The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Therese Popowkraupp - One of the best experts on this subject based on the ideXlab platform.
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single versus dual respiratory virus infections in hospitalized infants impact on clinical Course of Disease and interferon gamma response
Pediatric Infectious Disease Journal, 2005Co-Authors: Judith H Aberle, Stephan W Aberle, Elisabeth Pracher, Hanspeter Hutter, Michael Kundi, Therese PopowkrauppAbstract:Background:Dual respiratory viral infections are frequently associated with lower respiratory tract illness in infants. This study aimed to determine the impact of a dual respiratory viral infection on specific aspects of the infant's immune response and the clinical Course of illness.Methods:A pros
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screening for possible failure of herpes simplex virus pcr in cerebrospinal fluid for the diagnosis of herpes simplex encephalitis
Journal of Medical Virology, 2001Co-Authors: Elisabeth Puchhammerstockl, Michael Kundi, Therese Popowkraupp, Elisabeth Presterl, Cornelia Croy, Stefan W Aberle, H Hofmann, Ursula Wenninger, Irene GodlAbstract:The objectives of this study were to evaluate the reliability of herpes simplex virus (HSV) PCR testing in cerebrospinal fluid (CSF) for the detection of herpes simplex encephalitis. This was done by examining retrospectively the clinical follow-up of a large group of patients tested routinely by HSV-PCR. In addition, an attempt was made to assess the incidence of herpes simplex encephalitis in a central European population. CSF samples from 1,427 patients from all Vienna hospitals were submitted for HSV-PCR testing during a period of 4 years and 8 months. Herpes simplex encephalitis was detected by PCR in 12 cases and by serological methods in one additional patient. Retrospective analysis of the Course of Disease, which was possible in 799 PCR-negative patients, led to the identification of three additional cases in which herpes simplex encephalitis appears to have occurred despite negative PCR results. Failure of the PCR in these patients is most likely due to the time of obtaining CSF during the Course of Disease. A high specificity of the assay was demonstrated by the lack of false positive results in any of the 708 cases in which other causes for the neurological symptoms had been identified in the follow-up. The incidence of herpes simplex encephalitis in the population of Vienna was between 1 case/469,000–577,000 individuals/year. The highest annual incidence was detected in the age group between 3 months and 3 years, which, however, could not be confirmed statistically. J. Med. Virol. 64:531–536, 2001. © 2001 Wiley-Liss, Inc.
Marianne Wallenius - One of the best experts on this subject based on the ideXlab platform.
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Disease activity during pregnancy and the first year postpartum in women with systemic lupus erythematosus
Arthritis Care and Research, 2017Co-Authors: Carina Gotestam Skorpen, Ingemargrethe Gilboe, Johan F Skomsvoll, Oyvind Palm, Hege Svean Koksvik, Stian Lydersen, B Jakobsen, Kjell A Salvesen, Marianne WalleniusAbstract:Objectives: Disease activity measured by validated methods has been sparsely examined during and after pregnancy in women with systemic lupus erythematosus (SLE). The aim of this study was to describe the longitudinal Course of Disease activity during pregnancy and the first year postpartum using the Lupus Activity Index in Pregnancy (LAI-P). Methods: RevNatus is a nationwide Norwegian prospective observational register including women diagnosed with inflammatory rheumatic Diseases. LAI-P is a modified version of Lupus Activity Index (LAI), with a good ability to assess Disease activity in pregnant women with SLE. These indexes were used to assess Disease activity at six visits (1st, 2nd and 3rd trimester and at 6 weeks, 6 months and 12 months postpartum). The longitudinal Course of Disease activity was analyzed using an ordinal logistic mixed model. Results: A total of 757 visits in 145 pregnancies in women with SLE were included in the analysis. More than half (51.6%) of the Disease activity scores indicated remission and only 6.3% indicated moderate Disease activity. The model showed a statistically significant and clinically relevant change in Disease activity over time, and a higher Disease activity 6 and 12 months postpartum compared to the 3rd trimester and 6 weeks postpartum. Conclusion: The majority of women had low or no Disease activity at conception and during pregnancy, with higher Disease activity at 6 and 12 months after delivery. This points to the importance of tight Disease control not only before and during pregnancy, but also in the first year postpartum. This article is protected by copyright. All rights reserved.
Michael Kundi - One of the best experts on this subject based on the ideXlab platform.
