulomb Blockade, in accordance with phase correlation theory in a single junction system. It is also revealed that the Coulomb Blockade is very sensitive to phase modulation in the MWNT, which also acts as a high-impedance transmission line.
Massimiliano Di Ventra - One of the best experts on this subject based on the ideXlab platform.
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Surface effects on ionic Coulomb Blockade in nanometer-size pores
Nanotechnology, 2017Co-Authors: Hiroya Tanaka, Hideo Iizuka, Yuriy V. Pershin, Massimiliano Di VentraAbstract:Ionic Coulomb Blockade in nanopores is a phenomenon that shares some similarities but also differences with its electronic counterpart. Here, we investigate this phenomenon extensively using all-atom molecular dynamics of ionic transport through nanopores of about one nanometer in diameter and up to several nanometers in length. Our goal is to better understand the role of atomic roughness and structure of the pore walls in the ionic Coulomb Blockade. Our numerical results reveal the following general trends. First, the nanopore selectivity changes with its diameter, and the nanopore position in the membrane influences the current strength. Second, the ionic transport through the nanopore takes place in a hopping-like fashion over a set of discretized states caused by local electric fields due to membrane atoms. In some cases, this creates a slow-varying 'crystal-like' structure of ions inside the nanopore. Third, while at a given voltage, the resistance of the nanopore depends on its length, the slope of this dependence appears to be independent of the molarity of ions. An effective kinetic model that captures the ionic Coulomb Blockade behavior observed in MD simulations is formulated.
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observation of ionic Coulomb Blockade in nanopores
Nature Materials, 2016Co-Authors: Jiandong Feng, Michael Graf, Dumitru Dumcenco, Massimiliano Di Ventra, Aleksandra RadenovicAbstract:Ionic Coulomb Blockade—the ionic counterpart of the electronic Coulomb Blockade—has been observed in a single subnanometre MoS2 pore junction.
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Ionic Coulomb Blockade in nanopores
Journal of Physics: Condensed Matter, 2013Co-Authors: Matt Krems, Massimiliano Di VentraAbstract:An understanding of the dynamics of ions in nanopores is essential for applications ranging from single-molecule detection to DNA sequencing. We show both analytically and by means of molecular dynamics simulations that under specific conditions ion–ion interactions in nanopores lead to the phenomenon of ionic Coulomb Blockade, namely the build up of ions inside a nanopore with specific capacitance impeding the flow of additional ions due to Coulomb repulsion. This is the counterpart of electronic Coulomb Blockade observed in mesoscopic systems. We discuss the analogies with and differences from the electronic case as well as experimental situations in which this phenomenon could be detected.
P. V. E. Mcclintock - One of the best experts on this subject based on the ideXlab platform.
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Nanopores: Ionic Coulomb Blockade.
Nature Materials, 2016Co-Authors: I. Kaufman, P. V. E. McclintockAbstract:Classical ionic conduction through an inorganic monolayer nanopore is analogous to the quantum-mechanical phenomenon of electronic Coulomb Blockade in quantum dots.
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Coulomb Blockade model of permeation and selectivity in biological ion channels
New Journal of Physics, 2015Co-Authors: Kh. I. Kaufman, P. V. E. Mcclintock, R. S. EisenbergAbstract:Biological ion channels are protein nanotubes embedded in, and passing through, the bilipid membranes of cells. Physiologically, they are of crucial importance in that they allow ions to pass into and out of cells, fast and efficiently, though in a highly selective way. Here we show that the conduction and selectivity of calcium/sodium ion channels can be described in terms of ionic Coulomb Blockade in a simplified electrostatic and Brownian dynamics model of the channel. The Coulomb Blockade phenomenon arises from the discreteness of electrical charge, the strong electrostatic interaction, and an electrostatic exclusion principle. The model predicts a periodic pattern of Ca2+ conduction versus the fixed charge Qf at the selectivity filter (conduction bands) with a period equal to the ionic charge. It thus provides provisional explanations of some observed and modelled conduction and valence selectivity phenomena, including the anomalous mole fraction effect and the calcium conduction bands. Ionic Coulomb Blockade and resonant conduction are similar to electronic Coulomb Blockade and resonant tunnelling in quantum dots. The same considerations may also be applicable to other kinds of channel, as well as to charged artificial nanopores.
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Coulomb Blockade oscillations in biological ion channels
2015 International Conference on Noise and Fluctuations (ICNF), 2015Co-Authors: Kh. I. Kaufman, W. Gibby, D. G. Luchinsky, P. V. E. Mcclintock, R. S. EisenbergAbstract:The conduction and selectivity of calcium/sodium ion channels are described in terms of ionic Coulomb Blockade, a phenomenon based on charge discreteness, an electrostatic exclusion principle, and stochastic ion motion through the channel. This novel approach provides a unified explanation of numerous observed and modelled conductance and selectivity phenomena, including the anomalous mole fraction effect and discrete conduction bands. Ionic Coulomb Blockade and resonant conduction are similar to electronic Coulomb Blockade and resonant tunnelling in quantum dots. The model is equally applicable to other nanopores.
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Ionic Coulomb Blockade and Resonant Conduction in Biological Ion Channels
arXiv: Biological Physics, 2014Co-Authors: I. Kh. Kaufman, P. V. E. Mcclintock, R. S. EisenbergAbstract:The conduction and selectivity of calcium/sodium ion channels are described in terms of ionic Coulomb Blockade, a phenomenon based on charge discreteness and an electrostatic model of an ion channel. This novel approach provides a unified explanation of numerous observed and modelled conductance and selectivity phenomena, including the anomalous mole fraction effect and discrete conduction bands. Ionic Coulomb Blockade and resonant conduction are similar to electronic Coulomb Blockade and resonant tunnelling in quantum dots. The model is equally applicable to other nanopores.
