The Experts below are selected from a list of 342 Experts worldwide ranked by ideXlab platform
Zev Rosenwaks - One of the best experts on this subject based on the ideXlab platform.
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Cyst Aspiration or gnrh antagonist administration for ovarian Cysts detected at the start of fresh in vitro fertilization cycles
Gynecological Endocrinology, 2016Co-Authors: Nigel Pereira, Selma Amrane, Elie Hobeika, Jovana P Lekovich, Pak H Chung, Zev RosenwaksAbstract:The primary objective of this study is to investigate the effect of transvaginal ultrasonogram (TVUS)-guided Cyst Aspiration or gonadotropin releasing hormone antagonist (GnRH-ant) administration for the management of solitary ovarian Cysts detected at the start of in vitro fertilization (IVF) cycles on the outcomes of the same cycles. This is a single-center, retrospective, cohort study of patients who had TVUS-guided Cyst Aspiration or GnRH-ant treatment for ovarian Cysts detected at the start of IVF during a 5-year period. Four hundred and three patients met inclusion criteria: 41 (10.2%) underwent Cyst Aspiration and 362 (89.2%) were treated with GnRH-ant. There was no difference in the demographics or baseline IVF cycle characteristics of the two groups. Patients treated with GnRH-ant had a longer duration of ovarian stimulation (10.8 ± 3.45 days versus 9.05 ± 4.06 days, p = 0.003) and required higher gonadotropin doses (3887.7 ± 1097.8 IU versus 3293.7 ± 990.5 IU; p = 0.01) compared with the Cyst Aspiration group. There was no difference in the clinical pregnancy (43.9% versus 41.4%), spontaneous miscarriage (9.76% versus 8.01%) and live birth (34.1% versus 33.4%) rates between the groups. Our findings suggest that Cyst Aspiration is comparable to GnRH-ant administration for the management of solitary ovarian Cysts detected at the start of IVF cycles.
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Cyst Aspiration or gnrh antagonist administration for ovarian Cysts detected at the start of fresh in vitro fertilization cycles
Gynecological Endocrinology, 2016Co-Authors: Nigel Pereira, Selma Amrane, Elie Hobeika, Jovana P Lekovich, P Chung, Zev RosenwaksAbstract:AbstractThe primary objective of this study is to investigate the effect of transvaginal ultrasonogram (TVUS)-guided Cyst Aspiration or gonadotropin releasing hormone antagonist (GnRH-ant) administration for the management of solitary ovarian Cysts detected at the start of in vitro fertilization (IVF) cycles on the outcomes of the same cycles. This is a single-center, retrospective, cohort study of patients who had TVUS-guided Cyst Aspiration or GnRH-ant treatment for ovarian Cysts detected at the start of IVF during a 5-year period. Four hundred and three patients met inclusion criteria: 41 (10.2%) underwent Cyst Aspiration and 362 (89.2%) were treated with GnRH-ant. There was no difference in the demographics or baseline IVF cycle characteristics of the two groups. Patients treated with GnRH-ant had a longer duration of ovarian stimulation (10.8 ± 3.45 days versus 9.05 ± 4.06 days, p = 0.003) and required higher gonadotropin doses (3887.7 ± 1097.8 IU versus 3293.7 ± 990.5 IU; p = 0.01) compared with the...
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Cyst Aspiration versus gnrh antagonist adminitration for ovarian Cysts detected at the start of fresh in vitro fertilization cycles
Fertility and Sterility, 2015Co-Authors: Nigel Pereira, Selma Amrane, Elie Hobeika, Jovana P Lekovich, P Chung, Zev RosenwaksAbstract:OBJECTIVE: To explore whether assisted reproductive technology (ART) increase the molecular karyotype abnormality rate of miscarriage. DESIGN: Retrospective study. MATERIALSANDMETHODS: IRB approval was obtained. Miscarriage tissues underwent DNA extraction and 23-chromosome SNP microarray analysis using humanCytoSNP-12 DNA beadchips and GenomeStudio software. RESULTS: 618 coupes were enrolled. The mean age was 31.9 5.1 years. 144 experienced natural conception (NC) and 474 were pregnant by ART. Of the 474 cases, 36 underwent artificial insemination (AI), 244 fresh in vitro fertilization-embryo transfer (IVF-ET), 66 fresh intracytoplasmic sperm injection (ICSI)-embryo transfer and 128 thawed embryo transfer. The total abnormal molecular karyotype rate was 70.9% (438/618). There was no significant difference in the abnormal molecular karyotype rate between ART (70.5%) and NC (72.%). The abnormal molecular karyotype rate in the subgroup of ICSI was 65.6%,which was lower than that of AI+NC( 71.7%) and IVF( 72.2%) ,However, there was no significant difference between them. In the cases aged over 35 years, the abnormal molecular karyotype rate was 83.3%,which was higher than 66.4% in the cases aged 35 years and under . CONCLUSIONS: ART does not increase abnormal molecular karyotype rate of abortion tissue. Moreover, in terms of fertilization mode, compared with the IVF and AI+NC, ICSI does not increase abnormal molecular karyotype rate of miscarriage. Abnormal molecular karyotype rate is increased in the cases aged over 35 years in both NC and ART. To our knowledge, this is the largest and most comprehesive trial conducted evaluating SNP molecular karyotyping of spontaneous miscarriage after ART.
