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Kok-khiang Peh - One of the best experts on this subject based on the ideXlab platform.
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Stability indicating HPLC-UV method for detection of curcumin in Curcuma Longa Extract and emulsion formulation
Food Chemistry, 2015Co-Authors: Haroon Khalid Syed, Kai Bin Liew, Gabriel Onn Kit Loh, Kok-khiang PehAbstract:A stability-indicating HPLC-UV method for the determination of curcumin in Curcuma Longa Extract and emulsion was developed. The system suitability parameters, theoretical plates (N), tailing factor (T), capacity factor (K′), height equivalent of a theoretical plate (H) and resolution (Rs) were calculated. Stress degradation studies (acid, base, oxidation, heat and UV light) of curcumin were performed in emulsion. It was found that N > 6500, T < 1.1, K′ was 2.68-3.75, HETP about 37 and Rs was 1.8. The method was linear from 2 to 200 μg/mL with a correlation coefficient of 0.9998. The intra-day precision and accuracy for curcumin were ≤0.87% and ≤2.0%, while the inter-day precision and accuracy values were ≤2.1% and ≤-1.92. Curcumin degraded in emulsion under acid, alkali and UV light. In conclusion, the stability-indicating method could be employed to determine curcumin in bulk and emulsions.
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Stability indicating HPLC-UV method for detection of curcumin in Curcuma Longa Extract and emulsion formulation
Food chemistry, 2014Co-Authors: Haroon Khalid Syed, Gabriel Onn Kit Loh, Kai Bin Liew, Kok-khiang PehAbstract:A stability-indicating HPLC-UV method for the determination of curcumin in Curcuma Longa Extract and emulsion was developed. The system suitability parameters, theoretical plates (N), tailing factor (T), capacity factor (K'), height equivalent of a theoretical plate (H) and resolution (Rs) were calculated. Stress degradation studies (acid, base, oxidation, heat and UV light) of curcumin were performed in emulsion. It was found that N>6500, T
Haroon Khalid Syed - One of the best experts on this subject based on the ideXlab platform.
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Stability indicating HPLC-UV method for detection of curcumin in Curcuma Longa Extract and emulsion formulation
Food Chemistry, 2015Co-Authors: Haroon Khalid Syed, Kai Bin Liew, Gabriel Onn Kit Loh, Kok-khiang PehAbstract:A stability-indicating HPLC-UV method for the determination of curcumin in Curcuma Longa Extract and emulsion was developed. The system suitability parameters, theoretical plates (N), tailing factor (T), capacity factor (K′), height equivalent of a theoretical plate (H) and resolution (Rs) were calculated. Stress degradation studies (acid, base, oxidation, heat and UV light) of curcumin were performed in emulsion. It was found that N > 6500, T < 1.1, K′ was 2.68-3.75, HETP about 37 and Rs was 1.8. The method was linear from 2 to 200 μg/mL with a correlation coefficient of 0.9998. The intra-day precision and accuracy for curcumin were ≤0.87% and ≤2.0%, while the inter-day precision and accuracy values were ≤2.1% and ≤-1.92. Curcumin degraded in emulsion under acid, alkali and UV light. In conclusion, the stability-indicating method could be employed to determine curcumin in bulk and emulsions.
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Stability indicating HPLC-UV method for detection of curcumin in Curcuma Longa Extract and emulsion formulation
Food chemistry, 2014Co-Authors: Haroon Khalid Syed, Gabriel Onn Kit Loh, Kai Bin Liew, Kok-khiang PehAbstract:A stability-indicating HPLC-UV method for the determination of curcumin in Curcuma Longa Extract and emulsion was developed. The system suitability parameters, theoretical plates (N), tailing factor (T), capacity factor (K'), height equivalent of a theoretical plate (H) and resolution (Rs) were calculated. Stress degradation studies (acid, base, oxidation, heat and UV light) of curcumin were performed in emulsion. It was found that N>6500, T
Gabriel Onn Kit Loh - One of the best experts on this subject based on the ideXlab platform.
