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Aaryn L Rogers - One of the best experts on this subject based on the ideXlab platform.
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Synthesis, characterization, and crystal structures of organonickel(II) complexes coordinated to novel 1-bromo-2,6-bis{[(λ5-phosphanylidene)imino]methyl}benzene NCN-pincer ligands.
Acta crystallographica. Section C Structural chemistry, 2019Co-Authors: Gary L Guillet, Skyler L Pitts, Kirkland W Sheriff, Donna N Rucker, Aaryn L RogersAbstract:A novel family of four 1-bromo-2,6-bis{[(λ5-phosphanylidene)imino]methyl}benzene ligands has been synthesized and characterized. The phosphiniminomethyl substituents are decorated with either three phenyl Groups, two phenyl and one Cyclohexyl Group, one phenyl and two Cyclohexyl Groups, or three Cyclohexyl Groups. Each ligand was metallated using zero-valent nickel through an oxidative addition to form a family of organonickel(II) complexes, namely (2,6-bis{[(triphenyl-λ5-phosphanylidene)imino]methyl}phenyl-κ3N,C1,N')bromidonickel(II) dichloromethane hemisolvate, [NiBr(C44H37N2P2)]·0.5CH2Cl2, (2,6-bis{[(Cyclohexyldiphenyl-λ5-phosphanylidene)imino]methyl}phenyl-κ3N,C1,N')bromidonickel(II) diethyl ether hemisolvate, [NiBr(C44H49N2P2)]·0.5C4H10O, (2,6-bis{[(diCyclohexylphenyl-λ5-phosphanylidene)imino]methyl}phenyl-κ3N,C1,N')bromidonickel(II), [NiBr(C44H61N2P2)], and (2,6-bis{[(triCyclohexyl-λ5-phosphanylidene)imino]methyl}phenyl-κ3N,C1,N')bromidonickel(II), [NiBr(C44H73N2P2)]. This family of complexes represents a useful opportunity to investigate the impact of incrementally changing the steric characteristics of a complex on its structure and reactivity.
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Synthesis, characterization, and crystal structures of organonickel(II) complexes coordinated to novel 1‐bromo‐2,6‐bis{[(λ5‐phosphanylidene)imino]methyl}benzene NCN‐pincer ligands
Acta Crystallographica Section C-crystal Structure Communications, 2019Co-Authors: Gary L Guillet, Skyler L Pitts, Kirkland W Sheriff, Donna N Rucker, Aaryn L RogersAbstract:: A novel family of four 1-bromo-2,6-bis{[(λ5-phosphanylidene)imino]methyl}benzene ligands has been synthesized and characterized. The phosphiniminomethyl substituents are decorated with either three phenyl Groups, two phenyl and one Cyclohexyl Group, one phenyl and two Cyclohexyl Groups, or three Cyclohexyl Groups. Each ligand was metallated using zero-valent nickel through an oxidative addition to form a family of organonickel(II) complexes, namely (2,6-bis{[(triphenyl-λ5-phosphanylidene)imino]methyl}phenyl-κ3N,C1,N')bromidonickel(II) dichloromethane hemisolvate, [NiBr(C44H37N2P2)]·0.5CH2Cl2, (2,6-bis{[(Cyclohexyldiphenyl-λ5-phosphanylidene)imino]methyl}phenyl-κ3N,C1,N')bromidonickel(II) diethyl ether hemisolvate, [NiBr(C44H49N2P2)]·0.5C4H10O, (2,6-bis{[(diCyclohexylphenyl-λ5-phosphanylidene)imino]methyl}phenyl-κ3N,C1,N')bromidonickel(II), [NiBr(C44H61N2P2)], and (2,6-bis{[(triCyclohexyl-λ5-phosphanylidene)imino]methyl}phenyl-κ3N,C1,N')bromidonickel(II), [NiBr(C44H73N2P2)]. This family of complexes represents a useful opportunity to investigate the impact of incrementally changing the steric characteristics of a complex on its structure and reactivity.
C. Anjanamurthy - One of the best experts on this subject based on the ideXlab platform.
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Tetralone Acids as Intermediates for the Synthesis of Podophyllotoxin Analogues.
ChemInform, 2003Co-Authors: Y. B. Basavaraju, C. AnjanamurthyAbstract:Tetralone acids 6, 7 and 8 have been synthesised as intermediates for, the synthesis of podophyllotoxin analogues 3, 4 and 5. The possible steric hindrance of Cyclohexyl Group on drides 15 b,c to tetralone acids 7 and 8 is also discussed here
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Tetralone acids as intermediates for the synthesis of podophyllotoxin analogues
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry, 2003Co-Authors: Y. B. Basavaraju, C. AnjanamurthyAbstract:Tetralone acids 6, 7 and 8 have been synthesised as intermediates for the synthesis of podophyllotoxin analogues 3, 4 and 5. The possible steric hindrance of Cyclohexyl Group on the intramolecular Friedel-Crafts acylationreaction of anhydrides 15 b,c to tetralone acids 7 and 8 is also discussed here.
