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Charles Couillard - One of the best experts on this subject based on the ideXlab platform.

  • evidence that Cranberry Juice may improve augmentation index in overweight men
    Nutrition Research, 2013
    Co-Authors: Guillaume Ruel, Annie Lapointe, Sonia Pomerleau, Patrick Couture, Simone Lemieux, Benoit Lamarche, Charles Couillard
    Abstract:

    The stiffening of arteries is a key step in atherogenesis leading to cardiovascular disease. It has been suggested that dietary polyphenols may be cardioprotective through possible favorable effects on oxidative stress and vascular function. The present study was undertaken in order to examine the effect of consuming low-calorie Cranberry Juice cocktail (CJC), a source of polyphenols, on arterial stiffness in abdominally obese men. We hypothesize that regular CJC consumption will reduce circulating oxidized low-density lipoproteins concentrations and have a beneficial impact on endothelial function. Thirty-five men (mean age ± SD: 45 ± 10 years) were randomly assigned to drink 500 mL CJC/day (27% Juice) or 500 mL placebo Juice (PJ)/day for 4 weeks in a double-blind crossover design. Augmentation index (AIx), an index of arterial stiffness, was measured by applanation tonometry of the radial artery and the cardiometabolic profile was assessed in each participant before and after each phase of the study. We found no significant difference in AIx changes between men who consumed CJC or PJ for 4 weeks (P = .5820). Furthermore, there was no between-treatment difference in changes in AIx responses to salbutamol (P = .6303) and glyceryl trinitrate (P = .4224). No significant difference was noted in other cardiometabolic variables between men consuming PJ or CJC. However, a significant within group decrease in AIx (mean decrease ± SE; -14.0 ± 5.8%, P = .019) was noted following the consumption of 500 mL CJC/day for 4 weeks. Our results indicate that the effect of chronic consumption of CJC on AIx was not significantly different from changes associated with the consumption of PJ. However, the significant within-group decrease in AIx following CJC consumption in abdominally obese men may deserve further investigation.

  • low calorie Cranberry Juice supplementation reduces plasma oxidized ldl and cell adhesion molecule concentrations in men
    British Journal of Nutrition, 2008
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Simone Lemieux, Benoit Lamarche, Charles Couillard
    Abstract:

    consumption may be cardioprotective through possible favourable impacts on LDL particle oxidation and endothelial activation. The present study was undertaken to determine the effect of the daily consumption of low-calorie Cranberry Juice cocktail on plasma OxLDL, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin concentrations in men. Thirty men (mean age 51 (SD 10) years) were recruited and asked to consume increasing daily doses of Cranberry Juice cocktail (125, 250 and 500ml/d) over three successive periods of 4 weeks. Plasma OxLDL and adhesion molecule concentrations were measured by ELISA before and after each phase. We noted a significant decrease in plasma OxLDL concentrations following the intervention (P,0·0001). We also found that plasma ICAM-1 (P,0·0001) and VCAM-1 (P,0·05) concentrations decreased significantly during the course of the study. In summary, the present results show that daily Cranberry Juice cocktail consumption is associated with decreases in plasma OxLDL, ICAM-1 and VCAM-1 concentrations in men. Cranberry: Flavonoids: Oxidized LDL: Cardiovascular disease: ICAM-1: VCAM-1 CVD is the leading cause of death in North America 1 and it is well recognized that LDL-cholesterol is a major risk factor associated to CVD 2 . However, not all CVD patients show high LDL-cholesterol concentrations and it has been shown that variations in the physical properties and composition of LDL particles such as LDL oxidation could explain, at least in part, the atherogenicity of LDL 3,4 even in the absence of high LDL-cholesterol concentrations. As oxidized LDL (OxLDL) are not recognized by the LDL receptor but rather by scavenger receptors at the surface of sub-endothelial resident macrophages, LDL oxidation favours the unrestricted uptake of cholesterol, thereby leading to the formation of foam cells, which is the first step in the formation of the earliest atherosclerotic lesions known as fatty streaks 2 .

  • favourable impact of low calorie Cranberry Juice consumption on plasma hdl cholesterol concentrations in men
    British Journal of Nutrition, 2006
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Simone Lemieux, Benoit Lamarche, Charles Couillard
    Abstract:

    A low HDL-cholesterol concentration is an independent risk factor for CVD. Studies have suggested that flavonoid consumption may be cardioprotective, and a favourable impact on circulating HDL-cholesterol concentrations has been suggested to partially explain this association. The aim of the present study was to determine the effect of consuming increasing daily doses of low-calorie Cranberry Juice cocktail (CJC) on the plasma lipid profile of abdominally obese men. For that purpose, thirty men (mean age 51 (SD 10) years) consumed increasing doses of CJC during three successive periods of 4 weeks (125ml/d, 250ml/d, 500ml/d). Before the study and after each phase, we measured changes in physical and metabolic variables. We noted a significant increase in plasma HDL-cholesterol concentration after the consumption of 250ml CJC/d (þ8·6 ^ 14·0% v. 0ml CJC/d; P,0·01), an effect that plateaued during the last phase of the study (500ml CJC/d: þ8·1 ^ 10·0% v. 0ml CJC/d; P,0·0001). Multivariate analyses revealed that changes in plasma apo A-I (R 2 ¼ 48%, P,0·0001) and triacylglycerol (R 2 ¼ 16%, P,0·005) concentrations were the only variables significantly contributing to the variation in plasma HDL-cholesterol concentration noted in response to the intervention. No variation was observed in total as well as in LDL and VLDL cholesterol. The present results show that daily CJC consumption is associated with an increase in plasma HDL-cholesterol concentrations in abdominally obese men. We hypothesise that polyphenolic compounds from cranberries may be responsible for this effect, supporting the notion that the consumption of flavonoid-rich foods can be

