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Christianah Y. Isimi - One of the best experts on this subject based on the ideXlab platform.
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Formulation and Evaluation of Cyperus esculentus (Tiger Nut) Starch-Alginate Microbeads in the Oral Delivery of Ibuprofen
Journal of Pharmaceutical Innovation, 2020Co-Authors: Olubunmi J. Olayemi, Yonni E. Apeji, Christianah Y. IsimiAbstract:Purpose Microencapsulation is a technique employed in the development of controlled drug delivery systems. It is beneficial in reducing dosing frequency, ensuring targeted drug delivery, and improving drug bioavailability. The objective of this study was to evaluate the effectiveness of Cyperus esculentus starch and its derivative in the development of microbeads for sustained delivery of ibuprofen. Methods Ibuprofen-loaded microbeads were prepared by ionotropic gelation using Cyperus esculentus starch and its derivative in combination with sodium alginate at concentrations of 1:1, 1:2, and 2:1 and calcium chloride solution as cross-linker. Morphology of the microbeads by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR), and differential scanning calorimetry (DSC) were investigated. Entrapment efficiency, swelling capacity, mucoadhesion, and in vitro drug release were also evaluated. Results SEM showed that the microbeads were spherical to irregular in shape, FT-IR returned prominent peaks specific for ibuprofen and absence of new peaks, DSC revealed evidence of entrapment of ibuprofen in the microbeads, and entrapment efficiency ranged between 46.05 and 89.86%. Microbeads prepared with native and cross-linked starches showed better mucoadhesion, and those prepared with cross-linked starch blend exhibited highest swelling capacity. In vitro release was pH dependent, and increasing the concentration of cross-linked starch in the blend caused greater retardation of drug release (45.19%) than the formulations containing native starch-alginate blend or sodium alginate alone. Conclusion The blend of cross-linked Cyperus esculentus starch and sodium alginate shows propensity to sustain ibuprofen release and could be exploited for targeted delivery especially to the lower GIT.
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Formulation and Evaluation of Cyperus esculentus (Tiger Nut) Starch-Alginate Microbeads in the Oral Delivery of Ibuprofen
Journal of Pharmaceutical Innovation, 2020Co-Authors: Olubunmi J. Olayemi, Yonni E. Apeji, Christianah Y. IsimiAbstract:Microencapsulation is a technique employed in the development of controlled drug delivery systems. It is beneficial in reducing dosing frequency, ensuring targeted drug delivery, and improving drug bioavailability. The objective of this study was to evaluate the effectiveness of Cyperus esculentus starch and its derivative in the development of microbeads for sustained delivery of ibuprofen. Ibuprofen-loaded microbeads were prepared by ionotropic gelation using Cyperus esculentus starch and its derivative in combination with sodium alginate at concentrations of 1:1, 1:2, and 2:1 and calcium chloride solution as cross-linker. Morphology of the microbeads by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR), and differential scanning calorimetry (DSC) were investigated. Entrapment efficiency, swelling capacity, mucoadhesion, and in vitro drug release were also evaluated. SEM showed that the microbeads were spherical to irregular in shape, FT-IR returned prominent peaks specific for ibuprofen and absence of new peaks, DSC revealed evidence of entrapment of ibuprofen in the microbeads, and entrapment efficiency ranged between 46.05 and 89.86%. Microbeads prepared with native and cross-linked starches showed better mucoadhesion, and those prepared with cross-linked starch blend exhibited highest swelling capacity. In vitro release was pH dependent, and increasing the concentration of cross-linked starch in the blend caused greater retardation of drug release (45.19%) than the formulations containing native starch-alginate blend or sodium alginate alone. The blend of cross-linked Cyperus esculentus starch and sodium alginate shows propensity to sustain ibuprofen release and could be exploited for targeted delivery especially to the lower GIT.
D Kubmarawa - One of the best experts on this subject based on the ideXlab platform.