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Stability indicating HPLC-UV method for detection of curcumin in Curcuma Longa Extract and emulsion formulation
Food Chemistry, 2015Co-Authors: Haroon Khalid Syed, Kai Bin Liew, Gabriel Onn Kit Loh, Kok-khiang PehAbstract:A stability-indicating HPLC-UV method for the determination of curcumin in Curcuma Longa Extract and emulsion was developed. The system suitability parameters, theoretical plates (N), tailing factor (T), capacity factor (K′), height equivalent of a theoretical plate (H) and resolution (Rs) were calculated. Stress degradation studies (acid, base, oxidation, heat and UV light) of curcumin were performed in emulsion. It was found that N > 6500, T < 1.1, K′ was 2.68-3.75, HETP about 37 and Rs was 1.8. The method was linear from 2 to 200 μg/mL with a correlation coefficient of 0.9998. The intra-day precision and accuracy for curcumin were ≤0.87% and ≤2.0%, while the inter-day precision and accuracy values were ≤2.1% and ≤-1.92. Curcumin degraded in emulsion under acid, alkali and UV light. In conclusion, the stability-indicating method could be employed to determine curcumin in bulk and emulsions.
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Stability indicating HPLC-UV method for detection of curcumin in Curcuma Longa Extract and emulsion formulation
Food chemistry, 2014Co-Authors: Haroon Khalid Syed, Gabriel Onn Kit Loh, Kai Bin Liew, Kok-khiang PehAbstract:A stability-indicating HPLC-UV method for the determination of curcumin in Curcuma Longa Extract and emulsion was developed. The system suitability parameters, theoretical plates (N), tailing factor (T), capacity factor (K'), height equivalent of a theoretical plate (H) and resolution (Rs) were calculated. Stress degradation studies (acid, base, oxidation, heat and UV light) of curcumin were performed in emulsion. It was found that N>6500, T
Jurgen Fripp - One of the best experts on this subject based on the ideXlab platform.
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Effectiveness of Curcuma Longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial.
Annals of internal medicine, 2020Co-Authors: Zhiqiang Wang, Tania Winzenberg, Guoqi Cai, L. Laslett, Dawn Aitken, Ingrid Hopper, Ambrish Singh, Robert Jones, Graeme Jones, Jurgen FrippAbstract:Background Current pharmacologic therapies for patients with osteoarthritis are suboptimal. Objective To determine the efficacy of Curcuma Longa Extract (CL) for reducing knee symptoms and effusion-synovitis in patients with symptomatic knee osteoarthritis and knee effusion-synovitis. Design Randomized, double-blind, placebo-controlled trial. (Australian New Zealand Clinical Trials Registry: ACTRN12618000080224). Setting Single-center study with patients from southern Tasmania, Australia. Participants 70 participants with symptomatic knee osteoarthritis and ultrasonography-defined effusion-synovitis. Intervention 2 capsules of CL (n = 36) or matched placebo (n = 34) per day for 12 weeks. Measurements The 2 primary outcomes were changes in knee pain on a visual analogue scale (VAS) and effusion-synovitis volume on magnetic resonance imaging (MRI). The key secondary outcomes were change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and cartilage composition values. Outcomes were assessed over 12 weeks. Results CL improved VAS pain compared with placebo by -9.1 mm (95% CI, -17.8 to -0.4 mm [P = 0.039]) but did not change effusion-synovitis volume (3.2 mL [CI, -0.3 to 6.8 mL]). CL also improved WOMAC knee pain (-47.2 mm [CI, -81.2 to -13.2 mm]; P = 0.006) but not lateral femoral cartilage T2 relaxation time (-0.4 ms [CI, -1.1 to 0.3 ms]). The incidence of adverse events was similar in the CL (n = 14 [39%]) and placebo (n = 18 [53%]) groups (P = 0.16); 2 events in the CL group and 5 in the placebo group may have been treatment related. Limitation Modest sample size and short duration. Conclusion CL was more effective than placebo for knee pain but did not affect knee effusion-synovitis or cartilage composition. Multicenter trials with larger sample sizes are needed to assess the clinical significance of these findings. Primary funding source University of Tasmania and Natural Remedies Private Limited.