  • changes in plasma antioxidant capacity and oxidized low density lipoprotein levels in men after short term Cranberry Juice consumption
    Metabolism-clinical and Experimental, 2005
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Benoit Lamarche, Charles Couillard
    Abstract:

    Low-density lipoprotein (LDL) oxidation is closely implicated in the development of atherosclerotic cardiovascular disease (CVD), and thus, reducing LDL susceptibility to oxidation with antoxidants could be of importance in CVD prevention. Flavonoids, polyphenolic compounds found in a large selection of fruits and vegetables, have been characterized as having a strong antioxidant potential, and intake of flavonoid-rich foods has been related to decreased morbidity and mortality from heart disease. The present study was therefore undertaken to investigate the effect of flavonoid-rich Cranberry Juice supplementation on plasma lipoprotein levels and LDL oxidation. For that purpose, 21 men (age +/- SD, 38 +/- 8 years) were enrolled in a 14-day intervention and instructed to drink Cranberry Juice 7 mL/kg body weight per day. Physical and metabolic measures including plasma lipid and oxidized LDL (OxLDL) concentrations as well as antioxidant capacity were performed before and after the intervention. At baseline, we found that plasma OxLDL levels were significantly associated with waist circumference ( r = 0.47, P = .0296) as well as plasma triglyceride ( r = 0.68, P = .0007) and apolipoprotein B ( r = 0.91, P < .0001) concentrations. The intervention led to a reduction in plasma OxLDL levels (-9.9% +/- 17.8%, P = .0131) and increase in antioxidant capacity (+6.5% +/- 10.3%, P = .0140). However, no relationship was found between both of these changes ( r = -.01, not significant). The intervention did not result in any improvement of plasma lipoprotein-lipid or inflammatory marker concentrations. Our results show that short-term Cranberry Juice supplementation is associated with significant increase in plasma antioxidant capacity and reduction in circulating OxLDL concentrations. Although the physiological relevance of our observations needs to be further examined, our study supports the potential role of antioxidant-rich foods in maintaining health and preventing CVD.

  • changes in plasma antioxidant capacity and oxidized low density lipoprotein levels in men after short term Cranberry Juice consumption
    Metabolism-clinical and Experimental, 2005
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Benoit Lamarche, Charles Couillard
    Abstract:

    Abstract Low-density lipoprotein (LDL) oxidation is closely implicated in the development of atherosclerotic cardiovascular disease (CVD), and thus, reducing LDL susceptibility to oxidation with antoxidants could be of importance in CVD prevention. Flavonoids, polyphenolic compounds found in a large selection of fruits and vegetables, have been characterized as having a strong antioxidant potential, and intake of flavonoid-rich foods has been related to decreased morbidity and mortality from heart disease. The present study was therefore undertaken to investigate the effect of flavonoid-rich Cranberry Juice supplementation on plasma lipoprotein levels and LDL oxidation. For that purpose, 21 men (age ± SD, 38 ± 8 years) were enrolled in a 14-day intervention and instructed to drink Cranberry Juice 7 mL/kg body weight per day. Physical and metabolic measures including plasma lipid and oxidized LDL (OxLDL) concentrations as well as antioxidant capacity were performed before and after the intervention. At baseline, we found that plasma OxLDL levels were significantly associated with waist circumference (r = 0.47, P = .0296) as well as plasma triglyceride (r = 0.68, P = .0007) and apolipoprotein B (r = 0.91, P

Guillaume Ruel - One of the best experts on this subject based on the ideXlab platform.

  • evidence that Cranberry Juice may improve augmentation index in overweight men
    Nutrition Research, 2013
    Co-Authors: Guillaume Ruel, Annie Lapointe, Sonia Pomerleau, Patrick Couture, Simone Lemieux, Benoit Lamarche, Charles Couillard
    Abstract:

    The stiffening of arteries is a key step in atherogenesis leading to cardiovascular disease. It has been suggested that dietary polyphenols may be cardioprotective through possible favorable effects on oxidative stress and vascular function. The present study was undertaken in order to examine the effect of consuming low-calorie Cranberry Juice cocktail (CJC), a source of polyphenols, on arterial stiffness in abdominally obese men. We hypothesize that regular CJC consumption will reduce circulating oxidized low-density lipoproteins concentrations and have a beneficial impact on endothelial function. Thirty-five men (mean age ± SD: 45 ± 10 years) were randomly assigned to drink 500 mL CJC/day (27% Juice) or 500 mL placebo Juice (PJ)/day for 4 weeks in a double-blind crossover design. Augmentation index (AIx), an index of arterial stiffness, was measured by applanation tonometry of the radial artery and the cardiometabolic profile was assessed in each participant before and after each phase of the study. We found no significant difference in AIx changes between men who consumed CJC or PJ for 4 weeks (P = .5820). Furthermore, there was no between-treatment difference in changes in AIx responses to salbutamol (P = .6303) and glyceryl trinitrate (P = .4224). No significant difference was noted in other cardiometabolic variables between men consuming PJ or CJC. However, a significant within group decrease in AIx (mean decrease ± SE; -14.0 ± 5.8%, P = .019) was noted following the consumption of 500 mL CJC/day for 4 weeks. Our results indicate that the effect of chronic consumption of CJC on AIx was not significantly different from changes associated with the consumption of PJ. However, the significant within-group decrease in AIx following CJC consumption in abdominally obese men may deserve further investigation.

