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Andrea Motta - One of the best experts on this subject based on the ideXlab platform.
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Sphaeropsidins D and E, two other pimarane diterpenes, produced in vitro by the plant pathogenic fungus Sphaeropsis sapinea f. sp. cupressi
Phytochemistry, 2002Co-Authors: Antonio Evidente, Lorenzo Sparapano, Giovanni Bruno, Andrea MottaAbstract:Abstract Two pimarane diterpenes structurally related to sphaeropsidins were isolated from the liquid culture of Sphaeropsis sapinea f. sp. cupressi, a plant pathogenic fungus causing a form of canker disease of Italian cypress (Cupressus sempervirens L.). The two metabolites, characterised by spectroscopic methods, were named sphaeropsidins D (0.40 mg l−1) and E (0.16 mg l−1). The same fungus produced sphaeropsidins A, B and C, sphaeropsidone and episphaeropsidone, which proved to be phytotoxic to cypress, and chlorosphaeropsidone and epichlorosphaeropsidone showing no phytotoxicity. Sphaeropsidin D assayed at 0.1 mg ml−1 on severed cypress twigs caused leaf browning and necrosis on Cupressus macrocarpa, but no symptoms were observed on C. sempervirens and C. arizonica. Symptoms appeared in a period of time (6 days after toxin-treatment) shorter than that for sphaeropsidin A. Sphaeropsidin E assayed at 0.2 mg ml−1 did not produce any symptom on the same cypress species tested with sphaeropsidin D.
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Sapinofuranones A and B, two new 2(3H)-dihydrofuranones produced by sphaeropsis sapinea, a common pathogen of conifers
Journal of natural products, 1999Co-Authors: Antonio Evidente, Lorenzo Sparapano, Olga Fierro, Giovanni Bruno, Andrea MottaAbstract:Two new 5-substituted dihydrofuranones, named sapinofuranones A and B (1 and 2), were isolated from liquid cultures of Sphaeropsis sapinea, a phytopathogenic fungus causing a wide range of disease symptoms on conifers. A fungal strain isolated from Cupressus macrocarpa produced both 1 and 2 at concentrations higher than those produced by the strain isolated from Cupressus sempervirens. Bioassay of 1 and 2 gave epinasty and brown discoloration on petioles of tomato leaves, sapwood stain on inner cortical tissues of the stem of cypress seedlings, and yellowing and needle blight on pine seedlings. Compounds 1 and 2 were characterized, using spectroscopic and chemical methods, as two new 4-[(2Z,4E)-1-hydroxy-2,4-hexadienyl]butan-4-olides, which are epimers at C-1 of the side chain. The absolute stereochemistry of this chiral center, determined by application of the Mosher's method, proved to be S and R in 1 and 2, respectively.
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Sphaeropsidone and episphaeropsidone, phytotoxic dimedone methylethers produced by Sphaeropsis sapinea f. sp. Cupressi grown in liquid culture
Phytochemistry, 1998Co-Authors: Antonio Evidente, Lorenzo Sparapano, Olga Fierro, Giovanni Bruno, Federico Giordano, Andrea MottaAbstract:Abstract Two phytotoxic dimedone methyl ethers, named sphaeropsidone and episphaeropsidone, were isolated from Sphaeropsis sapinea f. sp. cupressi , a phytopathogenic fungus causing a canker disease of Italian cypress ( Cupressus sempervirens L.). The same fungus produced the sphaeropsidins A, B and C, which are three phytotoxins recently chemically characterized as pimarane diterpenes. Sphaeropsidone and episphaeropsidone were characterized, using essentially spectroscopic methods, as two new phytotoxic disubstituted 7-oxabicyclo[4.1.0]hept-3-en-2-ones, which are epimers at C-5. Assayed on severed twigs of cypress, sphaeropsidone caused browning and necrosis on Cupressus macrocarpa , no symptoms on C. sempervirens and chlorosis on C. arizonica . Episphaeropsidone caused necrosis on C. macrocarpa , browning and necrosis on C. sempervirens and necrosis on C. arizonica . On the non-host plant tomato, both phytotoxins caused wilting. In a microbial assay, both compounds showed an inhibitory effect on the growth of five fungal species tested. The growth of Verticillium dahliae was enhanced by both dimedone methyl ethers.
