The Experts below are selected from a list of 81 Experts worldwide ranked by ideXlab platform
Mojgan Noroozi Karimabad - One of the best experts on this subject based on the ideXlab platform.
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CXCL9 cxcl10 angiostasis cxc Chemokines in parallel with the cxcl12 as an angiogenesis cxc Chemokine are variously expressed in pre eclamptic women and their neonates
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 2019Co-Authors: Shokoofeh Darakhshan, Gholamhossein Hassanshahi, Zohreh Mofidifar, Boshra Soltani, Mojgan Noroozi KarimabadAbstract:Abstract Background The disorder of pre-eclampsia is described as a complicated gestational state in which some of bio-molecules, including cytokines and Chemokines are involved. The main purpose of the current study was examining of the circulating levels of CXCL9, CXCL10 as inducible, angiostasis Chemokines as well as CXCL12 as an angiogenesis, homeostatic Chemokine, in pregnant women with and without pre-eclampsia and their neonates. Methods Peripheral blood and cord samples were collected from 53 preeclampsia patients and 53 normal pregnant women without preeclampsia and their related neonates. The differences in serum levels of CXCL9, CXCL10 and CXCL12 and the placental tissue expression of these Chemokines were investigated by ELISA and western blot analysis, respectively. Results Findings of the present study demonstrated that the levels of CXCL9 Chemokine in parallel with CXCL12 as homeostatic Chemokine were induced in pre-eclamptic women compared with normal pregnant women while CXCL10 remained unchanged. The CXCL9 and CXCL10 were both decreased in neonates who were delivered by pre-eclamptic women in compare to normal pregnant women. A CXCL12 level was elevated in neonates and has followed a similar fashion as mothers. Conclusion According to the results, the CXC Chemokines are involved in pathogenesis of pre-eclampsia and play important roles in several processes such as neovascularization, embryonic development and inflammatory responses that are mediated by pre-eclampsia.
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CXCL9/CXCL10 angiostasis CXC-Chemokines in parallel with the CXCL12 as an angiogenesis CXC-Chemokine are variously expressed in pre-eclamptic-women and their neonates.
Pregnancy hypertension, 2019Co-Authors: Shokoofeh Darakhshan, Gholamhossein Hassanshahi, Zohreh Mofidifar, Boshra Soltani, Mojgan Noroozi KarimabadAbstract:Abstract Background The disorder of pre-eclampsia is described as a complicated gestational state in which some of bio-molecules, including cytokines and Chemokines are involved. The main purpose of the current study was examining of the circulating levels of CXCL9, CXCL10 as inducible, angiostasis Chemokines as well as CXCL12 as an angiogenesis, homeostatic Chemokine, in pregnant women with and without pre-eclampsia and their neonates. Methods Peripheral blood and cord samples were collected from 53 preeclampsia patients and 53 normal pregnant women without preeclampsia and their related neonates. The differences in serum levels of CXCL9, CXCL10 and CXCL12 and the placental tissue expression of these Chemokines were investigated by ELISA and western blot analysis, respectively. Results Findings of the present study demonstrated that the levels of CXCL9 Chemokine in parallel with CXCL12 as homeostatic Chemokine were induced in pre-eclamptic women compared with normal pregnant women while CXCL10 remained unchanged. The CXCL9 and CXCL10 were both decreased in neonates who were delivered by pre-eclamptic women in compare to normal pregnant women. A CXCL12 level was elevated in neonates and has followed a similar fashion as mothers. Conclusion According to the results, the CXC Chemokines are involved in pathogenesis of pre-eclampsia and play important roles in several processes such as neovascularization, embryonic development and inflammatory responses that are mediated by pre-eclampsia.
Shokoofeh Darakhshan - One of the best experts on this subject based on the ideXlab platform.
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CXCL9 cxcl10 angiostasis cxc Chemokines in parallel with the cxcl12 as an angiogenesis cxc Chemokine are variously expressed in pre eclamptic women and their neonates
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 2019Co-Authors: Shokoofeh Darakhshan, Gholamhossein Hassanshahi, Zohreh Mofidifar, Boshra Soltani, Mojgan Noroozi KarimabadAbstract:Abstract Background The disorder of pre-eclampsia is described as a complicated gestational state in which some of bio-molecules, including cytokines and Chemokines are involved. The main purpose of the current study was examining of the circulating levels of CXCL9, CXCL10 as inducible, angiostasis Chemokines as well as CXCL12 as an angiogenesis, homeostatic Chemokine, in pregnant women with and without pre-eclampsia and their neonates. Methods Peripheral blood and cord samples were collected from 53 preeclampsia patients and 53 normal pregnant women without preeclampsia and their related neonates. The differences in serum levels of CXCL9, CXCL10 and CXCL12 and the placental tissue expression of these Chemokines were investigated by ELISA and western blot analysis, respectively. Results Findings of the present study demonstrated that the levels of CXCL9 Chemokine in parallel with CXCL12 as homeostatic Chemokine were induced in pre-eclamptic women compared with normal pregnant women while CXCL10 remained unchanged. The CXCL9 and CXCL10 were both decreased in neonates who were delivered by pre-eclamptic women in compare to normal pregnant women. A CXCL12 level was elevated in neonates and has followed a similar fashion as mothers. Conclusion According to the results, the CXC Chemokines are involved in pathogenesis of pre-eclampsia and play important roles in several processes such as neovascularization, embryonic development and inflammatory responses that are mediated by pre-eclampsia.
