The Experts below are selected from a list of 2550 Experts worldwide ranked by ideXlab platform
Susumu Kanazawa - One of the best experts on this subject based on the ideXlab platform.
-
computed tomography fluoroscopy guided Cutting Needle biopsy of pulmonary nodules 8 mm a retrospective study including 117 nodules
European Journal of Radiology, 2020Co-Authors: Yanqing Zhao, Yusuke Matsui, Takao Hiraki, Hideo Gobara, Shinichi Toyooka, Toshihiro Iguchi, Koji Tomita, Mayu Uka, Susumu KanazawaAbstract:Abstract Purpose To evaluate the diagnostic yield and safety of computed tomography (CT) fluoroscopy-guided Cutting Needle biopsy (CNB) for pulmonary nodules ≤ 8 mm. Method Data of CT fluoroscopy-guided CNB for pulmonary nodules ≤ 8 mm performed in a single institution were retrospectively analyzed. One hundred and seventeen biopsy procedures for 117 pulmonary nodules (mean size, 7.4 mm) in 114 patients were included in the study. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall diagnostic accuracy were calculated. Univariate analyses were performed to elucidate the risk factors for diagnostic failure (i.e., non-diagnostic, false-positive, or false-negative results). Complications were graded per the Clavien-Dindo Classification. Results One (0.9 %) non-diagnostic biopsy result was found. The diagnostic accuracy was 95.7 % (112/117). The sensitivity and specificity were 95.8 % (91/95) and 95.5 % (21/22), respectively. PPV and NPV were 98.9 % (91/92) and 87.5 % (21/24), respectively. Univariate analyses showed that nodules in the lower lobes (p = 0.006) and prone biopsy position (p = 0.021) were the significant risk factors for diagnostic failure. The incidence of pneumothorax requiring chest tube placement (Grade IIIa) was 6.8 % (8/117). No Grade IIIb or higher complications were observed. Conclusion CT fluoroscopy-guided CNB for pulmonary nodules ≤ 8 mm showed a high diagnostic yield without severe complications.
-
Role of Computed Tomography Fluoroscopy–Guided Cutting Needle Biopsy of Lung Lesions After Transbronchial Examination Resulting in Negative Diagnosis
Clinical lung cancer, 2011Co-Authors: Yusuke Matsui, Takao Hiraki, Hidefumi Mimura, Hideo Gobara, Daisaku Inoue, Tatsuhiko Iishi, Shinichi Toyooka, Susumu KanazawaAbstract:Abstract Introduction: Computed tomography (CT)–guided lung biopsy is occasionally used for the lesions that were diagnosed as nonmalignant by transbronchial examination despite the fact that other clinical data suggested those as malignant. The purpose of this study is to evaluate the outcomes of CT fluoroscopy–guided Cutting Needle biopsy of lung lesions after transbronchial examination resulting in negative diagnosis. Patients and Methods We retrospectively evaluated the outcomes of CT fluoroscopy–guided lung biopsy for 351 lesions (mean size, 2.8 cm) that were found to be nonmalignant by transbronchial examination. Diagnostic yield, including sensitivity and specificity for the diagnosis of malignancy, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. Various variables were analyzed to determine the factors for diagnostic failure. Results The biopsy result was nondiagnostic, true-positive, true-negative, false-positive, or false-negative for 2, 262, 70, 0, or 17 lesions, respectively. Thus, the sensitivity, specificity, PPV, NPV, and accuracy of CT fluoroscopy–guided Cutting Needle biopsy was found to be 93% (262/281), 100% (70/70), 100% (262/262), 80% (70/87), and 94% (332/351), respectively. There was no significant risk factor for diagnostic failure. Conclusion Computed tomography fluoroscopy–guided Cutting Needle lung biopsy is a useful technique to correct or confirm negative diagnosis by transbronchial examination.
