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Jorge Alboressaavedra - One of the best experts on this subject based on the ideXlab platform.
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Cylindroma dermal analog tumor of the breast
American Journal of Clinical Pathology, 2005Co-Authors: Jorge Alboressaavedra, Steven Cooper Heard, Bernadette Mclaren, Hideko Kamino, Agnieszka WitkiewiczAbstract:We compared 4 breast Cylindromas with 50 dermal Cylindromas and 8 adenoid cystic breast carcinomas. Except for a modest increase in the number of eccrine ducts and reactive Langerhans cells in dermal Cylindromas, breast and dermal Cylindromas showed identical histologic and immunohistochemical features. Both were characterized by epithelial islands containing central basaloid cells and peripheral myoepithelial cells surrounded by a thickened, continuous, periodic acid–Schiff–positive basement membrane that was immunoreactive for collagen IV. Clusters of sebaceous cells and a few eccrine ducts are described in breast Cylindromas. Cytokeratin 7 labeled predominantly the central basaloid cells, and smooth muscle actin stained peripheral myoepithelial cells in breast and dermal Cylindromas. Eccrine ducts were highlighted by epithelial membrane antigen and carcinoembryonic antigen. S-100 protein and CD1a showed a variable number of dendritic Langerhans cells. Cylindromas of the breast and skin did not express cytokeratin 20, gross cystic disease fluid protein 15, or estrogen or progesterone receptor. Breast Cylindroma might be confused with the solid variant of adenoid cystic carcinoma, especially in needle core biopsy specimens, because they share nodular and trabecular patterns, basaloid cells, myoepithelial cells, eccrine ducts, and hyaline globules of basement membrane material. However, adenoid cystic carcinoma displays an infiltrative growth pattern, cytologic atypia, and mitotic figures and lacks the continuous, thickened basement membrane.
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Cylindroma dermal analog tumor of the breast a comparison with Cylindroma of the skin and adenoid cystic carcinoma of the breast
American Journal of Clinical Pathology, 2005Co-Authors: Jorge Alboressaavedra, Steven Cooper Heard, Bernadette Mclaren, Hideko Kamino, Agnieszka WitkiewiczAbstract:: We compared 4 breast Cylindromas with 50 dermal Cylindromas and 8 adenoid cystic breast carcinomas. Except for a modest increase in the number of eccrine ducts and reactive Langerhans cells in dermal Cylindromas, breast and dermal Cylindromas showed identical histologic and immunohistochemical features. Both were characterized by epithelial islands containing central basaloid cells and peripheral myoepithelial cells surrounded by a thickened, continuous, periodic acid-Schiff-positive basement membrane that was immunoreactive for collagen IV. Clusters of sebaceous cells and a few eccrine ducts are described in breast Cylindromas. Cytokeratin 7 labeled predominantly the central basaloid cells, and smooth muscle actin stained peripheral myoepithelial cells in breast and dermal Cylindromas. Eccrine ducts were highlighted by epithelial membrane antigen and carcinoembryonic antigen. S-100 protein and CD1a showed a variable number of dendritic Langerhans cells. Cylindromas of the breast and skin did not express cytokeratin 20, gross cystic disease fluid protein 15, or estrogen or progesterone receptor. Breast Cylindroma might be confused with the solid variant of adenoid cystic carcinoma, especially in needle core biopsy specimens, because they share nodular and trabecular patterns, basaloid cells, myoepithelial cells, eccrine ducts, and hyaline globules of basement membrane material. However, adenoid cystic carcinoma displays an infiltrative growth pattern, cytologic atypia, and mitotic figures and lacks the continuous, thickened basement membrane.
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solitary Cylindroma dermal analog tumor of the breast a previously undescribed neoplasm at this site
The American Journal of Surgical Pathology, 2001Co-Authors: Sefik T Gokaslan, Brian Carlile, Michal Dudák, Jorge AlboressaavedraAbstract:: The authors report a previously undescribed small, well-demarcated breast tumor similar to a dermal Cylindroma in a 63-year-old woman. The tumor was an incidental finding in a lumpectomy specimen for infiltrating lobular carcinoma. The Cylindroma was surrounded by normal-appearing breast parenchyma and had the typical "jigsaw" pattern of epithelial basaloid islands. The islands showed focal squamous and myoepithelial differentiation. A notable number of reactive dendritic Langerhans cells permeated the epithelial cell islands, a feature considered to be characteristic of dermal Cylindroma. There was also ductal differentiation. Thick bands of hyaline periodic acid-Schiff (PAS) stain and collagen IV-positive basement membrane material bordered the cell islands, and PAS-collagen IV-positive hyaline globules were seen within the cell islands. There was no nuclear pleomorphism or mitotic figures. The Cylindroma did not express gross cystic disease fluid protein 15, carcinoembryonic antigen, estrogen and progesterone receptors, or cytokeratin 20 (CK20). There was diffuse and strong immunoreactivity to CK AE1/AE3, and focal reactivity for CK7 and smooth muscle actin. Cylindroma of the breast should be distinguished from adenoid cystic carcinoma and basal cell carcinoma. Although clearly epithelial, the exact histogenesis and cell phenotype of this unusual dermal type Cylindroma of the breast are unknown.
