The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Kiyoyuki Yamada - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of dolastatin G and nordolastatin G, cytotoxic 35-membered Cyclodepsipeptides of marine origin
Tetrahedron Letters, 1996Co-Authors: Tsuyoshi Mutou, Hideo Kigoshi, Makoto Ojika, Takashi Kondo, Takunobu Shibata, Kiyoyuki YamadaAbstract:Abstract The synthesis of dolastatin G (1) and nordolastatin G (2), new cytotoxic Cyclodepsipeptides from the Japanese sea hare Dolabella auricularia, was achieved enantioselectively, and the present result confirmed their stereostructures unambiguously.
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Isolation and stereostructure of aurilide, a novel Cyclodepsipeptide from the Japanese sea hare Dolabella auricularia
Tetrahedron Letters, 1996Co-Authors: Kiyotake Suenaga, Hideo Kigoshi, Tsuyoshi Mutou, Takahiro Shibata, Takashi Itoh, Kiyoyuki YamadaAbstract:Abstract Aurilide ( 1 ), a new 26-membered Cyclodepsipeptide, has been isolated from the Japanese sea hare Dolabella auricularia . The gross structure of 1 was established by spectroscopic analysis. The absolute stereostructure of 1 was determined by HPLC analysis of amino acid components and isoleucic acid obtained from acidic hydrolysis of 1 and by the enantioselective synthesis of the tris( p -bromobenzoate) 3 derived from the dihydroxy acid moiety.
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Total Synthesis of Doliculide, a Potent Cytotoxic Cyclodepsipeptide from the Japanese Sea Hare Dolabella auricularia
The Journal of Organic Chemistry, 1994Co-Authors: Hiroyuki Ishiwata, Hiroki Sone, Hideo Kigoshi, Kiyoyuki YamadaAbstract:The total synthesis of doliculide (1), a potent cytotoxic Cyclodepsipeptide from the Japanese sea hare, has been achieved
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Isolation and stereostructure of doliculide, a cytotoxic Cyclodepsipeptide from the Japanese sea hare Dolabella auricularia
The Journal of Organic Chemistry, 1994Co-Authors: Hiroyuki Ishiwata, Takayuki Nemoto, Makoto Ojika, Kiyoyuki YamadaAbstract:Doliculide (1), a cytotoxic Cyclodepsipeptide of mixed peptide-polyketide biogenesis, has been isolated from the Japanese sea hare Dolabella auricularia and its stereostructure determined by spectral and chemical methods
Catherine Lange - One of the best experts on this subject based on the ideXlab platform.
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Characterization of Cyclodepsipeptide-glutathionyl conjugates by negative-ion fast-atom bombardment linked-scan mass spectrometry.
Rapid communications in mass spectrometry : RCM, 1994Co-Authors: C. Loutelier, Jean-claude Cherton, Albert Marcual, Catherine LangeAbstract:A Cyclodepsipeptide-glutathionyl conjugate has been analysed for the first time using negative-ion fast-atom bombardment linked-scan mass spectroscopy. Fragment anions produced by collision-induced dissociation are discussed.
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Conjugation reactions of Cyclodepsipeptide to glutathionyl adducts by direct `in-beam' synthesis under negative-ion fast-atom bombardment conditions
Rapid communications in mass spectrometry : RCM, 1994Co-Authors: C. Loutelier, Jean-claude Cherton, Catherine LangeAbstract:The conjugation products of E-destruxin (Cyclodepsipeptide) with glutathione have been identified by fast-atom bombardment mass spectrometry. Appropriate conditions were developed for Cyclodepsipeptide substrate, which enabled the direct, dynamic mass spectra analysis of spontaneous as well as glutathione-s-transferase catalyzed conjugation reactions. Application to the most active cyclopeptide in the series of destruxins yielded glutathionyl adduct.
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Cationization of destruxins (Cyclodepsipeptides) under fast‐atom bombardment
Rapid Communications in Mass Spectrometry, 1991Co-Authors: Catherine Lange, C. Mulheim, A. Vey, M. PaisAbstract:Cationization ability is presented using fast-atom bombardment mass spectrometry and fast-atom bombardment tandem mass spectrometry. The sodium cation has the best potential for cationizing A- and E-destruxins (Cyclodepsipeptides), E-destruxin having a greater ability to cationize with Na+ than A-destruxin.
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Direct determination of the sequence of destruxins (Cyclodepsipeptides) using negative-ion fast-atom bombardment mass spectrometry
Rapid Communications in Mass Spectrometry, 1991Co-Authors: Catherine Lange, C. Mulheim, A. Vey, M. Pais, Jean-louis AubagnacAbstract:Fast-atom bombardment negative-ion mass spectra of various natural destruxins (Cyclodepsipeptides) using a glycerol matrix are investigated to clarify their regular pattern of fragmentation. Deprotonated molecules allow characterization of the molecular weight. Also, at lower masses, anion Y of significant intensities permit the determination of their amino acid sequences.
