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Michel Daudon - One of the best experts on this subject based on the ideXlab platform.

  • Clinical value of Crystalluria and quantitative morphoconstitutional analysis of urinary calculi
    International journal of surgery (London England), 2016
    Co-Authors: Vincent Frochot, Michel Daudon
    Abstract:

    Abstract Crystalluria is a marker of urine supersaturation with substances deriving from metabolic disorders, inherited diseases or drugs. The investigation of Crystalluria must be done according to a protocol which includes the delivery to the laboratory of a proper urine sample, the use of a microscope equipped with polarized light, the accurate knowledge of urine pH, and a comprehensive examination of the crystals, which is based on their identification, quantification and size measurement. For unusual crystals, infrared spectroscopy may also be needed. If the formation of stones is always preceded by Crystalluria, the reverse is not true. In addition to the crystalline composition, stone morphology provides valuable information on stone activity and, for some crystalline species, major information regarding the underlying pathology. Fourier transform infrared spectroscopy (FTIR) reliably identify specific forms of nephrolithiasis, as common-type stones made of calcium oxalate (CaOx) and/or calcium phosphate that is combined with morphology classification; using this method, stones may be classified into 6 types subdivided in 22 subtypes. The investigation of Crystalluria is an inexpensive and valuable tool for the detection and the monitoring of inherited and acquired diseases associated with urinary stone formation or acute or chronic renal function impairment from intrarenal crystal precipitation. Selective FTIR identification of the composition of core (or the umbilication), middle part, and surface of every stone allows identification of the initiating lithogenic process (in the nucleus or in the Randall's plaque) and the factors which subsequently contributed to stone growth. In conclusion, the proposed morpho-constitutional method of urinary stone analysis, which moreover is rapid and low cost, provides clinically relevant orientations for targeted etiologic evaluation.

  • Respective influence of calcium and oxalate urine concentration on the formation of calcium oxalate monohydrate or dihydrate crystals
    Comptes Rendus Chimie, 2016
    Co-Authors: Michel Daudon, Emmanuel Letavernier, Vincent Frochot, Jean-philippe Haymann, Dominique Bazin, Paul Jungers
    Abstract:

    Clinical interest for the identification of the crystalline phase of CaOx, either monohydrate (COM) or dihydrate (COD), in Crystalluria analysis is debated. In the present study, we simultaneously determined calcium and oxalate concentration and identified the two crystalline phases of CaOx crystals in 1288 first morning urine samples from 407 CaOx stone formers with Crystalluria.

  • Images in Nephrology (Section Editor: G. H. Nield) Amoxycillin, a rare but possible cause of Crystalluria
    2015
    Co-Authors: Giovanni B. Fogazzi, Lucia Saglimbeni, Michel Daudon
    Abstract:

    Crystalluria caused by amoxycillin is a rare event that may be asymptomatic or may have severe renal implications. In January 2002 a urine sample from a 64-year-old woman which contained a large amount of unusual crystals was referred to us. Macroscopically the urine was normal. By dipstick, pH was 5.5, relative density 1.030, and albumin" haemoglobin and leukocyte esterase were negative. However, after centrifugation for 10 min at 400 g, removal of the supernatant urine, and resuspension of the sediment, the specimen showed a whitish and chalky appearance. The sediment, examined by phase-contrast microscopy at low (1603) and high (4003) magnifications, showed hyaline casts (qqq), candida (q), squamous cells (qq) and a massive Crystalluria

  • Prediction of successful treatment by extracorporeal shock wave lithotripsy based on Crystalluria-composition correlations of urinary calculi
    Asian Pacific Journal of Tropical Disease, 2015
    Co-Authors: Nadia Messaoudi, Michel Daudon, Kada Sennour, Zohra Kaid Omar, Abderrahmane Attar, Ahmed Addou
    Abstract:

    Abstract Objective To provide correlations between Crystalluria and chemical structure of calculi in situ to help making decision in the use of the extracorporeal shock wave lithotripsy (ESWL). Methods A Crystalluria study was carried out on 644 morning urines of 172 nephrolithiasis patients (111 males and 61 females), and 235 of them were in situ stone carriers. After treating by ESWL, the recovered calculi have been analyzed by Fourier transform infrared spectroscopy and their compositions were correlated to the nature of urinary crystals. Results We obtained successful treatment for 109 patients out of 157 and 63 patients out of 78 with stones had a treatment failure (33.2%). The correlations showed that for the overwhelming Crystalluria containing calcium oxalate dihydrate (COD) with mixed crystals without calcium oxalate monohydrate, we should have 68% to 88 % success rate. However, the obtained result was 79%. Similarly, for Crystalluria with COD + calcium oxalate monohydrate ± carbapatite, the prediction was 11% to 45% and the result was approximately 39%. When the majority of Crystalluria was calcium phosphate, the prediction of 50% to 80% was confirmed by 71% success rate. For those majority containing magnesium ammonium phosphate hexahydrate (struvite) ± diammonium urate ± COD, we predicted between 80% to 100%, and the result gave a success rate of 84%. Conclusions The analysis of Crystalluria of morning urine can help to know the composition of calculi in situ and can predict the success rate of ESWL for maximum efficiency.