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FRI0383 A RANDOMISED PLACEBO-CONTROLLED CLINICAL TRIAL OF Curcuma Longa Extract FOR TREATING SYMPTOMS AND EFFUSION-SYNOVITIS OF KNEE OSTEOARTHRITIS (CURKOA TRIAL)
Annals of the Rheumatic Diseases, 2020Co-Authors: Benny Antony, Zhiqiang Wang, Tania Winzenberg, Guoqi Cai, L. Laslett, Dawn Aitken, Ingrid Hopper, Ambrish Singh, Robert Jones, Jurgen FrippAbstract:Background:Pharmacological therapies are limited, associated with off-target effects, are frequently contraindicated, and only modestly effective for pain in osteoarthritis (OA). Effusion and synovitis are common in OA and are associated with symptomatic and structural progression of OA.Curcuma Longa(Turmeric) Extract has anti-inflammatory effects and is gaining popularity in the treatment of OA despite the lack of high-quality evidence.Objectives:The CurKOA trial aimed to determine the efficacy ofCurcuma LongaExtract for reducing knee symptoms and effusion-synovitis in patients with symptomatic knee OA and knee effusion-synovitis.Methods:In this randomised, double-blind, placebo-controlled trial, participants with significant knee pain (≥ 40 mm on a 100-mm visual analog scale [VAS]), symptomatic knee OA (by ACR criteria) and ultrasound defined effusion-synovitis were randomised to receiveCurcuma LongaExtract (80% aqueous based Extract standardized to turmerosaccharides + 20% curcuminoids, 2 × 500 mg capsules/day) or identical placebo for 12 weeks. Knee MRI scans were obtained at baseline and 12 weeks. Coprimary outcomes were changes in knee pain assessed by VAS and change in knee effusion-synovitis volume assessed by MRI over 12 weeks.Results:Among 70 participants (36 receivedCurcuma Longa, 34 received placebo, age 61.8±8.6 years, 56% female),Curcuma Longasignificantly improved VAS knee pain compared to placebo (-9.11mm, 95% confidence interval [CI] [- 17.79 to -0.44]) over 12 weeks, equivalent to a standardised effect size of 0.50. There was no significant between group difference in change in effusion-synovitis volume (3.24 mL [-0.33, 6.82]). There were significantly greater reductions in WOMAC knee pain (-47.22mm [-81.22, -13.22]), WOMAC function (-112.26mm [-222.79 to -1.74]) and significantly more OARSI-OMERACT treatment responders (63% treatment vs. 38% placebo [Risk Ratio=1.64 (1.00 to 2.70)]) in theCurcuma Longagroup compared to the placebo group. There was no significant between-group difference in lateral femoral cartilage T2 relaxation time (-0.38 ms [- 1.10 to 0.34]) assessed from compositional MRI. The incidence of adverse events was similar in theCurcuma Longa(n=14 (39%)) and placebo (n=18 (53%)) groups over 12 weeks (P=0.24).Conclusion:An Extract ofCurcuma Longasignificantly improved knee pain in an inflammatory phenotype of knee OA patients over 12 weeks compared to placebo but had no effect on knee effusion-synovitis and cartilage composition assessed using MRI. The moderate effect size of the treatment supports the use ofCurcuma LongaExtract for the symptomatic management of knee OA.Figure 1.Change in VAS and WOMAC subscale scores in treatment and control groups over the course of the study. (VAS = Visual analog scale, WOMAC = Western Ontario and McMaster University Index, CL = Curcuma Longa Extract)Disclosure of Interests:None declared
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FRI0383 A RANDOMISED PLACEBO-CONTROLLED CLINICAL TRIAL OF Curcuma Longa Extract FOR TREATING SYMPTOMS AND EFFUSION-SYNOVITIS OF KNEE OSTEOARTHRITIS (CURKOA TRIAL)