-
role of computed tomography fluoroscopy guided Cutting Needle biopsy of lung lesions after transbronchial examination resulting in negative diagnosis
Clinical Lung Cancer, 2011Co-Authors: Yusuke Matsui, Takao Hiraki, Hidefumi Mimura, Hideo Gobara, Daisaku Inoue, Tatsuhiko Iishi, Shinichi Toyooka, Susumu KanazawaAbstract:Abstract Introduction: Computed tomography (CT)–guided lung biopsy is occasionally used for the lesions that were diagnosed as nonmalignant by transbronchial examination despite the fact that other clinical data suggested those as malignant. The purpose of this study is to evaluate the outcomes of CT fluoroscopy–guided Cutting Needle biopsy of lung lesions after transbronchial examination resulting in negative diagnosis. Patients and Methods We retrospectively evaluated the outcomes of CT fluoroscopy–guided lung biopsy for 351 lesions (mean size, 2.8 cm) that were found to be nonmalignant by transbronchial examination. Diagnostic yield, including sensitivity and specificity for the diagnosis of malignancy, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. Various variables were analyzed to determine the factors for diagnostic failure. Results The biopsy result was nondiagnostic, true-positive, true-negative, false-positive, or false-negative for 2, 262, 70, 0, or 17 lesions, respectively. Thus, the sensitivity, specificity, PPV, NPV, and accuracy of CT fluoroscopy–guided Cutting Needle biopsy was found to be 93% (262/281), 100% (70/70), 100% (262/262), 80% (70/87), and 94% (332/351), respectively. There was no significant risk factor for diagnostic failure. Conclusion Computed tomography fluoroscopy–guided Cutting Needle lung biopsy is a useful technique to correct or confirm negative diagnosis by transbronchial examination.
-
CT fluoroscopy-guided Cutting Needle biopsy of focal pure ground-glass opacity lung lesions: diagnostic yield in 83 lesions.
European journal of radiology, 2010Co-Authors: Daisaku Inoue, Yusuke Matsui, Takao Hiraki, Hidefumi Mimura, Hideo Gobara, Tatsuhiko Iishi, Shinichi Toyooka, Katsuya Kato, Kentaro Shibamoto, Susumu KanazawaAbstract:Abstract Objective The objective of our study was to retrospectively determine the diagnostic yield of CT fluoroscopy-guided Cutting Needle biopsy of focal pure ground-glass opacity lung lesions. Materials and methods Biopsies were performed using 20-G coaxial Cutting Needles for 83 focal pure ground-glass opacity lung lesions (mean lesion size, 12.1 mm). After excluding the lesions for which biopsy specimens were unobtainable and final diagnoses were undetermined, the diagnostic yield, including sensitivity and specificity for a diagnosis of malignancy and accuracy, was calculated. The lesions were then divided into 2 groups: the diagnostic failure group, comprising lesions with false-negative results and for which a biopsy specimen was unobtainable; and the diagnostic success group, comprising lesions with true-negative results and true-positive results. Various variables were compared between the 2 groups by univariate analysis. Results Biopsy specimens were obtained from 82 lesions, while specimens could not be obtained from 1 lesion. Final diagnosis was undetermined in 16 lesions. The sensitivity and specificity for a diagnosis of malignancy were 95% (58/61) and 100% (5/5), respectively. Diagnostic accuracy was 95% (63/66). The 4 lesions in diagnostic failure group were smaller, deeper, and more likely to be located in the lower lobe and further, for those lesions, number of specimens obtained was smaller, compared with 63 lesions in diagnostic success group. However, none of the differences were statistically significant. Conclusion CT fluoroscopy-guided Cutting Needle biopsy provided high diagnostic yield for focal pure ground-glass opacity lung lesions.
Yusuke Matsui - One of the best experts on this subject based on the ideXlab platform.