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CXCL9/CXCL10 angiostasis CXC-Chemokines in parallel with the CXCL12 as an angiogenesis CXC-Chemokine are variously expressed in pre-eclamptic-women and their neonates.
Pregnancy hypertension, 2019Co-Authors: Shokoofeh Darakhshan, Gholamhossein Hassanshahi, Zohreh Mofidifar, Boshra Soltani, Mojgan Noroozi KarimabadAbstract:Abstract Background The disorder of pre-eclampsia is described as a complicated gestational state in which some of bio-molecules, including cytokines and Chemokines are involved. The main purpose of the current study was examining of the circulating levels of CXCL9, CXCL10 as inducible, angiostasis Chemokines as well as CXCL12 as an angiogenesis, homeostatic Chemokine, in pregnant women with and without pre-eclampsia and their neonates. Methods Peripheral blood and cord samples were collected from 53 preeclampsia patients and 53 normal pregnant women without preeclampsia and their related neonates. The differences in serum levels of CXCL9, CXCL10 and CXCL12 and the placental tissue expression of these Chemokines were investigated by ELISA and western blot analysis, respectively. Results Findings of the present study demonstrated that the levels of CXCL9 Chemokine in parallel with CXCL12 as homeostatic Chemokine were induced in pre-eclamptic women compared with normal pregnant women while CXCL10 remained unchanged. The CXCL9 and CXCL10 were both decreased in neonates who were delivered by pre-eclamptic women in compare to normal pregnant women. A CXCL12 level was elevated in neonates and has followed a similar fashion as mothers. Conclusion According to the results, the CXC Chemokines are involved in pathogenesis of pre-eclampsia and play important roles in several processes such as neovascularization, embryonic development and inflammatory responses that are mediated by pre-eclampsia.
Brian K. Coombes - One of the best experts on this subject based on the ideXlab platform.
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CXCL9 contributes to antimicrobial protection of the gut during citrobacter rodentium infection independent of Chemokine-receptor signaling.
PLOS Pathogens, 2015Co-Authors: Sarah A. Reid-yu, Brian R. Tuinema, Cherrie N. Small, Lydia Xing, Brian K. CoombesAbstract:Chemokines have been shown to be effective bactericidal molecules against a variety of bacteria and fungi in vitro. These direct antimicrobial effects are independent of their chemotactic activities involving immunological receptors. However, the direct biological role that these proteins may play in host defense, particularly against intestinal pathogens, is poorly understood. Here, we show that CXCL9, an ELR- Chemokine, exhibits direct antimicrobial activity against Citrobacter rodentium, an attaching/effacing pathogen that infects the gut mucosa. Inhibition of this antimicrobial activity in vivo using anti-CXCL9 antibodies increases host susceptibility to C. rodentium infection with pronounced bacterial penetration into crypts, increased bacterial load, and worsened tissue pathology. Using Rag1-/- mice and CXCR3-/- mice, we demonstrate that the role for CXCL9 in protecting the gut mucosa is independent of an adaptive response or its immunological receptor, CXCR3. Finally, we provide evidence that phagocytes function in tandem with NK cells for robust CXCL9 responses to C. rodentium. These findings identify a novel role for the immune cell-derived CXCL9 Chemokine in directing a protective antimicrobial response in the intestinal mucosa.
Ralph A. Reisfeld - One of the best experts on this subject based on the ideXlab platform.