Annals of the Rheumatic Diseases, 2020Co-Authors: Benny Antony, Zhiqiang Wang, Tania Winzenberg, Guoqi Cai, L. Laslett, Dawn Aitken, Ingrid Hopper, Ambrish Singh, Robert Jones, Jurgen FrippAbstract:Background: Pharmacological therapies are limited, associated with off-target effects, are frequently contraindicated, and only modestly effective for pain in osteoarthritis (OA). Effusion and synovitis are common in OA and are associated with symptomatic and structural progression of OA. Curcuma Longa (Turmeric) Extract has anti-inflammatory effects and is gaining popularity in the treatment of OA despite the lack of high-quality evidence. Objectives: The CurKOA trial aimed to determine the efficacy of Curcuma Longa Extract for reducing knee symptoms and effusion-synovitis in patients with symptomatic knee OA and knee effusion-synovitis. Methods: In this randomised, double-blind, placebo-controlled trial, participants with significant knee pain (≥ 40 mm on a 100-mm visual analog scale [VAS]), symptomatic knee OA (by ACR criteria) and ultrasound defined effusion-synovitis were randomised to receive Curcuma Longa Extract (80% aqueous based Extract standardized to turmerosaccharides + 20% curcuminoids, 2 × 500 mg capsules/day) or identical placebo for 12 weeks. Knee MRI scans were obtained at baseline and 12 weeks. Coprimary outcomes were changes in knee pain assessed by VAS and change in knee effusion-synovitis volume assessed by MRI over 12 weeks. Results: Among 70 participants (36 received Curcuma Longa, 34 received placebo, age 61.8±8.6 years, 56% female), Curcuma Longa significantly improved VAS knee pain compared to placebo (-9.11mm, 95% confidence interval [CI] [- 17.79 to -0.44]) over 12 weeks, equivalent to a standardised effect size of 0.50. There was no significant between group difference in change in effusion-synovitis volume (3.24 mL [-0.33, 6.82]). There were significantly greater reductions in WOMAC knee pain (-47.22mm [-81.22, -13.22]), WOMAC function (-112.26mm [-222.79 to -1.74]) and significantly more OARSI-OMERACT treatment responders (63% treatment vs. 38% placebo [Risk Ratio=1.64 (1.00 to 2.70)]) in the Curcuma Longa group compared to the placebo group. There was no significant between-group difference in lateral femoral cartilage T2 relaxation time (-0.38 ms [- 1.10 to 0.34]) assessed from compositional MRI. The incidence of adverse events was similar in the Curcuma Longa (n=14 (39%)) and placebo (n=18 (53%)) groups over 12 weeks (P=0.24). Conclusion: An Extract of Curcuma Longa significantly improved knee pain in an inflammatory phenotype of knee OA patients over 12 weeks compared to placebo but had no effect on knee effusion-synovitis and cartilage composition assessed using MRI. The moderate effect size of the treatment supports the use of Curcuma Longa Extract for the symptomatic management of knee OA. Disclosure of Interests: None declared
Kai Bin Liew - One of the best experts on this subject based on the ideXlab platform.
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Stability indicating HPLC-UV method for detection of curcumin in Curcuma Longa Extract and emulsion formulation
Food chemistry, 2014Co-Authors: Haroon Khalid Syed, Gabriel Onn Kit Loh, Kai Bin Liew, Kok-khiang PehAbstract:A stability-indicating HPLC-UV method for the determination of curcumin in Curcuma Longa Extract and emulsion was developed. The system suitability parameters, theoretical plates (N), tailing factor (T), capacity factor (K'), height equivalent of a theoretical plate (H) and resolution (Rs) were calculated. Stress degradation studies (acid, base, oxidation, heat and UV light) of curcumin were performed in emulsion. It was found that N>6500, T