-
computed tomography fluoroscopy guided Cutting Needle biopsy of pulmonary nodules 8 mm a retrospective study including 117 nodules
European Journal of Radiology, 2020Co-Authors: Yanqing Zhao, Yusuke Matsui, Takao Hiraki, Hideo Gobara, Shinichi Toyooka, Toshihiro Iguchi, Koji Tomita, Mayu Uka, Susumu KanazawaAbstract:Abstract Purpose To evaluate the diagnostic yield and safety of computed tomography (CT) fluoroscopy-guided Cutting Needle biopsy (CNB) for pulmonary nodules ≤ 8 mm. Method Data of CT fluoroscopy-guided CNB for pulmonary nodules ≤ 8 mm performed in a single institution were retrospectively analyzed. One hundred and seventeen biopsy procedures for 117 pulmonary nodules (mean size, 7.4 mm) in 114 patients were included in the study. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall diagnostic accuracy were calculated. Univariate analyses were performed to elucidate the risk factors for diagnostic failure (i.e., non-diagnostic, false-positive, or false-negative results). Complications were graded per the Clavien-Dindo Classification. Results One (0.9 %) non-diagnostic biopsy result was found. The diagnostic accuracy was 95.7 % (112/117). The sensitivity and specificity were 95.8 % (91/95) and 95.5 % (21/22), respectively. PPV and NPV were 98.9 % (91/92) and 87.5 % (21/24), respectively. Univariate analyses showed that nodules in the lower lobes (p = 0.006) and prone biopsy position (p = 0.021) were the significant risk factors for diagnostic failure. The incidence of pneumothorax requiring chest tube placement (Grade IIIa) was 6.8 % (8/117). No Grade IIIb or higher complications were observed. Conclusion CT fluoroscopy-guided CNB for pulmonary nodules ≤ 8 mm showed a high diagnostic yield without severe complications.
-
Role of Computed Tomography Fluoroscopy–Guided Cutting Needle Biopsy of Lung Lesions After Transbronchial Examination Resulting in Negative Diagnosis
Clinical lung cancer, 2011Co-Authors: Yusuke Matsui, Takao Hiraki, Hidefumi Mimura, Hideo Gobara, Daisaku Inoue, Tatsuhiko Iishi, Shinichi Toyooka, Susumu KanazawaAbstract:Abstract Introduction: Computed tomography (CT)–guided lung biopsy is occasionally used for the lesions that were diagnosed as nonmalignant by transbronchial examination despite the fact that other clinical data suggested those as malignant. The purpose of this study is to evaluate the outcomes of CT fluoroscopy–guided Cutting Needle biopsy of lung lesions after transbronchial examination resulting in negative diagnosis. Patients and Methods We retrospectively evaluated the outcomes of CT fluoroscopy–guided lung biopsy for 351 lesions (mean size, 2.8 cm) that were found to be nonmalignant by transbronchial examination. Diagnostic yield, including sensitivity and specificity for the diagnosis of malignancy, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. Various variables were analyzed to determine the factors for diagnostic failure. Results The biopsy result was nondiagnostic, true-positive, true-negative, false-positive, or false-negative for 2, 262, 70, 0, or 17 lesions, respectively. Thus, the sensitivity, specificity, PPV, NPV, and accuracy of CT fluoroscopy–guided Cutting Needle biopsy was found to be 93% (262/281), 100% (70/70), 100% (262/262), 80% (70/87), and 94% (332/351), respectively. There was no significant risk factor for diagnostic failure. Conclusion Computed tomography fluoroscopy–guided Cutting Needle lung biopsy is a useful technique to correct or confirm negative diagnosis by transbronchial examination.
-
role of computed tomography fluoroscopy guided Cutting Needle biopsy of lung lesions after transbronchial examination resulting in negative diagnosis
Clinical Lung Cancer, 2011Co-Authors: Yusuke Matsui, Takao Hiraki, Hidefumi Mimura, Hideo Gobara, Daisaku Inoue, Tatsuhiko Iishi, Shinichi Toyooka, Susumu KanazawaAbstract:Abstract Introduction: Computed tomography (CT)–guided lung biopsy is occasionally used for the lesions that were diagnosed as nonmalignant by transbronchial examination despite the fact that other clinical data suggested those as malignant. The purpose of this study is to evaluate the outcomes of CT fluoroscopy–guided Cutting Needle biopsy of lung lesions after transbronchial examination resulting in negative diagnosis. Patients and Methods We retrospectively evaluated the outcomes of CT fluoroscopy–guided lung biopsy for 351 lesions (mean size, 2.8 cm) that were found to be nonmalignant by transbronchial examination. Diagnostic yield, including sensitivity and specificity for the diagnosis of malignancy, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. Various variables were analyzed to determine the factors for diagnostic failure. Results The biopsy result was nondiagnostic, true-positive, true-negative, false-positive, or false-negative for 2, 262, 70, 0, or 17 lesions, respectively. Thus, the sensitivity, specificity, PPV, NPV, and accuracy of CT fluoroscopy–guided Cutting Needle biopsy was found to be 93% (262/281), 100% (70/70), 100% (262/262), 80% (70/87), and 94% (332/351), respectively. There was no significant risk factor for diagnostic failure. Conclusion Computed tomography fluoroscopy–guided Cutting Needle lung biopsy is a useful technique to correct or confirm negative diagnosis by transbronchial examination.
