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Asieh Ehsaei - One of the best experts on this subject based on the ideXlab platform.
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effect of cyclopentolate versus tropicamide on anterior segment angle parameters in three refractive groups
Clinical and Experimental Optometry, 2020Co-Authors: Nasrin Moghadas Sharif, Nasser Shoeibi, Maryam Heydari, Negareh Yazdani, Somayeh Ghasemimoghaddam, Asieh EhsaeiAbstract:CLINICAL RELEVANCE Frequent clinical application of Cycloplegia in clinical practice makes it essential to assess how this condition influences anterior segment angle parameters. BACKGROUND This study aims to compare the effects of cyclopentolate and tropicamide on anterior segment angle parameters in three adult refractive groups. METHODS Sixty healthy individuals were recruited and assigned into three refractive groups according to inclusion criteria. At baseline visit, anterior segment angle parameters were measured using anterior segment optical coherence tomography in the right eye. All measurements were repeated at two separate visits, one week apart, after administration of tropicamide 1% and cyclopentolate 1% at similar conditions. Main outcome measures were angle-opening distance, trabecular iris angle, trabecular iris space area and anterior chamber depth. Anterior segment angle parameters were recorded at temporal areas (180 degrees). RESULTS Sixty participants (29 men and 31 women, age: 27.82 ± 4.71 years) completed the experiment. Baseline mean spherical equivalents were +1.52 ± 1.20 D, -0.04 ± 0.33 D and -1.91 ± 0.91 D in hyperopic, emmetropic and myopic groups, respectively. No statistically significant differences were found between tropicamide and cyclopentolate for all angle parameters in three refractive groups. Both drops induced an increase in all parameters in three refractive groups. Analysis between refractive groups revealed that a more hyperopic refraction was associated with less trabecular iris angle, angle-opening distance and anterior chamber depth parameters in baseline, after tropicamide and cyclopentolate instillations. CONCLUSIONS Topical application of cycloplegic eye drops in healthy individuals leads to small but significant changes in anterior chamber depth and anterior segment angle parameters, regardless of refractive status. Moreover, lower values of anterior chamber depth and anterior segment angle parameters in hyperopic individuals after administration of cycloplegic drops should be taken into account during biometric measurement and phakic intraocular lens implantation. Due to shorter effect and recovery time and less ocular/systemic reaction of tropicamide versus cyclopentolate, tropicamide could be a recommended cycloplegic agent for diagnostic and therapeutic procedures.
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Effect of cyclopentolate versus tropicamide on anterior segment angle parameters in three refractive groups.
Clinical & experimental optometry, 2020Co-Authors: Nasrin Moghadas Sharif, Nasser Shoeibi, Maryam Heydari, Negareh Yazdani, Somayeh Ghasemi-moghaddam, Asieh EhsaeiAbstract:Frequent clinical application of Cycloplegia in clinical practice makes it essential to assess how this condition influences anterior segment angle parameters. This study aims to compare the effects of cyclopentolate and tropicamide on anterior segment angle parameters in three adult refractive groups. Sixty healthy individuals were recruited and assigned into three refractive groups according to inclusion criteria. At baseline visit, anterior segment angle parameters were measured using anterior segment optical coherence tomography in the right eye. All measurements were repeated at two separate visits, one week apart, after administration of tropicamide 1% and cyclopentolate 1% at similar conditions. Main outcome measures were angle-opening distance, trabecular iris angle, trabecular iris space area and anterior chamber depth. Anterior segment angle parameters were recorded at temporal areas (180 degrees). Sixty participants (29 men and 31 women, age: 27.82 ± 4.71 years) completed the experiment. Baseline mean spherical equivalents were +1.52 ± 1.20 D, -0.04 ± 0.33 D and -1.91 ± 0.91 D in hyperopic, emmetropic and myopic groups, respectively. No statistically significant differences were found between tropicamide and cyclopentolate for all angle parameters in three refractive groups. Both drops induced an increase in all parameters in three refractive groups. Analysis between refractive groups revealed that a more hyperopic refraction was associated with less trabecular iris angle, angle-opening distance and anterior chamber depth parameters in baseline, after tropicamide and cyclopentolate instillations. Topical application of cycloplegic eye drops in healthy individuals leads to small but significant changes in anterior chamber depth and anterior segment angle parameters, regardless of refractive status. Moreover, lower values of anterior chamber depth and anterior segment angle parameters in hyperopic individuals after administration of cycloplegic drops should be taken into account during biometric measurement and phakic intraocular lens implantation. Due to shorter effect and recovery time and less ocular/systemic reaction of tropicamide versus cyclopentolate, tropicamide could be a recommended cycloplegic agent for diagnostic and therapeutic procedures. © 2020 Optometry Australia.
