The Experts below are selected from a list of 4515 Experts worldwide ranked by ideXlab platform
Peter Vandenabeele - One of the best experts on this subject based on the ideXlab platform.
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Initiation and execution mechanisms of necroptosis: an overview
Cell Death & Differentiation, 2017Co-Authors: Sasker Grootjans, Tom Vanden Berghe, Peter VandenabeeleAbstract:Necroptosis is a form of regulated cell Death, which is induced by ligand binding to TNF family Death Domain Receptors, pattern recognizing Receptors and virus sensors. The common feature of these receptor systems is the implication of proteins, which contain a receptor interaction protein kinase (RIPK) homology interaction motif (RHIM) mediating recruitment and activation of receptor-interacting protein kinase 3 (RIPK3), which ultimately activates the necroptosis executioner mixed lineage kinase Domain-like (MLKL). In case of the TNF family members, the initiator is the survival- and cell Death-regulating RIPK1 kinase, in the case of Toll-like receptor 3/4 (TLR3/4), a RHIM-containing adaptor, called TRIF, while in the case of Z-DNA-binding protein ZBP1/DAI, the cytosolic viral sensor itself contains a RHIM Domain. In this review, we discuss the different protein complexes that serve as nucleation platforms for necroptosis and the mechanism of execution of necroptosis. Transgenic models (knockout, kinase-dead knock-in) and pharmacologic inhibition indicate that RIPK1, RIPK3 or MLKL are implicated in many inflammatory, degenerative and infectious diseases. However, the conclusion of necroptosis being solely involved in the etiology of diseases is blurred by the pleiotropic roles of RIPK1 and RIPK3 in other cellular processes such as apoptosis and inflammasome activation.
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apoptotic and necrotic cell Death induced by Death Domain Receptors
Cellular and Molecular Life Sciences, 2001Co-Authors: Geertrui Denecker, Wim Declercq, Dominique Vercammen, Peter VandenabeeleAbstract:Apoptosis and necrosis are two distinct forms of cell Death. Caspases are indispensable as initiators and effectors of apoptotic cell Death and are involved in many of the morphological and biochemical features of apoptosis. Major changes in mitochondrial membrane integrity and release of proapoptotic factors, such as cytochrome c from the mitochondrial intermembrane space, play an important sensor and amplifying role during apoptotic cell Death. In vitro studies of cell Death in cell lines have revealed that inhibition of the classical caspase-dependent apoptotic pathway leads in several cases to necrotic cell Death. Thus, the same cell Death stimulus can result either in apoptotic or necrotic cell Death, depending on the availability of activated caspase. Therefore, Death Domain Receptors may initiate an active caspase-independent necrotic signaling pathway. In this review, we describe what is known about the apoptotic and necrotic cell Death pathways. Principal elements of necrosis include mitochondrial oxidative phosphorylation, reactive oxygen production, and non-caspase proteolytic cascades depending on serine proteases, calpains, or cathepsins.
Geertrui Denecker - One of the best experts on this subject based on the ideXlab platform.
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apoptotic and necrotic cell Death induced by Death Domain Receptors
Cellular and Molecular Life Sciences, 2001Co-Authors: Geertrui Denecker, Wim Declercq, Dominique Vercammen, Peter VandenabeeleAbstract:Apoptosis and necrosis are two distinct forms of cell Death. Caspases are indispensable as initiators and effectors of apoptotic cell Death and are involved in many of the morphological and biochemical features of apoptosis. Major changes in mitochondrial membrane integrity and release of proapoptotic factors, such as cytochrome c from the mitochondrial intermembrane space, play an important sensor and amplifying role during apoptotic cell Death. In vitro studies of cell Death in cell lines have revealed that inhibition of the classical caspase-dependent apoptotic pathway leads in several cases to necrotic cell Death. Thus, the same cell Death stimulus can result either in apoptotic or necrotic cell Death, depending on the availability of activated caspase. Therefore, Death Domain Receptors may initiate an active caspase-independent necrotic signaling pathway. In this review, we describe what is known about the apoptotic and necrotic cell Death pathways. Principal elements of necrosis include mitochondrial oxidative phosphorylation, reactive oxygen production, and non-caspase proteolytic cascades depending on serine proteases, calpains, or cathepsins.
