Cytopathology

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Gary M Velan - One of the best experts on this subject based on the ideXlab platform.

  • Cytopathology whole slide images and adaptive tutorials for senior medical students: a randomized crossover trial
    Diagnostic Pathology, 2016
    Co-Authors: Rakesh K. Kumar, Wendy M. Pryor, Elizabeth L. Salisbury, Gary M Velan
    Abstract:

    Background Diagnostic Cytopathology is an essential part of clinical decision-making. However, due to a combination of factors including curriculum reform and shortage of pathologists to teach introductory Cytopathology, this area of pathology receives little or no formal attention in most medical school curricula. We have previously described the successful use of efficient and effective digital learning resources, including whole slide images (WSI) and virtual microscopy adaptive tutorials (VMATs), to teach Cytopathology to pathology specialist trainees – a group that had prior exposure to Cytopathology in their day to day practice. Consequently, in the current study we attempted to demonstrate the efficiency and efficacy of this eLearning resource in a cohort of senior medical students that was completely naïve to the subject matter (Cytopathology). Methods We evaluated both the quantitative and qualitative impact of these digital educational materials for learning Cytopathology compared with existing resources (e-textbooks and online atlases). The senior medical students were recruited from The University of New South Wales Australia for a randomized cross-over trial. Online assessments, administered after each arm of the trial, contained questions which related directly to a whole slide image. Two categories of questions in the assessments (focusing on either diagnosis or identification of cellular features) were utilized to determine efficacy. User experience and perceptions of efficiency were evaluated using online questionnaires containing Likert scale items and open-ended questions. Results For this cohort of senior medical students, virtual microscopy adaptive tutorials (VMATs) proved to be at least as effective as existing digital resources for learning Cytopathology. Importantly, virtual microscopy adaptive tutorials had superior efficacy in facilitating accurate diagnosis on whole slide images. Student perceptions of VMATs were positive, particularly regarding the immediate feedback, interactivity and equity of learning which this learning resource provides. Conclusions Virtual microscopy adaptive tutorials have the potential to improve the efficacy of learning microscopic pathology for medical students. The enhanced learning experience provided by these eLearning tools merits further investigation of their utility for other cohorts, including specialist trainees.

  • Cytopathology whole slide images and adaptive tutorials for senior medical students: a randomized crossover trial
    Diagnostic pathology, 2016
    Co-Authors: Simone L. Van Es, Rakesh K. Kumar, Wendy M. Pryor, Elizabeth Salisbury, Gary M Velan
    Abstract:

    Background Diagnostic Cytopathology is an essential part of clinical decision-making. However, due to a combination of factors including curriculum reform and shortage of pathologists to teach introductory Cytopathology, this area of pathology receives little or no formal attention in most medical school curricula. We have previously described the successful use of efficient and effective digital learning resources, including whole slide images (WSI) and virtual microscopy adaptive tutorials (VMATs), to teach Cytopathology to pathology specialist trainees – a group that had prior exposure to Cytopathology in their day to day practice. Consequently, in the current study we attempted to demonstrate the efficiency and efficacy of this eLearning resource in a cohort of senior medical students that was completely naive to the subject matter (Cytopathology).

  • Cytopathology whole slide images and adaptive tutorials for postgraduate pathology trainees a randomized crossover trial
    Human Pathology, 2015
    Co-Authors: Simone L. Van Es, Rakesh K. Kumar, Elizabeth Salisbury, Wendy Pryor, Gary M Velan
    Abstract:

    To determine whether Cytopathology whole slide images and virtual microscopy adaptive tutorials aid learning by postgraduate trainees, we designed a randomized crossover trial to evaluate the quantitative and qualitative impact of whole slide images and virtual microscopy adaptive tutorials compared with traditional glass slide and textbook methods of learning Cytopathology. Forty-three anatomical pathology registrars were recruited from Australia, New Zealand, and Malaysia. Online assessments were used to determine efficacy, whereas user experience and perceptions of efficiency were evaluated using online Likert scales and open-ended questions. Outcomes of online assessments indicated that, with respect to performance, learning with whole slide images and virtual microscopy adaptive tutorials was equivalent to using traditional methods. High-impact learning, efficiency, and equity of learning from virtual microscopy adaptive tutorials were strong themes identified in open-ended responses. Participants raised concern about the lack of z-axis capability in the Cytopathology whole slide images, suggesting that delivery of z-stacked whole slide images online may be important for future educational development. In this trial, learning Cytopathology with whole slide images and virtual microscopy adaptive tutorials was found to be as effective as and perceived as more efficient than learning from glass slides and textbooks. The use of whole slide images and virtual microscopy adaptive tutorials has the potential to provide equitable access to effective learning from teaching material of consistently high quality. It also has broader implications for continuing professional development and maintenance of competence and quality assurance in specialist practice.

