The Experts below are selected from a list of 6951 Experts worldwide ranked by ideXlab platform
Amita Bagal - One of the best experts on this subject based on the ideXlab platform.
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use of octyl 2 Cyanoacrylate for skin closure in facial plastic surgery
1998Co-Authors: Dean M Toriumi, Kevin Ogrady, Devang P Desai, Amita BagalAbstract:Octyl-2-Cyanoacrylate is a long carbon chain Cyanoacrylate derivative that is stronger and more pliable than its shorter chain derivatives. One hundred and eleven patients underwent elective surgical procedures by the same surgeon using either octyl-2-Cyanoacrylate or sutures for skin closure at the
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use of octyl 2 Cyanoacrylate for skin closure in facial plastic surgery
1998Co-Authors: Dean M Toriumi, Kevin Ogrady, Devang P Desai, Amita BagalAbstract:Octyl-2-Cyanoacrylate is a long carbon chain Cyanoacrylate derivative that is stronger and more pliable than its shorter chain derivatives. One hundred and eleven patients underwent elective surgical procedures by the same surgeon using either octyl-2-Cyanoacrylate or sutures for skin closure at the University of Illinois at Chicago. Most patients underwent excision of benign skin lesions with a mean wound size of 112 mm3. Patients were randomized into either control (vertical mattress suture closure) or test groups (closure with octyl-2-Cyanoacrylate). Surgical judgment was used to determine which wounds in each group required application of subcutaneous sutures to relieve tension and aid in skin edge eversion. Generally, full-thickness (through dermis) wounds larger than 1 cm3 required the use of subcutaneous sutures. The time required to close the epidermis with suture (mean, 3 minutes and 47 seconds) was about four times that of octyl-2-Cyanoacrylate (mean, 55 seconds). Wounds were evaluated at 5 to 7 days for infection, wound dehiscence, or tissue reaction, and at 90 days using the modified Hollander wound evaluation scale. At 1 year, photographs of the wounds were evaluated by two facial plastic surgeons that graded the cosmetic outcome using a previously validated visual analog scale. There were no instances of wound dehiscence, hematoma, or infection in either group. Results of wound evaluation at 90 days determined by the modified Hollander scal revealed equivalent cosmetic results in both groups. Results of the visual analog scale ratings showed scores of 21.7 +/- 16.3 for the 49 patients treated with octyl-2-Cyanoacrylate and 29.2 +/- 17.7 for the 51 control patients treated with sutures. The lower visual analog scale score represented a superior cosmetic outcome at 1 year with the octyl-2-Cyanoacrylate as compared with sutures. This difference is statistically significant at p = 0.03. Additionally, patient satisfaction was very high in the group treated with octyl-2-Cyanoacrylate.
Kenneth F Binmoeller - One of the best experts on this subject based on the ideXlab platform.
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a pilot study of 2 octyl Cyanoacrylate injection for treatment of gastric fundal varices in humans
2004Co-Authors: Daniel S Rengstorff, Kenneth F BinmoellerAbstract:Abstract Background N-butyl Cyanoacrylate injection has been shown to be effective and safe for the endoscopic treatment of gastric varices. N-butyl Cyanoacrylate is not available in the United States, but use of a similar agent, 2-octyl Cyanoacrylate, recently was approved for skin closure. This pilot study prospectively evaluated the efficacy and safety of 2-octyl Cyanoacrylate injection for treatment of gastric fundal varices. Methods Twenty-five patients with large gastric fundal varices with either stigmata of recent hemorrhage, a history of bleeding, or high-risk varices underwent intravariceal injection of undiluted 2-octyl Cyanoacrylate. The end points for this study were cessation of active bleeding, successful obliteration of visible varices, and prevention of bleeding. Results Within 2 weeks of treatment, 52% of patients had a history of significant variceal bleeding, and 12% had active gastric variceal bleeding at the time of injection. The rate of immediate hemostasis was 100%. Gastric variceal bleeding recurred in 4% of patients (mean follow-up 11 months). The overall mortality rate was 12%; the bleeding-related mortality rate was 4%. Conclusions Injection of 2-octyl Cyanoacrylate appears to be efficacious and safe for both prevention and control of gastric variceal hemorrhage. Larger studies are required to further establish the use of 2-octyl Cyanoacrylate for treatment of gastric fundal varices.
Sherief Abdelsalam - One of the best experts on this subject based on the ideXlab platform.
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endoscopic injection sclerotherapy versus n butyl 2 Cyanoacrylate injection in the management of actively bleeding esophageal varices a randomized controlled trial
2019Co-Authors: Mohamed A. Elsebaey, Mohamed A. Tawfik, Sherif Ezzat, Amal Selim, Heba Elashry, Sherief AbdelsalamAbstract:The management of acute esophageal variceal bleeding remains a clinical challenge. Band ligation is the main therapeutic option, but it may be technically difficult to perform in active bleeders. This may necessitate an alternative therapy for this group of patients. This study was conducted to assess the safety and efficacy of sclerotherapy versus Cyanoacrylate injection for management of actively bleeding esophageal varices in cirrhotic patients. This prospective study included 113 cirrhotic patients with actively bleeding esophageal varices. They were randomly treated by endoscopic sclerotherapy or Cyanoacrylate injection as banding was not suitable for those patients due to profuse bleeding making unclear endoscopic visual field. Primary outcome was incidence of active bleeding control and secondary outcomes were incidence of six weeks rebleeding, complications, and mortality among the studied patients. Initial bleeding control was significantly higher in Cyanoacrylate versus sclerotherapy groups (98.25, 83.93% respectively, P = 0.007). No significant differences between sclerotherapy and Cyanoacrylate groups regarding rebleeding (26.79, 19.30% respectively, P = 0.344), complications, hospital stay or mortality rate were observed. Based on this single-center prospective study, both of these therapies appear to have relatively favorable outcomes, although Cyanoacrylate injection may be superior to sclerotherapy for initial control of active bleeding. [ClinicalTrials.gov Identifier: NCT03388125 ]–Date of registration: January 2, 2018 “Retrospectively registered”.