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Sphaeropsidone and episphaeropsidone, phytotoxic dimedone methyl ethers produced by Sphaeropsis sapinea f. sp. cupressi grown in liquid culture
'Elsevier BV', 1998Co-Authors: Antonio Evidente, Lorenzo Sparapano, Olga Fierro, Giovanni Bruno, Federico Giordano, Andrea MottaAbstract:Two phytotoxic dimedone methyl ethers, named sphaeropsidone and episphaeropsidone, were isolated from Sphaeropsis sapinea f sp. cupressi, a phytopathogenic fungus causing a canker disease of Italian cypress (Cupressus sempervirens L.). The same fungus produced the sphaeropsidins A, B and C, which are three phytotoxins recently chemically characterized as pimarane diterpenes. Sphaeropsidone and episphaeropsidone were characterized, using essentially spectroscopic methods, as two new phytotoxic disubstituted 7-oxabicyclo[4.1.0]hept-3-en-2-ones, which are epimers at C-5. Assayed on severed twigs of cypress, sphaeropsidone caused browning and necrosis on Cupressus macrocarpa, no symptoms on C. sempervirens and chlorosis on C. arizonica. Episphaeropsidone caused necrosis on C. macrocarpa, browning and necrosis on C. sempervirens and necrosis on C. arizonica. On the non-host plant tomato, both phytotoxins caused wilting. In a microbial assay, both compounds showed an inhibitory effect on the growth of five fungal species tested. The growth of Vertcillium dahliae was enhanced by both dimedone methyl ethers. (C) 1998 Elsevier Science Ltd. All rights reserved
Antonio Evidente - One of the best experts on this subject based on the ideXlab platform.
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Sphaeropsidins D and E, two other pimarane diterpenes, produced in vitro by the plant pathogenic fungus Sphaeropsis sapinea f. sp. cupressi
Phytochemistry, 2002Co-Authors: Antonio Evidente, Lorenzo Sparapano, Giovanni Bruno, Andrea MottaAbstract:Abstract Two pimarane diterpenes structurally related to sphaeropsidins were isolated from the liquid culture of Sphaeropsis sapinea f. sp. cupressi, a plant pathogenic fungus causing a form of canker disease of Italian cypress (Cupressus sempervirens L.). The two metabolites, characterised by spectroscopic methods, were named sphaeropsidins D (0.40 mg l−1) and E (0.16 mg l−1). The same fungus produced sphaeropsidins A, B and C, sphaeropsidone and episphaeropsidone, which proved to be phytotoxic to cypress, and chlorosphaeropsidone and epichlorosphaeropsidone showing no phytotoxicity. Sphaeropsidin D assayed at 0.1 mg ml−1 on severed cypress twigs caused leaf browning and necrosis on Cupressus macrocarpa, but no symptoms were observed on C. sempervirens and C. arizonica. Symptoms appeared in a period of time (6 days after toxin-treatment) shorter than that for sphaeropsidin A. Sphaeropsidin E assayed at 0.2 mg ml−1 did not produce any symptom on the same cypress species tested with sphaeropsidin D.