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MIG (CXCL9) Chemokine Gene Therapy Combines with Antibody-Cytokine Fusion Protein to Suppress Growth and Dissemination of Murine Colon Carcinoma
Cancer research, 2001Co-Authors: J. Michael Ruehlmann, Rong Xiang, Andreas G. Niethammer, Ursula Pertl, Carrie S. Dolman, Stephen D. Gillies, Ralph A. ReisfeldAbstract:The induction of a CTL response capable of eradicating disseminated tumor metastases and the establishment of a persistent tumor-protective immunity remain major goals of cancer immunotherapy. Here, we demonstrate for the first time that the combination of interleukin 2 (IL-2) targeted to the tumor microenvironment by a recombinant antibody-IL-2 fusion protein (huKS1/4-IL-2) with gene therapy by the murine Chemokine MIG (CXCL9) markedly reduced s.c. tumor burden and decisively suppressed dissemination of experimental lung metastases of CT26-KSA colon carcinoma in syngeneic BALB/c mice. This combined therapy significantly prolonged the life span of these mice 3–4-fold by concurrently delivering MIG and IL-2 to the tumor site and thereby achieving chemoattraction of T cells together with their activation. The antitumor effect obtained was mediated predominantly by MHC class I antigen-restricted CD8+ T cells with help from MHC class II antigen-restricted CD4+ T lymphocytes. In addition, the MIG Chemokine also induced angiostatic effects in the tumor vasculature. Taken together, this combination of MIG Chemokine gene therapy with tumor-targeted cytokine IL-2 provides an approach for the rational design of novel cancer immunotherapy modalities.
Gholamhossein Hassanshahi - One of the best experts on this subject based on the ideXlab platform.
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CXCL9 cxcl10 angiostasis cxc Chemokines in parallel with the cxcl12 as an angiogenesis cxc Chemokine are variously expressed in pre eclamptic women and their neonates
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 2019Co-Authors: Shokoofeh Darakhshan, Gholamhossein Hassanshahi, Zohreh Mofidifar, Boshra Soltani, Mojgan Noroozi KarimabadAbstract:Abstract Background The disorder of pre-eclampsia is described as a complicated gestational state in which some of bio-molecules, including cytokines and Chemokines are involved. The main purpose of the current study was examining of the circulating levels of CXCL9, CXCL10 as inducible, angiostasis Chemokines as well as CXCL12 as an angiogenesis, homeostatic Chemokine, in pregnant women with and without pre-eclampsia and their neonates. Methods Peripheral blood and cord samples were collected from 53 preeclampsia patients and 53 normal pregnant women without preeclampsia and their related neonates. The differences in serum levels of CXCL9, CXCL10 and CXCL12 and the placental tissue expression of these Chemokines were investigated by ELISA and western blot analysis, respectively. Results Findings of the present study demonstrated that the levels of CXCL9 Chemokine in parallel with CXCL12 as homeostatic Chemokine were induced in pre-eclamptic women compared with normal pregnant women while CXCL10 remained unchanged. The CXCL9 and CXCL10 were both decreased in neonates who were delivered by pre-eclamptic women in compare to normal pregnant women. A CXCL12 level was elevated in neonates and has followed a similar fashion as mothers. Conclusion According to the results, the CXC Chemokines are involved in pathogenesis of pre-eclampsia and play important roles in several processes such as neovascularization, embryonic development and inflammatory responses that are mediated by pre-eclampsia.
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CXCL9/CXCL10 angiostasis CXC-Chemokines in parallel with the CXCL12 as an angiogenesis CXC-Chemokine are variously expressed in pre-eclamptic-women and their neonates.
Pregnancy hypertension, 2019Co-Authors: Shokoofeh Darakhshan, Gholamhossein Hassanshahi, Zohreh Mofidifar, Boshra Soltani, Mojgan Noroozi KarimabadAbstract:Abstract Background The disorder of pre-eclampsia is described as a complicated gestational state in which some of bio-molecules, including cytokines and Chemokines are involved. The main purpose of the current study was examining of the circulating levels of CXCL9, CXCL10 as inducible, angiostasis Chemokines as well as CXCL12 as an angiogenesis, homeostatic Chemokine, in pregnant women with and without pre-eclampsia and their neonates. Methods Peripheral blood and cord samples were collected from 53 preeclampsia patients and 53 normal pregnant women without preeclampsia and their related neonates. The differences in serum levels of CXCL9, CXCL10 and CXCL12 and the placental tissue expression of these Chemokines were investigated by ELISA and western blot analysis, respectively. Results Findings of the present study demonstrated that the levels of CXCL9 Chemokine in parallel with CXCL12 as homeostatic Chemokine were induced in pre-eclamptic women compared with normal pregnant women while CXCL10 remained unchanged. The CXCL9 and CXCL10 were both decreased in neonates who were delivered by pre-eclamptic women in compare to normal pregnant women. A CXCL12 level was elevated in neonates and has followed a similar fashion as mothers. Conclusion According to the results, the CXC Chemokines are involved in pathogenesis of pre-eclampsia and play important roles in several processes such as neovascularization, embryonic development and inflammatory responses that are mediated by pre-eclampsia.