Agnieszka Witkiewicz - One of the best experts on this subject based on the ideXlab platform.
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Cylindroma dermal analog tumor of the breast a comparison with Cylindroma of the skin and adenoid cystic carcinoma of the breast
American Journal of Clinical Pathology, 2005Co-Authors: Jorge Alboressaavedra, Steven Cooper Heard, Bernadette Mclaren, Hideko Kamino, Agnieszka WitkiewiczAbstract:: We compared 4 breast Cylindromas with 50 dermal Cylindromas and 8 adenoid cystic breast carcinomas. Except for a modest increase in the number of eccrine ducts and reactive Langerhans cells in dermal Cylindromas, breast and dermal Cylindromas showed identical histologic and immunohistochemical features. Both were characterized by epithelial islands containing central basaloid cells and peripheral myoepithelial cells surrounded by a thickened, continuous, periodic acid-Schiff-positive basement membrane that was immunoreactive for collagen IV. Clusters of sebaceous cells and a few eccrine ducts are described in breast Cylindromas. Cytokeratin 7 labeled predominantly the central basaloid cells, and smooth muscle actin stained peripheral myoepithelial cells in breast and dermal Cylindromas. Eccrine ducts were highlighted by epithelial membrane antigen and carcinoembryonic antigen. S-100 protein and CD1a showed a variable number of dendritic Langerhans cells. Cylindromas of the breast and skin did not express cytokeratin 20, gross cystic disease fluid protein 15, or estrogen or progesterone receptor. Breast Cylindroma might be confused with the solid variant of adenoid cystic carcinoma, especially in needle core biopsy specimens, because they share nodular and trabecular patterns, basaloid cells, myoepithelial cells, eccrine ducts, and hyaline globules of basement membrane material. However, adenoid cystic carcinoma displays an infiltrative growth pattern, cytologic atypia, and mitotic figures and lacks the continuous, thickened basement membrane.
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Cylindroma dermal analog tumor of the breast
American Journal of Clinical Pathology, 2005Co-Authors: Jorge Alboressaavedra, Steven Cooper Heard, Bernadette Mclaren, Hideko Kamino, Agnieszka WitkiewiczAbstract:We compared 4 breast Cylindromas with 50 dermal Cylindromas and 8 adenoid cystic breast carcinomas. Except for a modest increase in the number of eccrine ducts and reactive Langerhans cells in dermal Cylindromas, breast and dermal Cylindromas showed identical histologic and immunohistochemical features. Both were characterized by epithelial islands containing central basaloid cells and peripheral myoepithelial cells surrounded by a thickened, continuous, periodic acid–Schiff–positive basement membrane that was immunoreactive for collagen IV. Clusters of sebaceous cells and a few eccrine ducts are described in breast Cylindromas. Cytokeratin 7 labeled predominantly the central basaloid cells, and smooth muscle actin stained peripheral myoepithelial cells in breast and dermal Cylindromas. Eccrine ducts were highlighted by epithelial membrane antigen and carcinoembryonic antigen. S-100 protein and CD1a showed a variable number of dendritic Langerhans cells. Cylindromas of the breast and skin did not express cytokeratin 20, gross cystic disease fluid protein 15, or estrogen or progesterone receptor. Breast Cylindroma might be confused with the solid variant of adenoid cystic carcinoma, especially in needle core biopsy specimens, because they share nodular and trabecular patterns, basaloid cells, myoepithelial cells, eccrine ducts, and hyaline globules of basement membrane material. However, adenoid cystic carcinoma displays an infiltrative growth pattern, cytologic atypia, and mitotic figures and lacks the continuous, thickened basement membrane.
Gerald Pierard - One of the best experts on this subject based on the ideXlab platform.