  • Prediction of successful treatment by extracorporeal shock wave lithotripsy based on Crystalluriacomposition correlations of urinary calculi
    Asian Pacific Journal of Tropical Disease Editorial Office, 2015
    Co-Authors: Nadia Messaoudi, Michel Daudon, Kada Sennour, Zohra Kaid Omar, Abderrahmane Attar, Ahmed Addou
    Abstract:

    Objective: To provide correlations between Crystalluria and chemical structure of calculi in situ to help making decision in the use of the extracorporeal shock wave lithotripsy (ESWL). Methods: A Crystalluria study was carried out on 644 morning urines of 172 nephrolithiasis patients (111 males and 61 females), and 235 of them were in situ stone carriers. After treating by ESWL, the recovered calculi have been analyzed by Fourier transform infrared spectroscopy and their compositions were correlated to the nature of urinary crystals. Results: We obtained successful treatment for 109 patients out of 157 and 63 patients out of 78 with stones had a treatment failure (33.2%). The correlations showed that for the overwhelming Crystalluria containing calcium oxalate dihydrate (COD) with mixed crystals without calcium oxalate monohydrate, we should have 68% to 88 % success rate. However, the obtained result was 79%. Similarly, for Crystalluria with COD + calcium oxalate monohydrate ± carbapatite, the prediction was 11% to 45% and the result was approximately 39%. When the majority of Crystalluria was calcium phosphate, the prediction of 50% to 80% was confirmed by 71% success rate. For those majority containing magnesium ammonium phosphate hexahydrate (struvite) ± diammonium urate ± COD, we predicted between 80% to 100%, and the result gave a success rate of 84%. Conclusions: The analysis of Crystalluria of morning urine can help to know the composition of calculi in situ and can predict the success rate of ESWL for maximum efficiency

Ronald H. Goldschmidt - One of the best experts on this subject based on the ideXlab platform.

  • Sulfadiazine-induced Crystalluria and renal failure in a patient with AIDS.
    The Journal of the American Board of Family Practice, 1999
    Co-Authors: Betty J. Dong, Rudolph A. Rodriguez, Ronald H. Goldschmidt
    Abstract:

    Cerebral toxoplasmosis is one of the most treatable opportunistic infections of the central nervous system in patients with the acquired immunodeficiency syndrome (AIDS).l,2 A combination of sulfadiazine and pyrimethamine is the therapy of choice, producing a favorable clinical response in 68 to 95 percent of patients receiving this regimen.3,4 Reports of sulfadiazine-induced Crystalluria and renal failure were common during the 1940s and 1950s, before more soluble sulfonamides, such as trimethoprim-sulfamethoxazole (TMP/SMX) , became available. Recently, case reports of sulfadiazine nephrotoxicity have reappeared as widespread use of this regimen for human immunodeficiency virus (HIV)-related cerebral toxoplasmosis increased.5-17 We report a patient with AIDS and central nervous system toxoplasmosis who developed nonoliguric renal failure caused by sulfadiazine-induced Crystalluria.

Paul Jungers - One of the best experts on this subject based on the ideXlab platform.

  • Respective influence of calcium and oxalate urine concentration on the formation of calcium oxalate monohydrate or dihydrate crystals
    Comptes Rendus Chimie, 2016
    Co-Authors: Michel Daudon, Emmanuel Letavernier, Vincent Frochot, Jean-philippe Haymann, Dominique Bazin, Paul Jungers
    Abstract:

    Clinical interest for the identification of the crystalline phase of CaOx, either monohydrate (COM) or dihydrate (COD), in Crystalluria analysis is debated. In the present study, we simultaneously determined calcium and oxalate concentration and identified the two crystalline phases of CaOx crystals in 1288 first morning urine samples from 407 CaOx stone formers with Crystalluria.