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Sapinofuranones A and B, two new 2(3H)-dihydrofuranones produced by sphaeropsis sapinea, a common pathogen of conifers
Journal of natural products, 1999Co-Authors: Antonio Evidente, Lorenzo Sparapano, Olga Fierro, Giovanni Bruno, Andrea MottaAbstract:Two new 5-substituted dihydrofuranones, named sapinofuranones A and B (1 and 2), were isolated from liquid cultures of Sphaeropsis sapinea, a phytopathogenic fungus causing a wide range of disease symptoms on conifers. A fungal strain isolated from Cupressus macrocarpa produced both 1 and 2 at concentrations higher than those produced by the strain isolated from Cupressus sempervirens. Bioassay of 1 and 2 gave epinasty and brown discoloration on petioles of tomato leaves, sapwood stain on inner cortical tissues of the stem of cypress seedlings, and yellowing and needle blight on pine seedlings. Compounds 1 and 2 were characterized, using spectroscopic and chemical methods, as two new 4-[(2Z,4E)-1-hydroxy-2,4-hexadienyl]butan-4-olides, which are epimers at C-1 of the side chain. The absolute stereochemistry of this chiral center, determined by application of the Mosher's method, proved to be S and R in 1 and 2, respectively.
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Sphaeropsidone and episphaeropsidone, phytotoxic dimedone methylethers produced by Sphaeropsis sapinea f. sp. Cupressi grown in liquid culture
Phytochemistry, 1998Co-Authors: Antonio Evidente, Lorenzo Sparapano, Olga Fierro, Giovanni Bruno, Federico Giordano, Andrea MottaAbstract:Abstract Two phytotoxic dimedone methyl ethers, named sphaeropsidone and episphaeropsidone, were isolated from Sphaeropsis sapinea f. sp. cupressi , a phytopathogenic fungus causing a canker disease of Italian cypress ( Cupressus sempervirens L.). The same fungus produced the sphaeropsidins A, B and C, which are three phytotoxins recently chemically characterized as pimarane diterpenes. Sphaeropsidone and episphaeropsidone were characterized, using essentially spectroscopic methods, as two new phytotoxic disubstituted 7-oxabicyclo[4.1.0]hept-3-en-2-ones, which are epimers at C-5. Assayed on severed twigs of cypress, sphaeropsidone caused browning and necrosis on Cupressus macrocarpa , no symptoms on C. sempervirens and chlorosis on C. arizonica . Episphaeropsidone caused necrosis on C. macrocarpa , browning and necrosis on C. sempervirens and necrosis on C. arizonica . On the non-host plant tomato, both phytotoxins caused wilting. In a microbial assay, both compounds showed an inhibitory effect on the growth of five fungal species tested. The growth of Verticillium dahliae was enhanced by both dimedone methyl ethers.
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Sphaeropsidone and episphaeropsidone, phytotoxic dimedone methyl ethers produced by Sphaeropsis sapinea f. sp. cupressi grown in liquid culture
'Elsevier BV', 1998Co-Authors: Antonio Evidente, Lorenzo Sparapano, Olga Fierro, Giovanni Bruno, Federico Giordano, Andrea MottaAbstract:Two phytotoxic dimedone methyl ethers, named sphaeropsidone and episphaeropsidone, were isolated from Sphaeropsis sapinea f sp. cupressi, a phytopathogenic fungus causing a canker disease of Italian cypress (Cupressus sempervirens L.). The same fungus produced the sphaeropsidins A, B and C, which are three phytotoxins recently chemically characterized as pimarane diterpenes. Sphaeropsidone and episphaeropsidone were characterized, using essentially spectroscopic methods, as two new phytotoxic disubstituted 7-oxabicyclo[4.1.0]hept-3-en-2-ones, which are epimers at C-5. Assayed on severed twigs of cypress, sphaeropsidone caused browning and necrosis on Cupressus macrocarpa, no symptoms on C. sempervirens and chlorosis on C. arizonica. Episphaeropsidone caused necrosis on C. macrocarpa, browning and necrosis on C. sempervirens and necrosis on C. arizonica. On the non-host plant tomato, both phytotoxins caused wilting. In a microbial assay, both compounds showed an inhibitory effect on the growth of five fungal species tested. The growth of Vertcillium dahliae was enhanced by both dimedone methyl ethers. (C) 1998 Elsevier Science Ltd. All rights reserved
Mohamed M Abdeldaim - One of the best experts on this subject based on the ideXlab platform.