-
CT fluoroscopy-guided Cutting Needle biopsy of focal pure ground-glass opacity lung lesions: diagnostic yield in 83 lesions.
European journal of radiology, 2010Co-Authors: Daisaku Inoue, Yusuke Matsui, Takao Hiraki, Hidefumi Mimura, Hideo Gobara, Tatsuhiko Iishi, Shinichi Toyooka, Katsuya Kato, Kentaro Shibamoto, Susumu KanazawaAbstract:Abstract Objective The objective of our study was to retrospectively determine the diagnostic yield of CT fluoroscopy-guided Cutting Needle biopsy of focal pure ground-glass opacity lung lesions. Materials and methods Biopsies were performed using 20-G coaxial Cutting Needles for 83 focal pure ground-glass opacity lung lesions (mean lesion size, 12.1 mm). After excluding the lesions for which biopsy specimens were unobtainable and final diagnoses were undetermined, the diagnostic yield, including sensitivity and specificity for a diagnosis of malignancy and accuracy, was calculated. The lesions were then divided into 2 groups: the diagnostic failure group, comprising lesions with false-negative results and for which a biopsy specimen was unobtainable; and the diagnostic success group, comprising lesions with true-negative results and true-positive results. Various variables were compared between the 2 groups by univariate analysis. Results Biopsy specimens were obtained from 82 lesions, while specimens could not be obtained from 1 lesion. Final diagnosis was undetermined in 16 lesions. The sensitivity and specificity for a diagnosis of malignancy were 95% (58/61) and 100% (5/5), respectively. Diagnostic accuracy was 95% (63/66). The 4 lesions in diagnostic failure group were smaller, deeper, and more likely to be located in the lower lobe and further, for those lesions, number of specimens obtained was smaller, compared with 63 lesions in diagnostic success group. However, none of the differences were statistically significant. Conclusion CT fluoroscopy-guided Cutting Needle biopsy provided high diagnostic yield for focal pure ground-glass opacity lung lesions.
Tao Wang - One of the best experts on this subject based on the ideXlab platform.
-
computed tomography guided percutaneous Cutting Needle biopsy for small 20 mm lung nodules
Medicine, 2017Co-Authors: Wei Cao, Yi-bing Shi, Tao WangAbstract:The goal of this study is to determine the feasibility, diagnostic accuracy, and risk factor of complications of computed tomography (CT)-guided percutaneous Cutting Needle biopsy (PCNB) for small lung nodules.From January 2014 to May 2015, 141 patients with small lung nodule were performed with CT-guided PCNB procedure. Data on technical success, diagnostic accuracy, and complication were collected and analyzed.Technical success of CT-guided PCNB for small lung nodules was 100%. A total of 141 nodules were punctured. The mean time of the procedure was 15.7 ± 4.3 minutes. The PCNB results included malignancy (n = 79), suspected malignancy (n = 6), specific benign lesion (n = 8), nonspecific benign lesion (n = 47), and invalid diagnosis (n = 1). The final diagnosis of the 141 nodules included malignancy (n = 90), benign (n = 37), and nondiagnostic lesion (n = 14). The nondiagnostic nodules were not included for calculating the diagnostic accuracy. The sensitivity, specificity, and overall diagnostic accuracy of CT-guided PCNB for small lung nodule were 94.4% (85/90), 100% (37/37), and 96.1% (122/127), respectively. Pneumothorax and lung hemorrhage (≥ grade 2) occurred in 17 (12.1%) and 22 (15.6%) patients, respectively. Based on the univariate and multivariate logistic analyses, the risk factors of pneumothorax included nonprone position (P = .019) and longer procedure time (P = .018). The independent risk factor of lung hemorrhage (≥ grade 2) was deeper lesion distance from pleura along Needle path (P = .024).This study demonstrates that CT-guided PCNB can provide a high diagnostic accuracy for small lung nodule with acceptable complications.