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comparison of cyclopentolate versus tropicamide Cycloplegia a systematic review and meta analysis
Journal of Optometry, 2017Co-Authors: Negareh Yazdani, Ramin Sadeghi, Hamed Momenimoghaddam, Leili Zarifmahmoudi, Asieh EhsaeiAbstract:Purpose The aim of the present meta-analysis is to compare the efficacy of cyclopentolate and tropicamide in controlling accommodation during refraction. Methods A comprehensive literature search was performed in PubMed, Scopus, Science direct and Ovid databases by the key words: "tropicamide"; "cyclopentolate"; "Cycloplegia" and "cycloplegic" from inception to April 2016. Methodological quality of the literature was evaluated according to the Oxford Center for Evidence Based Medicine and modified Newcastle-Ottawa scale. Statistical analyses were performed using Comprehensive Meta-Analysis (version 2; Biostat Inc., USA). Results The present meta-analysis included six studies (three randomized controlled trials and three case-control studies). Pooled standardized difference in the mean changes in the refractive error was 0.175 D [lower and upper limits: -0.089; 0.438] more plus in the cyclopentolate group compared to the tropicamide group; however, this difference was not statistically significant (p=0.194; Cochrane Q value=171.72 (p Conclusion We suggest that tropicamide may be considered as a viable substitute for cyclopentolate due to its rapid onset of action. Although these results should be used cautiously in infants and in patients with high hyperopia or strabismus when using tropicamide as the sole cycloplegic agent especially in situations that the findings are variable or there is no consistency between the examination results and clinical manifestations of the visual problems.
Negareh Yazdani - One of the best experts on this subject based on the ideXlab platform.
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effect of cyclopentolate versus tropicamide on anterior segment angle parameters in three refractive groups
Clinical and Experimental Optometry, 2020Co-Authors: Nasrin Moghadas Sharif, Nasser Shoeibi, Maryam Heydari, Negareh Yazdani, Somayeh Ghasemimoghaddam, Asieh EhsaeiAbstract:CLINICAL RELEVANCE Frequent clinical application of Cycloplegia in clinical practice makes it essential to assess how this condition influences anterior segment angle parameters. BACKGROUND This study aims to compare the effects of cyclopentolate and tropicamide on anterior segment angle parameters in three adult refractive groups. METHODS Sixty healthy individuals were recruited and assigned into three refractive groups according to inclusion criteria. At baseline visit, anterior segment angle parameters were measured using anterior segment optical coherence tomography in the right eye. All measurements were repeated at two separate visits, one week apart, after administration of tropicamide 1% and cyclopentolate 1% at similar conditions. Main outcome measures were angle-opening distance, trabecular iris angle, trabecular iris space area and anterior chamber depth. Anterior segment angle parameters were recorded at temporal areas (180 degrees). RESULTS Sixty participants (29 men and 31 women, age: 27.82 ± 4.71 years) completed the experiment. Baseline mean spherical equivalents were +1.52 ± 1.20 D, -0.04 ± 0.33 D and -1.91 ± 0.91 D in hyperopic, emmetropic and myopic groups, respectively. No statistically significant differences were found between tropicamide and cyclopentolate for all angle parameters in three refractive groups. Both drops induced an increase in all parameters in three refractive groups. Analysis between refractive groups revealed that a more hyperopic refraction was associated with less trabecular iris angle, angle-opening distance and anterior chamber depth parameters in baseline, after tropicamide and cyclopentolate instillations. CONCLUSIONS Topical application of cycloplegic eye drops in healthy individuals leads to small but significant changes in anterior chamber depth and anterior segment angle parameters, regardless of refractive status. Moreover, lower values of anterior chamber depth and anterior segment angle parameters in hyperopic individuals after administration of cycloplegic drops should be taken into account during biometric measurement and phakic intraocular lens implantation. Due to shorter effect and recovery time and less ocular/systemic reaction of tropicamide versus cyclopentolate, tropicamide could be a recommended cycloplegic agent for diagnostic and therapeutic procedures.