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protective role of cupressuflavone from Cupressus macrocarpa against carbon tetrachloride induced hepato and nephrotoxicity in mice
Planta Medica, 2014Co-Authors: Eman Alsayed, Mohamed M AbdeldaimAbstract:The hepatoprotective and nephroprotective activity of cupressuflavone isolated from Cupressus macrocarpa was investigated against CCl4-induced toxicity in mice. Cupressuflavone was administered (40, 80, and 160 mg/kg/day) for five days. CCl4 was administered (0.5 mL/kg intraperitoneally) at the end of the experiment. A substantial increase (p < 0.001) in the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, total bilirubin, cholesterol, creatinine, uric acid, urea, and malondialdehyde was observed in the CCl4-treated group compared to the normal control group. In contrast, a significant reduction (p < 0.001) in glutathione and superoxide dismutase contents as well as the total protein level was evident in the CCl4-intoxicated mice. Cupressuflavone pretreatment markedly inhibited the CCl4-induced increase in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, cholesterol, creatinine, uric acid, urea, and malondialdehyde levels in a dose-dependent manner (p < 0.001 at all the tested doses). In addition, a significant (p
Lorenzo Sparapano - One of the best experts on this subject based on the ideXlab platform.
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Cupressus CALLUS AND CELL SUSPENSION CULTURES: EFFECT OF SEIRIDINS ON THEIR GROWTH AND SENSITIVITY
In Vitro Cellular & Developmental Biology - Plant, 2004Co-Authors: Lorenzo Sparapano, Giovanni BrunoAbstract:Abstract Cupressus macrocarpa and C. arizonica were examined for callus and cell culture production in vitro. Both species produced callus on agar-solidified MSCY medium supplemented with vitamins, antioxidants, 0.14 μM kinetin (KIN), and 10 μM 2,4-dichlorophenoxyacetic acid (2,4-D). Suspension cultures of both species were established in liquid MSCY medium. Seiridin (SE) and iso-seiridin (ISE), two phytotoxic butenolides produced by Seiridium cardinale, S. cupressi, and S. unicorne, the causal agents of many canker diseases of cypress, were tested on callus or cell suspension cultures. In the medium without other plant growth regulators (PGR), SE promoted cell proliferation of cypress better than ISE, for callus initiation, callus maintenance, and cell suspension cultures. The growth rates of cypress callus tissues and suspension cultures of both cypress species on media containing 50–150 μM SE or ISE were measured. At concentrations of 50 μM and higher, growth rates increased exponentially with the SE c...
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Sphaeropsidins D and E, two other pimarane diterpenes, produced in vitro by the plant pathogenic fungus Sphaeropsis sapinea f. sp. cupressi
Phytochemistry, 2002Co-Authors: Antonio Evidente, Lorenzo Sparapano, Giovanni Bruno, Andrea MottaAbstract:Abstract Two pimarane diterpenes structurally related to sphaeropsidins were isolated from the liquid culture of Sphaeropsis sapinea f. sp. cupressi, a plant pathogenic fungus causing a form of canker disease of Italian cypress (Cupressus sempervirens L.). The two metabolites, characterised by spectroscopic methods, were named sphaeropsidins D (0.40 mg l−1) and E (0.16 mg l−1). The same fungus produced sphaeropsidins A, B and C, sphaeropsidone and episphaeropsidone, which proved to be phytotoxic to cypress, and chlorosphaeropsidone and epichlorosphaeropsidone showing no phytotoxicity. Sphaeropsidin D assayed at 0.1 mg ml−1 on severed cypress twigs caused leaf browning and necrosis on Cupressus macrocarpa, but no symptoms were observed on C. sempervirens and C. arizonica. Symptoms appeared in a period of time (6 days after toxin-treatment) shorter than that for sphaeropsidin A. Sphaeropsidin E assayed at 0.2 mg ml−1 did not produce any symptom on the same cypress species tested with sphaeropsidin D.