-
Computed tomography-guided percutaneous Cutting Needle biopsy for small (≤ 20 mm) lung nodules.
Medicine, 2017Co-Authors: Wei Cao, Yi-bing Shi, Tao WangAbstract:The goal of this study is to determine the feasibility, diagnostic accuracy, and risk factor of complications of computed tomography (CT)-guided percutaneous Cutting Needle biopsy (PCNB) for small lung nodules.From January 2014 to May 2015, 141 patients with small lung nodule were performed with CT-guided PCNB procedure. Data on technical success, diagnostic accuracy, and complication were collected and analyzed.Technical success of CT-guided PCNB for small lung nodules was 100%. A total of 141 nodules were punctured. The mean time of the procedure was 15.7 ± 4.3 minutes. The PCNB results included malignancy (n = 79), suspected malignancy (n = 6), specific benign lesion (n = 8), nonspecific benign lesion (n = 47), and invalid diagnosis (n = 1). The final diagnosis of the 141 nodules included malignancy (n = 90), benign (n = 37), and nondiagnostic lesion (n = 14). The nondiagnostic nodules were not included for calculating the diagnostic accuracy. The sensitivity, specificity, and overall diagnostic accuracy of CT-guided PCNB for small lung nodule were 94.4% (85/90), 100% (37/37), and 96.1% (122/127), respectively. Pneumothorax and lung hemorrhage (≥ grade 2) occurred in 17 (12.1%) and 22 (15.6%) patients, respectively. Based on the univariate and multivariate logistic analyses, the risk factors of pneumothorax included nonprone position (P = .019) and longer procedure time (P = .018). The independent risk factor of lung hemorrhage (≥ grade 2) was deeper lesion distance from pleura along Needle path (P = .024).This study demonstrates that CT-guided PCNB can provide a high diagnostic accuracy for small lung nodule with acceptable complications.
Shinichi Toyooka - One of the best experts on this subject based on the ideXlab platform.
-
computed tomography fluoroscopy guided Cutting Needle biopsy of pulmonary nodules 8 mm a retrospective study including 117 nodules
European Journal of Radiology, 2020Co-Authors: Yanqing Zhao, Yusuke Matsui, Takao Hiraki, Hideo Gobara, Shinichi Toyooka, Toshihiro Iguchi, Koji Tomita, Mayu Uka, Susumu KanazawaAbstract:Abstract Purpose To evaluate the diagnostic yield and safety of computed tomography (CT) fluoroscopy-guided Cutting Needle biopsy (CNB) for pulmonary nodules ≤ 8 mm. Method Data of CT fluoroscopy-guided CNB for pulmonary nodules ≤ 8 mm performed in a single institution were retrospectively analyzed. One hundred and seventeen biopsy procedures for 117 pulmonary nodules (mean size, 7.4 mm) in 114 patients were included in the study. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall diagnostic accuracy were calculated. Univariate analyses were performed to elucidate the risk factors for diagnostic failure (i.e., non-diagnostic, false-positive, or false-negative results). Complications were graded per the Clavien-Dindo Classification. Results One (0.9 %) non-diagnostic biopsy result was found. The diagnostic accuracy was 95.7 % (112/117). The sensitivity and specificity were 95.8 % (91/95) and 95.5 % (21/22), respectively. PPV and NPV were 98.9 % (91/92) and 87.5 % (21/24), respectively. Univariate analyses showed that nodules in the lower lobes (p = 0.006) and prone biopsy position (p = 0.021) were the significant risk factors for diagnostic failure. The incidence of pneumothorax requiring chest tube placement (Grade IIIa) was 6.8 % (8/117). No Grade IIIb or higher complications were observed. Conclusion CT fluoroscopy-guided CNB for pulmonary nodules ≤ 8 mm showed a high diagnostic yield without severe complications.