Hideo Kigoshi - One of the best experts on this subject based on the ideXlab platform.
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Isolation and stereostructure of aurilide, a novel Cyclodepsipeptide from the Japanese sea hare Dolabella auricularia
Tetrahedron Letters, 1996Co-Authors: Kiyotake Suenaga, Hideo Kigoshi, Tsuyoshi Mutou, Takahiro Shibata, Takashi Itoh, Kiyoyuki YamadaAbstract:Abstract Aurilide ( 1 ), a new 26-membered Cyclodepsipeptide, has been isolated from the Japanese sea hare Dolabella auricularia . The gross structure of 1 was established by spectroscopic analysis. The absolute stereostructure of 1 was determined by HPLC analysis of amino acid components and isoleucic acid obtained from acidic hydrolysis of 1 and by the enantioselective synthesis of the tris( p -bromobenzoate) 3 derived from the dihydroxy acid moiety.
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Synthesis of dolastatin G and nordolastatin G, cytotoxic 35-membered Cyclodepsipeptides of marine origin
Tetrahedron Letters, 1996Co-Authors: Tsuyoshi Mutou, Hideo Kigoshi, Makoto Ojika, Takashi Kondo, Takunobu Shibata, Kiyoyuki YamadaAbstract:Abstract The synthesis of dolastatin G (1) and nordolastatin G (2), new cytotoxic Cyclodepsipeptides from the Japanese sea hare Dolabella auricularia, was achieved enantioselectively, and the present result confirmed their stereostructures unambiguously.
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Total Synthesis of Doliculide, a Potent Cytotoxic Cyclodepsipeptide from the Japanese Sea Hare Dolabella auricularia
The Journal of Organic Chemistry, 1994Co-Authors: Hiroyuki Ishiwata, Hiroki Sone, Hideo Kigoshi, Kiyoyuki YamadaAbstract:The total synthesis of doliculide (1), a potent cytotoxic Cyclodepsipeptide from the Japanese sea hare, has been achieved
Hiroyuki Ishiwata - One of the best experts on this subject based on the ideXlab platform.
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Total Synthesis of Doliculide, a Potent Cytotoxic Cyclodepsipeptide from the Japanese Sea Hare Dolabella auricularia
The Journal of Organic Chemistry, 1994Co-Authors: Hiroyuki Ishiwata, Hiroki Sone, Hideo Kigoshi, Kiyoyuki YamadaAbstract:The total synthesis of doliculide (1), a potent cytotoxic Cyclodepsipeptide from the Japanese sea hare, has been achieved
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Isolation and stereostructure of doliculide, a cytotoxic Cyclodepsipeptide from the Japanese sea hare Dolabella auricularia
The Journal of Organic Chemistry, 1994Co-Authors: Hiroyuki Ishiwata, Takayuki Nemoto, Makoto Ojika, Kiyoyuki YamadaAbstract:Doliculide (1), a cytotoxic Cyclodepsipeptide of mixed peptide-polyketide biogenesis, has been isolated from the Japanese sea hare Dolabella auricularia and its stereostructure determined by spectral and chemical methods
C. Loutelier - One of the best experts on this subject based on the ideXlab platform.
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Conjugation reactions of Cyclodepsipeptide to glutathionyl adducts by direct `in-beam' synthesis under negative-ion fast-atom bombardment conditions
Rapid communications in mass spectrometry : RCM, 1994Co-Authors: C. Loutelier, Jean-claude Cherton, Catherine LangeAbstract:The conjugation products of E-destruxin (Cyclodepsipeptide) with glutathione have been identified by fast-atom bombardment mass spectrometry. Appropriate conditions were developed for Cyclodepsipeptide substrate, which enabled the direct, dynamic mass spectra analysis of spontaneous as well as glutathione-s-transferase catalyzed conjugation reactions. Application to the most active cyclopeptide in the series of destruxins yielded glutathionyl adduct.
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Characterization of Cyclodepsipeptide-glutathionyl conjugates by negative-ion fast-atom bombardment linked-scan mass spectrometry.
Rapid communications in mass spectrometry : RCM, 1994Co-Authors: C. Loutelier, Jean-claude Cherton, Albert Marcual, Catherine LangeAbstract:A Cyclodepsipeptide-glutathionyl conjugate has been analysed for the first time using negative-ion fast-atom bombardment linked-scan mass spectroscopy. Fragment anions produced by collision-induced dissociation are discussed.