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Chemical constituents of the volatile oil of Cyperus esculentus L. from Nigeria
Flavour and Fragrance Journal, 2005Co-Authors: D Kubmarawa, Isiaka A. Ogunwande, Domingo A. Okorie, Nureni O. Olawore, Adeleke A. KasaliAbstract:Volatile oils obtained by hydrodistillation of the tubers of two varieties (brown and black) of Cyperus esculentus L. (Cyperaceae) were analyzed by GC and GC-MS. Nine and 11 compounds, representing 91.7–99.7% of the total volatile oils were identified, respectively, from the brown and black varieties. The most representative compounds were α-pinene (70.5–75.5%) and α-thujene (5.2–10.2%). Copyright © 2005 John Wiley & Sons, Ltd.
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a preliminary investigation into the biofuel characteristics of tigernut Cyperus esculentus oil
Bioresource Technology, 2001Co-Authors: J T Barminas, H M Maina, S Tahir, D Kubmarawa, K TswareAbstract:Laboratory scale experiments were carried out to produce and characterise biofuel from tigernut (Cyperus esculentus) oil. Transesterification of tigernut oil afforded methyl and ethyl esters, which had fuel properties similar to common biofuels, hence tigernut could be utilised as an alternative renewable energy resource.
Olubunmi J. Olayemi - One of the best experts on this subject based on the ideXlab platform.
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Formulation and Evaluation of Cyperus esculentus (Tiger Nut) Starch-Alginate Microbeads in the Oral Delivery of Ibuprofen
Journal of Pharmaceutical Innovation, 2020Co-Authors: Olubunmi J. Olayemi, Yonni E. Apeji, Christianah Y. IsimiAbstract:Purpose Microencapsulation is a technique employed in the development of controlled drug delivery systems. It is beneficial in reducing dosing frequency, ensuring targeted drug delivery, and improving drug bioavailability. The objective of this study was to evaluate the effectiveness of Cyperus esculentus starch and its derivative in the development of microbeads for sustained delivery of ibuprofen. Methods Ibuprofen-loaded microbeads were prepared by ionotropic gelation using Cyperus esculentus starch and its derivative in combination with sodium alginate at concentrations of 1:1, 1:2, and 2:1 and calcium chloride solution as cross-linker. Morphology of the microbeads by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR), and differential scanning calorimetry (DSC) were investigated. Entrapment efficiency, swelling capacity, mucoadhesion, and in vitro drug release were also evaluated. Results SEM showed that the microbeads were spherical to irregular in shape, FT-IR returned prominent peaks specific for ibuprofen and absence of new peaks, DSC revealed evidence of entrapment of ibuprofen in the microbeads, and entrapment efficiency ranged between 46.05 and 89.86%. Microbeads prepared with native and cross-linked starches showed better mucoadhesion, and those prepared with cross-linked starch blend exhibited highest swelling capacity. In vitro release was pH dependent, and increasing the concentration of cross-linked starch in the blend caused greater retardation of drug release (45.19%) than the formulations containing native starch-alginate blend or sodium alginate alone. Conclusion The blend of cross-linked Cyperus esculentus starch and sodium alginate shows propensity to sustain ibuprofen release and could be exploited for targeted delivery especially to the lower GIT.
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Formulation and Evaluation of Cyperus esculentus (Tiger Nut) Starch-Alginate Microbeads in the Oral Delivery of Ibuprofen
Journal of Pharmaceutical Innovation, 2020Co-Authors: Olubunmi J. Olayemi, Yonni E. Apeji, Christianah Y. IsimiAbstract:Microencapsulation is a technique employed in the development of controlled drug delivery systems. It is beneficial in reducing dosing frequency, ensuring targeted drug delivery, and improving drug bioavailability. The objective of this study was to evaluate the effectiveness of Cyperus esculentus starch and its derivative in the development of microbeads for sustained delivery of ibuprofen. Ibuprofen-loaded microbeads were prepared by ionotropic gelation using Cyperus esculentus starch and its derivative in combination with sodium alginate at concentrations of 1:1, 1:2, and 2:1 and calcium chloride solution as cross-linker. Morphology of the microbeads by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR), and differential scanning calorimetry (DSC) were investigated. Entrapment efficiency, swelling capacity, mucoadhesion, and in vitro drug release were also evaluated. SEM showed that the microbeads were spherical to irregular in shape, FT-IR returned prominent peaks specific for ibuprofen and absence of new peaks, DSC revealed evidence of entrapment of ibuprofen in the microbeads, and entrapment efficiency ranged between 46.05 and 89.86%. Microbeads prepared with native and cross-linked starches showed better mucoadhesion, and those prepared with cross-linked starch blend exhibited highest swelling capacity. In vitro release was pH dependent, and increasing the concentration of cross-linked starch in the blend caused greater retardation of drug release (45.19%) than the formulations containing native starch-alginate blend or sodium alginate alone. The blend of cross-linked Cyperus esculentus starch and sodium alginate shows propensity to sustain ibuprofen release and could be exploited for targeted delivery especially to the lower GIT.
