The Experts below are selected from a list of 6777 Experts worldwide ranked by ideXlab platform
Lijin Dong - One of the best experts on this subject based on the ideXlab platform.
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miCrostructure and stress corrosion Cracking of a sa508 309l 308l 316l dissimilar metal weld joint in primary pressurized water reactor environment
Journal of Materials Science & Technology, 2020Co-Authors: Lijin Dong, Qunjia Peng, Wei KeAbstract:Abstract Stress corrosion Cracking (SCC) of an SA508-309 L/308 L–316 L dissimilar metal weld joint in primary pressurized water reactor environment was investigated by the interrupted slow strain rate tension tests following a miCrostructure characterization. The 308 L weld metal shows a higher content of δ ferrite than the 309 L weld metal. In addition, no obvious Cr-Depletion but carbides precipitation at γ/δ phase boundaries was observed in both 308 L and 309 L weld metals. The slow strain rate tension tests showed that the SCC susceptibility of the base and weld metals of the dissimilar metal weld joint follows the order of SA508
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correlation of miCrostructure and stress corrosion Cracking initiation behaviour of the fusion boundary region in a sa508 cl 3 alloy 52m dissimilar weld joint in primary pressurized water reactor environment
Corrosion Science, 2017Co-Authors: Lijin Dong, Qunjia Peng, Wei Ke, Lei WangAbstract:Abstract Correlation of miCrostructure and stress corrosion Cracking (SCC) initiation behaviour of the fusion boundary (FB) region in a SA508 Cl. 3-Alloy 52M weld joint in primary pressurized water reactor environment was investigated. Cr-Depletion at the grain boundary and strength mismatch in the FB region are the two causes for SCC initiation in the FB region. The partially mixed zone between the dilution zone (DZ) of Alloy 52M and SA508 Cl. 3 has a retardation effect on SCC initiation. This is attributed to the deCrease of strength mismatch and the alleviation of strain concentration adjacent to the grain boundary in DZ.
Qunjia Peng - One of the best experts on this subject based on the ideXlab platform.
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miCrostructure and stress corrosion Cracking of a sa508 309l 308l 316l dissimilar metal weld joint in primary pressurized water reactor environment
Journal of Materials Science & Technology, 2020Co-Authors: Lijin Dong, Qunjia Peng, Wei KeAbstract:Abstract Stress corrosion Cracking (SCC) of an SA508-309 L/308 L–316 L dissimilar metal weld joint in primary pressurized water reactor environment was investigated by the interrupted slow strain rate tension tests following a miCrostructure characterization. The 308 L weld metal shows a higher content of δ ferrite than the 309 L weld metal. In addition, no obvious Cr-Depletion but carbides precipitation at γ/δ phase boundaries was observed in both 308 L and 309 L weld metals. The slow strain rate tension tests showed that the SCC susceptibility of the base and weld metals of the dissimilar metal weld joint follows the order of SA508
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corrosion of phase and phase boundary in proton irradiated 308l stainless steel weld metal in simulated pwr primary water
Corrosion Science, 2020Co-Authors: Qunjia Peng, Xiaodong Lin, Enhou Han, Jinna Mei, Lijie Qiao, Zhijie JiaoAbstract:Abstract The corrosion of austenite and δ-ferrite phases and the respective phase boundary was investigated in unirradiated and proton-irradiated 308 L stainless steel weld metal in a simulated-PWR environment. The results revealed that the inner oxide thickness was inCreased by irradiation for austenite but was largely unaffected for δ-ferrite. This behavior was attributed to the fact that irradiation generated numerous structure defects in austenite, but not in δ-ferrite. Following the 3-dpa (displacements per atom) irradiation, enhanced corrosion of δ-ferrite/austenite phase boundary occurred due to the irradiation-induced Cr-Depletion. M23C6 carbides along the phase boundary further enhanced corrosion regardless of the irradiation condition.
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irradiation induced segregation at phase boundaries in austenitic stainless steel weld metal
Scripta Materialia, 2018Co-Authors: Qunjia Peng, Xiaodong Lin, Enhou Han, Chen Sun, Zhijie JiaoAbstract:Abstract Irradiation-induced segregation (RIS) at phase boundaries in austenitic stainless steel weld metal was studied using atom probe tomography. Irradiation induced Depletion of Cr and Mn and enrichment of Ni and Si at the δ-ferrite/austenite, δ-ferrite/carbide and austenite/carbide phase boundaries. The vacancy mechanism and the solute-defect binding model were applied to interpret the RIS at the phase boundaries. The concentration gradients of Cr and Ni at the phase boundary regions reduced Cr Depletion but promoted Ni segregation, which caused a difference with the RIS at the grain boundary.
