The Experts below are selected from a list of 597 Experts worldwide ranked by ideXlab platform
Xianglan Piao - One of the best experts on this subject based on the ideXlab platform.
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a new Dammarane type saponin from gynostemma pentaphyllum induces apoptosis in a549 human lung carcinoma cells
ChemInform, 2016Co-Authors: Shaofang Xing, Moonhee Jang, Yurong Wang, Xianglan PiaoAbstract:The new Dammarane-type saponin gypenoside Jh1 (I) is isolated from Gynostemma pentaphyllum.
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a new Dammarane type saponin from gynostemma pentaphyllum induces apoptosis in a549 human lung carcinoma cells
Bioorganic & Medicinal Chemistry Letters, 2016Co-Authors: Shaofang Xing, Moonhee Jang, Yurong Wang, Xianglan PiaoAbstract:Gynostemma pentaphyllum has been widely used as a traditional herb for its antioxidant and immunostimulatory activities. We have previously reported several useful Dammarane-type saponins with cytotoxicity against A549 human lung cancer cells from heat-processed G. pentaphyllum. In this study, a new Dammarane-type saponin, 20(S)-2α,3β,12β-tetrahydroxydammar-3-O-β-d-glucopyranoside (namely gypenoside Jh1), was isolated from the ethanol extract of heat-processed G. pentaphyllum using column chromatography and semi-preparative HPLC. Gypenoside Jh1 exhibited strong cytotoxicity against A549 cells in a concentration-dependent manner, which was associated with apoptotic cell death characterized by morphological changes, Hoechst 33258 nuclear staining, Annexin V and propidium iodide binding and mitochondrial potentials assay. Quantitative analysis using flow cytometry also showed that the proportion of apoptotic cells was increased after gypenoside Jh1 treatment. These findings indicated that gypenoside Jh1 showed antiproliferative effects on A549 cells and mitochondrial-dependent pathway is involved in gypenoside Jh1-induced apoptosis.
Hisashi Matsuda - One of the best experts on this subject based on the ideXlab platform.
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Chemical structures of constituents from the whole plant of Bacopa monniera
Journal of Natural Medicines, 2016Co-Authors: Tomoe Ohta, Masayuki Yoshikawa, Seikou Nakamura, Souichi Nakashima, Yoshimi Oda, Takahiro Matsumoto, Masashi Fukaya, Mamiko Yano, Hisashi MatsudaAbstract:Two new Dammarane-type triterpene oligoglycosides, bacomosaponins A and B, and three new phenylethanoid glycosides, bacomosides A, B_1, and B_2, were isolated from the whole plant of Bacopa monniera Wettst. The chemical structures of the new constituents were characterized on the basis of chemical and physicochemical evidence. In the present study, bacomosaponins A and B with acyl groups were obtained from the whole plant of B. monniera . This is the first report of acylated Dammarane-type triterpene oligoglycosides isolated from B. monniera . In addition, Dammarane-type triterpene saponins significantly inhibited the aggregation of 42-mer amyloid β-protein.
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chemical constituents from seeds of panax ginseng structure of new Dammarane type triterpene ketone panaxadione and hplc comparisons of seeds and flesh
Chemical & Pharmaceutical Bulletin, 2009Co-Authors: Sachiko Sugimoto, Seikou Nakamura, Hisashi Matsuda, Niichiro Kitagawa, Masayuki YoshikawaAbstract:A new Dammarane-type triterpene ketone, panaxadione, was isolated from the seeds of Panax ginseng C. A. MEYER (Araliaceae) together with two Dammarane-type and lupane-type triterpenes, an aromatic oligoglycoside, three sterol glycosides, and three Dammarane-type triterpene oligoglycosides (ginsenosides Rd, Re, and Rg 2 ). The structure of a new compound was elucidated on the basis of physicochemical evidence. The relative contents of major ginsenosides in the seeds were compared with those of the flesh parts of young and mature fruits.