Shantel Hebert-magee - One of the best experts on this subject based on the ideXlab platform.

  • Training endosonographers in Cytopathology: improving the results of EUS-guided FNA.
    Gastrointestinal endoscopy, 2014
    Co-Authors: Shyam Varadarajulu, Bronte A. Holt, Ji Young Bang, Muhammad K. Hasan, Amy L. Logue, Ashutosh Tamhane, Robert H. Hawes, Shantel Hebert-magee
    Abstract:

    Background Although on-site Cytopathology services have a significant impact on efficiency and accuracy of EUS-guided FNA (EUS-FNA), the availability of this service is variable. Objective To evaluate the impact of an intensive 2-day training program to educate endosonographers in EUS-related Cytopathology. Design Pilot study. Setting Tertiary care medical center. Subjects Six endosonographers (5 male, median age, 35 years) with minimal previous Cytopathology exposure comprised the study cohort. Methods Pre- and posttraining testing was administered. Training commenced with a Cytopathology tutorial focusing on 4 performance measures: specimen adequacy, sample interpretation, specimen processing, and preliminary diagnosis. Eight live EUS-FNA cases were then performed, and study participants independently completed 4 questions based on performance measures for each case. The ability to independently smear and stain slides and operate a microscope was additionally assessed after a hands-on tutorial. Main Outcome Measurements Comparison of pretraining and posttraining scores, improvement in performance measures for live cases, and ability to independently handle specimens and operate a microscope. Results Compared with pretraining, mean posttraining test scores improved by 63% from 48 to 78 out of 100. Mean live case performance score was 95%. Performances improved from 89% on day 1 to 100% on day 2. After training, all endosonographers could independently smear/stain slides and operate a microscope. Limitations Long-term impact is unclear. Conclusions An intensive 2-day program was effective in training endosonographers in the basics of EUS-related Cytopathology. Incorporating basic Cytopathology in EUS fellowship curriculum will likely improve diagnostic performance of tissue acquisition procedures.

  • High-Quality Endoscopic Ultrasound-Guided Fine Needle Aspiration Tissue Acquisition
    Advances in Therapy, 2014
    Co-Authors: Bronte A. Holt, Shyam Varadarajulu, Shantel Hebert-magee
    Abstract:

    Endoscopic ultrasound-guided fine needle aspiration is a multistep procedure that involves proper clinical indication, correct selection of needles, adapting evidence-based techniques such as the fanning maneuver and not routinely using suction or the stylet for tissue sampling, and establishing reliable Cytopathology support. Integrating Cytopathology in the training curriculum and developing a more flexible platform of needles and echoendoscopes are likely to further advance the field of endosonography. This review aims to summarize the technical issues that are key to performing high-quality endoscopic ultrasound-guided fine needle aspiration.

  • How Can an Endosonographer Assess for Diagnostic Sufficiency and Options for Handling the Endoscopic Ultrasound-Guided Fine-Needle Aspiration Specimen and Ancillary Studies
    Gastrointestinal endoscopy clinics of North America, 2013
    Co-Authors: Shantel Hebert-magee
    Abstract:

    Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has become well established as a minimally invasive technique in diagnosing and staging various gastrointestinal, pancreaticobiliary, and retroperitoneal malignancies. The diagnostic accuracy of this procedure is significantly enhanced by the presence of on-site Cytopathology. However, in many EUS centers, Cytopathology is not readily available for on-site evaluation. This article is intended to assist the independent endosonographer in the assessment of diagnostic sufficiency and in specimen handling.