S.c. Umerie - One of the best experts on this subject based on the ideXlab platform.
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Brew wort from Cyperus esculentus tubers
Bioresource Technology, 1998Co-Authors: S.c. Umerie, A.s. UkaAbstract:Abstract Evaluation of waste grits of Cyperus esculentus tubers and a mashing trial of the grits using the commercial enzymes ‘Termamyl’ (α-amylase), ‘Cereflo’ (β-glucanase) and ‘Neutrase’ (proteinases) to ascertain their suitability for brewing and related industries, were carried out. The grits had a carbohydrate content of 75·88%, crude fibre 12·88% and fat 4·05%. The cold water extract was 19·69% and reducing sugar as glucose 8·93%. The wort had an extract value of 7·9°P, reducing sugar as glucose 66·4 mg ml −1 (53·12%), apparent attenuation limit of 82·82%, viscosity 1·5 cP, and was comparable with sorghum sort. The filtration time was short relative to sorghum wort and implied that the fibre of C. esculentus grits formed an efficient filter bed.
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Isolation and characterization of starch from Cyperus esculentus tubers
Bioresource Technology, 1997Co-Authors: S.c. Umerie, N.a.n. Obi, E.o. OkaforAbstract:Starch was extracted from the tubers of Cyperus esculentus with a yield of 20.51% on a dry weight basis. The starch, which was pure white in colour, was characterized in terms of granule size, cold water extracts, moisture and ash contents, paste stability, clarity, adhesive strength and line-spread at 50°C. The granule sizes compared well with those of rice starch, while the cold water extractives, moisture and ash contents were in keeping with standard values for starches. Solutions of the starch exhibited a good paste stability, clarity and adhesive strength. The line-spread test value indicated a use in feeds and confectioneries.
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Malt caramel from tubers of Cyperus esculentus
Bioresource Technology, 1996Co-Authors: S.c. Umerie, J.n. EnebeliAbstract:This work was done to ascertain the feasibility of obtaining caramel from malted tubers of Cyperus esculentus. The tubers of C. esculentus were partially germinated for 10 days and sun-dried for 24 h. The sun-dried samples were then kilned at 70°C for 24 h and at 120°C for 5 h for further caramelization. The kilned samples were finely crushed, infused with deionized water at 60°C and the malt extract heated up to 127°C, to give a brown-black syrupy substance, caramel, with specific gravity 38.97±0.77°Be. Reducing sugars as d-glucose in the unmalted tubers before and additional sugars after hydrolysis for 30 min were 24.75±4.54 and 64.80±2.28 mg/g of sample, and in the green malt 123.13±4.28 and 82.07±4.13 mg/g of sample, respectively.
Adeleke A. Kasali - One of the best experts on this subject based on the ideXlab platform.
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Chemical constituents of the volatile oil of Cyperus esculentus L. from Nigeria
Flavour and Fragrance Journal, 2005Co-Authors: D Kubmarawa, Isiaka A. Ogunwande, Domingo A. Okorie, Nureni O. Olawore, Adeleke A. KasaliAbstract:Volatile oils obtained by hydrodistillation of the tubers of two varieties (brown and black) of Cyperus esculentus L. (Cyperaceae) were analyzed by GC and GC-MS. Nine and 11 compounds, representing 91.7–99.7% of the total volatile oils were identified, respectively, from the brown and black varieties. The most representative compounds were α-pinene (70.5–75.5%) and α-thujene (5.2–10.2%). Copyright © 2005 John Wiley & Sons, Ltd.
