The Experts below are selected from a list of 567 Experts worldwide ranked by ideXlab platform
Lixiong Zhang - One of the best experts on this subject based on the ideXlab platform.
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Economical Process for Preparation of the 19-nor A Ring of Paricalcitol from (−)-Shikimic Acid
Organic Process Research & Development, 2019Co-Authors: Shengfeng Zhou, Runyu Zhu, Lixiong ZhangAbstract:An economical and efficient means of preparing the 19-nor A ring, a key precursor of the vitamin D receptor (VDR) activator Paricalcitol, is here described. This process begins with commercially available (−)-shikimic acid and was easily scaled up to kilograms in a total yield over 17.8%. Davis Oxidation was applied for the synthesis of the key precursor, α-hydroxyl carboxylic ester.
Shengfeng Zhou - One of the best experts on this subject based on the ideXlab platform.
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Economical Process for Preparation of the 19-nor A Ring of Paricalcitol from (−)-Shikimic Acid
Organic Process Research & Development, 2019Co-Authors: Shengfeng Zhou, Runyu Zhu, Lixiong ZhangAbstract:An economical and efficient means of preparing the 19-nor A ring, a key precursor of the vitamin D receptor (VDR) activator Paricalcitol, is here described. This process begins with commercially available (−)-shikimic acid and was easily scaled up to kilograms in a total yield over 17.8%. Davis Oxidation was applied for the synthesis of the key precursor, α-hydroxyl carboxylic ester.
Runyu Zhu - One of the best experts on this subject based on the ideXlab platform.
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Economical Process for Preparation of the 19-nor A Ring of Paricalcitol from (−)-Shikimic Acid
Organic Process Research & Development, 2019Co-Authors: Shengfeng Zhou, Runyu Zhu, Lixiong ZhangAbstract:An economical and efficient means of preparing the 19-nor A ring, a key precursor of the vitamin D receptor (VDR) activator Paricalcitol, is here described. This process begins with commercially available (−)-shikimic acid and was easily scaled up to kilograms in a total yield over 17.8%. Davis Oxidation was applied for the synthesis of the key precursor, α-hydroxyl carboxylic ester.
Liang Huang - One of the best experts on this subject based on the ideXlab platform.
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Novel Concise Synthesis of (−)-Clausenamide
Chinese Journal of Chemistry, 2013Co-Authors: Di Liu, Liang HuangAbstract:A six-step synthesis of (−)-clausenamide is described. Optically pure (R,E)-1,3-diphenylallylic alcohol was acetylated and then subjected to an Ireland-Claisen rearrangement, giving the γ,δ-unsaturated acid, which underwent a substrate-induced stereoselective bromolactonization to afford the expected all-equatorial substituted bromo-δ-lactone. An unusual chemo-selective aminolysis of the lactone resulted in the formation of a γ,δ-epoxy-amide in stereospecific manner. Base-promoted cyclization of this intermediate and the subsequent Davis Oxidation furnished the synthesis, delivering the final product in >99% ee and up to 34% overall yield.
Di Liu - One of the best experts on this subject based on the ideXlab platform.
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Novel Concise Synthesis of (−)-Clausenamide
Chinese Journal of Chemistry, 2013Co-Authors: Di Liu, Liang HuangAbstract:A six-step synthesis of (−)-clausenamide is described. Optically pure (R,E)-1,3-diphenylallylic alcohol was acetylated and then subjected to an Ireland-Claisen rearrangement, giving the γ,δ-unsaturated acid, which underwent a substrate-induced stereoselective bromolactonization to afford the expected all-equatorial substituted bromo-δ-lactone. An unusual chemo-selective aminolysis of the lactone resulted in the formation of a γ,δ-epoxy-amide in stereospecific manner. Base-promoted cyclization of this intermediate and the subsequent Davis Oxidation furnished the synthesis, delivering the final product in >99% ee and up to 34% overall yield.