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Effect of cyclopentolate versus tropicamide on anterior segment angle parameters in three refractive groups.
Clinical & experimental optometry, 2020Co-Authors: Nasrin Moghadas Sharif, Nasser Shoeibi, Maryam Heydari, Negareh Yazdani, Somayeh Ghasemi-moghaddam, Asieh EhsaeiAbstract:Frequent clinical application of Cycloplegia in clinical practice makes it essential to assess how this condition influences anterior segment angle parameters. This study aims to compare the effects of cyclopentolate and tropicamide on anterior segment angle parameters in three adult refractive groups. Sixty healthy individuals were recruited and assigned into three refractive groups according to inclusion criteria. At baseline visit, anterior segment angle parameters were measured using anterior segment optical coherence tomography in the right eye. All measurements were repeated at two separate visits, one week apart, after administration of tropicamide 1% and cyclopentolate 1% at similar conditions. Main outcome measures were angle-opening distance, trabecular iris angle, trabecular iris space area and anterior chamber depth. Anterior segment angle parameters were recorded at temporal areas (180 degrees). Sixty participants (29 men and 31 women, age: 27.82 ± 4.71 years) completed the experiment. Baseline mean spherical equivalents were +1.52 ± 1.20 D, -0.04 ± 0.33 D and -1.91 ± 0.91 D in hyperopic, emmetropic and myopic groups, respectively. No statistically significant differences were found between tropicamide and cyclopentolate for all angle parameters in three refractive groups. Both drops induced an increase in all parameters in three refractive groups. Analysis between refractive groups revealed that a more hyperopic refraction was associated with less trabecular iris angle, angle-opening distance and anterior chamber depth parameters in baseline, after tropicamide and cyclopentolate instillations. Topical application of cycloplegic eye drops in healthy individuals leads to small but significant changes in anterior chamber depth and anterior segment angle parameters, regardless of refractive status. Moreover, lower values of anterior chamber depth and anterior segment angle parameters in hyperopic individuals after administration of cycloplegic drops should be taken into account during biometric measurement and phakic intraocular lens implantation. Due to shorter effect and recovery time and less ocular/systemic reaction of tropicamide versus cyclopentolate, tropicamide could be a recommended cycloplegic agent for diagnostic and therapeutic procedures. © 2020 Optometry Australia.
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comparison of cyclopentolate versus tropicamide Cycloplegia a systematic review and meta analysis
Journal of Optometry, 2017Co-Authors: Negareh Yazdani, Ramin Sadeghi, Hamed Momenimoghaddam, Leili Zarifmahmoudi, Asieh EhsaeiAbstract:Purpose The aim of the present meta-analysis is to compare the efficacy of cyclopentolate and tropicamide in controlling accommodation during refraction. Methods A comprehensive literature search was performed in PubMed, Scopus, Science direct and Ovid databases by the key words: "tropicamide"; "cyclopentolate"; "Cycloplegia" and "cycloplegic" from inception to April 2016. Methodological quality of the literature was evaluated according to the Oxford Center for Evidence Based Medicine and modified Newcastle-Ottawa scale. Statistical analyses were performed using Comprehensive Meta-Analysis (version 2; Biostat Inc., USA). Results The present meta-analysis included six studies (three randomized controlled trials and three case-control studies). Pooled standardized difference in the mean changes in the refractive error was 0.175 D [lower and upper limits: -0.089; 0.438] more plus in the cyclopentolate group compared to the tropicamide group; however, this difference was not statistically significant (p=0.194; Cochrane Q value=171.72 (p Conclusion We suggest that tropicamide may be considered as a viable substitute for cyclopentolate due to its rapid onset of action. Although these results should be used cautiously in infants and in patients with high hyperopia or strabismus when using tropicamide as the sole cycloplegic agent especially in situations that the findings are variable or there is no consistency between the examination results and clinical manifestations of the visual problems.