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single versus dual respiratory virus infections in hospitalized infants impact on clinical Course of Disease and interferon gamma response
Pediatric Infectious Disease Journal, 2005Co-Authors: Judith H Aberle, Stephan W Aberle, Elisabeth Pracher, Hanspeter Hutter, Michael Kundi, Therese PopowkrauppAbstract:Background:Dual respiratory viral infections are frequently associated with lower respiratory tract illness in infants. This study aimed to determine the impact of a dual respiratory viral infection on specific aspects of the infant's immune response and the clinical Course of illness.Methods:A pros
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screening for possible failure of herpes simplex virus pcr in cerebrospinal fluid for the diagnosis of herpes simplex encephalitis
Journal of Medical Virology, 2001Co-Authors: Elisabeth Puchhammerstockl, Michael Kundi, Therese Popowkraupp, Elisabeth Presterl, Cornelia Croy, Stefan W Aberle, H Hofmann, Ursula Wenninger, Irene GodlAbstract:The objectives of this study were to evaluate the reliability of herpes simplex virus (HSV) PCR testing in cerebrospinal fluid (CSF) for the detection of herpes simplex encephalitis. This was done by examining retrospectively the clinical follow-up of a large group of patients tested routinely by HSV-PCR. In addition, an attempt was made to assess the incidence of herpes simplex encephalitis in a central European population. CSF samples from 1,427 patients from all Vienna hospitals were submitted for HSV-PCR testing during a period of 4 years and 8 months. Herpes simplex encephalitis was detected by PCR in 12 cases and by serological methods in one additional patient. Retrospective analysis of the Course of Disease, which was possible in 799 PCR-negative patients, led to the identification of three additional cases in which herpes simplex encephalitis appears to have occurred despite negative PCR results. Failure of the PCR in these patients is most likely due to the time of obtaining CSF during the Course of Disease. A high specificity of the assay was demonstrated by the lack of false positive results in any of the 708 cases in which other causes for the neurological symptoms had been identified in the follow-up. The incidence of herpes simplex encephalitis in the population of Vienna was between 1 case/469,000–577,000 individuals/year. The highest annual incidence was detected in the age group between 3 months and 3 years, which, however, could not be confirmed statistically. J. Med. Virol. 64:531–536, 2001. © 2001 Wiley-Liss, Inc.
Carina Gotestam Skorpen - One of the best experts on this subject based on the ideXlab platform.
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Disease activity during pregnancy and the first year postpartum in women with systemic lupus erythematosus
Arthritis Care and Research, 2017Co-Authors: Carina Gotestam Skorpen, Ingemargrethe Gilboe, Johan F Skomsvoll, Oyvind Palm, Hege Svean Koksvik, Stian Lydersen, B Jakobsen, Kjell A Salvesen, Marianne WalleniusAbstract:Objectives: Disease activity measured by validated methods has been sparsely examined during and after pregnancy in women with systemic lupus erythematosus (SLE). The aim of this study was to describe the longitudinal Course of Disease activity during pregnancy and the first year postpartum using the Lupus Activity Index in Pregnancy (LAI-P). Methods: RevNatus is a nationwide Norwegian prospective observational register including women diagnosed with inflammatory rheumatic Diseases. LAI-P is a modified version of Lupus Activity Index (LAI), with a good ability to assess Disease activity in pregnant women with SLE. These indexes were used to assess Disease activity at six visits (1st, 2nd and 3rd trimester and at 6 weeks, 6 months and 12 months postpartum). The longitudinal Course of Disease activity was analyzed using an ordinal logistic mixed model. Results: A total of 757 visits in 145 pregnancies in women with SLE were included in the analysis. More than half (51.6%) of the Disease activity scores indicated remission and only 6.3% indicated moderate Disease activity. The model showed a statistically significant and clinically relevant change in Disease activity over time, and a higher Disease activity 6 and 12 months postpartum compared to the 3rd trimester and 6 weeks postpartum. Conclusion: The majority of women had low or no Disease activity at conception and during pregnancy, with higher Disease activity at 6 and 12 months after delivery. This points to the importance of tight Disease control not only before and during pregnancy, but also in the first year postpartum. This article is protected by copyright. All rights reserved.
George F Reed - One of the best experts on this subject based on the ideXlab platform.
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epidemiology and Course of Disease in childhood uveitis
Ophthalmology, 2009Co-Authors: Janine A Smith, F Mackensen, Nida H Sen, Julie F Leigh, Angela S Watkins, Dmitry Pyatetsky, Howard H Tessler, Robert B Nussenblatt, James T Rosenbaum, George F ReedAbstract:Purpose To describe the Disease characteristics and visual outcome of pediatric uveitis. Design Retrospective, longitudinal observation. Participants Five hundred twenty-seven pediatric uveitis patients from the National Eye Institute, University of Illinois, Chicago, and Oregon Health Sciences University. Methods Retrospective chart review. Main Outcome Measures Demographics, uveitis Disease characteristics, complications, treatments, and visual outcomes were determined at baseline and at 1-, 3-, 5-, and 10-year time points. Results The patient population was 54% female; 62.4% white, 12.5% black, 2.7% Asian, 2.1% multiracial, and 14.61% Hispanic. Median age at diagnosis was 9.4 years. The leading diagnoses were idiopathic uveitis (28.8%), juvenile idiopathic arthritis-associated uveitis (20.9%), and pars planitis (17.1%). Insidious onset (58%) and persistent duration (75.3%) were most common. Anterior uveitis was predominant (44.6%). Complications were frequent, and cystoid macular edema (odds ratio [OR] 2.94; P = 0.006) and hypotony (OR, 4.54; P = 0.026) had the most significant visual impact. Ocular surgery was performed in 18.9% of patients. The prevalence of legal blindness was 9.23% at baseline, 6.52% at 1 year, 3.17% at 3 years, 15.15% at 5 years, and 7.69% at 10 years. Posterior uveitis and panuveitis had more severe vision loss. Hispanic ethnicity was associated with a higher prevalence of infectious uveitis and vision loss at baseline. Conclusions The rate and spectrum of vision threatening complications of pediatric uveitis are significant. Prospective studies using standard outcome measures and including diverse populations are needed to identify children most at risk. Financial Disclosure(s) The authors have no proprietary or commercial interest in any of the materials discussed in this article.
