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May Griffith - One of the best experts on this subject based on the ideXlab platform.

  • peg stabilized carbodiimide crosslinked collagen chitosan hydrogels for corneal tissue engineering
    Biomaterials, 2008
    Co-Authors: Mehrdad Rafat, Fengfu Li, Per Fagerholm, Neil Lagali, Mitchell A Watsky, Rejean Munger, Takeshi Matsuura, May Griffith
    Abstract:

    Implantable biomaterials that mimic the extracellular matrix (ECM) in key physical and physiological functions require components and microarchitectures that are carefully designed to maintain the correct balance between biofunctional and physical properties. Our goal was to develop hybrid polymer networks (HPN) that combine the bioactive features of natural materials and physical characteristics of synthetic ones to achieve synergy between the desirable mechanical properties of some components with the biological compatibility and physiological relevance of others. In this study, we developed collagen-chitosan composite hydrogels as corneal implants stabilized by either a simple carbodiimide cross-linker or a hybrid cross-linking system comprised of a long-range bi-functional cross-linker (e.g. poly(ethylene glycol) dibutyraldehyde (PEG-DBA)), and short-range amide-type Cross-Linkers (e.g. 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), and N-hydroxysuccinimide (NHS)). Optimum hybrid hydrogel demonstrated significantly enhanced mechanical strength and elasticity by 100 and 20%, respectively, compared to its non-hybrid counterpart. It demonstrated excellent optical properties, optimum mechanical properties and suturability, and good permeability to glucose and albumin. It had excellent biocompatibility and when implanted into pig corneas for 12 months, allowed seamless host-graft integration with successful regeneration of host corneal epithelium, stroma, and nerves. © 2008 Elsevier Ltd. All rights reserved.

  • peg stabilized carbodiimide crosslinked collagen chitosan hydrogels for corneal tissue engineering
    Biomaterials, 2008
    Co-Authors: Mehrdad Rafat, Per Fagerholm, Neil Lagali, Mitchell A Watsky, Rejean Munger, Takeshi Matsuura, May Griffith
    Abstract:

    Implantable biomaterials that mimic the extracellular matrix (ECM) in key physical and physiological functions require components and microarchitectures that are carefully designed to maintain the correct balance between biofunctional and physical properties. Our goal was to develop hybrid polymer networks (HPN) that combine the bioactive features of natural materials and physical characteristics of synthetic ones to achieve synergy between the desirable mechanical properties of some components with the biological compatibility and physiological relevance of others. In this study, we developed collagen-chitosan composite hydrogels as corneal implants stabilized by either a simple carbodiimide cross-linker or a hybrid cross-linking system comprised of a long-range bi-functional cross-linker (e.g. poly(ethylene glycol) dibutyraldehyde (PEG-DBA)), and short-range amide-type Cross-Linkers (e.g. 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), and N-hydroxysuccinimide (NHS)). Optimum hybrid hydrogel demonstrated significantly enhanced mechanical strength and elasticity by 100 and 20%, respectively, compared to its non-hybrid counterpart. It demonstrated excellent optical properties, optimum mechanical properties and suturability, and good permeability to glucose and albumin. It had excellent biocompatibility and when implanted into pig corneas for 12 months, allowed seamless host-graft integration with successful regeneration of host corneal epithelium, stroma, and nerves.

Mehrdad Rafat - One of the best experts on this subject based on the ideXlab platform.

  • peg stabilized carbodiimide crosslinked collagen chitosan hydrogels for corneal tissue engineering
    Biomaterials, 2008
    Co-Authors: Mehrdad Rafat, Fengfu Li, Per Fagerholm, Neil Lagali, Mitchell A Watsky, Rejean Munger, Takeshi Matsuura, May Griffith
    Abstract:

    Implantable biomaterials that mimic the extracellular matrix (ECM) in key physical and physiological functions require components and microarchitectures that are carefully designed to maintain the correct balance between biofunctional and physical properties. Our goal was to develop hybrid polymer networks (HPN) that combine the bioactive features of natural materials and physical characteristics of synthetic ones to achieve synergy between the desirable mechanical properties of some components with the biological compatibility and physiological relevance of others. In this study, we developed collagen-chitosan composite hydrogels as corneal implants stabilized by either a simple carbodiimide cross-linker or a hybrid cross-linking system comprised of a long-range bi-functional cross-linker (e.g. poly(ethylene glycol) dibutyraldehyde (PEG-DBA)), and short-range amide-type Cross-Linkers (e.g. 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), and N-hydroxysuccinimide (NHS)). Optimum hybrid hydrogel demonstrated significantly enhanced mechanical strength and elasticity by 100 and 20%, respectively, compared to its non-hybrid counterpart. It demonstrated excellent optical properties, optimum mechanical properties and suturability, and good permeability to glucose and albumin. It had excellent biocompatibility and when implanted into pig corneas for 12 months, allowed seamless host-graft integration with successful regeneration of host corneal epithelium, stroma, and nerves. © 2008 Elsevier Ltd. All rights reserved.