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new triterpene constituents foliasalacins a 1 a 4 b 1 b 3 and c from the leaves of salacia chinensis
Chemical & Pharmaceutical Bulletin, 2008Co-Authors: Masayuki Yoshikawa, Seikou Nakamura, Yi Zhang, Tao Wang, Hisashi MatsudaAbstract:Four Dammarane-type, three lupane-type, and an oleanane-type triterpenes named foliasalacins A(1) (1), A(2) (2), A(3) (3), A(4) (4), B(1) (5), B(2) (6), B(3) (7), and C (8) were isolated from the leaves of Salacia chinensis LINN. collected in Thailand. The structures of new triterpene constituents (1-8) were characterized on the basis of chemical and physiochemical evidence.
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medicinal flowers xvii new Dammarane type triterpene glycosides from flower buds of american ginseng panax quinquefolium l
Chemical & Pharmaceutical Bulletin, 2007Co-Authors: Seikou Nakamura, Hisashi Matsuda, Sachiko Sugimoto, Masayuki YoshikawaAbstract:Five new Dammarane-type triterpene glycosides, floralquinquenosides A, B, C, D, and E, were isolated from the flower buds of American ginseng, Panax quinquefolium L., together with 18 known Dammarane-type triterpene glycosides and 3 flavonoid glycosides. The structures of new floralquinquenosides were elucidated on the basis of chemical and physicochemical evidence.
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medicinal flowers xi structures of new Dammarane type triterpene diglycosides with hydroperoxide group from flower buds of panax ginseng
Chemical & Pharmaceutical Bulletin, 2007Co-Authors: Masayuki Yoshikawa, Seikou Nakamura, Sachiko Sugimoto, Hisashi MatsudaAbstract:Six new Dammarane-type triterpene diglycosides with a hydroperoxide group, floralginsenosides A, B, C, D, E, and F, were isolated from ginseng flower, the flower buds of Panax ginseng C. A. MEYER, together with seven known Dammarane-type triterpene oligoglycosides. The structures of new floralginsenosides were elucidated on the basis of chemical and physicochemical evidence.
Masayuki Yoshikawa - One of the best experts on this subject based on the ideXlab platform.
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Chemical structures of constituents from the whole plant of Bacopa monniera
Journal of Natural Medicines, 2016Co-Authors: Tomoe Ohta, Masayuki Yoshikawa, Seikou Nakamura, Souichi Nakashima, Yoshimi Oda, Takahiro Matsumoto, Masashi Fukaya, Mamiko Yano, Hisashi MatsudaAbstract:Two new Dammarane-type triterpene oligoglycosides, bacomosaponins A and B, and three new phenylethanoid glycosides, bacomosides A, B_1, and B_2, were isolated from the whole plant of Bacopa monniera Wettst. The chemical structures of the new constituents were characterized on the basis of chemical and physicochemical evidence. In the present study, bacomosaponins A and B with acyl groups were obtained from the whole plant of B. monniera . This is the first report of acylated Dammarane-type triterpene oligoglycosides isolated from B. monniera . In addition, Dammarane-type triterpene saponins significantly inhibited the aggregation of 42-mer amyloid β-protein.
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chemical constituents from seeds of panax ginseng structure of new Dammarane type triterpene ketone panaxadione and hplc comparisons of seeds and flesh
Chemical & Pharmaceutical Bulletin, 2009Co-Authors: Sachiko Sugimoto, Seikou Nakamura, Hisashi Matsuda, Niichiro Kitagawa, Masayuki YoshikawaAbstract:A new Dammarane-type triterpene ketone, panaxadione, was isolated from the seeds of Panax ginseng C. A. MEYER (Araliaceae) together with two Dammarane-type and lupane-type triterpenes, an aromatic oligoglycoside, three sterol glycosides, and three Dammarane-type triterpene oligoglycosides (ginsenosides Rd, Re, and Rg 2 ). The structure of a new compound was elucidated on the basis of physicochemical evidence. The relative contents of major ginsenosides in the seeds were compared with those of the flesh parts of young and mature fruits.
