The Experts below are selected from a list of 150 Experts worldwide ranked by ideXlab platform
Christopher S. Ennen - One of the best experts on this subject based on the ideXlab platform.
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Carney complex: a rare cause of Cushing syndrome in pregnancy.
Obstetrics & Gynecology, 2014Co-Authors: Alison Spaniol, Bethany M. Mulla, Jason G. Daily, Christopher S. EnnenAbstract:BACKGROUND: Carney complex is a rare, autosomal-dominant, multisystem disorder characterized by endocrine overactivity, spotty skin pigmentation, and Myxomas. CASE: We present the case of a 24-year-old primigravid woman with a pregnancy complicated by Carney complex. At 18 weeks of gestation, severe hypertension developed. Medical history was significant for chronic hypertension, nephrolithiasis, and an atrial Myxoma excised in 2011. She had Cushingoid features, an elevated 24-hour urine free cortisol, and a Cutaneous Myxoma. At 26 weeks of gestation, superimposed preeclampsia developed. She underwent a primary classical cesarean delivery, delivering a live female weighing 650 g. CONCLUSION: Carney complex is a rare cause of hypercortisolism and hypertension during pregnancy. It should be considered when features of Cushing syndrome and severe hypertension are present.
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Carney complex: a rare cause of Cushing syndrome in pregnancy.
Obstetrics and gynecology, 2014Co-Authors: Alison Spaniol, Bethany M. Mulla, Jason G. Daily, Christopher S. EnnenAbstract:Carney complex is a rare, autosomal-dominant, multisystem disorder characterized by endocrine overactivity, spotty skin pigmentation, and Myxomas. We present the case of a 24-year-old primigravid woman with a pregnancy complicated by Carney complex. At 18 weeks of gestation, severe hypertension developed. Medical history was significant for chronic hypertension, nephrolithiasis, and an atrial Myxoma excised in 2011. She had Cushingoid features, an elevated 24-hour urine free cortisol, and a Cutaneous Myxoma. At 26 weeks of gestation, superimposed preeclampsia developed. She underwent a primary classical cesarean delivery, delivering a live female weighing 650 g. Carney complex is a rare cause of hypercortisolism and hypertension during pregnancy. It should be considered when features of Cushing syndrome and severe hypertension are present.
J W Ryoo - One of the best experts on this subject based on the ideXlab platform.
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Solitary Cutaneous Myxoma.
Journal of the American Academy of Dermatology, 2000Co-Authors: S Alaiti, F P Nelson, J W RyooAbstract:We describe a case of a large pedunculated solitary Cutaneous Myxoma arising on the thigh of a 47-year-old man without evidence of Carney's complex, NAME, or LAMB syndromes. The diagnosis was confirmed by hematoxylin and eosin stain, special stains, and immunocytochemistry studies. The tumor was surgically resected with no evidence of recurrence after 6 months. Solitary Cutaneous Myxoma should be differentiated histologically from myxoid neurofibroma, neurothekeoma, and ossifying and nonossifying fibromyxoid tumor.
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Solitary Cutaneous Myxoma
Journal of the American Academy of Dermatology, 2000Co-Authors: S Alaiti, F P Nelson, J W RyooAbstract:We describe a case of a large pedunculated solitary Cutaneous Myxoma arising on the thigh of a 47-year-old man without evidence of Carney’s complex, NAME, or LAMB syndromes. The diagnosis was confirmed by hematoxylin and eosin stain, special stains, and immunocytochemistry studies. The tumor was surgically resected with no evidence of recurrence after 6 months. Solitary Cutaneous Myxoma should be differentiated histologically from myxoid neurofibroma, neurothekeoma, and ossifying and nonossifying fibromyxoid tumor. (J Am Acad Dermatol 2000;43:377-9.)
Alison Spaniol - One of the best experts on this subject based on the ideXlab platform.
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Carney complex: a rare cause of Cushing syndrome in pregnancy.
Obstetrics & Gynecology, 2014Co-Authors: Alison Spaniol, Bethany M. Mulla, Jason G. Daily, Christopher S. EnnenAbstract:BACKGROUND: Carney complex is a rare, autosomal-dominant, multisystem disorder characterized by endocrine overactivity, spotty skin pigmentation, and Myxomas. CASE: We present the case of a 24-year-old primigravid woman with a pregnancy complicated by Carney complex. At 18 weeks of gestation, severe hypertension developed. Medical history was significant for chronic hypertension, nephrolithiasis, and an atrial Myxoma excised in 2011. She had Cushingoid features, an elevated 24-hour urine free cortisol, and a Cutaneous Myxoma. At 26 weeks of gestation, superimposed preeclampsia developed. She underwent a primary classical cesarean delivery, delivering a live female weighing 650 g. CONCLUSION: Carney complex is a rare cause of hypercortisolism and hypertension during pregnancy. It should be considered when features of Cushing syndrome and severe hypertension are present.
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Carney complex: a rare cause of Cushing syndrome in pregnancy.
Obstetrics and gynecology, 2014Co-Authors: Alison Spaniol, Bethany M. Mulla, Jason G. Daily, Christopher S. EnnenAbstract:Carney complex is a rare, autosomal-dominant, multisystem disorder characterized by endocrine overactivity, spotty skin pigmentation, and Myxomas. We present the case of a 24-year-old primigravid woman with a pregnancy complicated by Carney complex. At 18 weeks of gestation, severe hypertension developed. Medical history was significant for chronic hypertension, nephrolithiasis, and an atrial Myxoma excised in 2011. She had Cushingoid features, an elevated 24-hour urine free cortisol, and a Cutaneous Myxoma. At 26 weeks of gestation, superimposed preeclampsia developed. She underwent a primary classical cesarean delivery, delivering a live female weighing 650 g. Carney complex is a rare cause of hypercortisolism and hypertension during pregnancy. It should be considered when features of Cushing syndrome and severe hypertension are present.