-
Role of Computed Tomography Fluoroscopy–Guided Cutting Needle Biopsy of Lung Lesions After Transbronchial Examination Resulting in Negative Diagnosis
Clinical lung cancer, 2011Co-Authors: Yusuke Matsui, Takao Hiraki, Hidefumi Mimura, Hideo Gobara, Daisaku Inoue, Tatsuhiko Iishi, Shinichi Toyooka, Susumu KanazawaAbstract:Abstract Introduction: Computed tomography (CT)–guided lung biopsy is occasionally used for the lesions that were diagnosed as nonmalignant by transbronchial examination despite the fact that other clinical data suggested those as malignant. The purpose of this study is to evaluate the outcomes of CT fluoroscopy–guided Cutting Needle biopsy of lung lesions after transbronchial examination resulting in negative diagnosis. Patients and Methods We retrospectively evaluated the outcomes of CT fluoroscopy–guided lung biopsy for 351 lesions (mean size, 2.8 cm) that were found to be nonmalignant by transbronchial examination. Diagnostic yield, including sensitivity and specificity for the diagnosis of malignancy, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. Various variables were analyzed to determine the factors for diagnostic failure. Results The biopsy result was nondiagnostic, true-positive, true-negative, false-positive, or false-negative for 2, 262, 70, 0, or 17 lesions, respectively. Thus, the sensitivity, specificity, PPV, NPV, and accuracy of CT fluoroscopy–guided Cutting Needle biopsy was found to be 93% (262/281), 100% (70/70), 100% (262/262), 80% (70/87), and 94% (332/351), respectively. There was no significant risk factor for diagnostic failure. Conclusion Computed tomography fluoroscopy–guided Cutting Needle lung biopsy is a useful technique to correct or confirm negative diagnosis by transbronchial examination.
-
role of computed tomography fluoroscopy guided Cutting Needle biopsy of lung lesions after transbronchial examination resulting in negative diagnosis
Clinical Lung Cancer, 2011Co-Authors: Yusuke Matsui, Takao Hiraki, Hidefumi Mimura, Hideo Gobara, Daisaku Inoue, Tatsuhiko Iishi, Shinichi Toyooka, Susumu KanazawaAbstract:Abstract Introduction: Computed tomography (CT)–guided lung biopsy is occasionally used for the lesions that were diagnosed as nonmalignant by transbronchial examination despite the fact that other clinical data suggested those as malignant. The purpose of this study is to evaluate the outcomes of CT fluoroscopy–guided Cutting Needle biopsy of lung lesions after transbronchial examination resulting in negative diagnosis. Patients and Methods We retrospectively evaluated the outcomes of CT fluoroscopy–guided lung biopsy for 351 lesions (mean size, 2.8 cm) that were found to be nonmalignant by transbronchial examination. Diagnostic yield, including sensitivity and specificity for the diagnosis of malignancy, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. Various variables were analyzed to determine the factors for diagnostic failure. Results The biopsy result was nondiagnostic, true-positive, true-negative, false-positive, or false-negative for 2, 262, 70, 0, or 17 lesions, respectively. Thus, the sensitivity, specificity, PPV, NPV, and accuracy of CT fluoroscopy–guided Cutting Needle biopsy was found to be 93% (262/281), 100% (70/70), 100% (262/262), 80% (70/87), and 94% (332/351), respectively. There was no significant risk factor for diagnostic failure. Conclusion Computed tomography fluoroscopy–guided Cutting Needle lung biopsy is a useful technique to correct or confirm negative diagnosis by transbronchial examination.
-
CT fluoroscopy-guided Cutting Needle biopsy of focal pure ground-glass opacity lung lesions: diagnostic yield in 83 lesions.