  • low calorie Cranberry Juice supplementation reduces plasma oxidized ldl and cell adhesion molecule concentrations in men
    British Journal of Nutrition, 2008
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Simone Lemieux, Benoit Lamarche, Charles Couillard
    Abstract:

    consumption may be cardioprotective through possible favourable impacts on LDL particle oxidation and endothelial activation. The present study was undertaken to determine the effect of the daily consumption of low-calorie Cranberry Juice cocktail on plasma OxLDL, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin concentrations in men. Thirty men (mean age 51 (SD 10) years) were recruited and asked to consume increasing daily doses of Cranberry Juice cocktail (125, 250 and 500ml/d) over three successive periods of 4 weeks. Plasma OxLDL and adhesion molecule concentrations were measured by ELISA before and after each phase. We noted a significant decrease in plasma OxLDL concentrations following the intervention (P,0·0001). We also found that plasma ICAM-1 (P,0·0001) and VCAM-1 (P,0·05) concentrations decreased significantly during the course of the study. In summary, the present results show that daily Cranberry Juice cocktail consumption is associated with decreases in plasma OxLDL, ICAM-1 and VCAM-1 concentrations in men. Cranberry: Flavonoids: Oxidized LDL: Cardiovascular disease: ICAM-1: VCAM-1 CVD is the leading cause of death in North America 1 and it is well recognized that LDL-cholesterol is a major risk factor associated to CVD 2 . However, not all CVD patients show high LDL-cholesterol concentrations and it has been shown that variations in the physical properties and composition of LDL particles such as LDL oxidation could explain, at least in part, the atherogenicity of LDL 3,4 even in the absence of high LDL-cholesterol concentrations. As oxidized LDL (OxLDL) are not recognized by the LDL receptor but rather by scavenger receptors at the surface of sub-endothelial resident macrophages, LDL oxidation favours the unrestricted uptake of cholesterol, thereby leading to the formation of foam cells, which is the first step in the formation of the earliest atherosclerotic lesions known as fatty streaks 2 .

  • favourable impact of low calorie Cranberry Juice consumption on plasma hdl cholesterol concentrations in men
    British Journal of Nutrition, 2006
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Simone Lemieux, Benoit Lamarche, Charles Couillard
    Abstract:

    A low HDL-cholesterol concentration is an independent risk factor for CVD. Studies have suggested that flavonoid consumption may be cardioprotective, and a favourable impact on circulating HDL-cholesterol concentrations has been suggested to partially explain this association. The aim of the present study was to determine the effect of consuming increasing daily doses of low-calorie Cranberry Juice cocktail (CJC) on the plasma lipid profile of abdominally obese men. For that purpose, thirty men (mean age 51 (SD 10) years) consumed increasing doses of CJC during three successive periods of 4 weeks (125ml/d, 250ml/d, 500ml/d). Before the study and after each phase, we measured changes in physical and metabolic variables. We noted a significant increase in plasma HDL-cholesterol concentration after the consumption of 250ml CJC/d (þ8·6 ^ 14·0% v. 0ml CJC/d; P,0·01), an effect that plateaued during the last phase of the study (500ml CJC/d: þ8·1 ^ 10·0% v. 0ml CJC/d; P,0·0001). Multivariate analyses revealed that changes in plasma apo A-I (R 2 ¼ 48%, P,0·0001) and triacylglycerol (R 2 ¼ 16%, P,0·005) concentrations were the only variables significantly contributing to the variation in plasma HDL-cholesterol concentration noted in response to the intervention. No variation was observed in total as well as in LDL and VLDL cholesterol. The present results show that daily CJC consumption is associated with an increase in plasma HDL-cholesterol concentrations in abdominally obese men. We hypothesise that polyphenolic compounds from cranberries may be responsible for this effect, supporting the notion that the consumption of flavonoid-rich foods can be

  • changes in plasma antioxidant capacity and oxidized low density lipoprotein levels in men after short term Cranberry Juice consumption
    Metabolism-clinical and Experimental, 2005
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Benoit Lamarche, Charles Couillard
    Abstract:

    Low-density lipoprotein (LDL) oxidation is closely implicated in the development of atherosclerotic cardiovascular disease (CVD), and thus, reducing LDL susceptibility to oxidation with antoxidants could be of importance in CVD prevention. Flavonoids, polyphenolic compounds found in a large selection of fruits and vegetables, have been characterized as having a strong antioxidant potential, and intake of flavonoid-rich foods has been related to decreased morbidity and mortality from heart disease. The present study was therefore undertaken to investigate the effect of flavonoid-rich Cranberry Juice supplementation on plasma lipoprotein levels and LDL oxidation. For that purpose, 21 men (age +/- SD, 38 +/- 8 years) were enrolled in a 14-day intervention and instructed to drink Cranberry Juice 7 mL/kg body weight per day. Physical and metabolic measures including plasma lipid and oxidized LDL (OxLDL) concentrations as well as antioxidant capacity were performed before and after the intervention. At baseline, we found that plasma OxLDL levels were significantly associated with waist circumference ( r = 0.47, P = .0296) as well as plasma triglyceride ( r = 0.68, P = .0007) and apolipoprotein B ( r = 0.91, P < .0001) concentrations. The intervention led to a reduction in plasma OxLDL levels (-9.9% +/- 17.8%, P = .0131) and increase in antioxidant capacity (+6.5% +/- 10.3%, P = .0140). However, no relationship was found between both of these changes ( r = -.01, not significant). The intervention did not result in any improvement of plasma lipoprotein-lipid or inflammatory marker concentrations. Our results show that short-term Cranberry Juice supplementation is associated with significant increase in plasma antioxidant capacity and reduction in circulating OxLDL concentrations. Although the physiological relevance of our observations needs to be further examined, our study supports the potential role of antioxidant-rich foods in maintaining health and preventing CVD.