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new triterpene constituents foliasalacins a 1 a 4 b 1 b 3 and c from the leaves of salacia chinensis
Chemical & Pharmaceutical Bulletin, 2008Co-Authors: Masayuki Yoshikawa, Seikou Nakamura, Yi Zhang, Tao Wang, Hisashi MatsudaAbstract:Four Dammarane-type, three lupane-type, and an oleanane-type triterpenes named foliasalacins A(1) (1), A(2) (2), A(3) (3), A(4) (4), B(1) (5), B(2) (6), B(3) (7), and C (8) were isolated from the leaves of Salacia chinensis LINN. collected in Thailand. The structures of new triterpene constituents (1-8) were characterized on the basis of chemical and physiochemical evidence.
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medicinal flowers xvii new Dammarane type triterpene glycosides from flower buds of american ginseng panax quinquefolium l
Chemical & Pharmaceutical Bulletin, 2007Co-Authors: Seikou Nakamura, Hisashi Matsuda, Sachiko Sugimoto, Masayuki YoshikawaAbstract:Five new Dammarane-type triterpene glycosides, floralquinquenosides A, B, C, D, and E, were isolated from the flower buds of American ginseng, Panax quinquefolium L., together with 18 known Dammarane-type triterpene glycosides and 3 flavonoid glycosides. The structures of new floralquinquenosides were elucidated on the basis of chemical and physicochemical evidence.
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medicinal flowers xi structures of new Dammarane type triterpene diglycosides with hydroperoxide group from flower buds of panax ginseng
Chemical & Pharmaceutical Bulletin, 2007Co-Authors: Masayuki Yoshikawa, Seikou Nakamura, Sachiko Sugimoto, Hisashi MatsudaAbstract:Six new Dammarane-type triterpene diglycosides with a hydroperoxide group, floralginsenosides A, B, C, D, E, and F, were isolated from ginseng flower, the flower buds of Panax ginseng C. A. MEYER, together with seven known Dammarane-type triterpene oligoglycosides. The structures of new floralginsenosides were elucidated on the basis of chemical and physicochemical evidence.
Zhihong Jiang - One of the best experts on this subject based on the ideXlab platform.
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Dammarane type triterpene saponins from the flowers of panax notoginseng
Molecules, 2009Co-Authors: Jing Rong Wang, Yuko Yamasaki, Takashi Tanaka, Isao Kouno, Zhihong JiangAbstract:Four new Dammarane-type triterpene saponins named floranotoginsenosides A (1), B (2), C (3) and D (4), together with five known triterpene saponins, were isolated from the flowers of Panax notoginseng. Their structures were elucidated on the basis of spectral and chemical evidence.
Shaofang Xing - One of the best experts on this subject based on the ideXlab platform.
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a new Dammarane type saponin from gynostemma pentaphyllum induces apoptosis in a549 human lung carcinoma cells
ChemInform, 2016Co-Authors: Shaofang Xing, Moonhee Jang, Yurong Wang, Xianglan PiaoAbstract:The new Dammarane-type saponin gypenoside Jh1 (I) is isolated from Gynostemma pentaphyllum.
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a new Dammarane type saponin from gynostemma pentaphyllum induces apoptosis in a549 human lung carcinoma cells
Bioorganic & Medicinal Chemistry Letters, 2016Co-Authors: Shaofang Xing, Moonhee Jang, Yurong Wang, Xianglan PiaoAbstract:Gynostemma pentaphyllum has been widely used as a traditional herb for its antioxidant and immunostimulatory activities. We have previously reported several useful Dammarane-type saponins with cytotoxicity against A549 human lung cancer cells from heat-processed G. pentaphyllum. In this study, a new Dammarane-type saponin, 20(S)-2α,3β,12β-tetrahydroxydammar-3-O-β-d-glucopyranoside (namely gypenoside Jh1), was isolated from the ethanol extract of heat-processed G. pentaphyllum using column chromatography and semi-preparative HPLC. Gypenoside Jh1 exhibited strong cytotoxicity against A549 cells in a concentration-dependent manner, which was associated with apoptotic cell death characterized by morphological changes, Hoechst 33258 nuclear staining, Annexin V and propidium iodide binding and mitochondrial potentials assay. Quantitative analysis using flow cytometry also showed that the proportion of apoptotic cells was increased after gypenoside Jh1 treatment. These findings indicated that gypenoside Jh1 showed antiproliferative effects on A549 cells and mitochondrial-dependent pathway is involved in gypenoside Jh1-induced apoptosis.
