Dandruff

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Lionel Breton - One of the best experts on this subject based on the ideXlab platform.

  • Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health.
    Frontiers in Cellular and Infection Microbiology, 2018
    Co-Authors: Rituja Saxena, Luc Souverain, Cecile Clavaud, Parul Mittal, Darshan B. Dhakan, Prashant Hegde, Mahesh M. Veeranagaiah, Subarna Saha, Nita Roy, Lionel Breton
    Abstract:

    Several scalp microbiome studies from different populations have revealed the association of Dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp microbiota in scalp disorder and health remains scarcely explored. Here, we examined the bacterial and fungal diversity of the scalp microbiome and their potential functional role in the healthy and Dandruff scalp of 140 Indian women. Propionibacterium acnes and Staphylococcus epidermidis emerged as the core bacterial species, where the former was associated with a healthy scalp and the latter with Dandruff scalp. Along with the commonly occurring Malassezia species (M. restricta and M. globosa) on the scalp, a strikingly high association of Dandruff with yet uncharacterised Malassezia species was observed in the core mycobiome. Functional analysis showed that the fungal microbiome was enriched in pathways majorly implicated in cell-host adhesion in the Dandruff scalp, while the bacterial microbiome showed a conspicuous enrichment of pathways related to the synthesis and metabolism of amino acids, biotin and other B-vitamins, which are reported as essential nutrients for hair growth. A systematic measurement of scalp clinical and physiological parameters was also carried out, which showed significant correlations with the microbiome and their associated functional pathways. The results point towards a new potential role of bacterial commensals in maintaining the scalp nutrient homoeostasis, and highlights an important and yet unknown role of the scalp microbiome, similar to the gut microbiome. This study, therefore, provides new perspectives on the better understading of the pathophysiology of Dandruff.

  • Table_3_Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health.docx
    2018
    Co-Authors: Rituja Saxena, Luc Souverain, Cecile Clavaud, Parul Mittal, Darshan B. Dhakan, Prashant Hegde, Mahesh M. Veeranagaiah, Subarna Saha, Nita Roy, Lionel Breton
    Abstract:

    Several scalp microbiome studies from different populations have revealed the association of Dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp microbiota in scalp disorders and health remains scarcely explored. Here, we examined the bacterial and fungal diversity of the scalp microbiome and their potential functional role in the healthy and Dandruff scalp of 140 Indian women. Propionibacterium acnes and Staphylococcus epidermidis emerged as the core bacterial species, where the former was associated with a healthy scalp and the latter with Dandruff scalp. Along with the commonly occurring Malassezia species (M. restricta and M. globosa) on the scalp, a strikingly high association of Dandruff with yet uncharacterized Malassezia species was observed in the core mycobiome. Functional analysis showed that the fungal microbiome was enriched in pathways majorly implicated in cell-host adhesion in the Dandruff scalp, while the bacterial microbiome showed a conspicuous enrichment of pathways related to the synthesis and metabolism of amino acids, biotin, and other B-vitamins, which are reported as essential nutrients for hair growth. A systematic measurement of scalp clinical and physiological parameters was also carried out, which showed significant correlations with the microbiome and their associated functional pathways. The results point toward a new potential role of bacterial commensals in maintaining the scalp nutrient homoeostasis and highlights an important and yet unknown role of the scalp microbiome, similar to the gut microbiome. This study, therefore, provides new perspectives on the better understanding of the pathophysiology of Dandruff.

  • Data_Sheet_1_Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health.DOCX
    2018
    Co-Authors: Rituja Saxena, Luc Souverain, Cecile Clavaud, Parul Mittal, Darshan B. Dhakan, Prashant Hegde, Mahesh M. Veeranagaiah, Subarna Saha, Nita Roy, Lionel Breton
    Abstract:

    Several scalp microbiome studies from different populations have revealed the association of Dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp microbiota in scalp disorders and health remains scarcely explored. Here, we examined the bacterial and fungal diversity of the scalp microbiome and their potential functional role in the healthy and Dandruff scalp of 140 Indian women. Propionibacterium acnes and Staphylococcus epidermidis emerged as the core bacterial species, where the former was associated with a healthy scalp and the latter with Dandruff scalp. Along with the commonly occurring Malassezia species (M. restricta and M. globosa) on the scalp, a strikingly high association of Dandruff with yet uncharacterized Malassezia species was observed in the core mycobiome. Functional analysis showed that the fungal microbiome was enriched in pathways majorly implicated in cell-host adhesion in the Dandruff scalp, while the bacterial microbiome showed a conspicuous enrichment of pathways related to the synthesis and metabolism of amino acids, biotin, and other B-vitamins, which are reported as essential nutrients for hair growth. A systematic measurement of scalp clinical and physiological parameters was also carried out, which showed significant correlations with the microbiome and their associated functional pathways. The results point toward a new potential role of bacterial commensals in maintaining the scalp nutrient homoeostasis and highlights an important and yet unknown role of the scalp microbiome, similar to the gut microbiome. This study, therefore, provides new perspectives on the better understanding of the pathophysiology of Dandruff.

  • Table_2_Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health.xlsx
    2018
    Co-Authors: Rituja Saxena, Luc Souverain, Cecile Clavaud, Parul Mittal, Darshan B. Dhakan, Prashant Hegde, Mahesh M. Veeranagaiah, Subarna Saha, Nita Roy, Lionel Breton
    Abstract:

    Several scalp microbiome studies from different populations have revealed the association of Dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp microbiota in scalp disorders and health remains scarcely explored. Here, we examined the bacterial and fungal diversity of the scalp microbiome and their potential functional role in the healthy and Dandruff scalp of 140 Indian women. Propionibacterium acnes and Staphylococcus epidermidis emerged as the core bacterial species, where the former was associated with a healthy scalp and the latter with Dandruff scalp. Along with the commonly occurring Malassezia species (M. restricta and M. globosa) on the scalp, a strikingly high association of Dandruff with yet uncharacterized Malassezia species was observed in the core mycobiome. Functional analysis showed that the fungal microbiome was enriched in pathways majorly implicated in cell-host adhesion in the Dandruff scalp, while the bacterial microbiome showed a conspicuous enrichment of pathways related to the synthesis and metabolism of amino acids, biotin, and other B-vitamins, which are reported as essential nutrients for hair growth. A systematic measurement of scalp clinical and physiological parameters was also carried out, which showed significant correlations with the microbiome and their associated functional pathways. The results point toward a new potential role of bacterial commensals in maintaining the scalp nutrient homoeostasis and highlights an important and yet unknown role of the scalp microbiome, similar to the gut microbiome. This study, therefore, provides new perspectives on the better understanding of the pathophysiology of Dandruff.

  • Dysbiotic Bacterial and Fungal Communities Not Restricted to Clinically Affected Skin Sites in Dandruff.
    Frontiers in Cellular and Infection Microbiology, 2016
    Co-Authors: Renan Cardoso Soares, Lionel Breton, Cecile Clavaud, Pedro H. Camargo-penna, Vanessa C. S. De Moraes, Rodrigo De Vecchi, Antonio S. K. Braz, Luciana C. Paulino
    Abstract:

    Dandruff is a prevalent chronic inflammatory skin condition of the scalp that has been associated with Malassezia yeasts. However, the microbial role has not been elucidated yet, and the etiology of the disorder remains poorly understood. Using high-throughput 16S rDNA and ITS1 sequencing, we characterized cutaneous bacterial and fungal microbiotas from healthy and Dandruff subjects, comparing scalp and forehead (lesional and non-lesional skin sites). Bacterial and fungal communities from Dandruff analyzed at genus level differed in comparison with healthy ones, presenting higher diversity and greater intragroup variation. The microbial shift was observed also in non-lesional sites from Dandruff subjects, suggesting that Dandruff is related to a systemic process that is not restricted to the site exhibiting clinical symptoms. In contrast, Malassezia microbiota analyzed at species level did not differ according to health status. A 2-step OTU assignment using combined databases substantially increased fungal assigned sequences, and revealed the presence of highly prevalent uncharacterized Malassezia organisms (>37% of the reads). Although clinical symptoms of Dandruff manifest locally, microbial dysbiosis beyond clinically affected skin sites suggests that subjects undergo systemic alterations, which could be considered for redefining therapeutic approaches.

Cecile Clavaud - One of the best experts on this subject based on the ideXlab platform.

  • Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health.
    Frontiers in Cellular and Infection Microbiology, 2018
    Co-Authors: Rituja Saxena, Luc Souverain, Cecile Clavaud, Parul Mittal, Darshan B. Dhakan, Prashant Hegde, Mahesh M. Veeranagaiah, Subarna Saha, Nita Roy, Lionel Breton
    Abstract:

    Several scalp microbiome studies from different populations have revealed the association of Dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp microbiota in scalp disorder and health remains scarcely explored. Here, we examined the bacterial and fungal diversity of the scalp microbiome and their potential functional role in the healthy and Dandruff scalp of 140 Indian women. Propionibacterium acnes and Staphylococcus epidermidis emerged as the core bacterial species, where the former was associated with a healthy scalp and the latter with Dandruff scalp. Along with the commonly occurring Malassezia species (M. restricta and M. globosa) on the scalp, a strikingly high association of Dandruff with yet uncharacterised Malassezia species was observed in the core mycobiome. Functional analysis showed that the fungal microbiome was enriched in pathways majorly implicated in cell-host adhesion in the Dandruff scalp, while the bacterial microbiome showed a conspicuous enrichment of pathways related to the synthesis and metabolism of amino acids, biotin and other B-vitamins, which are reported as essential nutrients for hair growth. A systematic measurement of scalp clinical and physiological parameters was also carried out, which showed significant correlations with the microbiome and their associated functional pathways. The results point towards a new potential role of bacterial commensals in maintaining the scalp nutrient homoeostasis, and highlights an important and yet unknown role of the scalp microbiome, similar to the gut microbiome. This study, therefore, provides new perspectives on the better understading of the pathophysiology of Dandruff.

  • Table_3_Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health.docx
    2018
    Co-Authors: Rituja Saxena, Luc Souverain, Cecile Clavaud, Parul Mittal, Darshan B. Dhakan, Prashant Hegde, Mahesh M. Veeranagaiah, Subarna Saha, Nita Roy, Lionel Breton
    Abstract:

    Several scalp microbiome studies from different populations have revealed the association of Dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp microbiota in scalp disorders and health remains scarcely explored. Here, we examined the bacterial and fungal diversity of the scalp microbiome and their potential functional role in the healthy and Dandruff scalp of 140 Indian women. Propionibacterium acnes and Staphylococcus epidermidis emerged as the core bacterial species, where the former was associated with a healthy scalp and the latter with Dandruff scalp. Along with the commonly occurring Malassezia species (M. restricta and M. globosa) on the scalp, a strikingly high association of Dandruff with yet uncharacterized Malassezia species was observed in the core mycobiome. Functional analysis showed that the fungal microbiome was enriched in pathways majorly implicated in cell-host adhesion in the Dandruff scalp, while the bacterial microbiome showed a conspicuous enrichment of pathways related to the synthesis and metabolism of amino acids, biotin, and other B-vitamins, which are reported as essential nutrients for hair growth. A systematic measurement of scalp clinical and physiological parameters was also carried out, which showed significant correlations with the microbiome and their associated functional pathways. The results point toward a new potential role of bacterial commensals in maintaining the scalp nutrient homoeostasis and highlights an important and yet unknown role of the scalp microbiome, similar to the gut microbiome. This study, therefore, provides new perspectives on the better understanding of the pathophysiology of Dandruff.

  • Data_Sheet_1_Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health.DOCX
    2018
    Co-Authors: Rituja Saxena, Luc Souverain, Cecile Clavaud, Parul Mittal, Darshan B. Dhakan, Prashant Hegde, Mahesh M. Veeranagaiah, Subarna Saha, Nita Roy, Lionel Breton
    Abstract:

    Several scalp microbiome studies from different populations have revealed the association of Dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp microbiota in scalp disorders and health remains scarcely explored. Here, we examined the bacterial and fungal diversity of the scalp microbiome and their potential functional role in the healthy and Dandruff scalp of 140 Indian women. Propionibacterium acnes and Staphylococcus epidermidis emerged as the core bacterial species, where the former was associated with a healthy scalp and the latter with Dandruff scalp. Along with the commonly occurring Malassezia species (M. restricta and M. globosa) on the scalp, a strikingly high association of Dandruff with yet uncharacterized Malassezia species was observed in the core mycobiome. Functional analysis showed that the fungal microbiome was enriched in pathways majorly implicated in cell-host adhesion in the Dandruff scalp, while the bacterial microbiome showed a conspicuous enrichment of pathways related to the synthesis and metabolism of amino acids, biotin, and other B-vitamins, which are reported as essential nutrients for hair growth. A systematic measurement of scalp clinical and physiological parameters was also carried out, which showed significant correlations with the microbiome and their associated functional pathways. The results point toward a new potential role of bacterial commensals in maintaining the scalp nutrient homoeostasis and highlights an important and yet unknown role of the scalp microbiome, similar to the gut microbiome. This study, therefore, provides new perspectives on the better understanding of the pathophysiology of Dandruff.