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distinct expression patterns of alpha1 iv and alpha5 iv collagen chains in Cylindroma and malignant Cylindroma
International Journal of Molecular Medicine, 2005Co-Authors: Pascale Quatresooz, Gerald PierardAbstract:Cutaneous Cylindromas are considered to derive from cells of the sweat gland apparatus. The composition of the thick hyaline eosinophilic basement membrane (BM)-like zone surrounding epithelial aggregates in Cylindromas is similar to that of the dermo-epidermal junction. The presence of type IV collagen has been documented, but the distribution of the different constitutive a chains of collagen IV has not been studied so far. Alterations in the expression of these alpha chains have been described in some other conditions including basal cell carcinomas, testes with spermatogenic dysfunction and colorectal carcinomas. The aim was to study the distribution of the alpha1 (IV) and alpha5 (IV) collagen chains in Cylindromas and malignant Cylindroma, and to compare it with the BM of sweat glands. Seven Cylindromas and one malignant Cylindroma were studied. They were formalin-fixed and paraffin-embedded before processing for immunohistochemistry. Immunostaining was assessed using the avidin-biotin-peroxidase technique with antibodies directed to the alpha1 (IV) and alpha5 (IV) collagen chains. In all Cylindromas, a thin continuous and sharply limited immunolabelling for the alpha1 (IV) collagen chain was abutted to the tumoral cell aggregates. A speckled immunoreactivity was found in the rest of the hyaline sheath. Globular structures encased in the cell aggregates also exhibited a thin peripheral rim positive for the alpha1 (IV) collagen chain. The immunoreactivity was faint and granular in the center of the globules. With the antibody directed against the alpha5 (IV) collagen chain, 3 Cylindromas did not show any staining, 2 cases presented discrete focal positivity in the mid-part of the BM-like zone, and 2 cases exhibited a positive staining pattern similar to that observed for the alpha1 (IV) collagen chain, but with a focal and more discrete intensity. The malignant Cylindroma showed a linear immunoreactivity for the alpha1 (IV) collagen chain undistinguishable from the pattern seen in the benign Cylindromas. No immunoreactivity was present for the alpha5 (IV) collagen chain in the malignant neoplasm. As reported for other BM components, the expressions of the alpha1 (IV) and alpha5 (IV) collagen chains are altered in the BM-like zone surrounding the epithelial clumps in Cylindromas. The molecular alteration is probably related to the ultrastructural particularities of this structure. The distinctive patterns of expression of the alpha1 (IV) and alpha5 (IV) collagen chains may be related to the histogenic sudoral origin of Cylindromas without any relationship with the benign or malignant nature of the neoplasm.
Salem Alowami - One of the best experts on this subject based on the ideXlab platform.
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Case Report Cylindroma with Stromal Adipose Tissue Metaplasia versus Arising in a Background of Nevus Lipomatosus
2016Co-Authors: Salem AlowamiAbstract:License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Nevus lipomatosus superficialis is a rare type of connective tissue nevus. Cylindroma is a benign skin appendage tumor with a predilection for the scalp of older females. We describe the case of a 56-year-old woman with a scalp lesion demonstrating histopathologic features consistent with benign Cylindroma arising within a nevus lipomatosus superficialis. To our knowledge, this lesion has not been raised in the literature in the differential for Cylindroma with what is presumed to be stromal adipose metaplasia. 1
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malignant Cylindroma arising as a solitary neck lesion
European Journal of Dermatology, 2014Co-Authors: Syed Morteza Abedi, Ihab Elshinnawy, Salem AlowamiAbstract:Cylindromas are classified by the World Health Organization (WHO) under appendageal tumors with benign apocrine and/or eccrine differentiation. Cylindromas are rare neoplasms that can be either solitary or multiple, with the latter being more prone to malignant transformation. Multiple Cylindromas are often seen in a genetic condition known as Brooke-Spiegler syndrome (chromosome 9 defect) [1, 2]. With regards to the site, the vast majority of Cylindromas (benign and malignant) occur in the head [...]
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Cylindroma with Stromal Adipose Tissue Metaplasia versus Arising in a Background of Nevus Lipomatosus.
Case Reports in Pathology, 2014Co-Authors: Salem AlowamiAbstract:Nevus lipomatosus superficialis is a rare type of connective tissue nevus. Cylindroma is a benign skin appendage tumor with a predilection for the scalp of older females. We describe the case of a 56-year-old woman with a scalp lesion demonstrating histopathologic features consistent with benign Cylindroma arising within a nevus lipomatosus superficialis. To our knowledge, this lesion has not been raised in the literature in the differential for Cylindroma with what is presumed to be stromal adipose metaplasia.
Fadi W. Abdul-karim - One of the best experts on this subject based on the ideXlab platform.
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Fine needle aspiration cytology of breast Cylindroma in a woman with familial Cylindromatosis: a case report.
Acta Cytologica, 2004Co-Authors: Nancy Wang, R. Leeming, Fadi W. Abdul-karimAbstract:BACKGROUND: That sweat gland type tumors occur occasionally in the breast is not surprising, as the breast and cutaneous sweat glands are embryologically related. Cylindromas present most commonly as solitary and sporadic dermal nodules on the face and scalp. Cases of multiple Cylindromas are dominantly inherited, and the neoplasms are referred to as "turban tumors" when multiple lesions cover the scalp. Primary Cylindroma of the breast has been reported once in the past. To the best of our knowledge, the fine needle aspiration cytology of primary breast Cylindroma and its occurrence in the setting of familial Cylindromatosis have not previously been reported. CASE: A 59-year-old woman presented with an ill-defined left breast mass. She had a personal and family history of dermal Cylindromas on the head and face. Fine needle aspiration cytology demonstrated small, uniform cells with oval nuclei and finely granular cytoplasm, with some cells arranged around conspicuous cylinders of dense, acellular material. Excisional biopsy was recommended to exclude adenoid cystic carcinoma. Tissue biopsy revealed a benign Cylindroma arising in breast parenchyma. CONCLUSION: Fine needle aspiration cytology of Cylindroma very closely mimics that of adenoid cystic carcinoma. Although extremely rare, primary breast Cylindroma is another entity to be included in the cytologic differential diagnosis of bland, basaloid cells associated with globular, extracellular material, a finding most commonly associated with adenoid cystic carcinoma.