Yingpu Sun - One of the best experts on this subject based on the ideXlab platform.
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comparative study on the pregnancy outcomes of in vitro fertilization embryo transfer between long acting gonadotropin releasing hormone agonist combined with transvaginal ultrasound guided Cyst Aspiration and long acting gonadotropin releasing hormo
Contemporary Clinical Trials, 2012Co-Authors: Yihong Guo, Yu Zhang, Yang Wang, Yile Zhang, Yingpu SunAbstract:Abstract Objective To retrospectively analyze the effects of long-acting gonadotropin-releasing hormone agonist (GnRH-a) combined with transvaginal ultrasound-guided Cyst Aspiration on the pregnancy outcomes of in vitro fertilization–embryo transfer (IVF–ET) in the infertile patients with ovarian endometriosis. Methods The 134 patients with ovarian endometriosis who underwent GnRH-a combined with transvaginal ultrasound-guided Cyst Aspiration and IVF–ET were served as experimental group. The 102 patients with ovarian endometriosis who underwent GnRH-a and IVF–ET were served as control group. After treatment, the Cyst size, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), number of ovum pick-up, fertility rate, cleavage rate, high-quality embryo rate, implantation rate, clinical pregnancy rate and abortion rate were compared between the two groups. Results In the 134 patients of experimental group, 138 Cysts disappeared after GnRH-a combined with three times of transvaginal ultrasound-guided Cyst Aspiration. In the 102 patients of control group, of the 114 Cysts, 34 disappeared after GnRH-a, 67 were decreased and 13 were unchanged. The abortion rate was significantly lower in experimental group than in control group. The level of serum E2 on HCG day, the number of ovarian follicles with 14 mm or more, the number of retrieved oocytes, high-quality embryo rate, implantation rate and clinical pregnancy rate were higher in experimental group than in control group (all P Conclusion GnRH-a combined with transvaginal ultrasound-guided Cyst Aspiration can obtain better therapeutic effects and pregnancy outcomes in infertile patients with ovarian endometriosis who underwent IVF–ET.
Vincent H Gattone - One of the best experts on this subject based on the ideXlab platform.