  • changes in plasma antioxidant capacity and oxidized low density lipoprotein levels in men after short term Cranberry Juice consumption
    Metabolism-clinical and Experimental, 2005
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Benoit Lamarche, Charles Couillard
    Abstract:

    Abstract Low-density lipoprotein (LDL) oxidation is closely implicated in the development of atherosclerotic cardiovascular disease (CVD), and thus, reducing LDL susceptibility to oxidation with antoxidants could be of importance in CVD prevention. Flavonoids, polyphenolic compounds found in a large selection of fruits and vegetables, have been characterized as having a strong antioxidant potential, and intake of flavonoid-rich foods has been related to decreased morbidity and mortality from heart disease. The present study was therefore undertaken to investigate the effect of flavonoid-rich Cranberry Juice supplementation on plasma lipoprotein levels and LDL oxidation. For that purpose, 21 men (age ± SD, 38 ± 8 years) were enrolled in a 14-day intervention and instructed to drink Cranberry Juice 7 mL/kg body weight per day. Physical and metabolic measures including plasma lipid and oxidized LDL (OxLDL) concentrations as well as antioxidant capacity were performed before and after the intervention. At baseline, we found that plasma OxLDL levels were significantly associated with waist circumference (r = 0.47, P = .0296) as well as plasma triglyceride (r = 0.68, P = .0007) and apolipoprotein B (r = 0.91, P

Patrick Couture - One of the best experts on this subject based on the ideXlab platform.

  • evidence that Cranberry Juice may improve augmentation index in overweight men
    Nutrition Research, 2013
    Co-Authors: Guillaume Ruel, Annie Lapointe, Sonia Pomerleau, Patrick Couture, Simone Lemieux, Benoit Lamarche, Charles Couillard
    Abstract:

    The stiffening of arteries is a key step in atherogenesis leading to cardiovascular disease. It has been suggested that dietary polyphenols may be cardioprotective through possible favorable effects on oxidative stress and vascular function. The present study was undertaken in order to examine the effect of consuming low-calorie Cranberry Juice cocktail (CJC), a source of polyphenols, on arterial stiffness in abdominally obese men. We hypothesize that regular CJC consumption will reduce circulating oxidized low-density lipoproteins concentrations and have a beneficial impact on endothelial function. Thirty-five men (mean age ± SD: 45 ± 10 years) were randomly assigned to drink 500 mL CJC/day (27% Juice) or 500 mL placebo Juice (PJ)/day for 4 weeks in a double-blind crossover design. Augmentation index (AIx), an index of arterial stiffness, was measured by applanation tonometry of the radial artery and the cardiometabolic profile was assessed in each participant before and after each phase of the study. We found no significant difference in AIx changes between men who consumed CJC or PJ for 4 weeks (P = .5820). Furthermore, there was no between-treatment difference in changes in AIx responses to salbutamol (P = .6303) and glyceryl trinitrate (P = .4224). No significant difference was noted in other cardiometabolic variables between men consuming PJ or CJC. However, a significant within group decrease in AIx (mean decrease ± SE; -14.0 ± 5.8%, P = .019) was noted following the consumption of 500 mL CJC/day for 4 weeks. Our results indicate that the effect of chronic consumption of CJC on AIx was not significantly different from changes associated with the consumption of PJ. However, the significant within-group decrease in AIx following CJC consumption in abdominally obese men may deserve further investigation.

  • low calorie Cranberry Juice supplementation reduces plasma oxidized ldl and cell adhesion molecule concentrations in men
    British Journal of Nutrition, 2008
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Simone Lemieux, Benoit Lamarche, Charles Couillard
    Abstract:

    consumption may be cardioprotective through possible favourable impacts on LDL particle oxidation and endothelial activation. The present study was undertaken to determine the effect of the daily consumption of low-calorie Cranberry Juice cocktail on plasma OxLDL, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin concentrations in men. Thirty men (mean age 51 (SD 10) years) were recruited and asked to consume increasing daily doses of Cranberry Juice cocktail (125, 250 and 500ml/d) over three successive periods of 4 weeks. Plasma OxLDL and adhesion molecule concentrations were measured by ELISA before and after each phase. We noted a significant decrease in plasma OxLDL concentrations following the intervention (P,0·0001). We also found that plasma ICAM-1 (P,0·0001) and VCAM-1 (P,0·05) concentrations decreased significantly during the course of the study. In summary, the present results show that daily Cranberry Juice cocktail consumption is associated with decreases in plasma OxLDL, ICAM-1 and VCAM-1 concentrations in men. Cranberry: Flavonoids: Oxidized LDL: Cardiovascular disease: ICAM-1: VCAM-1 CVD is the leading cause of death in North America 1 and it is well recognized that LDL-cholesterol is a major risk factor associated to CVD 2 . However, not all CVD patients show high LDL-cholesterol concentrations and it has been shown that variations in the physical properties and composition of LDL particles such as LDL oxidation could explain, at least in part, the atherogenicity of LDL 3,4 even in the absence of high LDL-cholesterol concentrations. As oxidized LDL (OxLDL) are not recognized by the LDL receptor but rather by scavenger receptors at the surface of sub-endothelial resident macrophages, LDL oxidation favours the unrestricted uptake of cholesterol, thereby leading to the formation of foam cells, which is the first step in the formation of the earliest atherosclerotic lesions known as fatty streaks 2 .

