The Experts below are selected from a list of 21630 Experts worldwide ranked by ideXlab platform
Richard L Wahl - One of the best experts on this subject based on the ideXlab platform.
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accuracy of image fusion of normal upper abdominal organs visualized with in111 octreotide spect ct using a 16 slice ct spect Scanner
The Journal of Nuclear Medicine, 2007Co-Authors: Dacian Bonta, Richard L WahlAbstract:1764 Objectives: Although SPECT/CT (HRCT) Scanners have the potential for precise fused registration of anatomic structures, physiological motion during the acquisition of both studies may alter the appearance of organ shape, size or location. The aim of this study was to assess the consistency in location and measured size of upper abdominal organs with In111 Octreotide SPECT and CT using a combined SPECT high resolution CT system. Methods: We evaluated ten consecutive patients who underwent clinical SPECT/CT scans for suspected/follow-up of somatostatin avid tumors using a 16 slice CT/SPECT system (Philips, Precedence). Both SPECT and CT images were acquired with patients in tidal breathing. CT scans were performed without iv. contrast. We separately determined the location of the cranial and caudal margins for liver, spleen, and bilateral kidneys, on SPECT and CT. Differences between the two modalities in terms of location and measured organ size were investigated. Results: The results of the analysis are presented in the attached table. The upper pole of the left kidney could not be reliably identified on the SPECT images due to proximity of spleen. Due to the mild uptake of radiotracer in the liver, and the narrow, elongated shape of the inferior liver tip, the full inferior extent of liver radiotracer activity was also not reliably assessed. Conclusions: The upper abdominal normal organs appear slightly larger on SPECT compared with CT with the windows selected for clinical interpretation. Intraperitoneal organs (spleen) had a larger cranio-caudal displacement between SPECT and CT than the retroperitoneal organs (kidneys). Overall, registration quality with the high quality CT/SPECT system was excellent.
Dacian Bonta - One of the best experts on this subject based on the ideXlab platform.
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accuracy of image fusion of normal upper abdominal organs visualized with in111 octreotide spect ct using a 16 slice ct spect Scanner
The Journal of Nuclear Medicine, 2007Co-Authors: Dacian Bonta, Richard L WahlAbstract:1764 Objectives: Although SPECT/CT (HRCT) Scanners have the potential for precise fused registration of anatomic structures, physiological motion during the acquisition of both studies may alter the appearance of organ shape, size or location. The aim of this study was to assess the consistency in location and measured size of upper abdominal organs with In111 Octreotide SPECT and CT using a combined SPECT high resolution CT system. Methods: We evaluated ten consecutive patients who underwent clinical SPECT/CT scans for suspected/follow-up of somatostatin avid tumors using a 16 slice CT/SPECT system (Philips, Precedence). Both SPECT and CT images were acquired with patients in tidal breathing. CT scans were performed without iv. contrast. We separately determined the location of the cranial and caudal margins for liver, spleen, and bilateral kidneys, on SPECT and CT. Differences between the two modalities in terms of location and measured organ size were investigated. Results: The results of the analysis are presented in the attached table. The upper pole of the left kidney could not be reliably identified on the SPECT images due to proximity of spleen. Due to the mild uptake of radiotracer in the liver, and the narrow, elongated shape of the inferior liver tip, the full inferior extent of liver radiotracer activity was also not reliably assessed. Conclusions: The upper abdominal normal organs appear slightly larger on SPECT compared with CT with the windows selected for clinical interpretation. Intraperitoneal organs (spleen) had a larger cranio-caudal displacement between SPECT and CT than the retroperitoneal organs (kidneys). Overall, registration quality with the high quality CT/SPECT system was excellent.
Bijoy Kundu - One of the best experts on this subject based on the ideXlab platform.
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non invasive determination of blood input function to compute rate of myocardial glucose uptake from dynamic fdg pet images of rat heart in vivo comparative study between the inferior vena cava and the left ventricular blood pool with spill over and
Physics in Medicine and Biology, 2019Co-Authors: Qiao Huang, James C Massey, Krzysztof Minczuk, Bijoy KunduAbstract:The purpose of this work was to compute blood input function from the inferior vena cava (IVC) with partial volume (PV) corrections and compare to that obtained from the left ventricular blood pool (LVBP) with spill-over (SP) and PV corrections. These were then used to compute and validate rates of myocardial 2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake (Ki) from dynamic positron emission tomography (PET) images of rat hearts in vivo in comparison to that obtained from invasive arterial blood sampling. Whole body 60 min dynamic FDG PET/CT imaging of n = 8 control Wistar Kyoto (WKY) rats were performed using Albira trimodal PET/CT/SPECT Scanner. Image derived blood input function (IDIF) obtained from IVC corrected for PV averaging (IVC-PV) and IDIF from the left ventricular blood pool (LVBP) with SP and PV corrections (LVBP-SP-PV) were computed. Next, computed Ki (indirect comparison) in a 5-parameter (using IVC-PV) and a 15-parameter (using LVBP-SP-PV) 3-compartment models in WKY rat hearts in vivo were compared to that obtained using arterial blood sampling reported in literature in control Spraque Dawley (SD) rats. Using IVC-PV in a three-compartment five-parameter model resulted in a ~46% deviation in the mean computed Ki compared to that obtained with LVBP-SP-PV in a three-compartment 15-parameter model with a ~57% deviation in the mean computed Ki. The mean computed Ki in WKY rat hearts using the above methods, however, did not differ significantly to that obtained from invasive arterial blood sampling in SD rat hearts (p = 0.91 for IVC-PV and p = 0.58 for LVBP-SP-PV). Hence, Ki obtained in WKY rat hearts with input curve from IVC (IVC-PV) in a dynamic FDG PET scan is comparatively more repetitive to that obtained from the LVBP (LVBP-SP-PV). Ki computed using both the methods, however, agree well with each other and that obtained using arterial blood sampling.