  • Serial Crystalluria determination and the risk of recurrence in calcium stone formers.
    Kidney international, 2005
    Co-Authors: Michel Daudon, Bernard Lacour, Carole Hennequin, Ghazi Boujelben, Paul Jungers
    Abstract:

    Serial Crystalluria determination and the risk of recurrence in calcium stone formers. Background Urinary crystal precipitation is the necessary initial step in kidney stone formation. However, clinical relevance of Crystalluria in the evaluation of stone formers is disputed. Methods We serially determined Crystalluria in first-voided morning urine samples, together with full 24-hour urine biochemistry, in 181 patients with idiopathic calcium nephrolithiasis who had formed at least one calcium-oxalate stone and were followed for at least 3 years under our care. All stone events which occurred prior to referral, then after entry in the study were recorded. Results As compared with 109 patients who had no evidence of stone recurrence during follow-up, the 72 patients who experienced ≥ one recurrent stone event had a lower daily urine volume (1.74 ± 0.06 vs. 2.26 ± 0.05 L/day (mean ± SEM) ( P P Conclusion These data provide evidence that Crystalluria, when repeatedly found in early morning urine samples, is highly predictive of the risk of stone recurrence in calcium stone formers. Serial search for Crystalluria, a simple and cheap method, may be proposed as a useful tool for the monitoring of calcium stone formers, in addition to urine biochemistry.

  • Clinical value of Crystalluria study
    Annales de biologie clinique, 2004
    Co-Authors: Michel Daudon, Paul Jungers, Bernard Lacour
    Abstract:

    Crystalluria is a marker of urine supersaturation present in both normal and pathological conditions. Indeed, nature and characteristics of the spontaneous Crystalluria are of clinical interest for detecting and following biological disorders involved in renal diseases. Method. Crystalluria examination should preferably be performed on first morning urine or fresh fasting voiding samples by polarised microscopy in a Malassez cell. Urine samples must be stored at 37 degrees C or at room temperature and examined within two hours following voiding. Results and discussion. Crystalluria should be interpreted according to various criteria: 1) chemical nature of crystals for abnormal crystals such as struvite, ammonium urate, cystine, dihydroxyadenine, xanthine or drugs; 2) crystalline phase of common chemical species as calcium oxalates, calcium phosphates and uric acids; 3) crystal morphology (calcium oxalates); 4) crystal size (calcium oxalates); 5) crystal abundance (calcium oxalates, calcium phosphates, uric acids, cystine); 6) crystal aggregation (calcium oxalates); 7) frequency of Crystalluria assessed on serial first morning urine samples, a very useful tool for long-term surveillance of patients. Within calcium oxalate Crystalluria, presence of whewellite is a marker of elevated oxalate concentration (urine oxalate > 0.3 mmol/L); a crystal number > 200/mm 3 is highly suggestive of heavy hyperoxaluria of genetic or absorptive origin. Predominant weddellite Crystalluria is most often indicative of an excessive urine calcium concentration (> 3.8 mmol/L); a dodecahedric aspect of the crystals is a marker for heavy hypercalciuria (> 6 mmol/L) while an increased crystal size (>or= 35 microm) is indicative of simultaneous hypercalciuria and hyperoxaluria. Calculation of the global crystal volume, especially when applied to calcium oxalates or cystine, is a clinically useful tool for the monitoring of patients suffering from primary hyperoxaluria or cystinuria. Lastly, presence of Crystalluria in more than 50% of serial first voided morning urine samples is in our experience the most reliable biological marker for detecting the risk of stone recurrence in lithiasic patients. Conclusion. Crystalluria examination is an essential laboratory test for detecting and following pathological conditions, which may induce renal stone disease or alter kidney function due to urine crystals.

  • Clinical value of Crystalluria and quantitative morphoconstitutional analysis of urinary calculi.
    Nephron. Physiology, 2004
    Co-Authors: Michel Daudon, Paul Jungers
    Abstract:

    Morphoconstitutional analysis of urinary calculi, i.e. morphologic examination combined with Fourier transform infrared spectroscopy (FTIR), is of decisive interest for the diagnosis of rare but severe inherited or acquired stone diseases such as cystine, 2,8-dihydroxyadenine, xanthine, struvite, ammonium urate or drug-containing calculi as well as primary hyperoxalurias. In the absence of early diagnosis and proper management, these diseases may lead to progressive loss of renal function. Among common forms of calcium oxalate (CaOx) stones, predominant CaOx monohydrate (whewellite) is mainly associated with hyperoxaluric conditions whereas predominant CaOx dihydrate (weddellite) is mainly associated with hypercalciuria, and this distinction is of interest to orient metabolic evaluation and preventive measures. Crystalluria examination, also based on morphology and FTIR, is a valuable diagnostic method when no stone is available for analysis. Presence of specific crystals (cystine, 2,8-dihydroxyadenine, struvite, ammonium urate) is diagnostic by itself. In all types of nephrolithiasis, serial Crystalluria determination appears as a simple, cheap and reliable method to evaluate the risk of stone formation and assess the effectiveness of preventive measures. Determination of urinary crystal volume was in our experience a useful tool in the management of patients with cystinuria or primary hyperoxaluria in the post-transplantation period. In conclusion, both accurate morphologic and FTIR analysis of stones and serial Crystalluria determination should be more largely used, in view of their value in the diagnosis and management of renal stone formers.