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Sapinofuranones A and B, two new 2(3H)-dihydrofuranones produced by sphaeropsis sapinea, a common pathogen of conifers
Journal of natural products, 1999Co-Authors: Antonio Evidente, Lorenzo Sparapano, Olga Fierro, Giovanni Bruno, Andrea MottaAbstract:Two new 5-substituted dihydrofuranones, named sapinofuranones A and B (1 and 2), were isolated from liquid cultures of Sphaeropsis sapinea, a phytopathogenic fungus causing a wide range of disease symptoms on conifers. A fungal strain isolated from Cupressus macrocarpa produced both 1 and 2 at concentrations higher than those produced by the strain isolated from Cupressus sempervirens. Bioassay of 1 and 2 gave epinasty and brown discoloration on petioles of tomato leaves, sapwood stain on inner cortical tissues of the stem of cypress seedlings, and yellowing and needle blight on pine seedlings. Compounds 1 and 2 were characterized, using spectroscopic and chemical methods, as two new 4-[(2Z,4E)-1-hydroxy-2,4-hexadienyl]butan-4-olides, which are epimers at C-1 of the side chain. The absolute stereochemistry of this chiral center, determined by application of the Mosher's method, proved to be S and R in 1 and 2, respectively.
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Sphaeropsidone and episphaeropsidone, phytotoxic dimedone methylethers produced by Sphaeropsis sapinea f. sp. Cupressi grown in liquid culture
Phytochemistry, 1998Co-Authors: Antonio Evidente, Lorenzo Sparapano, Olga Fierro, Giovanni Bruno, Federico Giordano, Andrea MottaAbstract:Abstract Two phytotoxic dimedone methyl ethers, named sphaeropsidone and episphaeropsidone, were isolated from Sphaeropsis sapinea f. sp. cupressi , a phytopathogenic fungus causing a canker disease of Italian cypress ( Cupressus sempervirens L.). The same fungus produced the sphaeropsidins A, B and C, which are three phytotoxins recently chemically characterized as pimarane diterpenes. Sphaeropsidone and episphaeropsidone were characterized, using essentially spectroscopic methods, as two new phytotoxic disubstituted 7-oxabicyclo[4.1.0]hept-3-en-2-ones, which are epimers at C-5. Assayed on severed twigs of cypress, sphaeropsidone caused browning and necrosis on Cupressus macrocarpa , no symptoms on C. sempervirens and chlorosis on C. arizonica . Episphaeropsidone caused necrosis on C. macrocarpa , browning and necrosis on C. sempervirens and necrosis on C. arizonica . On the non-host plant tomato, both phytotoxins caused wilting. In a microbial assay, both compounds showed an inhibitory effect on the growth of five fungal species tested. The growth of Verticillium dahliae was enhanced by both dimedone methyl ethers.
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Sphaeropsidone and episphaeropsidone, phytotoxic dimedone methyl ethers produced by Sphaeropsis sapinea f. sp. cupressi grown in liquid culture
'Elsevier BV', 1998Co-Authors: Antonio Evidente, Lorenzo Sparapano, Olga Fierro, Giovanni Bruno, Federico Giordano, Andrea MottaAbstract:Two phytotoxic dimedone methyl ethers, named sphaeropsidone and episphaeropsidone, were isolated from Sphaeropsis sapinea f sp. cupressi, a phytopathogenic fungus causing a canker disease of Italian cypress (Cupressus sempervirens L.). The same fungus produced the sphaeropsidins A, B and C, which are three phytotoxins recently chemically characterized as pimarane diterpenes. Sphaeropsidone and episphaeropsidone were characterized, using essentially spectroscopic methods, as two new phytotoxic disubstituted 7-oxabicyclo[4.1.0]hept-3-en-2-ones, which are epimers at C-5. Assayed on severed twigs of cypress, sphaeropsidone caused browning and necrosis on Cupressus macrocarpa, no symptoms on C. sempervirens and chlorosis on C. arizonica. Episphaeropsidone caused necrosis on C. macrocarpa, browning and necrosis on C. sempervirens and necrosis on C. arizonica. On the non-host plant tomato, both phytotoxins caused wilting. In a microbial assay, both compounds showed an inhibitory effect on the growth of five fungal species tested. The growth of Vertcillium dahliae was enhanced by both dimedone methyl ethers. (C) 1998 Elsevier Science Ltd. All rights reserved
Giovanni Bruno - One of the best experts on this subject based on the ideXlab platform.