  • favourable impact of low calorie Cranberry Juice consumption on plasma hdl cholesterol concentrations in men
    British Journal of Nutrition, 2006
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Simone Lemieux, Benoit Lamarche, Charles Couillard
    Abstract:

    A low HDL-cholesterol concentration is an independent risk factor for CVD. Studies have suggested that flavonoid consumption may be cardioprotective, and a favourable impact on circulating HDL-cholesterol concentrations has been suggested to partially explain this association. The aim of the present study was to determine the effect of consuming increasing daily doses of low-calorie Cranberry Juice cocktail (CJC) on the plasma lipid profile of abdominally obese men. For that purpose, thirty men (mean age 51 (SD 10) years) consumed increasing doses of CJC during three successive periods of 4 weeks (125ml/d, 250ml/d, 500ml/d). Before the study and after each phase, we measured changes in physical and metabolic variables. We noted a significant increase in plasma HDL-cholesterol concentration after the consumption of 250ml CJC/d (þ8·6 ^ 14·0% v. 0ml CJC/d; P,0·01), an effect that plateaued during the last phase of the study (500ml CJC/d: þ8·1 ^ 10·0% v. 0ml CJC/d; P,0·0001). Multivariate analyses revealed that changes in plasma apo A-I (R 2 ¼ 48%, P,0·0001) and triacylglycerol (R 2 ¼ 16%, P,0·005) concentrations were the only variables significantly contributing to the variation in plasma HDL-cholesterol concentration noted in response to the intervention. No variation was observed in total as well as in LDL and VLDL cholesterol. The present results show that daily CJC consumption is associated with an increase in plasma HDL-cholesterol concentrations in abdominally obese men. We hypothesise that polyphenolic compounds from cranberries may be responsible for this effect, supporting the notion that the consumption of flavonoid-rich foods can be

  • changes in plasma antioxidant capacity and oxidized low density lipoprotein levels in men after short term Cranberry Juice consumption
    Metabolism-clinical and Experimental, 2005
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Benoit Lamarche, Charles Couillard
    Abstract:

    Low-density lipoprotein (LDL) oxidation is closely implicated in the development of atherosclerotic cardiovascular disease (CVD), and thus, reducing LDL susceptibility to oxidation with antoxidants could be of importance in CVD prevention. Flavonoids, polyphenolic compounds found in a large selection of fruits and vegetables, have been characterized as having a strong antioxidant potential, and intake of flavonoid-rich foods has been related to decreased morbidity and mortality from heart disease. The present study was therefore undertaken to investigate the effect of flavonoid-rich Cranberry Juice supplementation on plasma lipoprotein levels and LDL oxidation. For that purpose, 21 men (age +/- SD, 38 +/- 8 years) were enrolled in a 14-day intervention and instructed to drink Cranberry Juice 7 mL/kg body weight per day. Physical and metabolic measures including plasma lipid and oxidized LDL (OxLDL) concentrations as well as antioxidant capacity were performed before and after the intervention. At baseline, we found that plasma OxLDL levels were significantly associated with waist circumference ( r = 0.47, P = .0296) as well as plasma triglyceride ( r = 0.68, P = .0007) and apolipoprotein B ( r = 0.91, P < .0001) concentrations. The intervention led to a reduction in plasma OxLDL levels (-9.9% +/- 17.8%, P = .0131) and increase in antioxidant capacity (+6.5% +/- 10.3%, P = .0140). However, no relationship was found between both of these changes ( r = -.01, not significant). The intervention did not result in any improvement of plasma lipoprotein-lipid or inflammatory marker concentrations. Our results show that short-term Cranberry Juice supplementation is associated with significant increase in plasma antioxidant capacity and reduction in circulating OxLDL concentrations. Although the physiological relevance of our observations needs to be further examined, our study supports the potential role of antioxidant-rich foods in maintaining health and preventing CVD.

  • changes in plasma antioxidant capacity and oxidized low density lipoprotein levels in men after short term Cranberry Juice consumption
    Metabolism-clinical and Experimental, 2005
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Benoit Lamarche, Charles Couillard
    Abstract:

    Abstract Low-density lipoprotein (LDL) oxidation is closely implicated in the development of atherosclerotic cardiovascular disease (CVD), and thus, reducing LDL susceptibility to oxidation with antoxidants could be of importance in CVD prevention. Flavonoids, polyphenolic compounds found in a large selection of fruits and vegetables, have been characterized as having a strong antioxidant potential, and intake of flavonoid-rich foods has been related to decreased morbidity and mortality from heart disease. The present study was therefore undertaken to investigate the effect of flavonoid-rich Cranberry Juice supplementation on plasma lipoprotein levels and LDL oxidation. For that purpose, 21 men (age ± SD, 38 ± 8 years) were enrolled in a 14-day intervention and instructed to drink Cranberry Juice 7 mL/kg body weight per day. Physical and metabolic measures including plasma lipid and oxidized LDL (OxLDL) concentrations as well as antioxidant capacity were performed before and after the intervention. At baseline, we found that plasma OxLDL levels were significantly associated with waist circumference (r = 0.47, P = .0296) as well as plasma triglyceride (r = 0.68, P = .0007) and apolipoprotein B (r = 0.91, P

Sonia Pomerleau - One of the best experts on this subject based on the ideXlab platform.

  • evidence that Cranberry Juice may improve augmentation index in overweight men
    Nutrition Research, 2013
    Co-Authors: Guillaume Ruel, Annie Lapointe, Sonia Pomerleau, Patrick Couture, Simone Lemieux, Benoit Lamarche, Charles Couillard
    Abstract:

    The stiffening of arteries is a key step in atherogenesis leading to cardiovascular disease. It has been suggested that dietary polyphenols may be cardioprotective through possible favorable effects on oxidative stress and vascular function. The present study was undertaken in order to examine the effect of consuming low-calorie Cranberry Juice cocktail (CJC), a source of polyphenols, on arterial stiffness in abdominally obese men. We hypothesize that regular CJC consumption will reduce circulating oxidized low-density lipoproteins concentrations and have a beneficial impact on endothelial function. Thirty-five men (mean age ± SD: 45 ± 10 years) were randomly assigned to drink 500 mL CJC/day (27% Juice) or 500 mL placebo Juice (PJ)/day for 4 weeks in a double-blind crossover design. Augmentation index (AIx), an index of arterial stiffness, was measured by applanation tonometry of the radial artery and the cardiometabolic profile was assessed in each participant before and after each phase of the study. We found no significant difference in AIx changes between men who consumed CJC or PJ for 4 weeks (P = .5820). Furthermore, there was no between-treatment difference in changes in AIx responses to salbutamol (P = .6303) and glyceryl trinitrate (P = .4224). No significant difference was noted in other cardiometabolic variables between men consuming PJ or CJC. However, a significant within group decrease in AIx (mean decrease ± SE; -14.0 ± 5.8%, P = .019) was noted following the consumption of 500 mL CJC/day for 4 weeks. Our results indicate that the effect of chronic consumption of CJC on AIx was not significantly different from changes associated with the consumption of PJ. However, the significant within-group decrease in AIx following CJC consumption in abdominally obese men may deserve further investigation.