Alan J Heeger - One of the best experts on this subject based on the ideXlab platform.
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A Novel Series of Efficient Thiophene-Based Light-Emitting Conjugated Polymers and Application in Polymer Light-Emitting Diodes
Macromolecules, 2000Co-Authors: Jian Pei, Alan J HeegerAbstract:A novel series of sol. conjugated polymers, poly[1,4-bis(4-alkyl-2-thienyl)-2,5-disubstituted phenylene]s, with different substituents on the phenylene ring (hydrogen, Me Group, or decyloxy Group) and on the thiophene ring (n-hexyl chain or Cyclohexyl Group) were synthesized through FeCl3-oxidative polymn. The structures of the polymers were fully verified by FT-IR, 1H and 13C NMR, and element anal. The high regioregularity of head-to-head linkage between two adjacent thiophene rings in the polymers was demonstrated. The electronic spectra of the polymers can be tuned by changing the substitution on both the phenylene and thiophene rings, emitting blue to green light. The electronic structures of the polymers can also be tuned by different substitutions, as demonstrated by electrochem. measurements (cyclic voltammetry). The abs. photoluminescence (PL) efficiencies of the polymers in neat films, which can be remarkably effected by the substitution on both the phenylene ring and the thiophene ring, can be up to 29%, much higher than the PL efficiencies in other polythiophene-based light-emitting materials. It was demonstrated that inserting substituted phenylene rings into the backbone of polythiophene is a useful approach to improve the PL efficiency of thiophene-based conjugated polymers. Blue to green electroluminescence (EL) was realized from some of the new polymers in single-layered light-emitting diodes with the configuration of ITO/polymer film/Ca or Al. One green light-emitting diode fabricated from the green-emissive polymer with the highest PL efficiency gave rise to the best EL performance, turning on at .apprx.8V and reaching an external EL quantum efficiency of 0.1%. [on SciFinder (R)]
Lars Farde - One of the best experts on this subject based on the ideXlab platform.
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Two C-Methyl Derivatives of [^11C]WAY-100635 – Effects of an Amido α-Methyl Group on Metabolism and Brain 5-HT_1A Receptor Radioligand Behavior in Monkey*
Molecular Imaging and Biology, 2005Co-Authors: Julie A. Mccarron, Sandrine Marchais-oberwinkler, Victor W. Pike, Jari Tarkiainen, Christer Halldin, Judit Sóvagó, Balàzs Gulyas, Hakan V. Wikström, Lars FardeAbstract:Purpose [ carbonyl -^11C] N -(2-(1-(4-(2-methoxyphenyl)-piperazinyl)ethyl)- N -pyridinyl)cyclohexanecarboxamide ([ carbonyl -^11C]WAY-100635) is an effective radioligand for imaging brain 5-HT_1A receptors with positron emission tomography (PET). However, this radioligand has some drawbacks for deriving relative regional receptor densities, including rapid metabolism, which acts against accurate definition of an arterial input function for compartmental modeling, and very low nonspecific binding in brain, which detracts from the accuracy of modeling by a simplified reference tissue (cerebellum) approach. Here, in a search for a radioligand that overcomes these limitations, we investigated the effects of introducing a single methyl Group at either of the carbon atoms alpha to the amide bond in [^11C]WAY-100635. Procedures Ligands with a methyl Group on the alpha carbon of the Cyclohexyl Group (SWAY) or the alpha carbon of the C_2H_4 linker (( R , S )-JWAY) were synthesized and tested for binding affinity and intrinsic activity at 5-HT_1A receptors. SWAY was labeled with carbon-11 ( t _1/2 = 20.4 minutes; β^+ = 99.8%) in its O - methyl Group and ( R , S )-JWAY in its carbonyl Group. Each radioligand was evaluated by PET experiments in cynomolgus monkey. Results SWAY and ( R , S )-JWAY were found to be high-affinity antagonists at 5-HT_1A receptors. After injection of [^11C]SWAY into monkey, radioactivity uptake in brain reached a maximum of 3% at 4.5 minutes and decreased to 0.7% at 72 minutes. However, over the time span of the experiment, radioactivity concentrations in 5-HT_1A receptor-rich brain regions were only fractionally higher than in cerebellum. Radioactivity represented by parent radioligand in plasma was 39% at 45 minutes. After injection of [^11C]( R , S )-JWAY alone, radioactivity uptake in brain reached a maximum of 4.8% at 2.5 minutes and decreased to 1.2% at 90 minutes. At this time, radioactivity concentration in 5-HT_1A receptor-rich brain regions was markedly greater than in cerebellum. In another PET experiment, the monkey was predosed with WAY-100635 before [^11C]( R , S )-JWAY injection. At 90 minutes after injection, the ratio of radioactivity in 5-HT_1A receptor-rich regions to that in cerebellum was reduced to near unity. Radioactivity represented by parent radioligand in plasma was 12% at 45 minutes. Conclusions [^11C]( R , S )-JWAY, but not [^11C]SWAY, gives a sizeable 5-HT_1A receptor-selective PET signal in monkey. The presence of a C -methyl Group adjacent to the amide bond in SWAY or ( R , S )-JWAY fails to counter metabolism.