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correlation of miCrostructure and stress corrosion Cracking initiation behaviour of the fusion boundary region in a sa508 cl 3 alloy 52m dissimilar weld joint in primary pressurized water reactor environment
Corrosion Science, 2017Co-Authors: Lijin Dong, Qunjia Peng, Wei Ke, Lei WangAbstract:Abstract Correlation of miCrostructure and stress corrosion Cracking (SCC) initiation behaviour of the fusion boundary (FB) region in a SA508 Cl. 3-Alloy 52M weld joint in primary pressurized water reactor environment was investigated. Cr-Depletion at the grain boundary and strength mismatch in the FB region are the two causes for SCC initiation in the FB region. The partially mixed zone between the dilution zone (DZ) of Alloy 52M and SA508 Cl. 3 has a retardation effect on SCC initiation. This is attributed to the deCrease of strength mismatch and the alleviation of strain concentration adjacent to the grain boundary in DZ.
Giovanni Cioni - One of the best experts on this subject based on the ideXlab platform.
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Fifteen-year follow-up of Italian families affected by arginine glycine amidinotransferase deficiency.
Orphanet journal of rare diseases, 2017Co-Authors: Roberta Battini, Michela Tosetti, M. Grazia Alessandrì, Claudia Casalini, Manuela Casarano, Giovanni CioniAbstract:Arginine:glycine amidinotransferase deficiency (AGAT-d) is a very rare inborn error of Creatine synthesis mainly characterized by absence of brain Creatine (Cr) peak, intellectual disability, severe language impairment and behavioural disorder and susceptible to supplementary Cr treatment per os. Serial examinations by magnetic resonance spectroscopy are required to evaluate Cr recovery in brain during treatment of high doses of Cr per os, which have been proved beneficial and effective in treating main clinical symptoms. A long term study with detailed reports on clinical, neurochemical and neuropsychological outcomes of the first Italian patients affected by AGAT-d here reported can represent a landmark in management of this disorder thus enhancing medical knowledge and clinical practice. We have evaluated the long term effects of Cr supplementation management in four Italian patients affected by AGAT-d, correlating specific treatments with serial clinical, biochemical and magnetic resonance spectroscopy examinations as well as the neuropsychological outcome by standardized developmental scales. Consecutive MRS examinations have confirmed that Cr Depletion in AGAT-d patients is reversible under Cr supplementation. Cr treatment is considered safe and well tolerated but side effects, including weight gain and kidney stones, have been reported. Early treatment prevents adverse developmental outcome, while patients diagnosed and treated at an older age showed partial but significant cognitive recovery with clear improvements in adaptive functioning.
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language disorder with mild intellectual disability in a child affected by a novel mutation of slc6a8 gene
Molecular Genetics and Metabolism, 2011Co-Authors: Roberta Battini, Michela Tosetti, Manuela Casarano, Anna Maria Chilosi, Francesca Moro, Alessandro Comparini, Maria Grazia Alessandri, Vincenzo Leuzzi, Giovanni CioniAbstract:Abstract We desCribe the clinical and molecular features of a child harboring a novel mutation in SLC6A8 gene in association with a milder phenotype than other Creatine transporter (CT1) deficient patients (OMIM 300352) [1–7]. The mutation c.757 G>C p.G253R in exon 4 of SLC6A8 was hemizygous in the child, aged 6 years and 6 months, who showed mild intellectual disability with severe speech and language delay. His carrier mother had borderline intellectual functioning. Although the neurochemical and biochemical parameters were fully consistent with those reported in the literature for subjects with CT1 deficit, in our patient within a general cognitive disability, a disCrepancy between nonverbal and verbal skills was observed, confirming the peculiar vulnerability of language development under brain Cr Depletion.