Rakesh K. Kumar - One of the best experts on this subject based on the ideXlab platform.

  • Cytopathology whole slide images and adaptive tutorials for senior medical students: a randomized crossover trial
    Diagnostic Pathology, 2016
    Co-Authors: Rakesh K. Kumar, Wendy M. Pryor, Elizabeth L. Salisbury, Gary M Velan
    Abstract:

    Background Diagnostic Cytopathology is an essential part of clinical decision-making. However, due to a combination of factors including curriculum reform and shortage of pathologists to teach introductory Cytopathology, this area of pathology receives little or no formal attention in most medical school curricula. We have previously described the successful use of efficient and effective digital learning resources, including whole slide images (WSI) and virtual microscopy adaptive tutorials (VMATs), to teach Cytopathology to pathology specialist trainees – a group that had prior exposure to Cytopathology in their day to day practice. Consequently, in the current study we attempted to demonstrate the efficiency and efficacy of this eLearning resource in a cohort of senior medical students that was completely naïve to the subject matter (Cytopathology). Methods We evaluated both the quantitative and qualitative impact of these digital educational materials for learning Cytopathology compared with existing resources (e-textbooks and online atlases). The senior medical students were recruited from The University of New South Wales Australia for a randomized cross-over trial. Online assessments, administered after each arm of the trial, contained questions which related directly to a whole slide image. Two categories of questions in the assessments (focusing on either diagnosis or identification of cellular features) were utilized to determine efficacy. User experience and perceptions of efficiency were evaluated using online questionnaires containing Likert scale items and open-ended questions. Results For this cohort of senior medical students, virtual microscopy adaptive tutorials (VMATs) proved to be at least as effective as existing digital resources for learning Cytopathology. Importantly, virtual microscopy adaptive tutorials had superior efficacy in facilitating accurate diagnosis on whole slide images. Student perceptions of VMATs were positive, particularly regarding the immediate feedback, interactivity and equity of learning which this learning resource provides. Conclusions Virtual microscopy adaptive tutorials have the potential to improve the efficacy of learning microscopic pathology for medical students. The enhanced learning experience provided by these eLearning tools merits further investigation of their utility for other cohorts, including specialist trainees.

  • Cytopathology whole slide images and adaptive tutorials for senior medical students: a randomized crossover trial
    Diagnostic pathology, 2016
    Co-Authors: Simone L. Van Es, Rakesh K. Kumar, Wendy M. Pryor, Elizabeth Salisbury, Gary M Velan
    Abstract:

    Background Diagnostic Cytopathology is an essential part of clinical decision-making. However, due to a combination of factors including curriculum reform and shortage of pathologists to teach introductory Cytopathology, this area of pathology receives little or no formal attention in most medical school curricula. We have previously described the successful use of efficient and effective digital learning resources, including whole slide images (WSI) and virtual microscopy adaptive tutorials (VMATs), to teach Cytopathology to pathology specialist trainees – a group that had prior exposure to Cytopathology in their day to day practice. Consequently, in the current study we attempted to demonstrate the efficiency and efficacy of this eLearning resource in a cohort of senior medical students that was completely naive to the subject matter (Cytopathology).

  • Cytopathology whole slide images and adaptive tutorials for postgraduate pathology trainees a randomized crossover trial
    Human Pathology, 2015
    Co-Authors: Simone L. Van Es, Rakesh K. Kumar, Elizabeth Salisbury, Wendy Pryor, Gary M Velan
    Abstract:

    To determine whether Cytopathology whole slide images and virtual microscopy adaptive tutorials aid learning by postgraduate trainees, we designed a randomized crossover trial to evaluate the quantitative and qualitative impact of whole slide images and virtual microscopy adaptive tutorials compared with traditional glass slide and textbook methods of learning Cytopathology. Forty-three anatomical pathology registrars were recruited from Australia, New Zealand, and Malaysia. Online assessments were used to determine efficacy, whereas user experience and perceptions of efficiency were evaluated using online Likert scales and open-ended questions. Outcomes of online assessments indicated that, with respect to performance, learning with whole slide images and virtual microscopy adaptive tutorials was equivalent to using traditional methods. High-impact learning, efficiency, and equity of learning from virtual microscopy adaptive tutorials were strong themes identified in open-ended responses. Participants raised concern about the lack of z-axis capability in the Cytopathology whole slide images, suggesting that delivery of z-stacked whole slide images online may be important for future educational development. In this trial, learning Cytopathology with whole slide images and virtual microscopy adaptive tutorials was found to be as effective as and perceived as more efficient than learning from glass slides and textbooks. The use of whole slide images and virtual microscopy adaptive tutorials has the potential to provide equitable access to effective learning from teaching material of consistently high quality. It also has broader implications for continuing professional development and maintenance of competence and quality assurance in specialist practice.