Gary L Guillet - One of the best experts on this subject based on the ideXlab platform.
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Synthesis, characterization, and crystal structures of organonickel(II) complexes coordinated to novel 1-bromo-2,6-bis{[(λ5-phosphanylidene)imino]methyl}benzene NCN-pincer ligands.
Acta crystallographica. Section C Structural chemistry, 2019Co-Authors: Gary L Guillet, Skyler L Pitts, Kirkland W Sheriff, Donna N Rucker, Aaryn L RogersAbstract:A novel family of four 1-bromo-2,6-bis{[(λ5-phosphanylidene)imino]methyl}benzene ligands has been synthesized and characterized. The phosphiniminomethyl substituents are decorated with either three phenyl Groups, two phenyl and one Cyclohexyl Group, one phenyl and two Cyclohexyl Groups, or three Cyclohexyl Groups. Each ligand was metallated using zero-valent nickel through an oxidative addition to form a family of organonickel(II) complexes, namely (2,6-bis{[(triphenyl-λ5-phosphanylidene)imino]methyl}phenyl-κ3N,C1,N')bromidonickel(II) dichloromethane hemisolvate, [NiBr(C44H37N2P2)]·0.5CH2Cl2, (2,6-bis{[(Cyclohexyldiphenyl-λ5-phosphanylidene)imino]methyl}phenyl-κ3N,C1,N')bromidonickel(II) diethyl ether hemisolvate, [NiBr(C44H49N2P2)]·0.5C4H10O, (2,6-bis{[(diCyclohexylphenyl-λ5-phosphanylidene)imino]methyl}phenyl-κ3N,C1,N')bromidonickel(II), [NiBr(C44H61N2P2)], and (2,6-bis{[(triCyclohexyl-λ5-phosphanylidene)imino]methyl}phenyl-κ3N,C1,N')bromidonickel(II), [NiBr(C44H73N2P2)]. This family of complexes represents a useful opportunity to investigate the impact of incrementally changing the steric characteristics of a complex on its structure and reactivity.
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Synthesis, characterization, and crystal structures of organonickel(II) complexes coordinated to novel 1‐bromo‐2,6‐bis{[(λ5‐phosphanylidene)imino]methyl}benzene NCN‐pincer ligands
Acta Crystallographica Section C-crystal Structure Communications, 2019Co-Authors: Gary L Guillet, Skyler L Pitts, Kirkland W Sheriff, Donna N Rucker, Aaryn L RogersAbstract:: A novel family of four 1-bromo-2,6-bis{[(λ5-phosphanylidene)imino]methyl}benzene ligands has been synthesized and characterized. The phosphiniminomethyl substituents are decorated with either three phenyl Groups, two phenyl and one Cyclohexyl Group, one phenyl and two Cyclohexyl Groups, or three Cyclohexyl Groups. Each ligand was metallated using zero-valent nickel through an oxidative addition to form a family of organonickel(II) complexes, namely (2,6-bis{[(triphenyl-λ5-phosphanylidene)imino]methyl}phenyl-κ3N,C1,N')bromidonickel(II) dichloromethane hemisolvate, [NiBr(C44H37N2P2)]·0.5CH2Cl2, (2,6-bis{[(Cyclohexyldiphenyl-λ5-phosphanylidene)imino]methyl}phenyl-κ3N,C1,N')bromidonickel(II) diethyl ether hemisolvate, [NiBr(C44H49N2P2)]·0.5C4H10O, (2,6-bis{[(diCyclohexylphenyl-λ5-phosphanylidene)imino]methyl}phenyl-κ3N,C1,N')bromidonickel(II), [NiBr(C44H61N2P2)], and (2,6-bis{[(triCyclohexyl-λ5-phosphanylidene)imino]methyl}phenyl-κ3N,C1,N')bromidonickel(II), [NiBr(C44H73N2P2)]. This family of complexes represents a useful opportunity to investigate the impact of incrementally changing the steric characteristics of a complex on its structure and reactivity.