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doi:10.1155/2010/274376 Research Article Pioglitazone Attenuates Cystic Burden in the PCK Rodent Model of PolyCystic Kidney Disease
2013Co-Authors: Bonnie L. Blazer-yost, Xiaofang Wang, Julie Haydon, Jeyhsin Chen, Tracy Eggleston-gulyas, Vincent H GattoneAbstract:Copyright © 2010 Bonnie L. Blazer-Yost et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PolyCystic kidney disease (PKD) is a genetic disorder characterized by growth of fluid-filled Cysts predominately in kidney tubules and liver bile ducts. Currently, the clinical management of PKD is limited to Cyst Aspiration, surgical resection or organ transplantation. Based on an observation that PPARγ agonists such as pioglitazone and rosiglitazone decrease mRNA levels of a Cl − transport protein, CFTR (Cystic fibrosis transmembrane conductance regulator), and the Cl − secretory response to vasopressin in cultured renal cells, it is hypothesized that PPARγ agonists will inhibit Cyst growth. The current studies show that a 7- or 14week pioglitazone feeding regimen inhibits renal and hepatic bile duct Cyst growth in the PCK rat, a rodent model orthologous to human PKD. These studies provide proof of concept for the mechanism of action of the PPARγ agonists and suggest that this class of drugs may be effective in controlling both renal and hepatic Cyst growth and fibrosis in PKD. 1
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pioglitazone attenuates Cystic burden in the pck rodent model of polyCystic kidney disease
Ppar Research, 2010Co-Authors: Bonnie L Blazeryost, Xiaofang Wang, Julie Haydon, Tracy Egglestongulyas, Jeyhsin Chen, Vincent H GattoneAbstract:PolyCystic kidney disease (PKD) is a genetic disorder characterized by growth of fluid-filled Cysts predominately in kidney tubules and liver bile ducts. Currently, the clinical management of PKD is limited to Cyst Aspiration, surgical resection or organ transplantation. Based on an observation that PPARγ agonists such as pioglitazone and rosiglitazone decrease mRNA levels of a Cl− transport protein, CFTR (Cystic fibrosis transmembrane conductance regulator), and the Cl− secretory response to vasopressin in cultured renal cells, it is hypothesized that PPARγ agonists will inhibit Cyst growth. The current studies show that a 7- or 14-week pioglitazone feeding regimen inhibits renal and hepatic bile duct Cyst growth in the PCK rat, a rodent model orthologous to human PKD. These studies provide proof of concept for the mechanism of action of the PPARγ agonists and suggest that this class of drugs may be effective in controlling both renal and hepatic Cyst growth and fibrosis in PKD.
Nigel Pereira - One of the best experts on this subject based on the ideXlab platform.
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Cyst Aspiration or gnrh antagonist administration for ovarian Cysts detected at the start of fresh in vitro fertilization cycles
Gynecological Endocrinology, 2016Co-Authors: Nigel Pereira, Selma Amrane, Elie Hobeika, Jovana P Lekovich, Pak H Chung, Zev RosenwaksAbstract:The primary objective of this study is to investigate the effect of transvaginal ultrasonogram (TVUS)-guided Cyst Aspiration or gonadotropin releasing hormone antagonist (GnRH-ant) administration for the management of solitary ovarian Cysts detected at the start of in vitro fertilization (IVF) cycles on the outcomes of the same cycles. This is a single-center, retrospective, cohort study of patients who had TVUS-guided Cyst Aspiration or GnRH-ant treatment for ovarian Cysts detected at the start of IVF during a 5-year period. Four hundred and three patients met inclusion criteria: 41 (10.2%) underwent Cyst Aspiration and 362 (89.2%) were treated with GnRH-ant. There was no difference in the demographics or baseline IVF cycle characteristics of the two groups. Patients treated with GnRH-ant had a longer duration of ovarian stimulation (10.8 ± 3.45 days versus 9.05 ± 4.06 days, p = 0.003) and required higher gonadotropin doses (3887.7 ± 1097.8 IU versus 3293.7 ± 990.5 IU; p = 0.01) compared with the Cyst Aspiration group. There was no difference in the clinical pregnancy (43.9% versus 41.4%), spontaneous miscarriage (9.76% versus 8.01%) and live birth (34.1% versus 33.4%) rates between the groups. Our findings suggest that Cyst Aspiration is comparable to GnRH-ant administration for the management of solitary ovarian Cysts detected at the start of IVF cycles.
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Cyst Aspiration or gnrh antagonist administration for ovarian Cysts detected at the start of fresh in vitro fertilization cycles
Gynecological Endocrinology, 2016Co-Authors: Nigel Pereira, Selma Amrane, Elie Hobeika, Jovana P Lekovich, P Chung, Zev RosenwaksAbstract:AbstractThe primary objective of this study is to investigate the effect of transvaginal ultrasonogram (TVUS)-guided Cyst Aspiration or gonadotropin releasing hormone antagonist (GnRH-ant) administration for the management of solitary ovarian Cysts detected at the start of in vitro fertilization (IVF) cycles on the outcomes of the same cycles. This is a single-center, retrospective, cohort study of patients who had TVUS-guided Cyst Aspiration or GnRH-ant treatment for ovarian Cysts detected at the start of IVF during a 5-year period. Four hundred and three patients met inclusion criteria: 41 (10.2%) underwent Cyst Aspiration and 362 (89.2%) were treated with GnRH-ant. There was no difference in the demographics or baseline IVF cycle characteristics of the two groups. Patients treated with GnRH-ant had a longer duration of ovarian stimulation (10.8 ± 3.45 days versus 9.05 ± 4.06 days, p = 0.003) and required higher gonadotropin doses (3887.7 ± 1097.8 IU versus 3293.7 ± 990.5 IU; p = 0.01) compared with the...