Hongshan Wei - One of the best experts on this subject based on the ideXlab platform.
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a retrospective analysis of Cyanoacrylate injection versus hemoclip placement for bleeding dieulafoy s lesion in duodenum
2018Co-Authors: Yu Jiang, Wen Jiang, Wenyan Liang, Hongshan WeiAbstract:Background. Duodenal Dieulafoy’s lesion (DL) is a rare disease that may lead to lethal hemorrhage in the upper gastrointestinal tract. The best technique for endoscopic intervention still remains unclear. In the present study, we performed a retrospective analysis of Cyanoacrylate injection versus hemoclip placement for treating bleeding DLs. Materials and Methods. We retrospectively analyzed eighteen patients from three medical centers between October 2008 and February 2016; six patients received Cyanoacrylate injection, while hemoclips were placed in 12 patients during the upper gastrointestinal endoscopy. Results. All patients received first endoscopic examination and/or endotherapy within 12 hours of admission to hospital. No difference was observed in the primary hemostasis rate or the recurrent hemorrhage rate between the Cyanoacrylate injection (CI) group and the hemoclip placement (HP) group, except that in one patient from the HP group melena was found three days after the first endotherapy. This patient received Cyanoacrylate injection once again. Conclusion. Both Cyanoacrylate injection and hemoclip placement are effective in treating duodenal DL, and neither of them causes significant side effects.
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A Retrospective Analysis of Cyanoacrylate Injection versus Hemoclip Placement for Bleeding Dieulafoy’s Lesion in Duodenum
2018Co-Authors: Yu Jiang, Wen Jiang, Wenyan Liang, Hongshan WeiAbstract:Background. Duodenal Dieulafoy’s lesion (DL) is a rare disease that may lead to lethal hemorrhage in the upper gastrointestinal tract. The best technique for endoscopic intervention still remains unclear. In the present study, we performed a retrospective analysis of Cyanoacrylate injection versus hemoclip placement for treating bleeding DLs. Materials and Methods. We retrospectively analyzed eighteen patients from three medical centers between October 2008 and February 2016; six patients received Cyanoacrylate injection, while hemoclips were placed in 12 patients during the upper gastrointestinal endoscopy. Results. All patients received first endoscopic examination and/or endotherapy within 12 hours of admission to hospital. No difference was observed in the primary hemostasis rate or the recurrent hemorrhage rate between the Cyanoacrylate injection (CI) group and the hemoclip placement (HP) group, except that in one patient from the HP group melena was found three days after the first endotherapy. This patient received Cyanoacrylate injection once again. Conclusion. Both Cyanoacrylate injection and hemoclip placement are effective in treating duodenal DL, and neither of them causes significant side effects
Stephen H Caldwell - One of the best experts on this subject based on the ideXlab platform.
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endoscopic Cyanoacrylate versus transjugular intrahepatic portosystemic shunt for gastric variceal bleeding a single center u s analysis
2009Co-Authors: Nicholas J Procaccini, Abdullah M S Alosaimi, Patrick G Northup, Curtis K Argo, Stephen H CaldwellAbstract:Background and Objectives Gastric variceal hemorrhage treatment remains a difficult issue for clinicians. There is controversy regarding whether first-line treatment should be endoscopic therapy with Cyanoacrylate glue or placement of a transjugular intrahepatic portosystemic shunt (TIPS). We compared these methods on the basis of rebleeding, survival, and complications. Design, Setting, Patients, and Interventions This was a retrospective cohort analysis of cirrhotic patients with gastric variceal hemorrhage treated with endoscopic Cyanoacrylate therapy or TIPS placement at a single U.S. center from 1997 to 2007. The groups were compared for rebleeding at 72 hours, 3 months, and 1 year; survival rates at 3 months and 1 year; and acute and extended complications and morbidity. Main Outcome Measurements and Results A total of 105 patients were included. There were no significant pretreatment differences between the 2 groups in age, sex, MELD (Model for End-Stage Liver Disease) score at the time of admission, or cause of liver disease. There were no significant differences in rebleeding at 72 hours, 3 months, and 1 year; survival at 3 months and 1 year; and aggregate long-term survival or acute complications. However, the TIPS group had a higher rate of long-term morbidity requiring hospitalization (41% with a TIPS and 1.6% in the Cyanoacrylate arm, P Limitations Retrospective and uncontrolled samples. Conclusion In patients with similar characteristics, Cyanoacrylate therapy performed as well as a TIPS in controlling and preventing gastric variceal hemorrhage with no significant differences in survival. Patients receiving Cyanoacrylate therapy experienced significantly less long-term morbidity related to therapy than patients who received a TIPS. Cyanoacrylate therapy appears to be safe and effective and compares favorably with TIPS therapy.