Jost B Jonas - One of the best experts on this subject based on the ideXlab platform.
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effect of Cycloplegia on the refractive status of children the shandong children eye study
PLOS ONE, 2015Co-Authors: Yuan Yuan Hu, Jian Feng Wu, Tai Liang Lu, Hui Wu, Xing Rong Wang, Hong Sheng Bi, Jost B JonasAbstract:Purpose To determine the effect of 1% cyclopentolate on the refractive status of children aged 4 to 18 years. Methods Using a random cluster sampling in a cross-sectional school-based study design, children with an age of 4–18 years were selected from kindergardens, primary schools, junior and senior high schools in a rural county and a city. Auto-refractometry was performed before and after inducing Cycloplegia which was achieved by 1% cyclopentolate eye drops. Results Out of 6364 eligible children, data of 5999 (94.3%) children were included in the statistical analysis. Mean age was 10.0±3.3 years (range: 4–18 years). Mean difference between cycloplegic and non-cycloplegic refractive error (DIFF) was 0.78±0.79D (median: 0.50D; range: -1.00D to +10.75D). In univariate analysis, DIFF decreased significantly with older age (P<0.001;correlation coefficient r:-0.24), more hyperopic non-cycloplegic refractive error (P<0.001;r = 0.13) and more hyperopic cycloplegic refractive error (P<0.001;r = 0.49). In multivariate analysis, higher DIFF was associated with higher cycloplegic refractive error (P<0.001; standardized regression coefficient beta:0.50; regression coefficient B: 0.19; 95% confidence interval (CI): 0.18, 0.20), followed by lower intraocular pressure (P<0.001; beta: -0.06; B: -0.02; 95%CI: -0.03, -0.01), rural region of habitation (P = 0.001; beta: -0.04; B: -0.07; 95%CI: -0.11, -0.03), and, to a minor degree, with age (P = 0.006; beta: 0.04; B: 0.009; 95%CI: 0.003, 0.016). 66.4% of all eyes with non-cycloplegic myopia (≤-0.50D) remained myopic after Cycloplegia while the remaining 33.6% of eyes became emmetropic (18.0%) or hyperopic (15.7%) under Cycloplegia. Prevalence of emmetropia decreased from 37.5% before Cycloplegia to 19.8% after Cycloplegia while the remaining eyes became hyperopic under Cycloplegia. Conclusions The error committed by using non-cycloplegic versus cycloplegic refractometry in children with mid to dark-brown iris color decreased with older age, and in parallel manner, with more myopic cycloplegic refractive error. Non-cycloplegic refractometric measures lead to a misclassification of refractive error in a significant proportion of children.
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Effect of Cycloplegia on the refractive status of children: the Shandong children eye study.
PLOS ONE, 2015Co-Authors: Yuan Yuan Hu, Jian Feng Wu, Tai Liang Lu, Hui Wu, Xing Rong Wang, Hong Sheng Bi, Jost B JonasAbstract:Purpose To determine the effect of 1% cyclopentolate on the refractive status of children aged 4 to 18 years. Methods Using a random cluster sampling in a cross-sectional school-based study design, children with an age of 4–18 years were selected from kindergardens, primary schools, junior and senior high schools in a rural county and a city. Auto-refractometry was performed before and after inducing Cycloplegia which was achieved by 1% cyclopentolate eye drops. Results Out of 6364 eligible children, data of 5999 (94.3%) children were included in the statistical analysis. Mean age was 10.0±3.3 years (range: 4–18 years). Mean difference between cycloplegic and non-cycloplegic refractive error (DIFF) was 0.78±0.79D (median: 0.50D; range: -1.00D to +10.75D). In univariate analysis, DIFF decreased significantly with older age (P
David A Mackey - One of the best experts on this subject based on the ideXlab platform.