Simone L. Van Es - One of the best experts on this subject based on the ideXlab platform.

  • Digital pathology: semper ad meliora.
    Pathology, 2019
    Co-Authors: Simone L. Van Es
    Abstract:

    Summary This review is an evidence-based summary of digital pathology: past, present and future. It discusses digital surgical pathology and the Cytopathology digitisation challenge as well as the performance of digital histopathology and Cytopathology as a diagnostic tool, particularly in contrast to user perceptions. Time and cost efficiency of digital pathology, learning curves, education and quality assurance, with the importance of validation of systems, is emphasised. The review concludes with a discussion of digital pathology as a source of ‘big data’ and where this might lead pathologists in the digital pathology future.

  • Constant quest for quality: Digital Cytopathology
    Journal of pathology informatics, 2018
    Co-Authors: Simone L. Van Es, Janelle Greaves, Jennifer Ross, Derek Holzhauser, Tony Badrick
    Abstract:

    Background: Special consideration should be given when creating and selecting Cytopathology specimens for digitization to maximize quality. Advances in scanning and viewing technology can also improve whole-slide imaging (WSI) output quality. Methods: Accumulated laboratory experience with digitization of glass Cytopathology slides was collected. Results: This paper describes characteristics of a Cytopathology glass slide that can reduce quality on resulting WSI. Important points in the glass Cytopathology slide selection process, preparation, scanning, and WSI-editing process that will maximize the quality of the resulting acquired digital image are covered. The paper outlines scanning solutions which have potential to predict issues with a glass Cytopathology slide before image acquisition, allowing for adjustment of the scanning approach. WSI viewing solutions that better simulate the traditional microscope experience are also discussed. Conclusion: In addition to taking advantage of technical advances, practical steps can taken to maximize quality of Cytopathology WSI.

  • Cytopathology whole slide images and adaptive tutorials for senior medical students: a randomized crossover trial
    Diagnostic pathology, 2016
    Co-Authors: Simone L. Van Es, Rakesh K. Kumar, Wendy M. Pryor, Elizabeth Salisbury, Gary M Velan
    Abstract:

    Background Diagnostic Cytopathology is an essential part of clinical decision-making. However, due to a combination of factors including curriculum reform and shortage of pathologists to teach introductory Cytopathology, this area of pathology receives little or no formal attention in most medical school curricula. We have previously described the successful use of efficient and effective digital learning resources, including whole slide images (WSI) and virtual microscopy adaptive tutorials (VMATs), to teach Cytopathology to pathology specialist trainees – a group that had prior exposure to Cytopathology in their day to day practice. Consequently, in the current study we attempted to demonstrate the efficiency and efficacy of this eLearning resource in a cohort of senior medical students that was completely naive to the subject matter (Cytopathology).

  • Cytopathology whole slide images and adaptive tutorials for postgraduate pathology trainees a randomized crossover trial
    Human Pathology, 2015
    Co-Authors: Simone L. Van Es, Rakesh K. Kumar, Elizabeth Salisbury, Wendy Pryor, Gary M Velan
    Abstract:

    To determine whether Cytopathology whole slide images and virtual microscopy adaptive tutorials aid learning by postgraduate trainees, we designed a randomized crossover trial to evaluate the quantitative and qualitative impact of whole slide images and virtual microscopy adaptive tutorials compared with traditional glass slide and textbook methods of learning Cytopathology. Forty-three anatomical pathology registrars were recruited from Australia, New Zealand, and Malaysia. Online assessments were used to determine efficacy, whereas user experience and perceptions of efficiency were evaluated using online Likert scales and open-ended questions. Outcomes of online assessments indicated that, with respect to performance, learning with whole slide images and virtual microscopy adaptive tutorials was equivalent to using traditional methods. High-impact learning, efficiency, and equity of learning from virtual microscopy adaptive tutorials were strong themes identified in open-ended responses. Participants raised concern about the lack of z-axis capability in the Cytopathology whole slide images, suggesting that delivery of z-stacked whole slide images online may be important for future educational development. In this trial, learning Cytopathology with whole slide images and virtual microscopy adaptive tutorials was found to be as effective as and perceived as more efficient than learning from glass slides and textbooks. The use of whole slide images and virtual microscopy adaptive tutorials has the potential to provide equitable access to effective learning from teaching material of consistently high quality. It also has broader implications for continuing professional development and maintenance of competence and quality assurance in specialist practice.

Zubair W. Baloch - One of the best experts on this subject based on the ideXlab platform.

  • The application of current classification systems in pediatric Cytopathology: Perspectives from the pediatric Cytopathology symposium at the 20th International Congress of Cytology 2019
    Cancer cytopathology, 2019
    Co-Authors: Sara E. Monaco, Zubair W. Baloch, Esther Diana Rossi, Lisa A. Teot, Colleen A. Wright
    Abstract:

    A pediatric Cytopathology symposium was held at the recent 20th International Congress of Cytology, which convened in Sydney, Australia, in May 2019. This educational event brought together cytopathologists from different countries and different institutions to discuss some of the practical considerations when applying current diagnostic classification systems to Cytopathology specimens from young (pediatric and adolescent) patients. Within the past decade, various classification systems have been developed to create more standardized terminology for Cytopathology specimen reporting among institutions, which can lead to improved management guidelines based on evidence-based medicine. It is well known that a majority of the peer-reviewed publications in Cytopathology discussing the usefulness of these classification schemes predominantly contain case cohorts of adult patients. Although pediatric cases are not excluded from following these diagnostic guidelines, there is less of an emphasis on this age group with respect to unique findings and management differences. Thus, discussing the role of these guidelines and their applications in pediatric cases at an international educational gathering can not only be beneficial in educating the Cytopathology community about the value of applying these classification systems to pediatric populations, but also can raise awareness of unique entities in cytologic specimens obtained from young patients.

  • Analysis of the bethesda system for reporting thyroid Cytopathology and similar precursor thyroid Cytopathology reporting schemes.
    Advances in anatomic pathology, 2012
    Co-Authors: Lawrence Q. Wong, Zubair W. Baloch
    Abstract:

    The Bethesda System for Reporting Thyroid Cytopathology is a standardized reporting system for classifying thyroid fine-needle aspiration results comprising of 6 diagnostic categories with unique risks of malignancy and recommendations for clinical management. The majority of thyroid nodules are benign; however, up to 30% of fine-needle aspiration of thyroid nodule results are equivocal. Until 2007, various diagnostic terms were used to classify such cases, including "atypical," "indeterminate," and rule-out or cannot exclude malignancy. A literature review of 13 original studies was conducted to evaluate whether utilization of the Bethesda System for Reporting Thyroid Cytopathology nomenclature represent an improvement over thyroid Cytopathology reporting schemes used before 2007 in diagnosing thyroid malignancy. The sensitivity and specificity of thyroid fine-needle aspiration was high in the studies that assessed the measures. However, a selection bias exists and most studies do not include indeterminate diagnosis in their calculations. Although the Bethesda System for Reporting Thyroid Cytopathology recommends a repeat fine-needle aspiration to follow-up nondiagnostic specimens, in the majority of studies, an appreciable number of cases underwent follow-up surgical biopsy or thyroidectomy. The diagnostic category of atypia/follicular lesion of undetermined significance remains heterogenous in terms of usage and clinical outcome. The majority of the studies that utilize the Bethesda System for Reporting Thyroid Cytopathology in this literature review retrospectively reclassified thyroid fine-needle aspiration into the Bethesda System for Reporting Thyroid Cytopathology nomenclature with reported malignancy rates that are similar between cases reclassified as atypia/follicular lesion of undetermined significance and follicular neoplasm/suspicious for follicular neoplasm.