  • Table_2_Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health.xlsx
    2018
    Co-Authors: Rituja Saxena, Luc Souverain, Cecile Clavaud, Parul Mittal, Darshan B. Dhakan, Prashant Hegde, Mahesh M. Veeranagaiah, Subarna Saha, Nita Roy, Lionel Breton
    Abstract:

    Several scalp microbiome studies from different populations have revealed the association of Dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp microbiota in scalp disorders and health remains scarcely explored. Here, we examined the bacterial and fungal diversity of the scalp microbiome and their potential functional role in the healthy and Dandruff scalp of 140 Indian women. Propionibacterium acnes and Staphylococcus epidermidis emerged as the core bacterial species, where the former was associated with a healthy scalp and the latter with Dandruff scalp. Along with the commonly occurring Malassezia species (M. restricta and M. globosa) on the scalp, a strikingly high association of Dandruff with yet uncharacterized Malassezia species was observed in the core mycobiome. Functional analysis showed that the fungal microbiome was enriched in pathways majorly implicated in cell-host adhesion in the Dandruff scalp, while the bacterial microbiome showed a conspicuous enrichment of pathways related to the synthesis and metabolism of amino acids, biotin, and other B-vitamins, which are reported as essential nutrients for hair growth. A systematic measurement of scalp clinical and physiological parameters was also carried out, which showed significant correlations with the microbiome and their associated functional pathways. The results point toward a new potential role of bacterial commensals in maintaining the scalp nutrient homoeostasis and highlights an important and yet unknown role of the scalp microbiome, similar to the gut microbiome. This study, therefore, provides new perspectives on the better understanding of the pathophysiology of Dandruff.

  • Dysbiotic Bacterial and Fungal Communities Not Restricted to Clinically Affected Skin Sites in Dandruff.
    Frontiers in Cellular and Infection Microbiology, 2016
    Co-Authors: Renan Cardoso Soares, Lionel Breton, Cecile Clavaud, Pedro H. Camargo-penna, Vanessa C. S. De Moraes, Rodrigo De Vecchi, Antonio S. K. Braz, Luciana C. Paulino
    Abstract:

    Dandruff is a prevalent chronic inflammatory skin condition of the scalp that has been associated with Malassezia yeasts. However, the microbial role has not been elucidated yet, and the etiology of the disorder remains poorly understood. Using high-throughput 16S rDNA and ITS1 sequencing, we characterized cutaneous bacterial and fungal microbiotas from healthy and Dandruff subjects, comparing scalp and forehead (lesional and non-lesional skin sites). Bacterial and fungal communities from Dandruff analyzed at genus level differed in comparison with healthy ones, presenting higher diversity and greater intragroup variation. The microbial shift was observed also in non-lesional sites from Dandruff subjects, suggesting that Dandruff is related to a systemic process that is not restricted to the site exhibiting clinical symptoms. In contrast, Malassezia microbiota analyzed at species level did not differ according to health status. A 2-step OTU assignment using combined databases substantially increased fungal assigned sequences, and revealed the presence of highly prevalent uncharacterized Malassezia organisms (>37% of the reads). Although clinical symptoms of Dandruff manifest locally, microbial dysbiosis beyond clinically affected skin sites suggests that subjects undergo systemic alterations, which could be considered for redefining therapeutic approaches.

Kevin John Mills - One of the best experts on this subject based on the ideXlab platform.

  • scalp stratum corneum histamine levels novel sampling method reveals association with itch resolution in Dandruff seborrhoeic dermatitis treatment
    Acta Dermato-venereologica, 2011
    Co-Authors: Kathy M Kerr, James Robert Schwartz, Thomas G Filloon, Angela Marie Fieno, Ken Wehmeyer, Jacek C Szepietowski, Kevin John Mills
    Abstract:

    Dandruff and seborrhoeic dermatitis are accompanied by bothersome itch. We have established a novel non-invasive methodology to sample histamine levels in the stratum corneum in order to facilitate an understanding of pruritogenesis in this condition. Histamine levels were assessed in two groups of subjects with Dandruff before and after 3 weeks of treatment with a commercial potentiated zinc pyrithione shampoo. A comparative population without Dandruff was also studied. Itch self-perception was quantified on a visual analogue scale. The histamine level in subjects with Dandruff was more than twice that in those who did not have Dandruff. Under conditions known to resolve flaking symptoms, the shampoo led to a reduction in histamine in subjects with Dandruff to a level that was statistically indistinguishable from those who did not have Dandruff. This reduction in histamine was accompanied by a highly significant reduction in the perception of itch intensity. These findings suggest an association between the subjective perception of itch in the scalp and the level of histamine in the skin.