European journal of radiology, 2010Co-Authors: Daisaku Inoue, Yusuke Matsui, Takao Hiraki, Hidefumi Mimura, Hideo Gobara, Tatsuhiko Iishi, Shinichi Toyooka, Katsuya Kato, Kentaro Shibamoto, Susumu KanazawaAbstract:Abstract Objective The objective of our study was to retrospectively determine the diagnostic yield of CT fluoroscopy-guided Cutting Needle biopsy of focal pure ground-glass opacity lung lesions. Materials and methods Biopsies were performed using 20-G coaxial Cutting Needles for 83 focal pure ground-glass opacity lung lesions (mean lesion size, 12.1 mm). After excluding the lesions for which biopsy specimens were unobtainable and final diagnoses were undetermined, the diagnostic yield, including sensitivity and specificity for a diagnosis of malignancy and accuracy, was calculated. The lesions were then divided into 2 groups: the diagnostic failure group, comprising lesions with false-negative results and for which a biopsy specimen was unobtainable; and the diagnostic success group, comprising lesions with true-negative results and true-positive results. Various variables were compared between the 2 groups by univariate analysis. Results Biopsy specimens were obtained from 82 lesions, while specimens could not be obtained from 1 lesion. Final diagnosis was undetermined in 16 lesions. The sensitivity and specificity for a diagnosis of malignancy were 95% (58/61) and 100% (5/5), respectively. Diagnostic accuracy was 95% (63/66). The 4 lesions in diagnostic failure group were smaller, deeper, and more likely to be located in the lower lobe and further, for those lesions, number of specimens obtained was smaller, compared with 63 lesions in diagnostic success group. However, none of the differences were statistically significant. Conclusion CT fluoroscopy-guided Cutting Needle biopsy provided high diagnostic yield for focal pure ground-glass opacity lung lesions.
Takao Hiraki - One of the best experts on this subject based on the ideXlab platform.
-
computed tomography fluoroscopy guided Cutting Needle biopsy of pulmonary nodules 8 mm a retrospective study including 117 nodules
European Journal of Radiology, 2020Co-Authors: Yanqing Zhao, Yusuke Matsui, Takao Hiraki, Hideo Gobara, Shinichi Toyooka, Toshihiro Iguchi, Koji Tomita, Mayu Uka, Susumu KanazawaAbstract:Abstract Purpose To evaluate the diagnostic yield and safety of computed tomography (CT) fluoroscopy-guided Cutting Needle biopsy (CNB) for pulmonary nodules ≤ 8 mm. Method Data of CT fluoroscopy-guided CNB for pulmonary nodules ≤ 8 mm performed in a single institution were retrospectively analyzed. One hundred and seventeen biopsy procedures for 117 pulmonary nodules (mean size, 7.4 mm) in 114 patients were included in the study. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall diagnostic accuracy were calculated. Univariate analyses were performed to elucidate the risk factors for diagnostic failure (i.e., non-diagnostic, false-positive, or false-negative results). Complications were graded per the Clavien-Dindo Classification. Results One (0.9 %) non-diagnostic biopsy result was found. The diagnostic accuracy was 95.7 % (112/117). The sensitivity and specificity were 95.8 % (91/95) and 95.5 % (21/22), respectively. PPV and NPV were 98.9 % (91/92) and 87.5 % (21/24), respectively. Univariate analyses showed that nodules in the lower lobes (p = 0.006) and prone biopsy position (p = 0.021) were the significant risk factors for diagnostic failure. The incidence of pneumothorax requiring chest tube placement (Grade IIIa) was 6.8 % (8/117). No Grade IIIb or higher complications were observed. Conclusion CT fluoroscopy-guided CNB for pulmonary nodules ≤ 8 mm showed a high diagnostic yield without severe complications.
-
Role of Computed Tomography Fluoroscopy–Guided Cutting Needle Biopsy of Lung Lesions After Transbronchial Examination Resulting in Negative Diagnosis
Clinical lung cancer, 2011Co-Authors: Yusuke Matsui, Takao Hiraki, Hidefumi Mimura, Hideo Gobara, Daisaku Inoue, Tatsuhiko Iishi, Shinichi Toyooka, Susumu KanazawaAbstract:Abstract Introduction: Computed tomography (CT)–guided lung biopsy is occasionally used for the lesions that were diagnosed as nonmalignant by transbronchial examination despite the fact that other clinical data suggested those as malignant. The purpose of this study is to evaluate the outcomes of CT fluoroscopy–guided Cutting Needle biopsy of lung lesions after transbronchial examination resulting in negative diagnosis. Patients and Methods We retrospectively evaluated the outcomes of CT fluoroscopy–guided lung biopsy for 351 lesions (mean size, 2.8 cm) that were found to be nonmalignant by transbronchial examination. Diagnostic yield, including sensitivity and specificity for the diagnosis of malignancy, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. Various variables were analyzed to determine the factors for diagnostic failure. Results The biopsy result was nondiagnostic, true-positive, true-negative, false-positive, or false-negative for 2, 262, 70, 0, or 17 lesions, respectively. Thus, the sensitivity, specificity, PPV, NPV, and accuracy of CT fluoroscopy–guided Cutting Needle biopsy was found to be 93% (262/281), 100% (70/70), 100% (262/262), 80% (70/87), and 94% (332/351), respectively. There was no significant risk factor for diagnostic failure. Conclusion Computed tomography fluoroscopy–guided Cutting Needle lung biopsy is a useful technique to correct or confirm negative diagnosis by transbronchial examination.