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arginine and glycine stimulate Creatine synthesis in Creatine transporter 1 deficient lymphoblasts
Analytical Biochemistry, 2008Co-Authors: Vincenzo Leuzzi, Manuela Casarano, Roberta Battini, Maria Grazia Alessandri, Giovanni CioniAbstract:Creatine transporter 1 (CT1) defect is an X-linked disease that causes severe neurological impairment. No treatment has been available for this condition so far. Because the transport of Creatine (Cr) precursors Gly and Arg is not affected in this disorder, we tested the possible corrective effect of these two amino acids on Cr Depletion in lymphoblasts lacking the transporter. Substrates enriched with Arg or Arg plus Gly inCreased the concentration of intracellular Cr in affected cells as well as in control cells. The greatest effect was obtained with 10 and 15 mM Arg and 10 mM Arg plus Gly. These results encourage an in vivo trial with Cr precursors in CT1 defect.
Xiaodong Lin - One of the best experts on this subject based on the ideXlab platform.
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corrosion of phase and phase boundary in proton irradiated 308l stainless steel weld metal in simulated pwr primary water
Corrosion Science, 2020Co-Authors: Qunjia Peng, Xiaodong Lin, Enhou Han, Jinna Mei, Lijie Qiao, Zhijie JiaoAbstract:Abstract The corrosion of austenite and δ-ferrite phases and the respective phase boundary was investigated in unirradiated and proton-irradiated 308 L stainless steel weld metal in a simulated-PWR environment. The results revealed that the inner oxide thickness was inCreased by irradiation for austenite but was largely unaffected for δ-ferrite. This behavior was attributed to the fact that irradiation generated numerous structure defects in austenite, but not in δ-ferrite. Following the 3-dpa (displacements per atom) irradiation, enhanced corrosion of δ-ferrite/austenite phase boundary occurred due to the irradiation-induced Cr-Depletion. M23C6 carbides along the phase boundary further enhanced corrosion regardless of the irradiation condition.
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irradiation induced segregation at phase boundaries in austenitic stainless steel weld metal
Scripta Materialia, 2018Co-Authors: Qunjia Peng, Xiaodong Lin, Enhou Han, Chen Sun, Zhijie JiaoAbstract:Abstract Irradiation-induced segregation (RIS) at phase boundaries in austenitic stainless steel weld metal was studied using atom probe tomography. Irradiation induced Depletion of Cr and Mn and enrichment of Ni and Si at the δ-ferrite/austenite, δ-ferrite/carbide and austenite/carbide phase boundaries. The vacancy mechanism and the solute-defect binding model were applied to interpret the RIS at the phase boundaries. The concentration gradients of Cr and Ni at the phase boundary regions reduced Cr Depletion but promoted Ni segregation, which caused a difference with the RIS at the grain boundary.
Wei Ke - One of the best experts on this subject based on the ideXlab platform.
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miCrostructure and stress corrosion Cracking of a sa508 309l 308l 316l dissimilar metal weld joint in primary pressurized water reactor environment
Journal of Materials Science & Technology, 2020Co-Authors: Lijin Dong, Qunjia Peng, Wei KeAbstract:Abstract Stress corrosion Cracking (SCC) of an SA508-309 L/308 L–316 L dissimilar metal weld joint in primary pressurized water reactor environment was investigated by the interrupted slow strain rate tension tests following a miCrostructure characterization. The 308 L weld metal shows a higher content of δ ferrite than the 309 L weld metal. In addition, no obvious Cr-Depletion but carbides precipitation at γ/δ phase boundaries was observed in both 308 L and 309 L weld metals. The slow strain rate tension tests showed that the SCC susceptibility of the base and weld metals of the dissimilar metal weld joint follows the order of SA508
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correlation of miCrostructure and stress corrosion Cracking initiation behaviour of the fusion boundary region in a sa508 cl 3 alloy 52m dissimilar weld joint in primary pressurized water reactor environment
Corrosion Science, 2017Co-Authors: Lijin Dong, Qunjia Peng, Wei Ke, Lei WangAbstract:Abstract Correlation of miCrostructure and stress corrosion Cracking (SCC) initiation behaviour of the fusion boundary (FB) region in a SA508 Cl. 3-Alloy 52M weld joint in primary pressurized water reactor environment was investigated. Cr-Depletion at the grain boundary and strength mismatch in the FB region are the two causes for SCC initiation in the FB region. The partially mixed zone between the dilution zone (DZ) of Alloy 52M and SA508 Cl. 3 has a retardation effect on SCC initiation. This is attributed to the deCrease of strength mismatch and the alleviation of strain concentration adjacent to the grain boundary in DZ.
