The Experts below are selected from a list of 60 Experts worldwide ranked by ideXlab platform
Agnieszka Szopa - One of the best experts on this subject based on the ideXlab platform.
-
Characteristics of bakuchiol - the compound with high biological activity and the main source of its acquisition - Cullen corylifolium (L.) Medik.
Natural product research, 2020Co-Authors: Karolina Jafernik, Ekiert Halina, Sezai Ercisli, Agnieszka SzopaAbstract:The article presents the characteristics of bakuchiol - a natural compound valuable in cosmetology and pharmacology. The only source for obtaining this specific meroterpenic phenol is the fruit of the species Cullen corylifolium (Psoralea corylifolia). Bakuchiol has recently been playing a significant role in cosmetology as a "natural substitute" for retinol, free of side effects. Clinical studies confirm valuable cosmetological properties of bakuchiol, such as anti-ageing, anti-pigmentation and anti-acne effects. Scientific research has also shown valuable pharmacological properties of bakuchiol, such as anti-cancer, hepatoprotective, cardioprotective, hypoglycemic, hypolipemic, and antidepressant. In addition, antioxidant, anti-inflammatory and antimicrobal activities of bakuchiol, valuable from the point of view of both cosmetology and therapy, have also been confirmed. A separate part of the article is devoted to the botanical, chemical and pharmacological characteristics of the species C. corylifolium as the main source for obtaining bakuchiol.
-
characteristics of bakuchiol the compound with high biological activity and the main source of its acquisition Cullen corylifolium l medik
Natural Product Research, 2020Co-Authors: Karolina Jafernik, Ekiert Halina, Sezai Ercisli, Agnieszka SzopaAbstract:The article presents the characteristics of bakuchiol – a natural compound valuable in cosmetology and pharmacology. The only source for obtaining this specific meroterpenic phenol is the fruit of ...
Karolina Jafernik - One of the best experts on this subject based on the ideXlab platform.
-
Characteristics of bakuchiol - the compound with high biological activity and the main source of its acquisition - Cullen corylifolium (L.) Medik.
Natural product research, 2020Co-Authors: Karolina Jafernik, Ekiert Halina, Sezai Ercisli, Agnieszka SzopaAbstract:The article presents the characteristics of bakuchiol - a natural compound valuable in cosmetology and pharmacology. The only source for obtaining this specific meroterpenic phenol is the fruit of the species Cullen corylifolium (Psoralea corylifolia). Bakuchiol has recently been playing a significant role in cosmetology as a "natural substitute" for retinol, free of side effects. Clinical studies confirm valuable cosmetological properties of bakuchiol, such as anti-ageing, anti-pigmentation and anti-acne effects. Scientific research has also shown valuable pharmacological properties of bakuchiol, such as anti-cancer, hepatoprotective, cardioprotective, hypoglycemic, hypolipemic, and antidepressant. In addition, antioxidant, anti-inflammatory and antimicrobal activities of bakuchiol, valuable from the point of view of both cosmetology and therapy, have also been confirmed. A separate part of the article is devoted to the botanical, chemical and pharmacological characteristics of the species C. corylifolium as the main source for obtaining bakuchiol.
-
characteristics of bakuchiol the compound with high biological activity and the main source of its acquisition Cullen corylifolium l medik
Natural Product Research, 2020Co-Authors: Karolina Jafernik, Ekiert Halina, Sezai Ercisli, Agnieszka SzopaAbstract:The article presents the characteristics of bakuchiol – a natural compound valuable in cosmetology and pharmacology. The only source for obtaining this specific meroterpenic phenol is the fruit of ...
Ekiert Halina - One of the best experts on this subject based on the ideXlab platform.
-
Characteristics of bakuchiol - the compound with high biological activity and the main source of its acquisition - Cullen corylifolium (L.) Medik.
Natural product research, 2020Co-Authors: Karolina Jafernik, Ekiert Halina, Sezai Ercisli, Agnieszka SzopaAbstract:The article presents the characteristics of bakuchiol - a natural compound valuable in cosmetology and pharmacology. The only source for obtaining this specific meroterpenic phenol is the fruit of the species Cullen corylifolium (Psoralea corylifolia). Bakuchiol has recently been playing a significant role in cosmetology as a "natural substitute" for retinol, free of side effects. Clinical studies confirm valuable cosmetological properties of bakuchiol, such as anti-ageing, anti-pigmentation and anti-acne effects. Scientific research has also shown valuable pharmacological properties of bakuchiol, such as anti-cancer, hepatoprotective, cardioprotective, hypoglycemic, hypolipemic, and antidepressant. In addition, antioxidant, anti-inflammatory and antimicrobal activities of bakuchiol, valuable from the point of view of both cosmetology and therapy, have also been confirmed. A separate part of the article is devoted to the botanical, chemical and pharmacological characteristics of the species C. corylifolium as the main source for obtaining bakuchiol.