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what is the appropriate age cut off for Cycloplegia in refraction
Acta Ophthalmologica, 2014Co-Authors: Paul G Sanfilippo, Olivia Bigault, Lisa S Kearns, Mei Ying Boon, Terri L Young, Christopher J Hammond, Alex W Hewitt, David A MackeyAbstract:Purpose To investigate the age range for which Cycloplegia provides additional information compared with non-cycloplegic refraction in teenagers and young adults. Methods Data for 1295 subjects (704 female; 591 male) from the Twins Eye Study in Tasmania (TEST) and the Brisbane Adolescent Twin Study (mean age: 19.65 ± 3.56, range: 13–26 years) were included. For all participants, Cycloplegia was induced by instillation of either one drop of 1% cyclopentolate (13–14 years) or one drop of 1% tropicamide (15–26 years). Pre- and postcycloplegic refractive errors for both eyes were measured using a Humphrey-598 automated refractor and spherical equivalents of refractive error were calculated. Generalized Estimating Equations (GEE) were used to model the spherical equivalent refraction (SER) for each eye against age (by year) and axial length (in the given eye). Results The mean group difference between pre- and postcycloplegic SER (post minus pre) was 0.17 ± 0.52 D and 0.12 ± 0.51 D for the right and left eyes, respectively, indicating that postcycloplegic refraction was generally more hyperopic/less myopic. The mean difference between pre- and postcycloplegic SER decreased from 0.36 ± 0.41 D in the 13-year-olds to 0.06 ± 0.50 D in people aged 25 years. After adjusting for family-relatedness, the difference between pre- and postCycloplegia SER was significant in all age groups up until the age of 20 years. Conclusions Non-cycloplegic autorefraction can result in group mean SER differences of greater myopia than cycloplegic autorefraction and occurs in teenagers (13–19 years of age), but not in adults 20–26 years. These data suggest that Cycloplegia is not required in population estimates of refractive error for young adults once they reach approximately 20 years of age.
Cihan Unlu - One of the best experts on this subject based on the ideXlab platform.
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comparison of autorefraction and photorefraction with and without Cycloplegia using 1 tropicamide in preschool children
Journal of Ophthalmology, 2019Co-Authors: Ertugrul Tan Yassa, Cihan UnluAbstract:Purpose. We aimed to investigate whether the accuracy of the Plusoptix A09 photorefractor in children with ametropia is enhanced by Cycloplegia with 1% tropicamide. Methods. A total of 70 eyes (70 children) were retrospectively reviewed. Noncycloplegic photorefraction, Cycloplegia with 1% tropicamide, cycloplegic photorefraction, and cycloplegic refraction with a tabletop autorefractometer were performed on all subjects in this order. Measurements were compared statistically. Results. The mean age was 45.9 ± 11.4 months. The mean spherical equivalent (0.61 ± 1.03 diopters (D); range, −2.38 to 3.63 D) and mean spherical power (1.16 ± 0.92 D; range, −1.25 to 3.75 D) values that were acquired from the photorefraction without Cycloplegia showed statistically significant differences from those of the autorefraction with Cycloplegia (mean spherical equivalent = 1.00 ± 1.27 D; range, −1.50 to 4.25 D, mean spherical power = 1.60 ± 1.14; range, −1.25 to 4.50 D). The mean difference for the spherical equivalent was −0.39 ± 0.93 D ( ; 95% limits of agreement (LoA) = −2.22 D to 1.44 D) and for spherical power was −0.44 ± 1.02 D ( ; LoA = −2.44 D to 1.56 D). Without Cycloplegia, Plusoptix A09 showed myopic shift, while after Cycloplegia, it showed hyperopic shift. Spherical equivalent (mean difference (MD) ± SD = 0.78 ± 1.00 D, ; LoA = −1.17 D to 2.72 D) and spherical power (MD ± SD = 0.73 ± 1.04 D, ; LoA = −1.31 D to 2.77 D) values were significantly different from those of autorefraction with Cycloplegia. Cylindrical power values obtained by photorefraction both with and without Cycloplegia were not statistically different from those of autorefraction with Cycloplegia ( ). Conclusion. Cycloplegia with 1% tropicamide did not improve the accuracy of photorefraction using Plusoptix A09 in preschool children. The spherical equivalent and spherical power values obtained by photorefraction with Cycloplegia were significantly higher from those obtained by autorefraction with Cycloplegia.
