The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
Takashi Takahashi - One of the best experts on this subject based on the ideXlab platform.
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construction of the abc ring system of taxanes via stereoselective one pot three component coupling and intramolecular alkylation of a protected Cyanohydrin ether
ChemInform, 2010Co-Authors: Takayuki Serizawa, Shigeru Miyamoto, Shinichiro Fuse, Takashi TakahashiAbstract:The 1,4-addition of cyclohexenone (II) to the protected Cyanohydrin ether (I) and subsequent addition of formaldehyde (III) to the resulting enolate proceed stereoselectively to afford the AC-ring system (IV).
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construction of the abc ring system of taxanes via stereoselective one pot three component coupling and intramolecular alkylation of a protected Cyanohydrin ether
Bulletin of the Chemical Society of Japan, 2010Co-Authors: Takayuki Serizawa, Shigeru Miyamoto, Shinichiro Fuse, Takashi TakahashiAbstract:Construction of the ABC ring system of taxanes via one-pot three-component coupling and intramolecular alkylation is accomplished. The 1,4-addition of a protected Cyanohydrin ether to 2-methyl-2-cy...
Jose M Sansano - One of the best experts on this subject based on the ideXlab platform.
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enantioenriched Cyanohydrin o phosphates synthesis and applications as chiral building blocks
Pure and Applied Chemistry, 2007Co-Authors: Alejandro Baeza, Jose M Sansano, Carmen NajeraAbstract:Aluminum complexes of the chiral (R)- or (S)-3,3'-bis(diethylaminomethyl)-1,1'- bi-2,2'-naphthol (BINOLAM) ligand behave as efficient catalysts for the enantioselective cyanation-O-functionalization of aldehydes, thereby leading to enantiomerically enriched O-silyl, O-methoxycarbonyl, or O-phosphate derivatives of Cyanohydrins. The enantio- enriched Cyanohydrin-O-phosphates are useful for the synthesis of several enantioenriched compounds such as α-hydroxy esters, β-amino alcohols, and γ-substituted α,β-unsaturated nitriles. Natural products such as (-)-aegeline and (-)-tembamide have been prepared in this manner.
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Solvent-Free Synthesis of Cyanohydrin Derivatives Catalysed by Triethylamine
Synthesis, 2005Co-Authors: Alejandro Baeza, Carmen Najera, Ma. De Gracia Retamosa, Jose M SansanoAbstract:A very simple one-step environmentally friendly procedure for the synthesis of 0-substituted Cyanohydrins from aldehydes and ketones, in the absence of solvent, employing minimum amounts of the corresponding cyanides has been optimised. Aldehydes react more rapidly than ketones using triethylamine as catalyst offering in both cases almost quantitative yields of the corresponding O-trimethylsilyl, O-methoxycarbonyl, O-benzoyl and O-acetyl Cyanohydrins.
Alejandro Baeza - One of the best experts on this subject based on the ideXlab platform.
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enantioenriched Cyanohydrin o phosphates synthesis and applications as chiral building blocks
Pure and Applied Chemistry, 2007Co-Authors: Alejandro Baeza, Jose M Sansano, Carmen NajeraAbstract:Aluminum complexes of the chiral (R)- or (S)-3,3'-bis(diethylaminomethyl)-1,1'- bi-2,2'-naphthol (BINOLAM) ligand behave as efficient catalysts for the enantioselective cyanation-O-functionalization of aldehydes, thereby leading to enantiomerically enriched O-silyl, O-methoxycarbonyl, or O-phosphate derivatives of Cyanohydrins. The enantio- enriched Cyanohydrin-O-phosphates are useful for the synthesis of several enantioenriched compounds such as α-hydroxy esters, β-amino alcohols, and γ-substituted α,β-unsaturated nitriles. Natural products such as (-)-aegeline and (-)-tembamide have been prepared in this manner.
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Solvent-Free Synthesis of Cyanohydrin Derivatives Catalysed by Triethylamine
Synthesis, 2005Co-Authors: Alejandro Baeza, Carmen Najera, Ma. De Gracia Retamosa, Jose M SansanoAbstract:A very simple one-step environmentally friendly procedure for the synthesis of 0-substituted Cyanohydrins from aldehydes and ketones, in the absence of solvent, employing minimum amounts of the corresponding cyanides has been optimised. Aldehydes react more rapidly than ketones using triethylamine as catalyst offering in both cases almost quantitative yields of the corresponding O-trimethylsilyl, O-methoxycarbonyl, O-benzoyl and O-acetyl Cyanohydrins.
Leiv K Sydnes - One of the best experts on this subject based on the ideXlab platform.
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the chemistry of acylals 3 Cyanohydrin esters from acylals with cyanide reagents
Organic Letters, 2000Co-Authors: Marcel Sandberg, Leiv K SydnesAbstract:When treated with KCN in DMSO at room temperature, acylals from aliphatic aldehydes gave the corresponding Cyanohydrin esters in good to excellent yields. Acylals from aromatic aldehydes were less reactive and gave several byproducts in addition to fair yields of Cyanohydrin under the same conditions. Trimethylsilyl cyanide mixed with titanium(IV) chloride afforded Cyanohydrin esters in good to excellent yields from both aliphatic and aromatic aldehydes.
Takayuki Serizawa - One of the best experts on this subject based on the ideXlab platform.
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construction of the abc ring system of taxanes via stereoselective one pot three component coupling and intramolecular alkylation of a protected Cyanohydrin ether
ChemInform, 2010Co-Authors: Takayuki Serizawa, Shigeru Miyamoto, Shinichiro Fuse, Takashi TakahashiAbstract:The 1,4-addition of cyclohexenone (II) to the protected Cyanohydrin ether (I) and subsequent addition of formaldehyde (III) to the resulting enolate proceed stereoselectively to afford the AC-ring system (IV).
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construction of the abc ring system of taxanes via stereoselective one pot three component coupling and intramolecular alkylation of a protected Cyanohydrin ether
Bulletin of the Chemical Society of Japan, 2010Co-Authors: Takayuki Serizawa, Shigeru Miyamoto, Shinichiro Fuse, Takashi TakahashiAbstract:Construction of the ABC ring system of taxanes via one-pot three-component coupling and intramolecular alkylation is accomplished. The 1,4-addition of a protected Cyanohydrin ether to 2-methyl-2-cy...