  • peg stabilized carbodiimide crosslinked collagen chitosan hydrogels for corneal tissue engineering
    Biomaterials, 2008
    Co-Authors: Mehrdad Rafat, Per Fagerholm, Neil Lagali, Mitchell A Watsky, Rejean Munger, Takeshi Matsuura, May Griffith
    Abstract:

    Implantable biomaterials that mimic the extracellular matrix (ECM) in key physical and physiological functions require components and microarchitectures that are carefully designed to maintain the correct balance between biofunctional and physical properties. Our goal was to develop hybrid polymer networks (HPN) that combine the bioactive features of natural materials and physical characteristics of synthetic ones to achieve synergy between the desirable mechanical properties of some components with the biological compatibility and physiological relevance of others. In this study, we developed collagen-chitosan composite hydrogels as corneal implants stabilized by either a simple carbodiimide cross-linker or a hybrid cross-linking system comprised of a long-range bi-functional cross-linker (e.g. poly(ethylene glycol) dibutyraldehyde (PEG-DBA)), and short-range amide-type Cross-Linkers (e.g. 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), and N-hydroxysuccinimide (NHS)). Optimum hybrid hydrogel demonstrated significantly enhanced mechanical strength and elasticity by 100 and 20%, respectively, compared to its non-hybrid counterpart. It demonstrated excellent optical properties, optimum mechanical properties and suturability, and good permeability to glucose and albumin. It had excellent biocompatibility and when implanted into pig corneas for 12 months, allowed seamless host-graft integration with successful regeneration of host corneal epithelium, stroma, and nerves.

Jongchan Lee - One of the best experts on this subject based on the ideXlab platform.

  • cross linked sulfonated poly arylene ether sulfone membranes formed by in situ casting and click reaction for applications in fuel cells
    Macromolecules, 2015
    Co-Authors: Kihyun Kim, Bokyung Jung, Sangho Cha, Sungkon Kim, Jongchan Lee
    Abstract:

    Sulfonated poly(arylene ether sulfone) membranes with cross-linked structures (C-SPAES) were simply prepared by simultaneously casting and heating the polymer solutions composed of sulfonated poly(arylene ether sulfone) with azidomethyl side groups (SPAES-N3), Cross-Linkers such as 1,4-diethynylbenzene and 4,4′-diazido-2,2′-stilbenedisulfonic acid disodium salt tetrahydrate, and a click reaction catalyst such as CuBr and N,N,N′,N″,N″-pentamethyldiethylenetriamine in N,N-dimethylacetamide, where SPAES-N3 were prepared by the substitution of sulfonated PAES (SPAES) through chloromethylation followed by azidation reaction. C-SPAES membranes obtained using the optimum amount of the Cross-Linkers showed much improved chemical and physical stabilities and mechanical strength compared with linear SPAES membrane. Since the cross-linked structures were formed by the cross-linker having sulfonic acid groups, C-SPAES membranes showed higher ion exchange capacity and proton conductivity than the linear SPAES membrane...

  • Cross-Linked Sulfonated Poly(arylene ether sulfone) Membranes Formed by in Situ Casting and Click Reaction for Applications in Fuel Cells
    2015
    Co-Authors: Kihyun Kim, Bokyung Jung, Sangho Cha, Sungkon Kim, Jongchan Lee
    Abstract:

    Sulfonated poly­(arylene ether sulfone) membranes with cross-linked structures (C-SPAES) were simply prepared by simultaneously casting and heating the polymer solutions composed of sulfonated poly­(arylene ether sulfone) with azidomethyl side groups (SPAES-N3), Cross-Linkers such as 1,4-diethynylbenzene and 4,4′-diazido-2,2′-stilbenedisulfonic acid disodium salt tetrahydrate, and a click reaction catalyst such as CuBr and N,N,N′,N″,N″-pentamethyldiethylenetriamine in N,N-dimethylacetamide, where SPAES-N3 were prepared by the substitution of sulfonated PAES (SPAES) through chloromethylation followed by azidation reaction. C-SPAES membranes obtained using the optimum amount of the Cross-Linkers showed much improved chemical and physical stabilities and mechanical strength compared with linear SPAES membrane. Since the cross-linked structures were formed by the cross-linker having sulfonic acid groups, C-SPAES membranes showed higher ion exchange capacity and proton conductivity than the linear SPAES membrane. Although the C-SPAES membrane can absorb more water than the linear SPAES membrane, less volume expansion was observed due to their physically stable cross-linked structures

Hao Pang - One of the best experts on this subject based on the ideXlab platform.