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Cupressus CALLUS AND CELL SUSPENSION CULTURES: EFFECT OF SEIRIDINS ON THEIR GROWTH AND SENSITIVITY
In Vitro Cellular & Developmental Biology - Plant, 2004Co-Authors: Lorenzo Sparapano, Giovanni BrunoAbstract:Abstract Cupressus macrocarpa and C. arizonica were examined for callus and cell culture production in vitro. Both species produced callus on agar-solidified MSCY medium supplemented with vitamins, antioxidants, 0.14 μM kinetin (KIN), and 10 μM 2,4-dichlorophenoxyacetic acid (2,4-D). Suspension cultures of both species were established in liquid MSCY medium. Seiridin (SE) and iso-seiridin (ISE), two phytotoxic butenolides produced by Seiridium cardinale, S. cupressi, and S. unicorne, the causal agents of many canker diseases of cypress, were tested on callus or cell suspension cultures. In the medium without other plant growth regulators (PGR), SE promoted cell proliferation of cypress better than ISE, for callus initiation, callus maintenance, and cell suspension cultures. The growth rates of cypress callus tissues and suspension cultures of both cypress species on media containing 50–150 μM SE or ISE were measured. At concentrations of 50 μM and higher, growth rates increased exponentially with the SE c...
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Sphaeropsidins D and E, two other pimarane diterpenes, produced in vitro by the plant pathogenic fungus Sphaeropsis sapinea f. sp. cupressi
Phytochemistry, 2002Co-Authors: Antonio Evidente, Lorenzo Sparapano, Giovanni Bruno, Andrea MottaAbstract:Abstract Two pimarane diterpenes structurally related to sphaeropsidins were isolated from the liquid culture of Sphaeropsis sapinea f. sp. cupressi, a plant pathogenic fungus causing a form of canker disease of Italian cypress (Cupressus sempervirens L.). The two metabolites, characterised by spectroscopic methods, were named sphaeropsidins D (0.40 mg l−1) and E (0.16 mg l−1). The same fungus produced sphaeropsidins A, B and C, sphaeropsidone and episphaeropsidone, which proved to be phytotoxic to cypress, and chlorosphaeropsidone and epichlorosphaeropsidone showing no phytotoxicity. Sphaeropsidin D assayed at 0.1 mg ml−1 on severed cypress twigs caused leaf browning and necrosis on Cupressus macrocarpa, but no symptoms were observed on C. sempervirens and C. arizonica. Symptoms appeared in a period of time (6 days after toxin-treatment) shorter than that for sphaeropsidin A. Sphaeropsidin E assayed at 0.2 mg ml−1 did not produce any symptom on the same cypress species tested with sphaeropsidin D.