  • low calorie Cranberry Juice supplementation reduces plasma oxidized ldl and cell adhesion molecule concentrations in men
    British Journal of Nutrition, 2008
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Simone Lemieux, Benoit Lamarche, Charles Couillard
    Abstract:

    consumption may be cardioprotective through possible favourable impacts on LDL particle oxidation and endothelial activation. The present study was undertaken to determine the effect of the daily consumption of low-calorie Cranberry Juice cocktail on plasma OxLDL, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin concentrations in men. Thirty men (mean age 51 (SD 10) years) were recruited and asked to consume increasing daily doses of Cranberry Juice cocktail (125, 250 and 500ml/d) over three successive periods of 4 weeks. Plasma OxLDL and adhesion molecule concentrations were measured by ELISA before and after each phase. We noted a significant decrease in plasma OxLDL concentrations following the intervention (P,0·0001). We also found that plasma ICAM-1 (P,0·0001) and VCAM-1 (P,0·05) concentrations decreased significantly during the course of the study. In summary, the present results show that daily Cranberry Juice cocktail consumption is associated with decreases in plasma OxLDL, ICAM-1 and VCAM-1 concentrations in men. Cranberry: Flavonoids: Oxidized LDL: Cardiovascular disease: ICAM-1: VCAM-1 CVD is the leading cause of death in North America 1 and it is well recognized that LDL-cholesterol is a major risk factor associated to CVD 2 . However, not all CVD patients show high LDL-cholesterol concentrations and it has been shown that variations in the physical properties and composition of LDL particles such as LDL oxidation could explain, at least in part, the atherogenicity of LDL 3,4 even in the absence of high LDL-cholesterol concentrations. As oxidized LDL (OxLDL) are not recognized by the LDL receptor but rather by scavenger receptors at the surface of sub-endothelial resident macrophages, LDL oxidation favours the unrestricted uptake of cholesterol, thereby leading to the formation of foam cells, which is the first step in the formation of the earliest atherosclerotic lesions known as fatty streaks 2 .

  • favourable impact of low calorie Cranberry Juice consumption on plasma hdl cholesterol concentrations in men
    British Journal of Nutrition, 2006
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Simone Lemieux, Benoit Lamarche, Charles Couillard
    Abstract:

    A low HDL-cholesterol concentration is an independent risk factor for CVD. Studies have suggested that flavonoid consumption may be cardioprotective, and a favourable impact on circulating HDL-cholesterol concentrations has been suggested to partially explain this association. The aim of the present study was to determine the effect of consuming increasing daily doses of low-calorie Cranberry Juice cocktail (CJC) on the plasma lipid profile of abdominally obese men. For that purpose, thirty men (mean age 51 (SD 10) years) consumed increasing doses of CJC during three successive periods of 4 weeks (125ml/d, 250ml/d, 500ml/d). Before the study and after each phase, we measured changes in physical and metabolic variables. We noted a significant increase in plasma HDL-cholesterol concentration after the consumption of 250ml CJC/d (þ8·6 ^ 14·0% v. 0ml CJC/d; P,0·01), an effect that plateaued during the last phase of the study (500ml CJC/d: þ8·1 ^ 10·0% v. 0ml CJC/d; P,0·0001). Multivariate analyses revealed that changes in plasma apo A-I (R 2 ¼ 48%, P,0·0001) and triacylglycerol (R 2 ¼ 16%, P,0·005) concentrations were the only variables significantly contributing to the variation in plasma HDL-cholesterol concentration noted in response to the intervention. No variation was observed in total as well as in LDL and VLDL cholesterol. The present results show that daily CJC consumption is associated with an increase in plasma HDL-cholesterol concentrations in abdominally obese men. We hypothesise that polyphenolic compounds from cranberries may be responsible for this effect, supporting the notion that the consumption of flavonoid-rich foods can be

  • changes in plasma antioxidant capacity and oxidized low density lipoprotein levels in men after short term Cranberry Juice consumption
    Metabolism-clinical and Experimental, 2005
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Benoit Lamarche, Charles Couillard
    Abstract:

    Low-density lipoprotein (LDL) oxidation is closely implicated in the development of atherosclerotic cardiovascular disease (CVD), and thus, reducing LDL susceptibility to oxidation with antoxidants could be of importance in CVD prevention. Flavonoids, polyphenolic compounds found in a large selection of fruits and vegetables, have been characterized as having a strong antioxidant potential, and intake of flavonoid-rich foods has been related to decreased morbidity and mortality from heart disease. The present study was therefore undertaken to investigate the effect of flavonoid-rich Cranberry Juice supplementation on plasma lipoprotein levels and LDL oxidation. For that purpose, 21 men (age +/- SD, 38 +/- 8 years) were enrolled in a 14-day intervention and instructed to drink Cranberry Juice 7 mL/kg body weight per day. Physical and metabolic measures including plasma lipid and oxidized LDL (OxLDL) concentrations as well as antioxidant capacity were performed before and after the intervention. At baseline, we found that plasma OxLDL levels were significantly associated with waist circumference ( r = 0.47, P = .0296) as well as plasma triglyceride ( r = 0.68, P = .0007) and apolipoprotein B ( r = 0.91, P < .0001) concentrations. The intervention led to a reduction in plasma OxLDL levels (-9.9% +/- 17.8%, P = .0131) and increase in antioxidant capacity (+6.5% +/- 10.3%, P = .0140). However, no relationship was found between both of these changes ( r = -.01, not significant). The intervention did not result in any improvement of plasma lipoprotein-lipid or inflammatory marker concentrations. Our results show that short-term Cranberry Juice supplementation is associated with significant increase in plasma antioxidant capacity and reduction in circulating OxLDL concentrations. Although the physiological relevance of our observations needs to be further examined, our study supports the potential role of antioxidant-rich foods in maintaining health and preventing CVD.

  • changes in plasma antioxidant capacity and oxidized low density lipoprotein levels in men after short term Cranberry Juice consumption
    Metabolism-clinical and Experimental, 2005
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Benoit Lamarche, Charles Couillard
    Abstract:

    Abstract Low-density lipoprotein (LDL) oxidation is closely implicated in the development of atherosclerotic cardiovascular disease (CVD), and thus, reducing LDL susceptibility to oxidation with antoxidants could be of importance in CVD prevention. Flavonoids, polyphenolic compounds found in a large selection of fruits and vegetables, have been characterized as having a strong antioxidant potential, and intake of flavonoid-rich foods has been related to decreased morbidity and mortality from heart disease. The present study was therefore undertaken to investigate the effect of flavonoid-rich Cranberry Juice supplementation on plasma lipoprotein levels and LDL oxidation. For that purpose, 21 men (age ± SD, 38 ± 8 years) were enrolled in a 14-day intervention and instructed to drink Cranberry Juice 7 mL/kg body weight per day. Physical and metabolic measures including plasma lipid and oxidized LDL (OxLDL) concentrations as well as antioxidant capacity were performed before and after the intervention. At baseline, we found that plasma OxLDL levels were significantly associated with waist circumference (r = 0.47, P = .0296) as well as plasma triglyceride (r = 0.68, P = .0007) and apolipoprotein B (r = 0.91, P

Benoit Lamarche - One of the best experts on this subject based on the ideXlab platform.

  • evidence that Cranberry Juice may improve augmentation index in overweight men
    Nutrition Research, 2013
    Co-Authors: Guillaume Ruel, Annie Lapointe, Sonia Pomerleau, Patrick Couture, Simone Lemieux, Benoit Lamarche, Charles Couillard
    Abstract:

    The stiffening of arteries is a key step in atherogenesis leading to cardiovascular disease. It has been suggested that dietary polyphenols may be cardioprotective through possible favorable effects on oxidative stress and vascular function. The present study was undertaken in order to examine the effect of consuming low-calorie Cranberry Juice cocktail (CJC), a source of polyphenols, on arterial stiffness in abdominally obese men. We hypothesize that regular CJC consumption will reduce circulating oxidized low-density lipoproteins concentrations and have a beneficial impact on endothelial function. Thirty-five men (mean age ± SD: 45 ± 10 years) were randomly assigned to drink 500 mL CJC/day (27% Juice) or 500 mL placebo Juice (PJ)/day for 4 weeks in a double-blind crossover design. Augmentation index (AIx), an index of arterial stiffness, was measured by applanation tonometry of the radial artery and the cardiometabolic profile was assessed in each participant before and after each phase of the study. We found no significant difference in AIx changes between men who consumed CJC or PJ for 4 weeks (P = .5820). Furthermore, there was no between-treatment difference in changes in AIx responses to salbutamol (P = .6303) and glyceryl trinitrate (P = .4224). No significant difference was noted in other cardiometabolic variables between men consuming PJ or CJC. However, a significant within group decrease in AIx (mean decrease ± SE; -14.0 ± 5.8%, P = .019) was noted following the consumption of 500 mL CJC/day for 4 weeks. Our results indicate that the effect of chronic consumption of CJC on AIx was not significantly different from changes associated with the consumption of PJ. However, the significant within-group decrease in AIx following CJC consumption in abdominally obese men may deserve further investigation.

  • low calorie Cranberry Juice supplementation reduces plasma oxidized ldl and cell adhesion molecule concentrations in men
    British Journal of Nutrition, 2008
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Simone Lemieux, Benoit Lamarche, Charles Couillard
    Abstract:

    consumption may be cardioprotective through possible favourable impacts on LDL particle oxidation and endothelial activation. The present study was undertaken to determine the effect of the daily consumption of low-calorie Cranberry Juice cocktail on plasma OxLDL, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin concentrations in men. Thirty men (mean age 51 (SD 10) years) were recruited and asked to consume increasing daily doses of Cranberry Juice cocktail (125, 250 and 500ml/d) over three successive periods of 4 weeks. Plasma OxLDL and adhesion molecule concentrations were measured by ELISA before and after each phase. We noted a significant decrease in plasma OxLDL concentrations following the intervention (P,0·0001). We also found that plasma ICAM-1 (P,0·0001) and VCAM-1 (P,0·05) concentrations decreased significantly during the course of the study. In summary, the present results show that daily Cranberry Juice cocktail consumption is associated with decreases in plasma OxLDL, ICAM-1 and VCAM-1 concentrations in men. Cranberry: Flavonoids: Oxidized LDL: Cardiovascular disease: ICAM-1: VCAM-1 CVD is the leading cause of death in North America 1 and it is well recognized that LDL-cholesterol is a major risk factor associated to CVD 2 . However, not all CVD patients show high LDL-cholesterol concentrations and it has been shown that variations in the physical properties and composition of LDL particles such as LDL oxidation could explain, at least in part, the atherogenicity of LDL 3,4 even in the absence of high LDL-cholesterol concentrations. As oxidized LDL (OxLDL) are not recognized by the LDL receptor but rather by scavenger receptors at the surface of sub-endothelial resident macrophages, LDL oxidation favours the unrestricted uptake of cholesterol, thereby leading to the formation of foam cells, which is the first step in the formation of the earliest atherosclerotic lesions known as fatty streaks 2 .