  • synthesis and characterization of high performance cross linked polycarboxylate superplasticizers
    Construction and Building Materials, 2019
    Co-Authors: Xiuju Lin, Bing Liao, Jingfei Zhang, Jianheng Huang, Hao Pang
    Abstract:

    Abstract Cross-linked sustained-release polycarboxylate superplasticizers (SPs) are superior alternative to the comb-type polycarboxylate SPs due to they offer both a high fluidity and a good retention effect for concrete slurry. In this context, a series of cross-linked polycarboxylate superplasticizers were synthesized using acrylic acid, methylallyl polyoxyethylene ether and four different Cross-Linkers containing ester groups, respectively. The key difference among these four Cross-Linkers is their molecular weights because they each possessed the different ethoxy content. The fluidity and fluidity retention tests, adsorption performance and scanning electron microscope tests showed that the cross-linked superplasticizers offered good dispersing effects and excellent slump performance. Excitingly, the maximum flow reached up to 394 mm at a water-cement ratio of 0.35 and this high fluidity could be simultaneously maintained for 2 h, which facilitated concrete transport over long distances, therefore improving the practical workability of concrete. Furthermore, it was found that the superplasticizers derived from Cross-Linkers with higher ethoxy group contents provided cement paste samples with improved fluidity. Evaluation of the hydration heat and setting time demonstrated that the cross-linked polycarboxylate superplasticizers could delay the hydration of cement and the final setting time had been extended by 4 h in comparation with blank samples. After 3, 7 and 28 d, the compressive strength of the cement mortar was improved with increases of molecular weight of the cross-linker in the cross-linked superplasticizers due to the elevation of ethoxy content.

Takeshi Matsuura - One of the best experts on this subject based on the ideXlab platform.

  • peg stabilized carbodiimide crosslinked collagen chitosan hydrogels for corneal tissue engineering
    Biomaterials, 2008
    Co-Authors: Mehrdad Rafat, Fengfu Li, Per Fagerholm, Neil Lagali, Mitchell A Watsky, Rejean Munger, Takeshi Matsuura, May Griffith
    Abstract:

    Implantable biomaterials that mimic the extracellular matrix (ECM) in key physical and physiological functions require components and microarchitectures that are carefully designed to maintain the correct balance between biofunctional and physical properties. Our goal was to develop hybrid polymer networks (HPN) that combine the bioactive features of natural materials and physical characteristics of synthetic ones to achieve synergy between the desirable mechanical properties of some components with the biological compatibility and physiological relevance of others. In this study, we developed collagen-chitosan composite hydrogels as corneal implants stabilized by either a simple carbodiimide cross-linker or a hybrid cross-linking system comprised of a long-range bi-functional cross-linker (e.g. poly(ethylene glycol) dibutyraldehyde (PEG-DBA)), and short-range amide-type Cross-Linkers (e.g. 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), and N-hydroxysuccinimide (NHS)). Optimum hybrid hydrogel demonstrated significantly enhanced mechanical strength and elasticity by 100 and 20%, respectively, compared to its non-hybrid counterpart. It demonstrated excellent optical properties, optimum mechanical properties and suturability, and good permeability to glucose and albumin. It had excellent biocompatibility and when implanted into pig corneas for 12 months, allowed seamless host-graft integration with successful regeneration of host corneal epithelium, stroma, and nerves. © 2008 Elsevier Ltd. All rights reserved.

  • peg stabilized carbodiimide crosslinked collagen chitosan hydrogels for corneal tissue engineering
    Biomaterials, 2008
    Co-Authors: Mehrdad Rafat, Per Fagerholm, Neil Lagali, Mitchell A Watsky, Rejean Munger, Takeshi Matsuura, May Griffith
    Abstract:

    Implantable biomaterials that mimic the extracellular matrix (ECM) in key physical and physiological functions require components and microarchitectures that are carefully designed to maintain the correct balance between biofunctional and physical properties. Our goal was to develop hybrid polymer networks (HPN) that combine the bioactive features of natural materials and physical characteristics of synthetic ones to achieve synergy between the desirable mechanical properties of some components with the biological compatibility and physiological relevance of others. In this study, we developed collagen-chitosan composite hydrogels as corneal implants stabilized by either a simple carbodiimide cross-linker or a hybrid cross-linking system comprised of a long-range bi-functional cross-linker (e.g. poly(ethylene glycol) dibutyraldehyde (PEG-DBA)), and short-range amide-type Cross-Linkers (e.g. 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), and N-hydroxysuccinimide (NHS)). Optimum hybrid hydrogel demonstrated significantly enhanced mechanical strength and elasticity by 100 and 20%, respectively, compared to its non-hybrid counterpart. It demonstrated excellent optical properties, optimum mechanical properties and suturability, and good permeability to glucose and albumin. It had excellent biocompatibility and when implanted into pig corneas for 12 months, allowed seamless host-graft integration with successful regeneration of host corneal epithelium, stroma, and nerves.