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Sapinofuranones A and B, two new 2(3H)-dihydrofuranones produced by sphaeropsis sapinea, a common pathogen of conifers
Journal of natural products, 1999Co-Authors: Antonio Evidente, Lorenzo Sparapano, Olga Fierro, Giovanni Bruno, Andrea MottaAbstract:Two new 5-substituted dihydrofuranones, named sapinofuranones A and B (1 and 2), were isolated from liquid cultures of Sphaeropsis sapinea, a phytopathogenic fungus causing a wide range of disease symptoms on conifers. A fungal strain isolated from Cupressus macrocarpa produced both 1 and 2 at concentrations higher than those produced by the strain isolated from Cupressus sempervirens. Bioassay of 1 and 2 gave epinasty and brown discoloration on petioles of tomato leaves, sapwood stain on inner cortical tissues of the stem of cypress seedlings, and yellowing and needle blight on pine seedlings. Compounds 1 and 2 were characterized, using spectroscopic and chemical methods, as two new 4-[(2Z,4E)-1-hydroxy-2,4-hexadienyl]butan-4-olides, which are epimers at C-1 of the side chain. The absolute stereochemistry of this chiral center, determined by application of the Mosher's method, proved to be S and R in 1 and 2, respectively.
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Sphaeropsidone and episphaeropsidone, phytotoxic dimedone methylethers produced by Sphaeropsis sapinea f. sp. Cupressi grown in liquid culture
Phytochemistry, 1998Co-Authors: Antonio Evidente, Lorenzo Sparapano, Olga Fierro, Giovanni Bruno, Federico Giordano, Andrea MottaAbstract:Abstract Two phytotoxic dimedone methyl ethers, named sphaeropsidone and episphaeropsidone, were isolated from Sphaeropsis sapinea f. sp. cupressi , a phytopathogenic fungus causing a canker disease of Italian cypress ( Cupressus sempervirens L.). The same fungus produced the sphaeropsidins A, B and C, which are three phytotoxins recently chemically characterized as pimarane diterpenes. Sphaeropsidone and episphaeropsidone were characterized, using essentially spectroscopic methods, as two new phytotoxic disubstituted 7-oxabicyclo[4.1.0]hept-3-en-2-ones, which are epimers at C-5. Assayed on severed twigs of cypress, sphaeropsidone caused browning and necrosis on Cupressus macrocarpa , no symptoms on C. sempervirens and chlorosis on C. arizonica . Episphaeropsidone caused necrosis on C. macrocarpa , browning and necrosis on C. sempervirens and necrosis on C. arizonica . On the non-host plant tomato, both phytotoxins caused wilting. In a microbial assay, both compounds showed an inhibitory effect on the growth of five fungal species tested. The growth of Verticillium dahliae was enhanced by both dimedone methyl ethers.
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Sphaeropsidone and episphaeropsidone, phytotoxic dimedone methyl ethers produced by Sphaeropsis sapinea f. sp. cupressi grown in liquid culture
'Elsevier BV', 1998Co-Authors: Antonio Evidente, Lorenzo Sparapano, Olga Fierro, Giovanni Bruno, Federico Giordano, Andrea MottaAbstract:Two phytotoxic dimedone methyl ethers, named sphaeropsidone and episphaeropsidone, were isolated from Sphaeropsis sapinea f sp. cupressi, a phytopathogenic fungus causing a canker disease of Italian cypress (Cupressus sempervirens L.). The same fungus produced the sphaeropsidins A, B and C, which are three phytotoxins recently chemically characterized as pimarane diterpenes. Sphaeropsidone and episphaeropsidone were characterized, using essentially spectroscopic methods, as two new phytotoxic disubstituted 7-oxabicyclo[4.1.0]hept-3-en-2-ones, which are epimers at C-5. Assayed on severed twigs of cypress, sphaeropsidone caused browning and necrosis on Cupressus macrocarpa, no symptoms on C. sempervirens and chlorosis on C. arizonica. Episphaeropsidone caused necrosis on C. macrocarpa, browning and necrosis on C. sempervirens and necrosis on C. arizonica. On the non-host plant tomato, both phytotoxins caused wilting. In a microbial assay, both compounds showed an inhibitory effect on the growth of five fungal species tested. The growth of Vertcillium dahliae was enhanced by both dimedone methyl ethers. (C) 1998 Elsevier Science Ltd. All rights reserved
