The Experts below are selected from a list of 3105 Experts worldwide ranked by ideXlab platform
Basanti Mukerji - One of the best experts on this subject based on the ideXlab platform.
-
acute and long term effects of nifedipine on pulmonary and systemic hemodynamics in patients with pulmonary hypertension associated with diffuse systemic sclerosis the CREST Syndrome and mixed connective tissue disease
American Journal of Cardiology, 1991Co-Authors: Martin A Alpert, Thomas A Pressly, Vaskar Mukerji, Charles R Lambert, Basanti MukerjiAbstract:Abstract Ten patients with pulmonary hypertension associated with diffuse systemic sclerosis (1 patient), the CREST Syndrome (calcinosis cutis, Reynaud's phenomenon, esophageal dysmotility, sclerodactyl, telangiectasia) (6 patients) and mixed connective tissue disease (3 patients) were studied to assess the effect of oral nifedipine on pulmonary and systemic hemodynamics. Each patient underwent right-sided cardiac catheterization just before nifedipine administration. Thereafter, oral nifedipine was administered in 10 mg increments every 90 minutes until pulmonary vascular resistance normalized or a total dose of 30 mg was achieved. Hemodynamic measurements were obtained at 30-minute intervals for 3 hours, then hourly for 9 hours (acute study). Hemodynamic studies were repeated 3 to 6 months after the initial catheterization with the minimum dose of oral nifedipine (administered every 8 hours) required to achieve maximal reduction of pulmonary vascular resistance in the acute study (long-term study). In the acute study, oral nifedipine produced a significant decrease in mean pulmonary vascular resistance, from 6.3 ± 3.8 to 4.3 ± 3.6 U (p
María De Lourdes Figuerola - One of the best experts on this subject based on the ideXlab platform.
-
Sporadic hemiplegic migraine and CREST Syndrome
The Journal of Headache and Pain, 2010Co-Authors: Martin Pablo Grecco, Miguel Pieroni, Marcela Otero, Jorge Luis Ferreiro, María De Lourdes FiguerolaAbstract:Hemiplegic migraines are characterised by attacks of migraine with aura accompanied by transient motor weakness. There are both familial and sporadic subtypes, which are now recognised as separate entities by the International Classification of Headache Disorders, edition II (ICHD-II). The sporadic subtype has been associated with other medical conditions, particularly rheumatological diseases. We report the case of a woman with sporadic hemiplegic migraine associated with CREST Syndrome (calcinosis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia). Since there is a close relationship between migraine and Raynaud’s phenomenon, it could be speculated that the sporadic hemiplegic migraines in our patient might be secondary to CREST Syndrome.
Jeanfrancois Meder - One of the best experts on this subject based on the ideXlab platform.
-
dysgenesis of the internal carotid artery associated with transsphenoidal encephalocele a neural CREST Syndrome
American Journal of Neuroradiology, 1999Co-Authors: J Blustajn, Irene Netchine, D Fredy, Pierre Bakouche, Jean Daniel Piekarski, Jeanfrancois MederAbstract:Summary: We describe two original cases of internal carotid artery dysgenesis associated with a malformative spectrum, which includes transsphenoidal encephalocele, optic nerve coloboma, hypopituitarism, and hypertelorism. Cephalic neural CREST cells migrate to various regions in the head and neck where they contribute to the development of structures as diverse as the anterior skull base, the walls of the craniofacial arteries, the forebrain, and the face. Data suggest that the link between these rare malformations is abnormal neural CREST development.
M Daniel D Barolet - One of the best experts on this subject based on the ideXlab platform.
-
pulsed versus continuous wave low level light therapy on osteoarticular signs and symptoms in limited scleroderma CREST Syndrome a case report
Journal of Biomedical Optics, 2014Co-Authors: M Daniel D BaroletAbstract:Limited cutaneous systemic sclerosis (lcSSc) was formerly known as CREST Syndrome in reference to the associated clinical features: calcinosis, Raynaud’s phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasias. The transforming growth factor beta has been identified as a major player in the pathogenic process, where low-level light therapy (LLLT) has been shown to modulate this cytokine superfamily. This case study was conducted to assess the efficacy of 940 nm using millisecond pulsing and continuous wave (CW) modes on osteoarticular signs and symptoms associated with lcSSc. The patient was treated two to three times a week for 13 weeks using a sequential pulsing mode on one elbow and a CW mode on the other. Efficacy assessments included inflammation, symptoms, pain, health scales, patient satisfaction, clinical global impression, and adverse effects monitoring. Considerable functional and morphologic improvements were observed after LLLT, with the best results seen with the pulsing mode. No adverse effects were noted. Pulsed LLLT represents a treatment alternative for osteoarticular signs and symptoms in limited scleroderma (CREST Syndrome).
J C A Hoorntje - One of the best experts on this subject based on the ideXlab platform.
-
pulmonary hypertension with limited cutaneous scleroderma CREST Syndrome
Netherlands Journal of Medicine, 2000Co-Authors: J C Berends, E C Dompeling, J G Van Der Star, J C A HoorntjeAbstract:A patient is described with a typical manifestation of pulmonary hypertension associated with limited cutaneous scleroderma, also known as CREST Syndrome. The patient was treated with a calcium antagonist, oral anticoagulation and, because of evidence for parenchymal inflammation of the lung, with low-dose prednisone and cyclophosphamide. This treatment resulted in initial improvement of diffusion capacity and exercise tolerance, however, 1 year after diagnosis the patient died of progressive pulmonary hypertension.