S Alaiti - One of the best experts on this subject based on the ideXlab platform.
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Solitary Cutaneous Myxoma.
Journal of the American Academy of Dermatology, 2000Co-Authors: S Alaiti, F P Nelson, J W RyooAbstract:We describe a case of a large pedunculated solitary Cutaneous Myxoma arising on the thigh of a 47-year-old man without evidence of Carney's complex, NAME, or LAMB syndromes. The diagnosis was confirmed by hematoxylin and eosin stain, special stains, and immunocytochemistry studies. The tumor was surgically resected with no evidence of recurrence after 6 months. Solitary Cutaneous Myxoma should be differentiated histologically from myxoid neurofibroma, neurothekeoma, and ossifying and nonossifying fibromyxoid tumor.
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Solitary Cutaneous Myxoma
Journal of the American Academy of Dermatology, 2000Co-Authors: S Alaiti, F P Nelson, J W RyooAbstract:We describe a case of a large pedunculated solitary Cutaneous Myxoma arising on the thigh of a 47-year-old man without evidence of Carney’s complex, NAME, or LAMB syndromes. The diagnosis was confirmed by hematoxylin and eosin stain, special stains, and immunocytochemistry studies. The tumor was surgically resected with no evidence of recurrence after 6 months. Solitary Cutaneous Myxoma should be differentiated histologically from myxoid neurofibroma, neurothekeoma, and ossifying and nonossifying fibromyxoid tumor. (J Am Acad Dermatol 2000;43:377-9.)
Gürkan Kaya - One of the best experts on this subject based on the ideXlab platform.
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CD44 and hyaluronate expression in follicular mucinosis.
Journal of cutaneous pathology, 2006Co-Authors: Gürkan Kaya, Eric Augsburger, P. Chavaz, Jean-hilaire SauratAbstract:Background: CD44 is a membrane glycoprotein and the major cell-surface receptor of hyaluronate (HA). Lack of CD44 expression in mouse epidermis leads to an abnormal HA accumulation in the dermis, indicating an important role of CD44 in local HA metabolism. Decrease of epidermal CD44 expression in patients of lichen sclerosus et atrophicus is potentially responsible for dermal deposition of HA in this disease. Stromal HA accumulation is associated with decreased or lost expression of CD44 in perifollicular solitary Cutaneous Myxoma, myxoid dermatofibroma, and dermatofibrosarcoma protuberans. Methods: We examined the expression of CD44 and HA in the skin biopsy specimens of 10 patients with follicular mucinosis by using CD44-specific antibodies and biotinylated HA-binding protein (HABP), respectively. Results: No difference of CD44 expression was observed in the follicular keratinocytes when compared with those of unaffected interfollicular epidermis. The follicular zones of mucin deposition were strongly positive for HA. A weak interkeratinocyte staining for HA was also observed in the interfollicular epidermis. However, HABP staining revealed a stronger reactivity in the follicular keratinocytes surrounding the mucin-accumulated areas compared to the interfollicular keratinocytes. Conclusion: Our results suggest an active secretion of HA by follicular cells in follicular mucinosis.
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Decreased CD44 expression and stromal hyaluronate accumulation in myxoid dermatofibroma.
Dermatology (Basel Switzerland), 2003Co-Authors: Emel Calikoglu, P. Chavaz, Jean-hilaire Saurat, Gürkan KayaAbstract:Background: Dermatofibroma (DF) is a common benign histiocytic tumor, which has several clinicopathological variants. Myxoid DF is one of these variants, which is characterized by a stromal mucin deposition. CD44 is a polymorphic transmembrane glycoprotein and the principal cell surface receptor of hyaluronate (HA), the major component of the extracellular matrix. In a recent study, we have observed an abnormal accumulation of HA in the superficial dermis of transgenic mice with a keratinocyte-specific CD44 expression defect. We have also shown that HA was accumulated in large amounts in the superficial dermis of lichen sclerosus et atrophicus (LSA) lesions and that the epidermal CD44 expression of LSA skin was significantly decreased or lost. In an another study, we have suggested that a decrease in CD44 expression in follicular epithelial proliferations might be correlated with an abnormal HA accumulation in perifollicular solitary Cutaneous Myxoma. Recently we have also demonstrated that classical DF lesions displayed a strong CD44 expression in tumor cells and a weak HA positivity in tumor stroma whereas CD44 expression was significantly reduced or absent in dermatofibrosarcoma lesions and the tumor stroma showed strong HA staining. Objective and Methods: Here we present 3 cases of myxoid DF, in which we explored the nature of the mucinous material in myxoid stroma by colloidal iron and hyaluronic acid binding protein stainings, as well as the expression of CD44 in the tumor cells by immunohistochemistry. Results: We show that HA is accumulated in the stroma of all myxoid DF lesions with a significant decrease in CD44 expression in the tumor cells. Conclusion: Our results suggest that a decrease in CD44 expression in the tumor cells may result in stromal myxoid changes characterized by an abnormal HA accumulation in myxoid DF.
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Hyaluronate Accumulation and Decreased CD44 Expression in Perifollicular Solitary Cutaneous Myxoma
Dermatology (Basel Switzerland), 2002Co-Authors: Emel Calikoglu, Eric Augsburger, Isabelle Masouyé, P. Chavaz, Jean-hilaire Saurat, Gürkan KayaAbstract:Background: Myxomas are rare Cutaneous tumors which may be solitary or associated with Carney’s complex, NAME or LAMB syndromes. The mucinous material which constitutes the stroma o