Dominique Vercammen - One of the best experts on this subject based on the ideXlab platform.
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apoptotic and necrotic cell Death induced by Death Domain Receptors
Cellular and Molecular Life Sciences, 2001Co-Authors: Geertrui Denecker, Wim Declercq, Dominique Vercammen, Peter VandenabeeleAbstract:Apoptosis and necrosis are two distinct forms of cell Death. Caspases are indispensable as initiators and effectors of apoptotic cell Death and are involved in many of the morphological and biochemical features of apoptosis. Major changes in mitochondrial membrane integrity and release of proapoptotic factors, such as cytochrome c from the mitochondrial intermembrane space, play an important sensor and amplifying role during apoptotic cell Death. In vitro studies of cell Death in cell lines have revealed that inhibition of the classical caspase-dependent apoptotic pathway leads in several cases to necrotic cell Death. Thus, the same cell Death stimulus can result either in apoptotic or necrotic cell Death, depending on the availability of activated caspase. Therefore, Death Domain Receptors may initiate an active caspase-independent necrotic signaling pathway. In this review, we describe what is known about the apoptotic and necrotic cell Death pathways. Principal elements of necrosis include mitochondrial oxidative phosphorylation, reactive oxygen production, and non-caspase proteolytic cascades depending on serine proteases, calpains, or cathepsins.
Wim Declercq - One of the best experts on this subject based on the ideXlab platform.
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apoptotic and necrotic cell Death induced by Death Domain Receptors
Cellular and Molecular Life Sciences, 2001Co-Authors: Geertrui Denecker, Wim Declercq, Dominique Vercammen, Peter VandenabeeleAbstract:Apoptosis and necrosis are two distinct forms of cell Death. Caspases are indispensable as initiators and effectors of apoptotic cell Death and are involved in many of the morphological and biochemical features of apoptosis. Major changes in mitochondrial membrane integrity and release of proapoptotic factors, such as cytochrome c from the mitochondrial intermembrane space, play an important sensor and amplifying role during apoptotic cell Death. In vitro studies of cell Death in cell lines have revealed that inhibition of the classical caspase-dependent apoptotic pathway leads in several cases to necrotic cell Death. Thus, the same cell Death stimulus can result either in apoptotic or necrotic cell Death, depending on the availability of activated caspase. Therefore, Death Domain Receptors may initiate an active caspase-independent necrotic signaling pathway. In this review, we describe what is known about the apoptotic and necrotic cell Death pathways. Principal elements of necrosis include mitochondrial oxidative phosphorylation, reactive oxygen production, and non-caspase proteolytic cascades depending on serine proteases, calpains, or cathepsins.
Leroy Hood - One of the best experts on this subject based on the ideXlab platform.
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mrit a novel Death effector Domain containing protein interacts with caspases and bclxl and initiates cell Death
Proceedings of the National Academy of Sciences of the United States of America, 1997Co-Authors: Preet M Chaudhary, Rodney T Riedel, Dale Baskin, Cynthia Friedman, Barbara J Trask, Stephen M Schwartz, Michael E Wright, Leroy HoodAbstract:Activation of the cascade of proteolytic caspases has been identified as the final common pathway of apoptosis in diverse biological systems. We have isolated a gene, termed MRIT, that possesses overall sequence homology to FLICE (MACH), a large proDomain caspase that links the aggregated complex of the Death Domain Receptors of the tumor necrosis factor receptor family to downstream caspases. However, unlike FLICE, the C-terminal Domain of MRIT lacks the caspase catalytic consensus sequence QAC(R/Q)G. Nonetheless MRIT activates caspase-dependent Death. Using yeast two-hybrid assays, we demonstrate that MRIT associates with caspases possessing large and small proDomains (FLICE, and CPP32/YAMA), as well as with the adaptor molecule FADD. In addition, MRIT simultaneously and independently interacts with BclXL and FLICE in mammalian cells. Thus, MRIT is a mammalian protein that interacts simultaneously with both caspases and a Bcl-2 family member.