  • Epidermal changes associated with symptomatic resolution of Dandruff: biomarkers of scalp health
    International Journal of Dermatology, 2010
    Co-Authors: Kathy M Kerr, James Robert Schwartz, Thomas G Filloon, Trevor John Darcy, James Patrick Henry, Haruko Mizoguchi, Stephen Morrall, Rohan Lalith Wimalasena, Gina M. Fadayel, Kevin John Mills
    Abstract:

    Background  Dandruff is a common scalp condition characterized by flakes, pruritus and sometimes mild erythema. These symptoms reflect underlying histopathologic and biochemical events that must be reversed if treatment is to be effective. Objectives  This study aimed to better characterize the state of the epidermis in Dandruff and to determine how a defined set of skin surface biomarkers of this state change during a successful course of treatment with a potentiated zinc pyrithione (ZPT) shampoo. Methods  A population of Dandruff sufferers was treated for 3 weeks with a commercial ZPT shampoo or a non-medicated product, and the effect of treatment on adherent scalp flake (ASF) scores was evaluated. Biopsies were taken from lesional sites at baseline and at the end of the study for histomorphometric and histopathologic analysis. Stratum corneum (SC) samples were likewise obtained for evaluation of biochemical markers of inflammation (IL-1α, IL-1RA, IL-8) and barrier integrity (keratin 1, 10, 11; involucrin; SC lipids; human serum albumin). The biomarker profile was evaluated first by comparison with that in non-Dandruff subjects at baseline, and then to determine whether any treatment-induced changes were correlated with reductions in flaking in Dandruff sufferers. Results  Taken together, our studies showed that treatment with the ZPT shampoo led to an improvement in the overall scalp condition as assessed by the resolution of flaking, reduction in epidermal thickness and inflammatory biomarkers, and a dramatic improvement in biomarkers of epidermal barrier integrity. Conclusions  The combination of biomarkers examined appears to be a good overall descriptor of the health of the scalp in Dandruff, and changes in these biomarkers track with tissue-level events that underlie clinical efficacy in the treatment of Dandruff by ZPT shampoo. For the first time, we demonstrate a set of tools that extend beyond flaking scores to provide insight into specific biological changes occurring on the scalp to enable an objective assessment of scalp health.

Roland Jourdain - One of the best experts on this subject based on the ideXlab platform.

  • iTRAQ-based quantitative proteomics of stratum corneum of Dandruff scalp reveals new insights into its aetiology and similarities with atopic dermatitis
    Archives of Dermatological Research, 2016
    Co-Authors: Nükhet Cavusoglu, Roland Jourdain, Charles El Rawadi, Caroline Delattre, Mark Donovan, Sylvie Bourassa, Arnaud Droit, Dominique Bernard
    Abstract:

    The study aimed at detecting differentially expressed proteins in the stratum corneum of Dandruff versus non-Dandruff scalps to better understand Dandruff aetiology. iTRAQ-based quantitative proteomic analysis revealed a total of 68 differentially expressed biomarkers. A detailed analysis of their known physiological functions provided new insights into the affected metabolic pathways of a Dandruff scalp. Dandruff scalp showed (1) profound changes in the expression and maturation of structural and epidermal differentiation related proteins, that are responsible for the integrity of the skin, (2) altered relevant factors that regulate skin hydration, and (3) an imbalanced physiological protease–protease inhibitor ratio. Stratum corneum proteins with antimicrobial activity, mainly those derived from sweat and sebaceous glands were also found modified. Comparing our data with those reported for atopic dermatitis revealed that about 50 % of the differentially expressed proteins in the superficial layers of the stratum corneum from Dandruff and atopic dermatitis are identical.