  • favourable impact of low calorie Cranberry Juice consumption on plasma hdl cholesterol concentrations in men
    British Journal of Nutrition, 2006
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Simone Lemieux, Benoit Lamarche, Charles Couillard
    Abstract:

    A low HDL-cholesterol concentration is an independent risk factor for CVD. Studies have suggested that flavonoid consumption may be cardioprotective, and a favourable impact on circulating HDL-cholesterol concentrations has been suggested to partially explain this association. The aim of the present study was to determine the effect of consuming increasing daily doses of low-calorie Cranberry Juice cocktail (CJC) on the plasma lipid profile of abdominally obese men. For that purpose, thirty men (mean age 51 (SD 10) years) consumed increasing doses of CJC during three successive periods of 4 weeks (125ml/d, 250ml/d, 500ml/d). Before the study and after each phase, we measured changes in physical and metabolic variables. We noted a significant increase in plasma HDL-cholesterol concentration after the consumption of 250ml CJC/d (þ8·6 ^ 14·0% v. 0ml CJC/d; P,0·01), an effect that plateaued during the last phase of the study (500ml CJC/d: þ8·1 ^ 10·0% v. 0ml CJC/d; P,0·0001). Multivariate analyses revealed that changes in plasma apo A-I (R 2 ¼ 48%, P,0·0001) and triacylglycerol (R 2 ¼ 16%, P,0·005) concentrations were the only variables significantly contributing to the variation in plasma HDL-cholesterol concentration noted in response to the intervention. No variation was observed in total as well as in LDL and VLDL cholesterol. The present results show that daily CJC consumption is associated with an increase in plasma HDL-cholesterol concentrations in abdominally obese men. We hypothesise that polyphenolic compounds from cranberries may be responsible for this effect, supporting the notion that the consumption of flavonoid-rich foods can be

  • changes in plasma antioxidant capacity and oxidized low density lipoprotein levels in men after short term Cranberry Juice consumption
    Metabolism-clinical and Experimental, 2005
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Benoit Lamarche, Charles Couillard
    Abstract:

    Low-density lipoprotein (LDL) oxidation is closely implicated in the development of atherosclerotic cardiovascular disease (CVD), and thus, reducing LDL susceptibility to oxidation with antoxidants could be of importance in CVD prevention. Flavonoids, polyphenolic compounds found in a large selection of fruits and vegetables, have been characterized as having a strong antioxidant potential, and intake of flavonoid-rich foods has been related to decreased morbidity and mortality from heart disease. The present study was therefore undertaken to investigate the effect of flavonoid-rich Cranberry Juice supplementation on plasma lipoprotein levels and LDL oxidation. For that purpose, 21 men (age +/- SD, 38 +/- 8 years) were enrolled in a 14-day intervention and instructed to drink Cranberry Juice 7 mL/kg body weight per day. Physical and metabolic measures including plasma lipid and oxidized LDL (OxLDL) concentrations as well as antioxidant capacity were performed before and after the intervention. At baseline, we found that plasma OxLDL levels were significantly associated with waist circumference ( r = 0.47, P = .0296) as well as plasma triglyceride ( r = 0.68, P = .0007) and apolipoprotein B ( r = 0.91, P < .0001) concentrations. The intervention led to a reduction in plasma OxLDL levels (-9.9% +/- 17.8%, P = .0131) and increase in antioxidant capacity (+6.5% +/- 10.3%, P = .0140). However, no relationship was found between both of these changes ( r = -.01, not significant). The intervention did not result in any improvement of plasma lipoprotein-lipid or inflammatory marker concentrations. Our results show that short-term Cranberry Juice supplementation is associated with significant increase in plasma antioxidant capacity and reduction in circulating OxLDL concentrations. Although the physiological relevance of our observations needs to be further examined, our study supports the potential role of antioxidant-rich foods in maintaining health and preventing CVD.

  • changes in plasma antioxidant capacity and oxidized low density lipoprotein levels in men after short term Cranberry Juice consumption
    Metabolism-clinical and Experimental, 2005
    Co-Authors: Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Benoit Lamarche, Charles Couillard
    Abstract:

    Abstract Low-density lipoprotein (LDL) oxidation is closely implicated in the development of atherosclerotic cardiovascular disease (CVD), and thus, reducing LDL susceptibility to oxidation with antoxidants could be of importance in CVD prevention. Flavonoids, polyphenolic compounds found in a large selection of fruits and vegetables, have been characterized as having a strong antioxidant potential, and intake of flavonoid-rich foods has been related to decreased morbidity and mortality from heart disease. The present study was therefore undertaken to investigate the effect of flavonoid-rich Cranberry Juice supplementation on plasma lipoprotein levels and LDL oxidation. For that purpose, 21 men (age ± SD, 38 ± 8 years) were enrolled in a 14-day intervention and instructed to drink Cranberry Juice 7 mL/kg body weight per day. Physical and metabolic measures including plasma lipid and oxidized LDL (OxLDL) concentrations as well as antioxidant capacity were performed before and after the intervention. At baseline, we found that plasma OxLDL levels were significantly associated with waist circumference (r = 0.47, P = .0296) as well as plasma triglyceride (r = 0.68, P = .0007) and apolipoprotein B (r = 0.91, P