Gadisseur Romy - One of the best experts on this subject based on the ideXlab platform.

  • Données cliniques à propos de cas rares de cristalluries de sulfaméthoxazole diagnostiquées par analyse infrarouge à transformée de Fourier
    'Elsevier BV', 2018
    Co-Authors: Castiglione Vincent, Cavalier Etienne, Gadisseur Romy
    Abstract:

    peer reviewedaudience: researcher, professionalThe data contained in this article are related to the article entitled “Case report: Uncommon Sulfamethoxazole Crystalluria” [1]. Sulfamethoxazole Crystalluria is very rare and crystals identification is complex [2], [3]. We identified seven patients with uncommon urine crystals that were composed of N-Acetyl-Sulfamethoxazole. Three of the patients developed an acute renal failure simultaneously to Crystalluria. Hence, this article describes the method of crystals identification thanks to infrared spectroscopy. The relevant clinical data of patients, including medical history, drug dosage and urine parameters related to the Crystalluria are presented

  • Données cliniques à propos de cas rares de cristalluries de sulfaméthoxazole diagnostiquées par analyse infrarouge à transformée de Fourier
    2018
    Co-Authors: Castiglione Vincent, Cavalier Etienne, Gadisseur Romy
    Abstract:

    The data contained in this article are related to the article entitled “Case report: Uncommon Sulfamethoxazole Crystalluria” [1]. Sulfamethoxazole Crystalluria is very rare and crystals identification is complex [2], [3]. We identified seven patients with uncommon urine crystals that were composed of N-Acetyl-Sulfamethoxazole. Three of the patients developed an acute renal failure simultaneously to Crystalluria. Hence, this article describes the method of crystals identification thanks to infrared spectroscopy. The relevant clinical data of patients, including medical history, drug dosage and urine parameters related to the Crystalluria are presented.Peer reviewe

  • Crystallurie rare de Sulfaméthoxazole
    2018
    Co-Authors: Castiglione Vincent, Cavalier Etienne, Gadisseur Romy
    Abstract:

    We report seven Caucasian patients with unusual Sulfamethoxazole Crystalluria on random urine sediment analysis. Crystals had very uncommon and various shapes and were identified thanks to infrared spectroscopy. An eGFR (MDRD) decrease was associated to Crystalluria onset in three patients.Peer reviewe

  • Crystallurie rare de Sulfaméthoxazole
    'Elsevier BV', 2018
    Co-Authors: Castiglione Vincent, Cavalier Etienne, Gadisseur Romy
    Abstract:

    peer reviewedaudience: researcher, professionalWe report seven Caucasian patients with unusual Sulfamethoxazole Crystalluria on random urine sediment analysis. Crystals had very uncommon and various shapes and were identified thanks to infrared spectroscopy. An eGFR (MDRD) decrease was associated to Crystalluria onset in three patients

Betty J. Dong - One of the best experts on this subject based on the ideXlab platform.

  • Sulfadiazine-induced Crystalluria and renal failure in a patient with AIDS.
    The Journal of the American Board of Family Practice, 1999
    Co-Authors: Betty J. Dong, Rudolph A. Rodriguez, Ronald H. Goldschmidt
    Abstract:

    Cerebral toxoplasmosis is one of the most treatable opportunistic infections of the central nervous system in patients with the acquired immunodeficiency syndrome (AIDS).l,2 A combination of sulfadiazine and pyrimethamine is the therapy of choice, producing a favorable clinical response in 68 to 95 percent of patients receiving this regimen.3,4 Reports of sulfadiazine-induced Crystalluria and renal failure were common during the 1940s and 1950s, before more soluble sulfonamides, such as trimethoprim-sulfamethoxazole (TMP/SMX) , became available. Recently, case reports of sulfadiazine nephrotoxicity have reappeared as widespread use of this regimen for human immunodeficiency virus (HIV)-related cerebral toxoplasmosis increased.5-17 We report a patient with AIDS and central nervous system toxoplasmosis who developed nonoliguric renal failure caused by sulfadiazine-induced Crystalluria.