  • Exploration of scalp surface lipids reveals squalene peroxide as a potential actor in Dandruff condition
    Archives of Dermatological Research, 2016
    Co-Authors: Roland Jourdain, Alain Moga, Philippe Vingler, Charles El Rawadi, Florence Pouradier, Luc Souverain, Philippe Bastien, Nicolas Amalric, Lionel Breton
    Abstract:

    Dandruff is a common but complex disorder with three major contributing factors: (1) individual predisposition, (2) scalp sebum and (3) Malassezia yeast colonization. To obtain further insights into the role of sebum in Dandruff biogenesis, we analyzed scalp lipid species in a cohort of ten Dandruff-free (control) and ten Dandruff-afflicted volunteers by gas chromatography coupled to mass spectrometry. Lipid peroxidation levels and biochemical markers of oxidative stress were also assessed. Squalene, a major sebum component, was significantly more peroxidized in Dandruff-affected scalps, resulting in significantly higher ratios of squalene monohydroperoxide (SQOOH)/squalene. This was observed when comparing Dandruff-affected zones of Dandruff subjects to both their non-affected zones and control subjects. In addition, other biomarkers such as malondialdehyde indicated that oxidative stress levels were raised on Dandruff scalps. Surprisingly, differences regarding either free or bound fatty acids were fairly rare and minor. Certain novel findings, especially squalene peroxidation levels, were then confirmed in a validation cohort of 24 Dandruff-affected subjects, by comparing Dandruff-affected and non-Dandruff zones from the same individuals. As SQOOH can induce both keratinocyte inflammatory responses and hyperproliferation in vitro, we hypothesized that increased SQOOH could be considered as a new etiological Dandruff factor via its ability to impair scalp barrier function. Our results also indicated that Malassezia could be a major source of squalene peroxidation on the scalp.

  • characterization of the major bacterial fungal populations colonizing Dandruff scalps in shanghai china shows microbial disequilibrium
    Experimental Dermatology, 2015
    Co-Authors: Lili Wang, Audrey Gueniche, Cecile Clavaud, Avner Barhen, Meng Cui, Jun Gao, Yuanyuan Liu, Chen Liu, Nakako Shibagaki, Roland Jourdain
    Abstract:

    Dandruff is a scalp disorder characterized by the formation of flaky white-yellowish scales due to an altered proliferation and differentiation status; a disrupted barrier function; a decrease in the level of hydration and of natural moisturizing factors (NMF) in the scalp, with a persistent and relapsing inflammatory condition. It was recently reported that an imbalance between bacterial and fungal species colonizing the scalp of French volunteers was associated with Dandruff condition. The purpose of the present study was to analyze the major bacterial and fungal species present on the scalp surface of Chinese volunteers and to investigate possible region-related variation in the microbiota linked to Dandruff condition. The data obtained from the Chinese populations were highly similar to those obtained in France, confirming that Dandruff scalps are associated with a higher incidence of Malassezia restricta and Staphylococcal sp. The ratios of Malassezia to Propionibacterium and Propionibacterium to Staphylococcus were also significantly higher in the Dandruff volunteers as compared to normal volunteers, suggesting that equilibrium between the major bacterial and fungal taxa found on the normal scalps is perturbed in the Dandruff scalps. The main difference between the French and Shanghai subjects was in their Staphylococcal biota. The results obtained in China and in France suggest that targeting one particular Malassezia sp. by antifungals instead of using large spectrum antifungals and rebalancing the Dandruff scalp microbiota could be common approach to improve Dandruff condition in the two countries.

  • Dandruff is associated with disequilibrium in the proportion of the major bacterial and fungal populations colonizing the scalp
    PLOS ONE, 2013
    Co-Authors: Cecile Clavaud, Roland Jourdain, Florence Pouradier, Avner Barhen, Magali Tichit, Christiane Bouchier, Charles El Rawadi, Jacques Guillot, Florence Menardszczebara, Lionel Breton
    Abstract:

    The bacterial and fungal communities associated with Dandruff were investigated using culture-independent methodologies in the French subjects. The major bacterial and fungal species inhabiting the scalp subject’s were identified by cloning and sequencing of the conserved ribosomal unit regions (16S for bacterial and 28S-ITS for fungal) and were further quantified by quantitative PCR. The two main bacterial species found on the scalp surface were Propionibacterium acnes and Staphylococcus epidermidis, while Malassezia restricta was the main fungal inhabitant. Dandruff was correlated with a higher incidence of M. restricta and S. epidermidis and a lower incidence of P. acnes compared to the control population (p<0.05). These results suggested for the first time using molecular methods, that Dandruff is linked to the balance between bacteria and fungi of the host scalp surface.