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Cyst Aspiration versus gnrh antagonist adminitration for ovarian Cysts detected at the start of fresh in vitro fertilization cycles
Fertility and Sterility, 2015Co-Authors: Nigel Pereira, Selma Amrane, Elie Hobeika, Jovana P Lekovich, P Chung, Zev RosenwaksAbstract:OBJECTIVE: To explore whether assisted reproductive technology (ART) increase the molecular karyotype abnormality rate of miscarriage. DESIGN: Retrospective study. MATERIALSANDMETHODS: IRB approval was obtained. Miscarriage tissues underwent DNA extraction and 23-chromosome SNP microarray analysis using humanCytoSNP-12 DNA beadchips and GenomeStudio software. RESULTS: 618 coupes were enrolled. The mean age was 31.9 5.1 years. 144 experienced natural conception (NC) and 474 were pregnant by ART. Of the 474 cases, 36 underwent artificial insemination (AI), 244 fresh in vitro fertilization-embryo transfer (IVF-ET), 66 fresh intracytoplasmic sperm injection (ICSI)-embryo transfer and 128 thawed embryo transfer. The total abnormal molecular karyotype rate was 70.9% (438/618). There was no significant difference in the abnormal molecular karyotype rate between ART (70.5%) and NC (72.%). The abnormal molecular karyotype rate in the subgroup of ICSI was 65.6%,which was lower than that of AI+NC( 71.7%) and IVF( 72.2%) ,However, there was no significant difference between them. In the cases aged over 35 years, the abnormal molecular karyotype rate was 83.3%,which was higher than 66.4% in the cases aged 35 years and under . CONCLUSIONS: ART does not increase abnormal molecular karyotype rate of abortion tissue. Moreover, in terms of fertilization mode, compared with the IVF and AI+NC, ICSI does not increase abnormal molecular karyotype rate of miscarriage. Abnormal molecular karyotype rate is increased in the cases aged over 35 years in both NC and ART. To our knowledge, this is the largest and most comprehesive trial conducted evaluating SNP molecular karyotyping of spontaneous miscarriage after ART.
Yihong Guo - One of the best experts on this subject based on the ideXlab platform.
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comparative study on the pregnancy outcomes of in vitro fertilization embryo transfer between long acting gonadotropin releasing hormone agonist combined with transvaginal ultrasound guided Cyst Aspiration and long acting gonadotropin releasing hormo
Contemporary Clinical Trials, 2012Co-Authors: Yihong Guo, Yu Zhang, Yang Wang, Yile Zhang, Yingpu SunAbstract:Abstract Objective To retrospectively analyze the effects of long-acting gonadotropin-releasing hormone agonist (GnRH-a) combined with transvaginal ultrasound-guided Cyst Aspiration on the pregnancy outcomes of in vitro fertilization–embryo transfer (IVF–ET) in the infertile patients with ovarian endometriosis. Methods The 134 patients with ovarian endometriosis who underwent GnRH-a combined with transvaginal ultrasound-guided Cyst Aspiration and IVF–ET were served as experimental group. The 102 patients with ovarian endometriosis who underwent GnRH-a and IVF–ET were served as control group. After treatment, the Cyst size, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), number of ovum pick-up, fertility rate, cleavage rate, high-quality embryo rate, implantation rate, clinical pregnancy rate and abortion rate were compared between the two groups. Results In the 134 patients of experimental group, 138 Cysts disappeared after GnRH-a combined with three times of transvaginal ultrasound-guided Cyst Aspiration. In the 102 patients of control group, of the 114 Cysts, 34 disappeared after GnRH-a, 67 were decreased and 13 were unchanged. The abortion rate was significantly lower in experimental group than in control group. The level of serum E2 on HCG day, the number of ovarian follicles with 14 mm or more, the number of retrieved oocytes, high-quality embryo rate, implantation rate and clinical pregnancy rate were higher in experimental group than in control group (all P Conclusion GnRH-a combined with transvaginal ultrasound-guided Cyst Aspiration can obtain better therapeutic effects and pregnancy outcomes in infertile patients with ovarian endometriosis who underwent IVF–ET.