Qiao Huang - One of the best experts on this subject based on the ideXlab platform.
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non invasive determination of blood input function to compute rate of myocardial glucose uptake from dynamic fdg pet images of rat heart in vivo comparative study between the inferior vena cava and the left ventricular blood pool with spill over and
Physics in Medicine and Biology, 2019Co-Authors: Qiao Huang, James C Massey, Krzysztof Minczuk, Bijoy KunduAbstract:The purpose of this work was to compute blood input function from the inferior vena cava (IVC) with partial volume (PV) corrections and compare to that obtained from the left ventricular blood pool (LVBP) with spill-over (SP) and PV corrections. These were then used to compute and validate rates of myocardial 2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake (Ki) from dynamic positron emission tomography (PET) images of rat hearts in vivo in comparison to that obtained from invasive arterial blood sampling. Whole body 60 min dynamic FDG PET/CT imaging of n = 8 control Wistar Kyoto (WKY) rats were performed using Albira trimodal PET/CT/SPECT Scanner. Image derived blood input function (IDIF) obtained from IVC corrected for PV averaging (IVC-PV) and IDIF from the left ventricular blood pool (LVBP) with SP and PV corrections (LVBP-SP-PV) were computed. Next, computed Ki (indirect comparison) in a 5-parameter (using IVC-PV) and a 15-parameter (using LVBP-SP-PV) 3-compartment models in WKY rat hearts in vivo were compared to that obtained using arterial blood sampling reported in literature in control Spraque Dawley (SD) rats. Using IVC-PV in a three-compartment five-parameter model resulted in a ~46% deviation in the mean computed Ki compared to that obtained with LVBP-SP-PV in a three-compartment 15-parameter model with a ~57% deviation in the mean computed Ki. The mean computed Ki in WKY rat hearts using the above methods, however, did not differ significantly to that obtained from invasive arterial blood sampling in SD rat hearts (p = 0.91 for IVC-PV and p = 0.58 for LVBP-SP-PV). Hence, Ki obtained in WKY rat hearts with input curve from IVC (IVC-PV) in a dynamic FDG PET scan is comparatively more repetitive to that obtained from the LVBP (LVBP-SP-PV). Ki computed using both the methods, however, agree well with each other and that obtained using arterial blood sampling.
James C Massey - One of the best experts on this subject based on the ideXlab platform.
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non invasive determination of blood input function to compute rate of myocardial glucose uptake from dynamic fdg pet images of rat heart in vivo comparative study between the inferior vena cava and the left ventricular blood pool with spill over and
Physics in Medicine and Biology, 2019Co-Authors: Qiao Huang, James C Massey, Krzysztof Minczuk, Bijoy KunduAbstract:The purpose of this work was to compute blood input function from the inferior vena cava (IVC) with partial volume (PV) corrections and compare to that obtained from the left ventricular blood pool (LVBP) with spill-over (SP) and PV corrections. These were then used to compute and validate rates of myocardial 2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake (Ki) from dynamic positron emission tomography (PET) images of rat hearts in vivo in comparison to that obtained from invasive arterial blood sampling. Whole body 60 min dynamic FDG PET/CT imaging of n = 8 control Wistar Kyoto (WKY) rats were performed using Albira trimodal PET/CT/SPECT Scanner. Image derived blood input function (IDIF) obtained from IVC corrected for PV averaging (IVC-PV) and IDIF from the left ventricular blood pool (LVBP) with SP and PV corrections (LVBP-SP-PV) were computed. Next, computed Ki (indirect comparison) in a 5-parameter (using IVC-PV) and a 15-parameter (using LVBP-SP-PV) 3-compartment models in WKY rat hearts in vivo were compared to that obtained using arterial blood sampling reported in literature in control Spraque Dawley (SD) rats. Using IVC-PV in a three-compartment five-parameter model resulted in a ~46% deviation in the mean computed Ki compared to that obtained with LVBP-SP-PV in a three-compartment 15-parameter model with a ~57% deviation in the mean computed Ki. The mean computed Ki in WKY rat hearts using the above methods, however, did not differ significantly to that obtained from invasive arterial blood sampling in SD rat hearts (p = 0.91 for IVC-PV and p = 0.58 for LVBP-SP-PV). Hence, Ki obtained in WKY rat hearts with input curve from IVC (IVC-PV) in a dynamic FDG PET scan is comparatively more repetitive to that obtained from the LVBP (LVBP-SP-PV). Ki computed using both the methods, however, agree well with each other and that obtained using arterial blood sampling.