-
characteristics of bakuchiol the compound with high biological activity and the main source of its acquisition Cullen corylifolium l medik
Natural Product Research, 2020Co-Authors: Karolina Jafernik, Ekiert Halina, Sezai Ercisli, Agnieszka SzopaAbstract:The article presents the characteristics of bakuchiol – a natural compound valuable in cosmetology and pharmacology. The only source for obtaining this specific meroterpenic phenol is the fruit of ...
Sezai Ercisli - One of the best experts on this subject based on the ideXlab platform.
-
Characteristics of bakuchiol - the compound with high biological activity and the main source of its acquisition - Cullen corylifolium (L.) Medik.
Natural product research, 2020Co-Authors: Karolina Jafernik, Ekiert Halina, Sezai Ercisli, Agnieszka SzopaAbstract:The article presents the characteristics of bakuchiol - a natural compound valuable in cosmetology and pharmacology. The only source for obtaining this specific meroterpenic phenol is the fruit of the species Cullen corylifolium (Psoralea corylifolia). Bakuchiol has recently been playing a significant role in cosmetology as a "natural substitute" for retinol, free of side effects. Clinical studies confirm valuable cosmetological properties of bakuchiol, such as anti-ageing, anti-pigmentation and anti-acne effects. Scientific research has also shown valuable pharmacological properties of bakuchiol, such as anti-cancer, hepatoprotective, cardioprotective, hypoglycemic, hypolipemic, and antidepressant. In addition, antioxidant, anti-inflammatory and antimicrobal activities of bakuchiol, valuable from the point of view of both cosmetology and therapy, have also been confirmed. A separate part of the article is devoted to the botanical, chemical and pharmacological characteristics of the species C. corylifolium as the main source for obtaining bakuchiol.
-
characteristics of bakuchiol the compound with high biological activity and the main source of its acquisition Cullen corylifolium l medik
Natural Product Research, 2020Co-Authors: Karolina Jafernik, Ekiert Halina, Sezai Ercisli, Agnieszka SzopaAbstract:The article presents the characteristics of bakuchiol – a natural compound valuable in cosmetology and pharmacology. The only source for obtaining this specific meroterpenic phenol is the fruit of ...
Yongjun Wang - One of the best experts on this subject based on the ideXlab platform.
-
Estrogenic properties of coumarins and meroterpene from the fruits of Cullen corylifolium: Experimental and computational studies.
Phytochemistry, 2018Co-Authors: Tiehua Zhang, Shuning Zhong, Ligang Hou, Xiaojia Xing, Tianzhu Guan, Jie Zhang, Yongjun WangAbstract:Coumarins and meroterpene from the fruits of Cullen corylifolium were evaluated for their ability to bind and activate human estrogen receptor α (hERα) by a combination of in vitro studies and molecular dynamics simulations. The recombinant hERα ligand binding domain (hERα-LBD) was produced in BL21 (DE3)pLysS and the fluorescence polarization (FP) assay was performed to determine the binding affinities of coumarins and meroterpene with receptor protein. These compounds displayed distinct binding potency toward hERα-LBD, generally increased with their increasing molecular length and Connolly solvent-excluded volume (CSEV). In an estrogen response element-luciferase (ERE-Luc) reporter gene assay, coumarins and meroterpene acted as agonists of human estrogen receptor α. Subsequently, molecular docking was conducted to elucidate the molecular mechanism behind their agonistic activities. Coumarins and meroterpene adopted an agonist conformation within the cavity of hERα-LBD. The hydrophobic and hydrogen-bonding interactions were dominant forces to stabilize their binding. The structure-activity relationship analysis suggested that the presence of hydroxyl groups and prenyl group were crucial for possessing estrogenic activities. Comparison of the calculated binding energies with the determined binding affinities yielded a good correlation (R2 = 0.9727). In conclusion, molecular modeling techniques can potentially be applied for in silico screening of selective estrogen receptor modulators (SERMs) from undescribed compounds.