-
role of computed tomography fluoroscopy guided Cutting Needle biopsy of lung lesions after transbronchial examination resulting in negative diagnosis
Clinical Lung Cancer, 2011Co-Authors: Yusuke Matsui, Takao Hiraki, Hidefumi Mimura, Hideo Gobara, Daisaku Inoue, Tatsuhiko Iishi, Shinichi Toyooka, Susumu KanazawaAbstract:Abstract Introduction: Computed tomography (CT)–guided lung biopsy is occasionally used for the lesions that were diagnosed as nonmalignant by transbronchial examination despite the fact that other clinical data suggested those as malignant. The purpose of this study is to evaluate the outcomes of CT fluoroscopy–guided Cutting Needle biopsy of lung lesions after transbronchial examination resulting in negative diagnosis. Patients and Methods We retrospectively evaluated the outcomes of CT fluoroscopy–guided lung biopsy for 351 lesions (mean size, 2.8 cm) that were found to be nonmalignant by transbronchial examination. Diagnostic yield, including sensitivity and specificity for the diagnosis of malignancy, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. Various variables were analyzed to determine the factors for diagnostic failure. Results The biopsy result was nondiagnostic, true-positive, true-negative, false-positive, or false-negative for 2, 262, 70, 0, or 17 lesions, respectively. Thus, the sensitivity, specificity, PPV, NPV, and accuracy of CT fluoroscopy–guided Cutting Needle biopsy was found to be 93% (262/281), 100% (70/70), 100% (262/262), 80% (70/87), and 94% (332/351), respectively. There was no significant risk factor for diagnostic failure. Conclusion Computed tomography fluoroscopy–guided Cutting Needle lung biopsy is a useful technique to correct or confirm negative diagnosis by transbronchial examination.
-
CT fluoroscopy-guided Cutting Needle biopsy of focal pure ground-glass opacity lung lesions: diagnostic yield in 83 lesions.
European journal of radiology, 2010Co-Authors: Daisaku Inoue, Yusuke Matsui, Takao Hiraki, Hidefumi Mimura, Hideo Gobara, Tatsuhiko Iishi, Shinichi Toyooka, Katsuya Kato, Kentaro Shibamoto, Susumu KanazawaAbstract:Abstract Objective The objective of our study was to retrospectively determine the diagnostic yield of CT fluoroscopy-guided Cutting Needle biopsy of focal pure ground-glass opacity lung lesions. Materials and methods Biopsies were performed using 20-G coaxial Cutting Needles for 83 focal pure ground-glass opacity lung lesions (mean lesion size, 12.1 mm). After excluding the lesions for which biopsy specimens were unobtainable and final diagnoses were undetermined, the diagnostic yield, including sensitivity and specificity for a diagnosis of malignancy and accuracy, was calculated. The lesions were then divided into 2 groups: the diagnostic failure group, comprising lesions with false-negative results and for which a biopsy specimen was unobtainable; and the diagnostic success group, comprising lesions with true-negative results and true-positive results. Various variables were compared between the 2 groups by univariate analysis. Results Biopsy specimens were obtained from 82 lesions, while specimens could not be obtained from 1 lesion. Final diagnosis was undetermined in 16 lesions. The sensitivity and specificity for a diagnosis of malignancy were 95% (58/61) and 100% (5/5), respectively. Diagnostic accuracy was 95% (63/66). The 4 lesions in diagnostic failure group were smaller, deeper, and more likely to be located in the lower lobe and further, for those lesions, number of specimens obtained was smaller, compared with 63 lesions in diagnostic success group. However, none of the differences were statistically significant. Conclusion CT fluoroscopy-guided Cutting Needle biopsy provided high diagnostic yield for focal pure ground-glass opacity lung lesions.