Shiladitya Sengupta - One of the best experts on this subject based on the ideXlab platform.

  • Evaluation of therapeutic potential of VB-001, a leave-on formulation, for the treatment of moderate adherent Dandruff
    BMC Dermatology, 2017
    Co-Authors: Anamika Bhattacharyya, Nilu Jain, Sudhanand Prasad, Shilpi Jain, Vishal Yadav, Shamik Ghosh, Shiladitya Sengupta
    Abstract:

    Background Dandruff is a common scalp condition characterized by excessive scaling and itch. Aberrant colonization of the scalp by commensal Malassezia spp. is a major contributor in the multifactorial etiology of Dandruff. Literature based understanding of Malassezia linked pathophysiology of Dandruff allowed us to comprehend a strategy to potentiate the efficacy of a known antifungal agent used in Dandruff therapy. The aim of this study was to determine the efficacy and skin safety of VB-001 antiDandruff leave-on formulation in comparison with marketed antiDandruff ZPTO shampoo in patients with moderate adherent Dandruff of the scalp. Methods Healthy males or females aged ≥ 15 years and ≤ 65 with a clinical diagnosis of moderate adherent Dandruff of the scalp were recruited for the study to monitor the effects of topical VB-001 versus those of marketed antiDandruff ZPTO shampoo. Results 168 subjects were randomized to the treatment (VB-001, n  = 84) and control (ZPTO shampoo, n  = 84) groups. The efficacy of each product was evaluated by comparing proportion of subjects who have shown reduction in flaking by ASFS (adherent scalp flaking score) and pruritus by IGA (investigator global assessment) score. VB-001 imparted consistently better reduction in ASFS and enabled early reduction of pruritus in comparison to marketed ZPTO shampoo. Conclusion VB-001, a leave-on formulation with ingredients chosen to selectively disturb the Malassezia niche on Dandruff scalp by denying extra nutritional benefits to the microbe, provides unique advantages over existing best in class ZPTO shampoo therapy. It has the potential to emerge as an attractive novel treatment for moderate adherent Dandruff. Trial registration CTRI Registration number: CTRI/2013/01/003283 . Registered on: 02/01/2013

  • Evaluation of therapeutic potential of VB-001, a leave-on formulation, for the treatment of moderate adherent Dandruff
    BMC Dermatology, 2017
    Co-Authors: Anamika Bhattacharyya, Nilu Jain, Sudhanand Prasad, Shilpi Jain, Vishal Yadav, Shamik Ghosh, Shiladitya Sengupta
    Abstract:

    Dandruff is a common scalp condition characterized by excessive scaling and itch. Aberrant colonization of the scalp by commensal Malassezia spp. is a major contributor in the multifactorial etiology of Dandruff. Literature based understanding of Malassezia linked pathophysiology of Dandruff allowed us to comprehend a strategy to potentiate the efficacy of a known antifungal agent used in Dandruff therapy. The aim of this study was to determine the efficacy and skin safety of VB-001 antiDandruff leave-on formulation in comparison with marketed antiDandruff ZPTO shampoo in patients with moderate adherent Dandruff of the scalp. Healthy males or females aged ≥ 15 years and ≤ 65 with a clinical diagnosis of moderate adherent Dandruff of the scalp were recruited for the study to monitor the effects of topical VB-001 versus those of marketed antiDandruff ZPTO shampoo. 168 subjects were randomized to the treatment (VB-001, n = 84) and control (ZPTO shampoo, n = 84) groups. The efficacy of each product was evaluated by comparing proportion of subjects who have shown reduction in flaking by ASFS (adherent scalp flaking score) and pruritus by IGA (investigator global assessment) score. VB-001 imparted consistently better reduction in ASFS and enabled early reduction of pruritus in comparison to marketed ZPTO shampoo. VB-001, a leave-on formulation with ingredients chosen to selectively disturb the Malassezia niche on Dandruff scalp by denying extra nutritional benefits to the microbe, provides unique advantages over existing best in class ZPTO shampoo therapy. It has the potential to emerge as an attractive novel treatment for moderate adherent Dandruff. CTRI Registration number: CTRI/2013/01/003283 . Registered on: 02/01/2013

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